Click here to switch to the map view.

The map label for this gene is dsbD [H]

Identifier: 78221737

GI number: 78221737

Start: 555493

End: 556179

Strand: Reverse

Name: dsbD [H]

Synonym: Gmet_0516

Alternate gene names: 78221737

Gene position: 556179-555493 (Counterclockwise)

Preceding gene: 78221738

Following gene: 78221736

Centisome position: 13.91

GC content: 65.21

Gene sequence:

>687_bases
ATGAGCCTCCTCGACAATATCGAGCAGATTGTCGCGACGCAGCCGCTTCTGGCCTTCGGCGCGGTCTTTATGGGAGGAGT
CCTCTCGTCTGCCTCCCCCTGCGTCCTGGCCACCATTCCGCTGGTGGTGGGATTCGTGGGGGGGCATGCGGGAGAAAGCC
GGAAGAAGGCCTTTCTCTACTCCCTCTCCTTCATCATCGGTCTGTCGCTTACCTTCACCATCTTCGGCGCTGCCGCGGCG
CTCCTGGGGACCATGTTCGGCACCGTGGGGGGATGGTGGTACGTGGCCGTGGGCGCCGTGGCGGTGGCCATGGGGCTCCA
GATGCTGGGGCTCTATGACCTGAACCTGCCGGCGCTGCCGCAATTCAGGCCGAAACGGGGCGGCCTCGTGGGTGCGCTCC
TCCTCGGCCTCTTCTTCGGGGTCGCCTCATCCCCCTGCGCCACGCCGGTCTTGGTCGTGATCCTCTCCTTCGCAGCCCTG
AAGGGGAATATCCTGGACGGGACGTTCCTCCTCTTCACCTACGCCCTCGGCCATTGCCTCCTCATGCTTGCCGCCGGCAC
CTTCACCGGCTTCGTGGAGGCCTTCGCCGCCTCACGGGGGGTAGCCGACATCTCCCTCTGGGGAAAACGGGTGAGCGGTT
TCATCATCGCACTGGCCGGGGCCTGGTTCATCTGGCGGGCATTCTGA

Upstream 100 bases:

>100_bases
CCCAGATATTTTTCGACGCCCGTGGGAAGGAAGTGAAGCGGCACATGGGCTTCATGGACAAGGCTGATATCGTCAAGGAA
CTGAATGCCCTGGGCGTGCG

Downstream 100 bases:

>100_bases
GCCTTAATACTCAAAGGAGACCTATCTAGTATGCTCTGCGACAAATTTCTTCGGCTTCAGGAACTCTATCGAAAGGCGGC
CATCCTGGCCCTCATTACCA

Product: cytochrome c biogenesis protein, transmembrane region

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSLLDNIEQIVATQPLLAFGAVFMGGVLSSASPCVLATIPLVVGFVGGHAGESRKKAFLYSLSFIIGLSLTFTIFGAAAA
LLGTMFGTVGGWWYVAVGAVAVAMGLQMLGLYDLNLPALPQFRPKRGGLVGALLLGLFFGVASSPCATPVLVVILSFAAL
KGNILDGTFLLFTYALGHCLLMLAAGTFTGFVEAFAASRGVADISLWGKRVSGFIIALAGAWFIWRAF

Sequences:

>Translated_228_residues
MSLLDNIEQIVATQPLLAFGAVFMGGVLSSASPCVLATIPLVVGFVGGHAGESRKKAFLYSLSFIIGLSLTFTIFGAAAA
LLGTMFGTVGGWWYVAVGAVAVAMGLQMLGLYDLNLPALPQFRPKRGGLVGALLLGLFFGVASSPCATPVLVVILSFAAL
KGNILDGTFLLFTYALGHCLLMLAAGTFTGFVEAFAASRGVADISLWGKRVSGFIIALAGAWFIWRAF
>Mature_227_residues
SLLDNIEQIVATQPLLAFGAVFMGGVLSSASPCVLATIPLVVGFVGGHAGESRKKAFLYSLSFIIGLSLTFTIFGAAAAL
LGTMFGTVGGWWYVAVGAVAVAMGLQMLGLYDLNLPALPQFRPKRGGLVGALLLGLFFGVASSPCATPVLVVILSFAALK
GNILDGTFLLFTYALGHCLLMLAAGTFTGFVEAFAASRGVADISLWGKRVSGFIIALAGAWFIWRAF

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG0785

COG function: function code O; Cytochrome c biogenesis protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=181, Percent_Identity=34.2541436464088, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 23706; Mature: 23574

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLDNIEQIVATQPLLAFGAVFMGGVLSSASPCVLATIPLVVGFVGGHAGESRKKAFLY
CCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
SLSFIIGLSLTFTIFGAAAALLGTMFGTVGGWWYVAVGAVAVAMGLQMLGLYDLNLPALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
QFRPKRGGLVGALLLGLFFGVASSPCATPVLVVILSFAALKGNILDGTFLLFTYALGHCL
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LMLAAGTFTGFVEAFAASRGVADISLWGKRVSGFIIALAGAWFIWRAF
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLLDNIEQIVATQPLLAFGAVFMGGVLSSASPCVLATIPLVVGFVGGHAGESRKKAFLY
CHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
SLSFIIGLSLTFTIFGAAAALLGTMFGTVGGWWYVAVGAVAVAMGLQMLGLYDLNLPALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
QFRPKRGGLVGALLLGLFFGVASSPCATPVLVVILSFAALKGNILDGTFLLFTYALGHCL
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LMLAAGTFTGFVEAFAASRGVADISLWGKRVSGFIIALAGAWFIWRAF
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]