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The map label for this gene is 78221969

Identifier: 78221969

GI number: 78221969

Start: 822514

End: 824277

Strand: Reverse

Name: 78221969

Synonym: Gmet_0749

Alternate gene names: NA

Gene position: 824277-822514 (Counterclockwise)

Preceding gene: 78221970

Following gene: 78221962

Centisome position: 20.62

GC content: 62.41

Gene sequence:

>1764_bases
ATGCGCTGCACGAAACGAGTTTGTGGAAAGATCACCCTTCACCTTGGCACCCTCGGCATCCTCTGCCTGGCAGCGGGAAT
GGCCGGTGCCGCACCCCCTCCCCAGAAGTTCGTAACCGATGAGCTCCTTGTCCAGTTCAAGGCTGGCGTCCACAAGGCCA
ATGCCGACACCGTCCTCAAGGGAGCCGGCGCCCGGGAAGCCGAGGAAATCGCTCCGATCCGGGTAAAGAGGATCAAGGTC
CCTGCTGCTGCCCGGGCAAAGGTCAAGGCTGCTCTGGCCAAGAATCCCCACGTAACGTTCGTCGAAGAGAATTACCTGGC
TGAGCAGACAATGGTTCCCAACGATCCCTCCTACGCCTCCCAGTGGCATCTCCCCAAGATTGCCGCTCCGGCGGGATGGG
ACATCTCCACCGGCTCCAGTTCCGTTGACATCGCCATCCTGGACTCGGGCGTCGATCCATCTCACCCGGACCTGGCCGGC
AAGCTTCTCCCCGGTTTCAACTTTGTCTTCAACAACACCGATACCCACGATGTGACCGGGCACGGGACAAAGGTCGCAGG
CTCGGCCGGGGCCATGGGTAATAACGGCGCCGGGGTTGCCGGCGTGGCGTGGCAGAACCAGATCATGCCCCTGGTGATCG
CGGATTCCACCGGCTACGCTACCTACTCGCGCATGGCCAGTGCCATCACCTACGCCGCCGATCATGGGGTCCGCATCATC
AATCTCAGCTACGGCGGCTCCACCAGTTCCTCGACTCTCCAGAATGCCGTGAACTACGCCTGGAACAAAGGAGCCATTGT
CTTTGCCTCGGCAGCCAACTACAACACGAGCACCCCCTACTATCCGGCCGCCTGCACCAACGCCGTGTCGGTGGCGGCCA
CCGACGCCAACGACGCCAAGGCGAGCTTTTCCAACTACGGCTCCACCATCGATATCGCGGCCCCCGGCGTCTCCATCCTC
ACCACCGCCAACGGCGGCGGCTATGCGAGCGTGAGCGGCACCTCCTTCTCCTCTCCCATCGCGGCGGGGCTCGGCGCGCT
GATCCTCTCCGTTAACCCGACCCTGACCAATGCCCAGGTGGTGGACATCATCACCAAAAATGCCGACGACATCGGCACCC
CCGGCTTCGATCAGTACTTCGGCTACGGCCGGATCAACGTCCTCAAGAGCCTCACGGCTGCCCAGAATGCAGTGCCGGTC
GGCGACACAACTGCCCCGACCGCATCGATCACCTCCCCCGCGAGTTCCAGTATCGTGAAAGGAAACGCGTCGGTGGCGGT
GGCGGCTTCTGACAACGTCGGCGTGGCCAAGGTGGAGCTCCGCATCAACGGCGCCCCCTTCGCCACGGCAACCACCGCGC
CCTACGCCTTCTCGTGGGACACCACCACCACGGCGGACGGCTCCTACACCCTGGAGGCCGTGGCCTTCGACGGCGCGGGA
AACATGGGGCAATCAAGCGCTGTTTCGGTCAAGGTTTCAAACACTCCCGACACCATCGCCCCGACCGTCGCCATCACCTC
CCCGGCCAACGGCGCAAAGGTCGGGACCAGTGCAACGATCACCATCACCGCCGGCGACAATGTGGGGGTAAGCCGCATCG
AGCTCTACATTGACGGCAAGCTGGCAACCAGCAAAACAGGCGTCACCAGCCTGTCTTACAGCTGGAATACGCGAAAAATC
GCTACCGGTGCCCACACCATACTGTCCAAAGCCTTCGATGCCGCCGGCAACACCACAACCACTTCCATAACGGTTTACAA
GTAA

Upstream 100 bases:

>100_bases
GGTCAGGATAGCCGGGTTGTCGAAGAGCAACGCCCGCCTTCCATAGGTACGGGGGTCTGTTTCTGAGGTAGGAAGCAAAC
TCAACCCATGGAGGTGGCGC

Downstream 100 bases:

>100_bases
CGCCGCTTCGACCACTATTCAGAACAAAGGGGACAGCCAATTGACTGTCCCCTTTCTCATTTCATCCCCAGGCGCACGAA
GGGGAGACAGCGCGTGCCGT

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKANADTVLKGAGAREAEEIAPIRVKRIKV
PAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYASQWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAG
KLLPGFNFVFNNTDTHDVTGHGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAKASFSNYGSTIDIAAPGVSIL
TTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQVVDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPV
GDTTAPTASITSPASSSIVKGNASVAVAASDNVGVAKVELRINGAPFATATTAPYAFSWDTTTTADGSYTLEAVAFDGAG
NMGQSSAVSVKVSNTPDTIAPTVAITSPANGAKVGTSATITITAGDNVGVSRIELYIDGKLATSKTGVTSLSYSWNTRKI
ATGAHTILSKAFDAAGNTTTTSITVYK

Sequences:

>Translated_587_residues
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKANADTVLKGAGAREAEEIAPIRVKRIKV
PAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYASQWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAG
KLLPGFNFVFNNTDTHDVTGHGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAKASFSNYGSTIDIAAPGVSIL
TTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQVVDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPV
GDTTAPTASITSPASSSIVKGNASVAVAASDNVGVAKVELRINGAPFATATTAPYAFSWDTTTTADGSYTLEAVAFDGAG
NMGQSSAVSVKVSNTPDTIAPTVAITSPANGAKVGTSATITITAGDNVGVSRIELYIDGKLATSKTGVTSLSYSWNTRKI
ATGAHTILSKAFDAAGNTTTTSITVYK
>Mature_587_residues
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKANADTVLKGAGAREAEEIAPIRVKRIKV
PAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYASQWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAG
KLLPGFNFVFNNTDTHDVTGHGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAKASFSNYGSTIDIAAPGVSIL
TTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQVVDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPV
GDTTAPTASITSPASSSIVKGNASVAVAASDNVGVAKVELRINGAPFATATTAPYAFSWDTTTTADGSYTLEAVAFDGAG
NMGQSSAVSVKVSNTPDTIAPTVAITSPANGAKVGTSATITITAGDNVGVSRIELYIDGKLATSKTGVTSLSYSWNTRKI
ATGAHTILSKAFDAAGNTTTTSITVYK

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4505579, Length=389, Percent_Identity=23.1362467866324, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI76443679, Length=365, Percent_Identity=24.1095890410959, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI31317307, Length=301, Percent_Identity=25.2491694352159, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988312, Length=372, Percent_Identity=25, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71988308, Length=372, Percent_Identity=25, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71988315, Length=372, Percent_Identity=25, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988301, Length=373, Percent_Identity=25.4691689008043, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988321, Length=372, Percent_Identity=25, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988297, Length=372, Percent_Identity=25, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983555, Length=328, Percent_Identity=25.609756097561, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=286, Percent_Identity=29.7202797202797, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324576, Length=293, Percent_Identity=27.9863481228669, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319893, Length=314, Percent_Identity=27.0700636942675, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 59750; Mature: 59750

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKANADTVLK
CCCHHHHHCEEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEE
GAGAREAEEIAPIRVKRIKVPAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYAS
CCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCHHCCCCCCCCCCCC
QWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAGKLLPGFNFVFNNTDTHDVTG
CCCCCEECCCCCCEECCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCCCC
HGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
CCCEECCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEE
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAK
EEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEEECCCCCH
ASFSNYGSTIDIAAPGVSILTTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQV
HHHHHCCCEEEEECCCEEEEEECCCCCEEEECCCCCCCHHHHCCEEEEEEECCCCCCCEE
VDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPVGDTTAPTASITSPASSSIVK
EEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE
GNASVAVAASDNVGVAKVELRINGAPFATATTAPYAFSWDTTTTADGSYTLEAVAFDGAG
CCCCEEEEECCCCCEEEEEEEECCCCCEEECCCCEEEECCCCEECCCCEEEEEEEECCCC
NMGQSSAVSVKVSNTPDTIAPTVAITSPANGAKVGTSATITITAGDNVGVSRIELYIDGK
CCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCEEEEEEECCE
LATSKTGVTSLSYSWNTRKIATGAHTILSKAFDAAGNTTTTSITVYK
EEECCCCCEEEEECCCCEEEECHHHHHHHHHHHCCCCCEEEEEEEEC
>Mature Secondary Structure
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKANADTVLK
CCCHHHHHCEEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEE
GAGAREAEEIAPIRVKRIKVPAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYAS
CCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCHHCCCCCCCCCCCC
QWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAGKLLPGFNFVFNNTDTHDVTG
CCCCCEECCCCCCEECCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCCCC
HGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
CCCEECCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEE
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAK
EEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEEECCCCCH
ASFSNYGSTIDIAAPGVSILTTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQV
HHHHHCCCEEEEECCCEEEEEECCCCCEEEECCCCCCCHHHHCCEEEEEEECCCCCCCEE
VDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPVGDTTAPTASITSPASSSIVK
EEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE
GNASVAVAASDNVGVAKVELRINGAPFATATTAPYAFSWDTTTTADGSYTLEAVAFDGAG
CCCCEEEEECCCCCEEEEEEEECCCCCEEECCCCEEEECCCCEECCCCEEEEEEEECCCC
NMGQSSAVSVKVSNTPDTIAPTVAITSPANGAKVGTSATITITAGDNVGVSRIELYIDGK
CCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCEEEEEEECCE
LATSKTGVTSLSYSWNTRKIATGAHTILSKAFDAAGNTTTTSITVYK
EEECCCCCEEEEECCCCEEEECHHHHHHHHHHHCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]