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The map label for this gene is tktB [C]

Identifier: 78221772

GI number: 78221772

Start: 588332

End: 589192

Strand: Direct

Name: tktB [C]

Synonym: Gmet_0551

Alternate gene names: 78221772

Gene position: 588332-589192 (Clockwise)

Preceding gene: 78221771

Following gene: 78221773

Centisome position: 14.72

GC content: 63.88

Gene sequence:

>861_bases
ATGACCATCAGTATGGAAAGGAACATCGTGGACAGCGAAAAGATTGCTCAACTCCAGGAGAAGGCCCGGCAACTCCGGGT
CGACATCGTCAAGACCCTCCACAAGTCCCAGTCGGGGCACACGGGAGGCTCCCTCTCGGCCATCGATATGGTTACGGCCC
TCTACTTCCAGGTGATGAAGCACAATCCGGCCGACCCGGCCTGGCCCGGGCGGGACCGTTTCGTCCTCTGCAAGGGGCAC
GCGGCCCCGGCCCTCTACGTGGCCCTGGCCGAGGCGGGGTACTTCCCCAAGGAGGACCTCATGACGCTGCGGCGCCTGGG
CTCCCATCTCCAGGGGCATCCCGACAGCAAGCAGACCCCCGGTGTCGAGGTCTGCACCGGCTCCCTGGGGCAGGGGCTTT
CCATGGCCAACGGCATGGCCCTGGGGCTTCGTCTTGACGGAAGCTCAAGCCGCGTTTACGCCTTGCTTGGTGACGGCGAA
CTCCAGGAGGGGCAAGTCTGGGAGGCCGCCATGGCTGCCGGCCACTACAAGCTCGACAATCTCTGCGCCCTGGTGGATGT
GAACCGTCTCCAGATCGACGGCGAAGTGGCCAAGGTCATGGCCGTGGAGCCGGTCACCGACAAGTTCCGGGCCTTTGGCT
GGAACGTGATCGACATTGACGGCCACGACATGGGAGCCATCGTGACCGCCCTGGGACAGGCCGCCGAGGCCAAGGGGAAG
CCGACCGTAATCGTTGCCCGTACCGTCAAGGGGAAAGGGGTTTCGTTCTTTGAGAACAAGGCTTCCTACCACGGCGTTGC
CCCCAGTGACGAGGAGCTTCCCAAGGCACTGGAGTGCCTGGGCGAACAGTGCTACCTGTAG

Upstream 100 bases:

>100_bases
AACCAGCTTCCGTCGCACCTCCCAAACCCCCAACCAAACCACAGGAAAAACCGTCCAGTCTCGACGACGTCATCCTCGAC
TTCCTCTTGACGGACGATAA

Downstream 100 bases:

>100_bases
GTAGGGCTGCGGCTTTCACACCGGCTCGCCGCCGTCCTCGTCGCTCCTTTGTGCGGCGTAGCGCTGCTACGCCTCCGCAG
TCTCTCCTGCGGGTGCGACG

Product: transketolase subunit A

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTISMERNIVDSEKIAQLQEKARQLRVDIVKTLHKSQSGHTGGSLSAIDMVTALYFQVMKHNPADPAWPGRDRFVLCKGH
AAPALYVALAEAGYFPKEDLMTLRRLGSHLQGHPDSKQTPGVEVCTGSLGQGLSMANGMALGLRLDGSSSRVYALLGDGE
LQEGQVWEAAMAAGHYKLDNLCALVDVNRLQIDGEVAKVMAVEPVTDKFRAFGWNVIDIDGHDMGAIVTALGQAAEAKGK
PTVIVARTVKGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL

Sequences:

>Translated_286_residues
MTISMERNIVDSEKIAQLQEKARQLRVDIVKTLHKSQSGHTGGSLSAIDMVTALYFQVMKHNPADPAWPGRDRFVLCKGH
AAPALYVALAEAGYFPKEDLMTLRRLGSHLQGHPDSKQTPGVEVCTGSLGQGLSMANGMALGLRLDGSSSRVYALLGDGE
LQEGQVWEAAMAAGHYKLDNLCALVDVNRLQIDGEVAKVMAVEPVTDKFRAFGWNVIDIDGHDMGAIVTALGQAAEAKGK
PTVIVARTVKGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL
>Mature_285_residues
TISMERNIVDSEKIAQLQEKARQLRVDIVKTLHKSQSGHTGGSLSAIDMVTALYFQVMKHNPADPAWPGRDRFVLCKGHA
APALYVALAEAGYFPKEDLMTLRRLGSHLQGHPDSKQTPGVEVCTGSLGQGLSMANGMALGLRLDGSSSRVYALLGDGEL
QEGQVWEAAMAAGHYKLDNLCALVDVNRLQIDGEVAKVMAVEPVTDKFRAFGWNVIDIDGHDMGAIVTALGQAAEAKGKP
TVIVARTVKGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=256, Percent_Identity=44.53125, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI205277463, Length=268, Percent_Identity=43.6567164179104, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4507521, Length=268, Percent_Identity=43.6567164179104, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI225637459, Length=249, Percent_Identity=34.5381526104418, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI225637461, Length=266, Percent_Identity=33.4586466165414, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI225637463, Length=216, Percent_Identity=35.6481481481481, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1788808, Length=276, Percent_Identity=38.0434782608696, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI48994911, Length=279, Percent_Identity=35.4838709677419, Blast_Score=160, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17539652, Length=249, Percent_Identity=44.9799196787149, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6325331, Length=256, Percent_Identity=41.40625, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6319593, Length=256, Percent_Identity=38.28125, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45551847, Length=273, Percent_Identity=40.6593406593407, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI45550715, Length=273, Percent_Identity=40.6593406593407, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24666278, Length=249, Percent_Identity=43.3734939759036, Blast_Score=204, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24645119, Length=233, Percent_Identity=43.7768240343348, Blast_Score=190, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 30776; Mature: 30644

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISMERNIVDSEKIAQLQEKARQLRVDIVKTLHKSQSGHTGGSLSAIDMVTALYFQVMK
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
HNPADPAWPGRDRFVLCKGHAAPALYVALAEAGYFPKEDLMTLRRLGSHLQGHPDSKQTP
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GVEVCTGSLGQGLSMANGMALGLRLDGSSSRVYALLGDGELQEGQVWEAAMAAGHYKLDN
CCEEECCCCCCCCHHCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCC
LCALVDVNRLQIDGEVAKVMAVEPVTDKFRAFGWNVIDIDGHDMGAIVTALGQAAEAKGK
EEEEEECCEEEECCCEEEEEEECCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCC
PTVIVARTVKGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL
CEEEEEEECCCCCCEEHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TISMERNIVDSEKIAQLQEKARQLRVDIVKTLHKSQSGHTGGSLSAIDMVTALYFQVMK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
HNPADPAWPGRDRFVLCKGHAAPALYVALAEAGYFPKEDLMTLRRLGSHLQGHPDSKQTP
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GVEVCTGSLGQGLSMANGMALGLRLDGSSSRVYALLGDGELQEGQVWEAAMAAGHYKLDN
CCEEECCCCCCCCHHCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCC
LCALVDVNRLQIDGEVAKVMAVEPVTDKFRAFGWNVIDIDGHDMGAIVTALGQAAEAKGK
EEEEEECCEEEECCCEEEEEEECCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCC
PTVIVARTVKGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL
CEEEEEEECCCCCCEEHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]