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The map label for this gene is map [H]

Identifier: 78221868

GI number: 78221868

Start: 710999

End: 711709

Strand: Direct

Name: map [H]

Synonym: Gmet_0648

Alternate gene names: 78221868

Gene position: 710999-711709 (Clockwise)

Preceding gene: 78221867

Following gene: 78221869

Centisome position: 17.79

GC content: 52.18

Gene sequence:

>711_bases
ATGCGCTCCGCTGGACAGATCGTGGCGGAGATTCTCGATATTTTGAGGTCTGAGGTACGGGCCGGCGTTACCACTTTGTT
TCTTGACGGACTTGCAGAGTCAGAAGCGCGGAAGCGTAAGGCGGTGGCTGCATTCAAGGGGTATGGGGGGTTCCCTTATG
CTCTTTGCTGCTCTCTTAATGAGCAGGTTGTTCATGGCATGCCAAGTAAGCGTGAATTAGTCGAGGGGGACATAGTCAGC
CTCGATTTCGGTGTTGTTTACAGCGGATATTACGCTGATGCCGCTATAACAGTGCCTGTTTCGAAGGTTACTGCCCAAGC
GGAGCGTCTTGTCAAGGTGACTGAAGAGTCTCTCTATTGTGCAATTGAGGCGGCAGTTCCCGGCAATAGGCTGTCAGATA
TTTCGCATGCAGTTCAGGGCTATGTGGAACGCCACGGATTTTCAGTCGTTAGGGATTTCGTGGGGCACGGGATCGGAAAG
AAGCTTCACGAAAGTCCGCAGGTTCCGAATTTTGGCGAGCCTGGCCGGGGAGTCAGGTTGAAACCAGGAATGGTTCTCGC
CATTGAGCCTATGATCAATGAGCGGAGCTATCAGGTGAAGGTGTTGGCTGATGGCTGGACGGCCGTCACATGTGATGGTG
GCCTGTCAGCTCATTTTGAACATACTGTTGCTATAACGGAGCATGGTCCGGAAATACTCAGTAAACTCTAG

Upstream 100 bases:

>100_bases
GATGCTCTTGGCTCAATAGAATCCGTTTCTCAATCAATTCAGAACATAGTGGCGAGTAGGTAGGGTGATTGTTCTAAAGT
CACCCCAGGAAATTGAAAAA

Downstream 100 bases:

>100_bases
TCGCATTCGAGGCATCGAAAGGATAAACGATGAAAGTAAGGGCATCAGTAAAAAAAATTTGTGACAAATGCAAGATAATC
AAGCGCAAGGGAATTGTTCG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MRSAGQIVAEILDILRSEVRAGVTTLFLDGLAESEARKRKAVAAFKGYGGFPYALCCSLNEQVVHGMPSKRELVEGDIVS
LDFGVVYSGYYADAAITVPVSKVTAQAERLVKVTEESLYCAIEAAVPGNRLSDISHAVQGYVERHGFSVVRDFVGHGIGK
KLHESPQVPNFGEPGRGVRLKPGMVLAIEPMINERSYQVKVLADGWTAVTCDGGLSAHFEHTVAITEHGPEILSKL

Sequences:

>Translated_236_residues
MRSAGQIVAEILDILRSEVRAGVTTLFLDGLAESEARKRKAVAAFKGYGGFPYALCCSLNEQVVHGMPSKRELVEGDIVS
LDFGVVYSGYYADAAITVPVSKVTAQAERLVKVTEESLYCAIEAAVPGNRLSDISHAVQGYVERHGFSVVRDFVGHGIGK
KLHESPQVPNFGEPGRGVRLKPGMVLAIEPMINERSYQVKVLADGWTAVTCDGGLSAHFEHTVAITEHGPEILSKL
>Mature_236_residues
MRSAGQIVAEILDILRSEVRAGVTTLFLDGLAESEARKRKAVAAFKGYGGFPYALCCSLNEQVVHGMPSKRELVEGDIVS
LDFGVVYSGYYADAAITVPVSKVTAQAERLVKVTEESLYCAIEAAVPGNRLSDISHAVQGYVERHGFSVVRDFVGHGIGK
KLHESPQVPNFGEPGRGVRLKPGMVLAIEPMINERSYQVKVLADGWTAVTCDGGLSAHFEHTVAITEHGPEILSKL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=235, Percent_Identity=39.5744680851064, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI40385867, Length=236, Percent_Identity=36.4406779661017, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1786364, Length=236, Percent_Identity=42.7966101694915, Blast_Score=202, Evalue=1e-53,
Organism=Escherichia coli, GI1788728, Length=137, Percent_Identity=32.1167883211679, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=236, Percent_Identity=36.864406779661, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323273, Length=235, Percent_Identity=40.4255319148936, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21355531, Length=235, Percent_Identity=40, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24583427, Length=237, Percent_Identity=35.4430379746835, Blast_Score=160, Evalue=5e-40,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 25438; Mature: 25438

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSAGQIVAEILDILRSEVRAGVTTLFLDGLAESEARKRKAVAAFKGYGGFPYALCCSLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCC
EQVVHGMPSKRELVEGDIVSLDFGVVYSGYYADAAITVPVSKVTAQAERLVKVTEESLYC
HHHHCCCCCCHHHHCCCEEEEEHHHEEECEECCEEEEEEHHHHHHHHHHHHHHHHCCEEE
AIEAAVPGNRLSDISHAVQGYVERHGFSVVRDFVGHGIGKKLHESPQVPNFGEPGRGVRL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEE
KPGMVLAIEPMINERSYQVKVLADGWTAVTCDGGLSAHFEHTVAITEHGPEILSKL
CCCEEEEEECCCCCCCEEEEEEECCCEEEEECCCCCCCEEEEEEEECCCHHHHHCC
>Mature Secondary Structure
MRSAGQIVAEILDILRSEVRAGVTTLFLDGLAESEARKRKAVAAFKGYGGFPYALCCSLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCC
EQVVHGMPSKRELVEGDIVSLDFGVVYSGYYADAAITVPVSKVTAQAERLVKVTEESLYC
HHHHCCCCCCHHHHCCCEEEEEHHHEEECEECCEEEEEEHHHHHHHHHHHHHHHHCCEEE
AIEAAVPGNRLSDISHAVQGYVERHGFSVVRDFVGHGIGKKLHESPQVPNFGEPGRGVRL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEE
KPGMVLAIEPMINERSYQVKVLADGWTAVTCDGGLSAHFEHTVAITEHGPEILSKL
CCCEEEEEECCCCCCCEEEEEEECCCEEEEECCCCCCCEEEEEEEECCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]