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The map label for this gene is dxs [C]

Identifier: 78221773

GI number: 78221773

Start: 589383

End: 590327

Strand: Direct

Name: dxs [C]

Synonym: Gmet_0552

Alternate gene names: 78221773

Gene position: 589383-590327 (Clockwise)

Preceding gene: 78221772

Following gene: 78221774

Centisome position: 14.74

GC content: 64.97

Gene sequence:

>945_bases
ATGAGTACCATGATCGCCACCCGCGACGCCTACGGGCAGACCCTGGCGGAGTTGGGGGAGGAAAACAGCAGCATCGTCGT
CCTGGACGCCGACCTTTCCGGCTCCACCAAAACCTCCACCTTTGCCAAGAAGTTCCCCGAGCGTTTCTTTAACATGGGGA
TCGCCGAGGCCAACATGGTCGGCACAGCTGCCGGCCTTGCCGCCGCCGGGAAGATTCCCTTCGTCTCCACCTTCGCCATC
TTTGCCGTGGGCCGGGCCTGGGAGCAGGTCCGCCAGTCGGCTGCCTATCCCAAGGCAAATGTGAAGATCGTCGCCACCCA
CGGTGGGATCACCGTGGGCGAGGACGGGGGCTCCCATCAGTCGGTGGAGGACATCGCCATCATGCGGGCCGTCCCCAACA
TGACCGTTATCGTGCCGGCAGACGGCCCCGAGACCGCCAAGGCGATCCGGGCCGCCGCCGCGTATAAAGGGCCGGTCTAC
GTGCGGCTTGGCCGCAACAAGGTGCCGACCGTCACCGCGGCCGATGCTCCCTTCGAGATCGGTAAAGGTGTTCAGTTGGC
CGACGGCACGGACCTCACCTTTGTCACCACCGGCCTCATGACCGCCCAGGCCCTGGCCGCCGCCGAGACCCTGAAAGGCG
AGGGGATTTCCGCCCGCGTGGTGCATCTGGCAACCGTAAAACCCCTGGATGGGGATATCCTCCTGAAGGCCGCTCGGGAG
ACCGGCGCCATCGTCACCGCCGAAGAGCACTCCATTGTCGGAGGGCTGGGAGGCGCCGTGGCCGAGTTCCTGGCGGAAAA
CTCCCCCGTTCCCCTGAAGCGGGTGGGGATCAACGACCGCTTCGGCACCTCCGGCAAGGCAGAGGAACTCCTCAAGTACT
TCGGTCTCATGCCGATAGATCTTGTGGAGGCTGCACGGGGGGTTGTCGCCCGAAAGGGGAAGTGA

Upstream 100 bases:

>100_bases
GGGTGCGACGATCCGGCGCAAAATCCGCAGCCCACGGGACATTCAATGGACGCAAATGAATTGCGCCCATACACAACTGA
ACAGAAAGGACATTAACTAT

Downstream 100 bases:

>100_bases
GGTGGCGATGGAGCCCCCCCGCTCCTCCCTGCTGACGTCCTCCTCCGGTTTCACCTACATCGCCGCCCTCATGATCATCG
TCATCATGGGGATCATGCTC

Product: transketolase subunit B

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSTMIATRDAYGQTLAELGEENSSIVVLDADLSGSTKTSTFAKKFPERFFNMGIAEANMVGTAAGLAAAGKIPFVSTFAI
FAVGRAWEQVRQSAAYPKANVKIVATHGGITVGEDGGSHQSVEDIAIMRAVPNMTVIVPADGPETAKAIRAAAAYKGPVY
VRLGRNKVPTVTAADAPFEIGKGVQLADGTDLTFVTTGLMTAQALAAAETLKGEGISARVVHLATVKPLDGDILLKAARE
TGAIVTAEEHSIVGGLGGAVAEFLAENSPVPLKRVGINDRFGTSGKAEELLKYFGLMPIDLVEAARGVVARKGK

Sequences:

>Translated_314_residues
MSTMIATRDAYGQTLAELGEENSSIVVLDADLSGSTKTSTFAKKFPERFFNMGIAEANMVGTAAGLAAAGKIPFVSTFAI
FAVGRAWEQVRQSAAYPKANVKIVATHGGITVGEDGGSHQSVEDIAIMRAVPNMTVIVPADGPETAKAIRAAAAYKGPVY
VRLGRNKVPTVTAADAPFEIGKGVQLADGTDLTFVTTGLMTAQALAAAETLKGEGISARVVHLATVKPLDGDILLKAARE
TGAIVTAEEHSIVGGLGGAVAEFLAENSPVPLKRVGINDRFGTSGKAEELLKYFGLMPIDLVEAARGVVARKGK
>Mature_313_residues
STMIATRDAYGQTLAELGEENSSIVVLDADLSGSTKTSTFAKKFPERFFNMGIAEANMVGTAAGLAAAGKIPFVSTFAIF
AVGRAWEQVRQSAAYPKANVKIVATHGGITVGEDGGSHQSVEDIAIMRAVPNMTVIVPADGPETAKAIRAAAAYKGPVYV
RLGRNKVPTVTAADAPFEIGKGVQLADGTDLTFVTTGLMTAQALAAAETLKGEGISARVVHLATVKPLDGDILLKAARET
GAIVTAEEHSIVGGLGGAVAEFLAENSPVPLKRVGINDRFGTSGKAEELLKYFGLMPIDLVEAARGVVARKGK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=311, Percent_Identity=39.5498392282958, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI4507521, Length=311, Percent_Identity=39.5498392282958, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI225637463, Length=309, Percent_Identity=36.2459546925566, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI225637459, Length=309, Percent_Identity=36.2459546925566, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI225637461, Length=309, Percent_Identity=36.2459546925566, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI133778974, Length=295, Percent_Identity=34.9152542372881, Blast_Score=171, Evalue=5e-43,
Organism=Escherichia coli, GI1786622, Length=289, Percent_Identity=33.2179930795848, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788808, Length=324, Percent_Identity=30.2469135802469, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI48994911, Length=270, Percent_Identity=30.3703703703704, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539652, Length=306, Percent_Identity=37.5816993464052, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6325331, Length=327, Percent_Identity=30.8868501529052, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319593, Length=329, Percent_Identity=29.7872340425532, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551847, Length=313, Percent_Identity=35.7827476038339, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI45550715, Length=313, Percent_Identity=35.7827476038339, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24645119, Length=313, Percent_Identity=35.7827476038339, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24666278, Length=311, Percent_Identity=34.0836012861736, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32541; Mature: 32409

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMIATRDAYGQTLAELGEENSSIVVLDADLSGSTKTSTFAKKFPERFFNMGIAEANMV
CCCEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
GTAAGLAAAGKIPFVSTFAIFAVGRAWEQVRQSAAYPKANVKIVATHGGITVGEDGGSHQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEECCCCCCCC
SVEDIAIMRAVPNMTVIVPADGPETAKAIRAAAAYKGPVYVRLGRNKVPTVTAADAPFEI
CHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHH
GKGVQLADGTDLTFVTTGLMTAQALAAAETLKGEGISARVVHLATVKPLDGDILLKAARE
CCCEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHEEEEHHC
TGAIVTAEEHSIVGGLGGAVAEFLAENSPVPLKRVGINDRFGTSGKAEELLKYFGLMPID
CCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCHH
LVEAARGVVARKGK
HHHHHHHHHHCCCC
>Mature Secondary Structure 
STMIATRDAYGQTLAELGEENSSIVVLDADLSGSTKTSTFAKKFPERFFNMGIAEANMV
CCEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
GTAAGLAAAGKIPFVSTFAIFAVGRAWEQVRQSAAYPKANVKIVATHGGITVGEDGGSHQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEECCCCCCCC
SVEDIAIMRAVPNMTVIVPADGPETAKAIRAAAAYKGPVYVRLGRNKVPTVTAADAPFEI
CHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHH
GKGVQLADGTDLTFVTTGLMTAQALAAAETLKGEGISARVVHLATVKPLDGDILLKAARE
CCCEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHEEEEHHC
TGAIVTAEEHSIVGGLGGAVAEFLAENSPVPLKRVGINDRFGTSGKAEELLKYFGLMPID
CCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCHH
LVEAARGVVARKGK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]