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The map label for this gene is pgsA1 [H]

Identifier: 78222042

GI number: 78222042

Start: 907831

End: 908427

Strand: Direct

Name: pgsA1 [H]

Synonym: Gmet_0822

Alternate gene names: 78222042

Gene position: 907831-908427 (Clockwise)

Preceding gene: 78222038

Following gene: 78222043

Centisome position: 22.71

GC content: 59.97

Gene sequence:

>597_bases
ATGGGCACTGTATCAGTCAATGAATCCGAAGGCCGAGGCGCCGCCACTGTGAACGGCATTGTGACCATACCCAACGCGTT
GACGGCGCTCCGGATAGTCCTGGTTCCCGCTCTCATCACGTTTCTTCTGGACGGAAACTTCCGGGCGGCCCTGACGGTTT
TCCTCGTGGCAGGCGTGAGCGATGCCCTCGACGGTTTCATCGCCCGGCGCTTCAACCAGCAAAGCCGCCTCGGTTCGTTC
CTCGATCCGCTGGCCGACAAGCTCCTGGTGGTTACCTCATCCCTTGTTCTTGCGGCCATCGGGCGGCTGCCATGGTGGCT
CGCTCTGGTCATTGTCGGCCGTGACCTGGTAATCGTTGCCGGTGCAATCGCCTATTACGGCCGCACGGGAACCCTGGAGA
TGGATCCCAGCATTGCCAGCAAGGCCAATACCTTTGTGCAGATATCCCTGATCCTGACGGTGCTCGCCCATGGGGCGGGG
ATGGAATTCCTTGGAGTTGTGCTGAAGCCCCTCTTTGTTCTTGCGCTCGCGATGACACTGGTTTCGGGGGGAGACTACAT
GGTGGTGTGGGGACGCCGGGCTTTCAGGAAAAACTGA

Upstream 100 bases:

>100_bases
ATAAATAAGGGCGCGAAGTGGCGAGAGTAGACGGATGATGTTTCTTTGGGTATCATAAGAACAACGTTTTAAGGTCTGAA
AGTGTAACAAAATACCATCA

Downstream 100 bases:

>100_bases
GCGATTGGGGAGAACAGCCAGCCGTGAGTAGTATTGACATGATTCCTCCTCAGGTGGTATTAGAGCTGATTCGCTAATGA
GCGGCGGTTATGGGGTGCCG

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MGTVSVNESEGRGAATVNGIVTIPNALTALRIVLVPALITFLLDGNFRAALTVFLVAGVSDALDGFIARRFNQQSRLGSF
LDPLADKLLVVTSSLVLAAIGRLPWWLALVIVGRDLVIVAGAIAYYGRTGTLEMDPSIASKANTFVQISLILTVLAHGAG
MEFLGVVLKPLFVLALAMTLVSGGDYMVVWGRRAFRKN

Sequences:

>Translated_198_residues
MGTVSVNESEGRGAATVNGIVTIPNALTALRIVLVPALITFLLDGNFRAALTVFLVAGVSDALDGFIARRFNQQSRLGSF
LDPLADKLLVVTSSLVLAAIGRLPWWLALVIVGRDLVIVAGAIAYYGRTGTLEMDPSIASKANTFVQISLILTVLAHGAG
MEFLGVVLKPLFVLALAMTLVSGGDYMVVWGRRAFRKN
>Mature_197_residues
GTVSVNESEGRGAATVNGIVTIPNALTALRIVLVPALITFLLDGNFRAALTVFLVAGVSDALDGFIARRFNQQSRLGSFL
DPLADKLLVVTSSLVLAAIGRLPWWLALVIVGRDLVIVAGAIAYYGRTGTLEMDPSIASKANTFVQISLILTVLAHGAGM
EFLGVVLKPLFVLALAMTLVSGGDYMVVWGRRAFRKN

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=188, Percent_Identity=35.1063829787234, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI10092647, Length=151, Percent_Identity=39.0728476821192, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1788220, Length=175, Percent_Identity=34.8571428571429, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71984834, Length=160, Percent_Identity=36.25, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71984838, Length=160, Percent_Identity=36.25, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320059, Length=154, Percent_Identity=33.1168831168831, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24650130, Length=150, Percent_Identity=36.6666666666667, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24650126, Length=150, Percent_Identity=36.6666666666667, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24650128, Length=150, Percent_Identity=36.6666666666667, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 21014; Mature: 20883

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTVSVNESEGRGAATVNGIVTIPNALTALRIVLVPALITFLLDGNFRAALTVFLVAGVS
CCCCCCCCCCCCCCEEECCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DALDGFIARRFNQQSRLGSFLDPLADKLLVVTSSLVLAAIGRLPWWLALVIVGRDLVIVA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
GAIAYYGRTGTLEMDPSIASKANTFVQISLILTVLAHGAGMEFLGVVLKPLFVLALAMTL
HHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VSGGDYMVVWGRRAFRKN
HCCCCEEEEECCHHHCCC
>Mature Secondary Structure 
GTVSVNESEGRGAATVNGIVTIPNALTALRIVLVPALITFLLDGNFRAALTVFLVAGVS
CCCCCCCCCCCCCEEECCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DALDGFIARRFNQQSRLGSFLDPLADKLLVVTSSLVLAAIGRLPWWLALVIVGRDLVIVA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
GAIAYYGRTGTLEMDPSIASKANTFVQISLILTVLAHGAGMEFLGVVLKPLFVLALAMTL
HHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VSGGDYMVVWGRRAFRKN
HCCCCEEEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]