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The map label for this gene is adk

Identifier: 78221867

GI number: 78221867

Start: 710293

End: 710961

Strand: Direct

Name: adk

Synonym: Gmet_0647

Alternate gene names: 78221867

Gene position: 710293-710961 (Clockwise)

Preceding gene: 78221866

Following gene: 78221868

Centisome position: 17.77

GC content: 51.57

Gene sequence:

>669_bases
GTGTCTGGAAATGAAAATGCGATGAATTTGATTTTCCTTGGTCCTCCTGGCGCAGGCAAGGGGACGCAAGCTAACCTTCT
TGTCGGTACGTATGGCATTCCGCAGATTTCTACCGGTGATATCCTGCGGTCAGCCGTTGCGAATCAGACTTCGCTGGGGA
TCACGGCTAAGTCCTATATGGATGCCGGTTCGCTTGTTCCTGATGAAGTTGTCGTGGGTATTGTTAATGAGCGACTTGCG
GCTGACGATTGTGCCGCTGGTTTTATTCTTGACGGATTCCCGCGGACTGTGGCCCAGGCTGATGCGCTGGGTGGCATGTT
GCAGGGGGCTGGGCGGTCGATTGCCCATGTTATATCGTTCGAAGTGGACTATGCGGTGTTGGTTGATCGTCTGACGGGAC
GGCGCATGTGTAGGGCATGTGGTCGTGGTTTCCATGTTCTGTATGATCGGCCATCCGTGGAAGGGCGCTGTGATAGTTGT
GGCGGGGAGCTTTATCAGAGAGATGATGATAAAGTGGAGACAATCCGTCGTCGTCTTGATGTTTATGACGAGCAGACTGT
TCCCCTTAAGTTGTATTATGAGCGTGCATCACTGCTGAGGAAGGTTGATGCTCTTGGCTCAATAGAATCCGTTTCTCAAT
CAATTCAGAACATAGTGGCGAGTAGGTAG

Upstream 100 bases:

>100_bases
TGGGTGTGGGGATGGATACCGCTGCTCAGATTGAGTCCCATTTGATAACCCGGAGTTATGAAGGGTTTATGAAGGGGGTA
AGGGTTAGGGGGAGGAAGTA

Downstream 100 bases:

>100_bases
GGTGATTGTTCTAAAGTCACCCCAGGAAATTGAAAAAATGCGCTCCGCTGGACAGATCGTGGCGGAGATTCTCGATATTT
TGAGGTCTGAGGTACGGGCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSGNENAMNLIFLGPPGAGKGTQANLLVGTYGIPQISTGDILRSAVANQTSLGITAKSYMDAGSLVPDEVVVGIVNERLA
ADDCAAGFILDGFPRTVAQADALGGMLQGAGRSIAHVISFEVDYAVLVDRLTGRRMCRACGRGFHVLYDRPSVEGRCDSC
GGELYQRDDDKVETIRRRLDVYDEQTVPLKLYYERASLLRKVDALGSIESVSQSIQNIVASR

Sequences:

>Translated_222_residues
MSGNENAMNLIFLGPPGAGKGTQANLLVGTYGIPQISTGDILRSAVANQTSLGITAKSYMDAGSLVPDEVVVGIVNERLA
ADDCAAGFILDGFPRTVAQADALGGMLQGAGRSIAHVISFEVDYAVLVDRLTGRRMCRACGRGFHVLYDRPSVEGRCDSC
GGELYQRDDDKVETIRRRLDVYDEQTVPLKLYYERASLLRKVDALGSIESVSQSIQNIVASR
>Mature_221_residues
SGNENAMNLIFLGPPGAGKGTQANLLVGTYGIPQISTGDILRSAVANQTSLGITAKSYMDAGSLVPDEVVVGIVNERLAA
DDCAAGFILDGFPRTVAQADALGGMLQGAGRSIAHVISFEVDYAVLVDRLTGRRMCRACGRGFHVLYDRPSVEGRCDSCG
GELYQRDDDKVETIRRRLDVYDEQTVPLKLYYERASLLRKVDALGSIESVSQSIQNIVASR

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=39.0243902439024, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=39.0243902439024, Blast_Score=154, Evalue=5e-38,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=34.6733668341709, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI310110345, Length=189, Percent_Identity=34.3915343915344, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI53832003, Length=189, Percent_Identity=34.3915343915344, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI8051579, Length=189, Percent_Identity=34.3915343915344, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI53832001, Length=189, Percent_Identity=34.3915343915344, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI4502011, Length=216, Percent_Identity=31.0185185185185, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=28.1081081081081, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI28144897, Length=209, Percent_Identity=29.1866028708134, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144899, Length=209, Percent_Identity=29.1866028708134, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7706497, Length=214, Percent_Identity=25.7009345794392, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=46.5437788018433, Blast_Score=197, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=40.7582938388626, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17567503, Length=204, Percent_Identity=31.8627450980392, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=31.7708333333333, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=213, Percent_Identity=25.8215962441315, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=216, Percent_Identity=26.3888888888889, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=218, Percent_Identity=39.4495412844037, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321018, Length=192, Percent_Identity=36.4583333333333, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322828, Length=219, Percent_Identity=26.4840182648402, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=215, Percent_Identity=40.9302325581395, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI17737899, Length=189, Percent_Identity=38.6243386243386, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24645822, Length=189, Percent_Identity=38.6243386243386, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI221459597, Length=218, Percent_Identity=25.6880733944954, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356893, Length=218, Percent_Identity=25.6880733944954, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24663208, Length=190, Percent_Identity=28.4210526315789, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647141, Length=190, Percent_Identity=28.4210526315789, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23832; Mature: 23701

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNENAMNLIFLGPPGAGKGTQANLLVGTYGIPQISTGDILRSAVANQTSLGITAKSYM
CCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHCCEEHHHHH
DAGSLVPDEVVVGIVNERLAADDCAAGFILDGFPRTVAQADALGGMLQGAGRSIAHVISF
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
EVDYAVLVDRLTGRRMCRACGRGFHVLYDRPSVEGRCDSCGGELYQRDDDKVETIRRRLD
CCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHH
VYDEQTVPLKLYYERASLLRKVDALGSIESVSQSIQNIVASR
HCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGNENAMNLIFLGPPGAGKGTQANLLVGTYGIPQISTGDILRSAVANQTSLGITAKSYM
CCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHCCEEHHHHH
DAGSLVPDEVVVGIVNERLAADDCAAGFILDGFPRTVAQADALGGMLQGAGRSIAHVISF
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
EVDYAVLVDRLTGRRMCRACGRGFHVLYDRPSVEGRCDSCGGELYQRDDDKVETIRRRLD
CCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHH
VYDEQTVPLKLYYERASLLRKVDALGSIESVSQSIQNIVASR
HCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA