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The map label for this gene is hisB

Identifier: 78221607

GI number: 78221607

Start: 430815

End: 431402

Strand: Direct

Name: hisB

Synonym: Gmet_0386

Alternate gene names: 78221607

Gene position: 430815-431402 (Clockwise)

Preceding gene: 78221606

Following gene: 78221608

Centisome position: 10.78

GC content: 61.73

Gene sequence:

>588_bases
ATGTCCCGGAAAGCCACCATCGAACGCGTCACCAAAGAAACCCAGATCAAACTCTCCCTGGAGATCGACGGGGCGGGCGA
GGCGAAGATCTGCACTTCGGTGCCGTTTCTCGACCACATGCTCGACCTCTTCGCCCGCCATGGCCTCTTCAACCTCCAGG
TGGACGCCAGGGGGGACATCGACATCGACTTCCACCACACGGTGGAGGATATCGGCATCGTCCTCGGCCAGGCGCTGAAG
GAAGCCCTGGGCGACAAGAAGGGAATCCGGCGCTACGGCCAGGCCAGCGTCCCCATGGACGAGACCCTTGCCAGTGTAGC
GGTGGACATCTCGGGGCGTCCCTACCTCGTCTACCACGTCGCGCTTCCCAAGGTGAAGATCGGTGAGTTTGACGTGGAGC
TGGTGCGAGAGTTTTTCCAGGCGGTGGTCAACAACCTGGGCGCCAATATCCACGTGAACGTCATGTACGGCGACAACGTC
CACCACATGGTCGAGGCCTGCTTCAAGGCCTTTGCCCGGGCCATGGACCAGGCGACCCAGGTGGATCCCCGGATCGAAGG
GGTCATGTCGACGAAGGGCAAGCTCTGA

Upstream 100 bases:

>100_bases
CATGGGATGAGGATCTCCATTGGCACCCGGGAGGAGATGGAGCAGACCCTCGCCGCCCTGAAAGAGATTGGCTAACTTCG
ATCCCCACGAGGAGGGTTCC

Downstream 100 bases:

>100_bases
TATGGCAACAATCGCAATCATCGACTACGGCATGGGTAATCTCCGCTCCGTCCAGAAGGGGTTCGAAAAGGTGGGGTTCG
AGGCGGTGGTGACCGCCGAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSRKATIERVTKETQIKLSLEIDGAGEAKICTSVPFLDHMLDLFARHGLFNLQVDARGDIDIDFHHTVEDIGIVLGQALK
EALGDKKGIRRYGQASVPMDETLASVAVDISGRPYLVYHVALPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNV
HHMVEACFKAFARAMDQATQVDPRIEGVMSTKGKL

Sequences:

>Translated_195_residues
MSRKATIERVTKETQIKLSLEIDGAGEAKICTSVPFLDHMLDLFARHGLFNLQVDARGDIDIDFHHTVEDIGIVLGQALK
EALGDKKGIRRYGQASVPMDETLASVAVDISGRPYLVYHVALPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNV
HHMVEACFKAFARAMDQATQVDPRIEGVMSTKGKL
>Mature_194_residues
SRKATIERVTKETQIKLSLEIDGAGEAKICTSVPFLDHMLDLFARHGLFNLQVDARGDIDIDFHHTVEDIGIVLGQALKE
ALGDKKGIRRYGQASVPMDETLASVAVDISGRPYLVYHVALPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNVH
HMVEACFKAFARAMDQATQVDPRIEGVMSTKGKL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=191, Percent_Identity=46.0732984293194, Blast_Score=169, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=35.9447004608295, Blast_Score=144, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_GEOMG (Q39YP5)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383354.1
- HSSP:   P34047
- ProteinModelPortal:   Q39YP5
- SMR:   Q39YP5
- STRING:   Q39YP5
- GeneID:   3739752
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0386
- NMPDR:   fig|269799.3.peg.398
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q39YP5
- ProtClustDB:   PRK00951
- BioCyc:   GMET269799:GMET_0386-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21577; Mature: 21446

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKATIERVTKETQIKLSLEIDGAGEAKICTSVPFLDHMLDLFARHGLFNLQVDARGDI
CCCCHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCE
DIDFHHTVEDIGIVLGQALKEALGDKKGIRRYGQASVPMDETLASVAVDISGRPYLVYHV
EEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCCEEEEEE
ALPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNVHHMVEACFKAFARAMDQATQ
ECCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHC
VDPRIEGVMSTKGKL
CCHHHHHHHHCCCCC
>Mature Secondary Structure 
SRKATIERVTKETQIKLSLEIDGAGEAKICTSVPFLDHMLDLFARHGLFNLQVDARGDI
CCCHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCE
DIDFHHTVEDIGIVLGQALKEALGDKKGIRRYGQASVPMDETLASVAVDISGRPYLVYHV
EEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCCEEEEEE
ALPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNVHHMVEACFKAFARAMDQATQ
ECCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHC
VDPRIEGVMSTKGKL
CCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA