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The map label for this gene is nuoBCD [H]

Identifier: 78221378

GI number: 78221378

Start: 183479

End: 185854

Strand: Direct

Name: nuoBCD [H]

Synonym: Gmet_0153

Alternate gene names: 78221378

Gene position: 183479-185854 (Clockwise)

Preceding gene: 78221377

Following gene: 78221379

Centisome position: 4.59

GC content: 65.66

Gene sequence:

>2376_bases
ATGGAAGAGACTGAAATCCCACAGAACATAGTGCTGACCCGCCTGGACGACCTCATCAACTGGGGGCGCGCCAATTCCCT
CTGGCCCATGTTCTTTGGGCTCTCCTGCTGCTTCGTGGAGATGATGACCTCCTTCACCTCCCGCTACGACATCTCCCGCT
TCGGGGCCGAGGTGCTCCGGGGGACTCCCCGGGAGGCGGACCTGATGGTCATCGCCGGCACGGTCTTCAAGAAGATGGCC
CCCTCCATCCTTCGCCTCTACGAGCAGATGGCCGAGCCCAAGTGGGTCATCTCCATGGGGAGCTGCGCCAACTCCGGCGG
CATGTACGACGTCTACAGCGTGGTCCAGGGGGTGAACCAGATCATCCCGGTGGATGTCCACGTCCCCGGCTGCCCGCCGC
GCCCCGAGGCGTTCCTCCAGGGGGTGATGCTCCTGCAGGAGAAGATCAGGCGGGAAGAGCGCCCCGCACGCAAAGTTCTT
CACATGGCCGGCGGGACCGAGGGGACCACCCGGCCGGTCCTCGTGGACGGGGTGACGAAATCCCGCGACACCCGCGGGCC
GGGGATGGAGGGAATCGCCATTCGCGGCACCCCGGTCCAGCATCCCCGCTTCTGGATGTCCCGTTCCGACGAGATGTGGC
GCCCTCCCGCGCCGCGGCACGACTATCCCGACTTCGGCCTCGCCGGAGAACTGGAGACGATCTTCGGCGGCCGGGTGGCG
GTGGAGCAGGCCGCCACCGACATGCTCACCTACCGCTGCCCTCCGGAGCTGGTGCCCGAGGTGCTGCGCCACCTGAAGAG
CCGAAGCTCCGCCCCCTTCCGGCGCCTGGAGGACGTGGTCTGCGTGGACGAATCGTGCCGCCGGGAGCGGGAGCGGTTCC
CGGACTTCACCGTCAACTACCACCTCCTGAACTTCGACATCCCCGGCCACCTCCGGATCAAGACGGAGCTGATGGGGGAG
ACCCCGGAGCTTCCGAGCGCGACCGGCGTCTTCCCCGCGGCCGACTGGTACGAGCGGGAGGCCTTCGACATGTACGGCAT
CCGCTTCGCCGGGCATCCGAACCTGCGCCGCATCCTCATGCCCCCCGACTGGGAGGGGCATCCCCTGCGCAAGGAGCACC
CCTTCCGGGCCACGGAGATGCCTCCCTACACCACCGACGATGCACGGCGCCACCAGGCCCTGCCGGCCAGCGATTTTTTC
GATAGAATCGACGAGGAGACCTTGATCATCAACCTGGGCCCCCAACATCCGGGGACCCACGGGATCATCCGCTTCATCCT
CAAGCTGGACGGCGAGGAGATCGTGGACATGGACACCGACATCGGCTACCACCACCGGGGGGCCGAGAAAATCGGCGAAC
GCCAGCACTGGAACCAGTTCATCCCCTACACCGACCGGATCGACTACCTGGCCGGGGTCCAGAACAACCTCGCCTACGTG
AACAGCGTGGAGCGGCTCTGCGGTATCACCGTGCCGGACCGGGCCATCACCATCCGGGTCATGCTGGCGGAGCTCTTCCG
GATCGCCAGCCATCTGGTCTGGCTCGGCACCTTTGCCGCCGACGTGGGGGCCATGACCCCGGTCTTCTACACCTTCACCG
ACCGGGAGAAGATCTTCGACATCATCGAGATGGTCACCGGCGGCCGGATGCACCCCTCCTGGTTCCGGATCGGCGGCGTG
ACCGAGGATCTCCCCGAGGGGTGGGACGGGGCGGTGAAGGAATTCCTCGACTGGATGCCGGGCCGGCTCAAGGAGTACGA
AGACCTCCTGAAGGAAAACCCAATCTTCAAGGCGCGGCTGAAAGGGGTCGGCGTCATTACGAAAGACGAGGCCATGGAGT
GGGGAATCACCGGCCCGAACCTTCGGGCCTGCGGCATGGCGTGGGACCTGCGGAAGAAAATCCCCTACAACGGCTACCAG
CACTTCCACTTCGAGATCCCCACGGAGGAAGGGGGGGACTGCTGGGCGCGGTACCGGATCAGGGTCGAGGAGATCCGCCA
GTCGCTCCACATCGTGGCGCAGTGCCGGAAGGAGATGCCCGCCGGCCGCTGGATCACCGACGACTACCGCTATGTCCTCC
CCAAGAAGAGGGACACGCTCCACGACATCGAGTCCCTCATCCACCACTTCATCAACGCCACCCGGGGGATGGCGCCCCCC
AGGGGGGAAAACTACAGCGCCATCGAGGCTCCCAAGGGGGAAAACGGCTACTTCGTGGTGAGCGACGGCCTCAACGTCCC
GTACCGGGTGCGGATCAAGACCCCGAGCTTTCCCCACATCCAGGCGCTCCCCCTCATGAGCCGAGGGTGGCTCGTGGCGG
ATTTTCTCGCCATCATCGGGTCCATCGACTTTGTACTGGCGGATCTGGACCGGTGA

Upstream 100 bases:

>100_bases
GGACCGCTTGTGCGACGTAGCGCTGCTACGTCTCCGCGCAGTCCTTCGACAGCCTTGATCTTGCGAAAAATCCACGTTTC
TCGAAAAGCAGGATTAAATA

Downstream 100 bases:

>100_bases
AAAGGTTTTTATGCTTACTAACCGTCTGAAATCTGATCTCCAGGCCCGCATCGCCCACGCCGTCACCAACCGCGAGGCGG
CGGTGGACGTGATAAAGGAG

Product: trifunctional NADH dehydrogenase I subunit B/C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit B/C/D; NDH-1 subunit B/C/D [H]

Number of amino acids: Translated: 791; Mature: 791

Protein sequence:

>791_residues
MEETEIPQNIVLTRLDDLINWGRANSLWPMFFGLSCCFVEMMTSFTSRYDISRFGAEVLRGTPREADLMVIAGTVFKKMA
PSILRLYEQMAEPKWVISMGSCANSGGMYDVYSVVQGVNQIIPVDVHVPGCPPRPEAFLQGVMLLQEKIRREERPARKVL
HMAGGTEGTTRPVLVDGVTKSRDTRGPGMEGIAIRGTPVQHPRFWMSRSDEMWRPPAPRHDYPDFGLAGELETIFGGRVA
VEQAATDMLTYRCPPELVPEVLRHLKSRSSAPFRRLEDVVCVDESCRRERERFPDFTVNYHLLNFDIPGHLRIKTELMGE
TPELPSATGVFPAADWYEREAFDMYGIRFAGHPNLRRILMPPDWEGHPLRKEHPFRATEMPPYTTDDARRHQALPASDFF
DRIDEETLIINLGPQHPGTHGIIRFILKLDGEEIVDMDTDIGYHHRGAEKIGERQHWNQFIPYTDRIDYLAGVQNNLAYV
NSVERLCGITVPDRAITIRVMLAELFRIASHLVWLGTFAADVGAMTPVFYTFTDREKIFDIIEMVTGGRMHPSWFRIGGV
TEDLPEGWDGAVKEFLDWMPGRLKEYEDLLKENPIFKARLKGVGVITKDEAMEWGITGPNLRACGMAWDLRKKIPYNGYQ
HFHFEIPTEEGGDCWARYRIRVEEIRQSLHIVAQCRKEMPAGRWITDDYRYVLPKKRDTLHDIESLIHHFINATRGMAPP
RGENYSAIEAPKGENGYFVVSDGLNVPYRVRIKTPSFPHIQALPLMSRGWLVADFLAIIGSIDFVLADLDR

Sequences:

>Translated_791_residues
MEETEIPQNIVLTRLDDLINWGRANSLWPMFFGLSCCFVEMMTSFTSRYDISRFGAEVLRGTPREADLMVIAGTVFKKMA
PSILRLYEQMAEPKWVISMGSCANSGGMYDVYSVVQGVNQIIPVDVHVPGCPPRPEAFLQGVMLLQEKIRREERPARKVL
HMAGGTEGTTRPVLVDGVTKSRDTRGPGMEGIAIRGTPVQHPRFWMSRSDEMWRPPAPRHDYPDFGLAGELETIFGGRVA
VEQAATDMLTYRCPPELVPEVLRHLKSRSSAPFRRLEDVVCVDESCRRERERFPDFTVNYHLLNFDIPGHLRIKTELMGE
TPELPSATGVFPAADWYEREAFDMYGIRFAGHPNLRRILMPPDWEGHPLRKEHPFRATEMPPYTTDDARRHQALPASDFF
DRIDEETLIINLGPQHPGTHGIIRFILKLDGEEIVDMDTDIGYHHRGAEKIGERQHWNQFIPYTDRIDYLAGVQNNLAYV
NSVERLCGITVPDRAITIRVMLAELFRIASHLVWLGTFAADVGAMTPVFYTFTDREKIFDIIEMVTGGRMHPSWFRIGGV
TEDLPEGWDGAVKEFLDWMPGRLKEYEDLLKENPIFKARLKGVGVITKDEAMEWGITGPNLRACGMAWDLRKKIPYNGYQ
HFHFEIPTEEGGDCWARYRIRVEEIRQSLHIVAQCRKEMPAGRWITDDYRYVLPKKRDTLHDIESLIHHFINATRGMAPP
RGENYSAIEAPKGENGYFVVSDGLNVPYRVRIKTPSFPHIQALPLMSRGWLVADFLAIIGSIDFVLADLDR
>Mature_791_residues
MEETEIPQNIVLTRLDDLINWGRANSLWPMFFGLSCCFVEMMTSFTSRYDISRFGAEVLRGTPREADLMVIAGTVFKKMA
PSILRLYEQMAEPKWVISMGSCANSGGMYDVYSVVQGVNQIIPVDVHVPGCPPRPEAFLQGVMLLQEKIRREERPARKVL
HMAGGTEGTTRPVLVDGVTKSRDTRGPGMEGIAIRGTPVQHPRFWMSRSDEMWRPPAPRHDYPDFGLAGELETIFGGRVA
VEQAATDMLTYRCPPELVPEVLRHLKSRSSAPFRRLEDVVCVDESCRRERERFPDFTVNYHLLNFDIPGHLRIKTELMGE
TPELPSATGVFPAADWYEREAFDMYGIRFAGHPNLRRILMPPDWEGHPLRKEHPFRATEMPPYTTDDARRHQALPASDFF
DRIDEETLIINLGPQHPGTHGIIRFILKLDGEEIVDMDTDIGYHHRGAEKIGERQHWNQFIPYTDRIDYLAGVQNNLAYV
NSVERLCGITVPDRAITIRVMLAELFRIASHLVWLGTFAADVGAMTPVFYTFTDREKIFDIIEMVTGGRMHPSWFRIGGV
TEDLPEGWDGAVKEFLDWMPGRLKEYEDLLKENPIFKARLKGVGVITKDEAMEWGITGPNLRACGMAWDLRKKIPYNGYQ
HFHFEIPTEEGGDCWARYRIRVEEIRQSLHIVAQCRKEMPAGRWITDDYRYVLPKKRDTLHDIESLIHHFINATRGMAPP
RGENYSAIEAPKGENGYFVVSDGLNVPYRVRIKTPSFPHIQALPLMSRGWLVADFLAIIGSIDFVLADLDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=386, Percent_Identity=44.8186528497409, Blast_Score=336, Evalue=4e-92,
Organism=Homo sapiens, GI260898743, Length=376, Percent_Identity=44.9468085106383, Blast_Score=328, Evalue=2e-89,
Organism=Homo sapiens, GI187281616, Length=145, Percent_Identity=56.551724137931, Blast_Score=186, Evalue=1e-46,
Organism=Homo sapiens, GI4758788, Length=121, Percent_Identity=42.9752066115703, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI145693162, Length=583, Percent_Identity=49.2281303602058, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1788624, Length=183, Percent_Identity=60.655737704918, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1789076, Length=486, Percent_Identity=30.4526748971193, Blast_Score=203, Evalue=4e-53,
Organism=Escherichia coli, GI1788832, Length=482, Percent_Identity=29.8755186721992, Blast_Score=185, Evalue=1e-47,
Organism=Escherichia coli, GI1789074, Length=140, Percent_Identity=38.5714285714286, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1788834, Length=122, Percent_Identity=39.344262295082, Blast_Score=93, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17555284, Length=386, Percent_Identity=44.0414507772021, Blast_Score=350, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17568379, Length=386, Percent_Identity=44.0414507772021, Blast_Score=348, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI17509685, Length=143, Percent_Identity=56.6433566433566, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71990788, Length=135, Percent_Identity=40, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32563621, Length=135, Percent_Identity=40, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24638644, Length=385, Percent_Identity=44.6753246753247, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI221459469, Length=385, Percent_Identity=41.2987012987013, Blast_Score=345, Evalue=7e-95,
Organism=Drosophila melanogaster, GI18859983, Length=141, Percent_Identity=58.1560283687943, Blast_Score=189, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24642371, Length=141, Percent_Identity=58.1560283687943, Blast_Score=189, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24651058, Length=139, Percent_Identity=57.5539568345324, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24656494, Length=135, Percent_Identity=44.4444444444444, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR001135
- InterPro:   IPR006137
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR020396
- InterPro:   IPR006138
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa; PF01058 Oxidored_q6 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 90370; Mature: 90370

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00542 COMPLEX1_30K ; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEETEIPQNIVLTRLDDLINWGRANSLWPMFFGLSCCFVEMMTSFTSRYDISRFGAEVLR
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTPREADLMVIAGTVFKKMAPSILRLYEQMAEPKWVISMGSCANSGGMYDVYSVVQGVNQ
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
IIPVDVHVPGCPPRPEAFLQGVMLLQEKIRREERPARKVLHMAGGTEGTTRPVLVDGVTK
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
SRDTRGPGMEGIAIRGTPVQHPRFWMSRSDEMWRPPAPRHDYPDFGLAGELETIFGGRVA
CCCCCCCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHH
VEQAATDMLTYRCPPELVPEVLRHLKSRSSAPFRRLEDVVCVDESCRRERERFPDFTVNY
HHHHHHHHHEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEE
HLLNFDIPGHLRIKTELMGETPELPSATGVFPAADWYEREAFDMYGIRFAGHPNLRRILM
EEEEECCCCCEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCEEEEC
PPDWEGHPLRKEHPFRATEMPPYTTDDARRHQALPASDFFDRIDEETLIINLGPQHPGTH
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHCCCCEEEEEECCCCCCHH
GIIRFILKLDGEEIVDMDTDIGYHHRGAEKIGERQHWNQFIPYTDRIDYLAGVQNNLAYV
HHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHH
NSVERLCGITVPDRAITIRVMLAELFRIASHLVWLGTFAADVGAMTPVFYTFTDREKIFD
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
IIEMVTGGRMHPSWFRIGGVTEDLPEGWDGAVKEFLDWMPGRLKEYEDLLKENPIFKARL
HHHHHHCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEHH
KGVGVITKDEAMEWGITGPNLRACGMAWDLRKKIPYNGYQHFHFEIPTEEGGDCWARYRI
CCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEHHHHE
RVEEIRQSLHIVAQCRKEMPAGRWITDDYRYVLPKKRDTLHDIESLIHHFINATRGMAPP
EHHHHHHHHHHHHHHHHHCCCCCEECCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
RGENYSAIEAPKGENGYFVVSDGLNVPYRVRIKTPSFPHIQALPLMSRGWLVADFLAIIG
CCCCCCEEECCCCCCCEEEEECCCCCCEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHH
SIDFVLADLDR
HHHHHHCCCCC
>Mature Secondary Structure
MEETEIPQNIVLTRLDDLINWGRANSLWPMFFGLSCCFVEMMTSFTSRYDISRFGAEVLR
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTPREADLMVIAGTVFKKMAPSILRLYEQMAEPKWVISMGSCANSGGMYDVYSVVQGVNQ
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
IIPVDVHVPGCPPRPEAFLQGVMLLQEKIRREERPARKVLHMAGGTEGTTRPVLVDGVTK
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
SRDTRGPGMEGIAIRGTPVQHPRFWMSRSDEMWRPPAPRHDYPDFGLAGELETIFGGRVA
CCCCCCCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHH
VEQAATDMLTYRCPPELVPEVLRHLKSRSSAPFRRLEDVVCVDESCRRERERFPDFTVNY
HHHHHHHHHEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEE
HLLNFDIPGHLRIKTELMGETPELPSATGVFPAADWYEREAFDMYGIRFAGHPNLRRILM
EEEEECCCCCEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCEEEEC
PPDWEGHPLRKEHPFRATEMPPYTTDDARRHQALPASDFFDRIDEETLIINLGPQHPGTH
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHCCCCEEEEEECCCCCCHH
GIIRFILKLDGEEIVDMDTDIGYHHRGAEKIGERQHWNQFIPYTDRIDYLAGVQNNLAYV
HHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHH
NSVERLCGITVPDRAITIRVMLAELFRIASHLVWLGTFAADVGAMTPVFYTFTDREKIFD
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
IIEMVTGGRMHPSWFRIGGVTEDLPEGWDGAVKEFLDWMPGRLKEYEDLLKENPIFKARL
HHHHHHCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEHH
KGVGVITKDEAMEWGITGPNLRACGMAWDLRKKIPYNGYQHFHFEIPTEEGGDCWARYRI
CCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEHHHHE
RVEEIRQSLHIVAQCRKEMPAGRWITDDYRYVLPKKRDTLHDIESLIHHFINATRGMAPP
EHHHHHHHHHHHHHHHHHCCCCCEECCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
RGENYSAIEAPKGENGYFVVSDGLNVPYRVRIKTPSFPHIQALPLMSRGWLVADFLAIIG
CCCCCCEEECCCCCCCEEEEECCCCCCEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHH
SIDFVLADLDR
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA