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The map label for this gene is tkt [H]

Identifier: 78221402

GI number: 78221402

Start: 206604

End: 208610

Strand: Direct

Name: tkt [H]

Synonym: Gmet_0178

Alternate gene names: 78221402

Gene position: 206604-208610 (Clockwise)

Preceding gene: 78221399

Following gene: 78221403

Centisome position: 5.17

GC content: 69.86

Gene sequence:

>2007_bases
ATGTCAGCACCAGTACTTACCAGCGAAGACGCCCGCCTCGGCGCCGATACCCTCAGAATGCTGGCGGTGGACGCCGTGGA
GGCGGCCAACTCGGGCCATCCCGGGCTCCCCATGGGGGCTGCGGACTATGCCTTCCTCCTCTGGCATTCCCACCTTCGCT
TTGCCCCCACCGACCCGGAATGGGCCGGACGGGACCGCTTCGTCCTCTCGGCGGGGCACGGCTCCATGCTCCTCTATAGC
CTCCTCCACCTCTTCGGCTTTGACCTCCCCCTGGACGAGCTGAAACGGTTCCGCCAGTGGGGGAGCCGCACCCCGGGCCA
CCCGGAGTTCGGCCACACCCCCGGCGTCGAGGTGACCACCGGCCCCCTGGGGCAGGGGTTCGCCATGGGGGTCGGCATGG
CCCTGGCGGCCCGGATGGCCTCTGCCCGCTTTGCCGACGAGCGCTTCGACCCGTGCGGCCACCAGGTCTACGCCATCGTG
AGCGATGGGGACCTCATGGAGGGAATCAGCCAGGAGGCGGCCTCCCTGGCGGGACACCTGAAGCTCGGCAACATCGTTTA
TATCTACGACGACAACCGGATCACCATCGAGGGGTCCACGGATCTCGCCTTTTCGGATGATACGGCCGGACGCTTCACGG
CCCTGGGGTGGCAGGTGCAGAAGGTGGACGGCCACGATATCGGCCAGGTGGGGGAGGCCCTCTGGCGGGCCAAGGTGGAG
CGGGACCGCCCCTCCCTCATCATTGCCCGGACCCACATCGCCCAGGGCTCGCCGGGAAAGCACGACACGGCCGCCGCCCA
CGGCTCCCCCCTGGGCGCCGAAGAGGCGGCCGCCACCCGCAGGAATCTTGGGTGGCCCGATGAACTGTTCCACGTGCCGG
AGCGGGTGCGTGAGATCTGCGACAAGCGTCGGGAGGAGCTTGTCGCGGCCTACGCCGCCTGGGAGGATGAGTTCCGCCGC
TGGCGCCGCCGCAACCCCGACAAGGCCCGGCTCTGGGACGGCATGTGGCAGAAGGCGATCCCGAAAGACCTGGAAACCCG
GCTCCTAGCCGCCGTTGAGGGGAGTACCGGCGCCACCCGCGCCCTGTCGGGAAAGGTGATCCAGGCCGCGGCCGCGGCAA
TGCCGGCCCTGGCCGGCGGCTCCGCCGACCTGGAACCCTCCACCAACACCTGGATCGCGGAATCACCGTCGGTGCTTGCG
GGGAGCTACAGGGGGCGGAACCTCCACTTCGGCATCCGTGAGCACGCCATGGCCGCCGTCATGAACGGCATGGCCCGCTA
CGGCTGCTTCATCCCCTACGGCGCCACCTTCCTGGTCTTCTCCGACTACTGCCGGCCAAGCATCCGGCTCGCGGCCCTCA
TGAAGCAGCAGGCGATCTACGTCTTCACCCACGACTCGATCTTCCTGGGGGAGGACGGCCCCACCCACCAGCCGGTGGAG
CAGCTCTCGTCGCTGCGGCTCATTCCCAATCTCCGGGTCATCCGCCCCGCCGACGGCCCCGAGACGGCCCTGGCCTGGAA
CGCGGCCCTGCGCCGCGCCGACGGCCCCACGGCCCTCATCCTCACCCGCCAGAAGGTGCCGGCCATCATGCGGGAGGAAC
CACTGGATGCGAAAACCTTCGCCAAGGGGGGGTACGCGGTCCGGCAAGACGGGGCAACGCCCGACGTGGTCATCATGGCA
AGCGGTTCCGAGGTGGGGCTGGCCCTGGCCGCGGCAGATATCCTGGCCGGCGAAGGGGTGACGGCCCGGGTAGTGTCGGT
CCCCTCTCTCGAAACCTTCCTGGCCCAGCCCGAGGCGTACCGGCGCCGGCTCCTGCCGGGCCGCGTCCCCCGGGTGGCGG
TGGAGGCAGGGCACGGCGGCCTCTGGTGGCGACTCCTCGGCCCGGGGGGCCTCTTCATCGGCATGGAGGGCTTCGGTGCC
TCGGCCCCGGAAAAGGTCCTTGCCGAGCAGTTCGGCTTCACCCCGCCCCAAGTGGCCCAGCGGGTAAGAGAGCTCGTGGG
GCGCTAG

Upstream 100 bases:

>100_bases
CGTGTGTGTCGTCGGGCATTGTCGGATCTCCTTTGAGAGAAAGTGTACCCGACCGCAGCCGTTTGAGAAGCTTTGAACAA
CAATTGTCAGGGAGGACACC

Downstream 100 bases:

>100_bases
AGGATTATGGGAACCCGATCGAAGCGAAGCGAGCGGTGCGGCCGCTGCCGCATGCATCTGGAGCGGTGCGTCTGCCCGGC
CATCCCCCGGTATGACCTGA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MSAPVLTSEDARLGADTLRMLAVDAVEAANSGHPGLPMGAADYAFLLWHSHLRFAPTDPEWAGRDRFVLSAGHGSMLLYS
LLHLFGFDLPLDELKRFRQWGSRTPGHPEFGHTPGVEVTTGPLGQGFAMGVGMALAARMASARFADERFDPCGHQVYAIV
SDGDLMEGISQEAASLAGHLKLGNIVYIYDDNRITIEGSTDLAFSDDTAGRFTALGWQVQKVDGHDIGQVGEALWRAKVE
RDRPSLIIARTHIAQGSPGKHDTAAAHGSPLGAEEAAATRRNLGWPDELFHVPERVREICDKRREELVAAYAAWEDEFRR
WRRRNPDKARLWDGMWQKAIPKDLETRLLAAVEGSTGATRALSGKVIQAAAAAMPALAGGSADLEPSTNTWIAESPSVLA
GSYRGRNLHFGIREHAMAAVMNGMARYGCFIPYGATFLVFSDYCRPSIRLAALMKQQAIYVFTHDSIFLGEDGPTHQPVE
QLSSLRLIPNLRVIRPADGPETALAWNAALRRADGPTALILTRQKVPAIMREEPLDAKTFAKGGYAVRQDGATPDVVIMA
SGSEVGLALAAADILAGEGVTARVVSVPSLETFLAQPEAYRRRLLPGRVPRVAVEAGHGGLWWRLLGPGGLFIGMEGFGA
SAPEKVLAEQFGFTPPQVAQRVRELVGR

Sequences:

>Translated_668_residues
MSAPVLTSEDARLGADTLRMLAVDAVEAANSGHPGLPMGAADYAFLLWHSHLRFAPTDPEWAGRDRFVLSAGHGSMLLYS
LLHLFGFDLPLDELKRFRQWGSRTPGHPEFGHTPGVEVTTGPLGQGFAMGVGMALAARMASARFADERFDPCGHQVYAIV
SDGDLMEGISQEAASLAGHLKLGNIVYIYDDNRITIEGSTDLAFSDDTAGRFTALGWQVQKVDGHDIGQVGEALWRAKVE
RDRPSLIIARTHIAQGSPGKHDTAAAHGSPLGAEEAAATRRNLGWPDELFHVPERVREICDKRREELVAAYAAWEDEFRR
WRRRNPDKARLWDGMWQKAIPKDLETRLLAAVEGSTGATRALSGKVIQAAAAAMPALAGGSADLEPSTNTWIAESPSVLA
GSYRGRNLHFGIREHAMAAVMNGMARYGCFIPYGATFLVFSDYCRPSIRLAALMKQQAIYVFTHDSIFLGEDGPTHQPVE
QLSSLRLIPNLRVIRPADGPETALAWNAALRRADGPTALILTRQKVPAIMREEPLDAKTFAKGGYAVRQDGATPDVVIMA
SGSEVGLALAAADILAGEGVTARVVSVPSLETFLAQPEAYRRRLLPGRVPRVAVEAGHGGLWWRLLGPGGLFIGMEGFGA
SAPEKVLAEQFGFTPPQVAQRVRELVGR
>Mature_667_residues
SAPVLTSEDARLGADTLRMLAVDAVEAANSGHPGLPMGAADYAFLLWHSHLRFAPTDPEWAGRDRFVLSAGHGSMLLYSL
LHLFGFDLPLDELKRFRQWGSRTPGHPEFGHTPGVEVTTGPLGQGFAMGVGMALAARMASARFADERFDPCGHQVYAIVS
DGDLMEGISQEAASLAGHLKLGNIVYIYDDNRITIEGSTDLAFSDDTAGRFTALGWQVQKVDGHDIGQVGEALWRAKVER
DRPSLIIARTHIAQGSPGKHDTAAAHGSPLGAEEAAATRRNLGWPDELFHVPERVREICDKRREELVAAYAAWEDEFRRW
RRRNPDKARLWDGMWQKAIPKDLETRLLAAVEGSTGATRALSGKVIQAAAAAMPALAGGSADLEPSTNTWIAESPSVLAG
SYRGRNLHFGIREHAMAAVMNGMARYGCFIPYGATFLVFSDYCRPSIRLAALMKQQAIYVFTHDSIFLGEDGPTHQPVEQ
LSSLRLIPNLRVIRPADGPETALAWNAALRRADGPTALILTRQKVPAIMREEPLDAKTFAKGGYAVRQDGATPDVVIMAS
GSEVGLALAAADILAGEGVTARVVSVPSLETFLAQPEAYRRRLLPGRVPRVAVEAGHGGLWWRLLGPGGLFIGMEGFGAS
APEKVLAEQFGFTPPQVAQRVRELVGR

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=671, Percent_Identity=27.2727272727273, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI4507521, Length=671, Percent_Identity=27.2727272727273, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI133778974, Length=275, Percent_Identity=32, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI225637459, Length=626, Percent_Identity=23.482428115016, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI225637463, Length=550, Percent_Identity=23.8181818181818, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI225637461, Length=550, Percent_Identity=23.8181818181818, Blast_Score=123, Evalue=6e-28,
Organism=Escherichia coli, GI1788808, Length=660, Percent_Identity=47.8787878787879, Blast_Score=594, Evalue=1e-171,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=46.8277945619335, Blast_Score=586, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17539652, Length=589, Percent_Identity=27.3344651952462, Blast_Score=165, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=43.5171385991058, Blast_Score=524, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6319593, Length=675, Percent_Identity=39.7037037037037, Blast_Score=469, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45551847, Length=685, Percent_Identity=26.5693430656934, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI45550715, Length=685, Percent_Identity=26.5693430656934, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24645119, Length=646, Percent_Identity=26.3157894736842, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24666278, Length=620, Percent_Identity=24.8387096774194, Blast_Score=150, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72305; Mature: 72174

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPVLTSEDARLGADTLRMLAVDAVEAANSGHPGLPMGAADYAFLLWHSHLRFAPTDPE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHEEHHHCCEECCCCCC
WAGRDRFVLSAGHGSMLLYSLLHLFGFDLPLDELKRFRQWGSRTPGHPEFGHTPGVEVTT
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEC
GPLGQGFAMGVGMALAARMASARFADERFDPCGHQVYAIVSDGDLMEGISQEAASLAGHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCE
KLGNIVYIYDDNRITIEGSTDLAFSDDTAGRFTALGWQVQKVDGHDIGQVGEALWRAKVE
EECCEEEEEECCEEEEECCCCEEECCCCCCCEEEECEEEEECCCCCHHHHHHHHHHHHHC
RDRPSLIIARTHIAQGSPGKHDTAAAHGSPLGAEEAAATRRNLGWPDELFHVPERVREIC
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
DKRREELVAAYAAWEDEFRRWRRRNPDKARLWDGMWQKAIPKDLETRLLAAVEGSTGATR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHEECCCCCCCH
ALSGKVIQAAAAAMPALAGGSADLEPSTNTWIAESPSVLAGSYRGRNLHFGIREHAMAAV
HHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCEEECCCCCCEEECCHHHHHHHHH
MNGMARYGCFIPYGATFLVFSDYCRPSIRLAALMKQQAIYVFTHDSIFLGEDGPTHQPVE
HHHHHHHCCCCCCCCEEEEEHHCCCCHHHHHHHHHCCEEEEEEECEEEECCCCCCCHHHH
QLSSLRLIPNLRVIRPADGPETALAWNAALRRADGPTALILTRQKVPAIMREEPLDAKTF
HHHHEEECCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCCHHHH
AKGGYAVRQDGATPDVVIMASGSEVGLALAAADILAGEGVTARVVSVPSLETFLAQPEAY
CCCCCEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCHHH
RRRLLPGRVPRVAVEAGHGGLWWRLLGPGGLFIGMEGFGASAPEKVLAEQFGFTPPQVAQ
HHHCCCCCCCEEEEECCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHH
RVRELVGR
HHHHHHCC
>Mature Secondary Structure 
SAPVLTSEDARLGADTLRMLAVDAVEAANSGHPGLPMGAADYAFLLWHSHLRFAPTDPE
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHEEHHHCCEECCCCCC
WAGRDRFVLSAGHGSMLLYSLLHLFGFDLPLDELKRFRQWGSRTPGHPEFGHTPGVEVTT
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEC
GPLGQGFAMGVGMALAARMASARFADERFDPCGHQVYAIVSDGDLMEGISQEAASLAGHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCE
KLGNIVYIYDDNRITIEGSTDLAFSDDTAGRFTALGWQVQKVDGHDIGQVGEALWRAKVE
EECCEEEEEECCEEEEECCCCEEECCCCCCCEEEECEEEEECCCCCHHHHHHHHHHHHHC
RDRPSLIIARTHIAQGSPGKHDTAAAHGSPLGAEEAAATRRNLGWPDELFHVPERVREIC
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
DKRREELVAAYAAWEDEFRRWRRRNPDKARLWDGMWQKAIPKDLETRLLAAVEGSTGATR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHEECCCCCCCH
ALSGKVIQAAAAAMPALAGGSADLEPSTNTWIAESPSVLAGSYRGRNLHFGIREHAMAAV
HHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCEEECCCCCCEEECCHHHHHHHHH
MNGMARYGCFIPYGATFLVFSDYCRPSIRLAALMKQQAIYVFTHDSIFLGEDGPTHQPVE
HHHHHHHCCCCCCCCEEEEEHHCCCCHHHHHHHHHCCEEEEEEECEEEECCCCCCCHHHH
QLSSLRLIPNLRVIRPADGPETALAWNAALRRADGPTALILTRQKVPAIMREEPLDAKTF
HHHHEEECCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCCHHHH
AKGGYAVRQDGATPDVVIMASGSEVGLALAAADILAGEGVTARVVSVPSLETFLAQPEAY
CCCCCEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCHHH
RRRLLPGRVPRVAVEAGHGGLWWRLLGPGGLFIGMEGFGASAPEKVLAEQFGFTPPQVAQ
HHHCCCCCCCEEEEECCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHH
RVRELVGR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]