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The map label for this gene is ppiA [H]

Identifier: 78221364

GI number: 78221364

Start: 165784

End: 166383

Strand: Direct

Name: ppiA [H]

Synonym: Gmet_0137

Alternate gene names: 78221364

Gene position: 165784-166383 (Clockwise)

Preceding gene: 78221363

Following gene: 78221365

Centisome position: 4.15

GC content: 61.33

Gene sequence:

>600_bases
ATGTTCAAACGGATTATCCTGGCCCTGACAATCTGCGGTCTTTTCAGCGTGCTTCTCATCGCCGGCAATGCCGATGCCGC
GGCAAAGGCCGAAAAGGCCAAGAACCCCGTGGTTCTCATGGAGACGACCCTCGGTCCCGTGAAGATCGAGCTCTACCCCG
ACAAGGCGCCGGTATCGGTGAAGAACTTCCTCGACTACGTGAACAGCGGCTTCTACAACGGCACCATCTTCCACCGGGTC
ATCCCCGGCTTCATGGCCCAGGGGGGCGGCTTCACCGCCGACCGGAAGCAGAAGGAAACGAAGGCCCCCATCAAGAACGA
AGCCGCTAACGGCCTCAAGAACGACCGGGGGACCATCGCCATGGCCCGCACCGCCAACCCCGACAGCGCCACGGCCCAGT
TCTTCATCAACGTGGTGAACAACGACGGTCTCAACCGCCCGAACCCGGACGGCTTCGGCTACGCCGTCTTCGGCAAGGTG
GTCGAAGGGATGGACGTGGTGGACAAAATCGTCGCCACCCCCACCCAGCGCCTCAACATGGTCTTTGCCAACCTCCCGGT
GACGCCGGTGGTCATCACGTCGATGAAGGCCGTCAAATAA

Upstream 100 bases:

>100_bases
CTGCGCAAGCCTGACGCGGAAGGCGATGAAATGATTGACGAGAAGGCTGCATCCTCATTATAATTCAGCGGTTTGATTAT
CGACTCGGAGGAGTGACACT

Downstream 100 bases:

>100_bases
CGGGGCAGGCAACACGCACGTTTCACAAGAGGGCGTCCTGACGGGCGCCCTTTTTTGTGGTATATCCTCCTGTGTCCGCA
ACAAACCATGACGCGAGGTA

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MFKRIILALTICGLFSVLLIAGNADAAAKAEKAKNPVVLMETTLGPVKIELYPDKAPVSVKNFLDYVNSGFYNGTIFHRV
IPGFMAQGGGFTADRKQKETKAPIKNEAANGLKNDRGTIAMARTANPDSATAQFFINVVNNDGLNRPNPDGFGYAVFGKV
VEGMDVVDKIVATPTQRLNMVFANLPVTPVVITSMKAVK

Sequences:

>Translated_199_residues
MFKRIILALTICGLFSVLLIAGNADAAAKAEKAKNPVVLMETTLGPVKIELYPDKAPVSVKNFLDYVNSGFYNGTIFHRV
IPGFMAQGGGFTADRKQKETKAPIKNEAANGLKNDRGTIAMARTANPDSATAQFFINVVNNDGLNRPNPDGFGYAVFGKV
VEGMDVVDKIVATPTQRLNMVFANLPVTPVVITSMKAVK
>Mature_199_residues
MFKRIILALTICGLFSVLLIAGNADAAAKAEKAKNPVVLMETTLGPVKIELYPDKAPVSVKNFLDYVNSGFYNGTIFHRV
IPGFMAQGGGFTADRKQKETKAPIKNEAANGLKNDRGTIAMARTANPDSATAQFFINVVNNDGLNRPNPDGFGYAVFGKV
VEGMDVVDKIVATPTQRLNMVFANLPVTPVVITSMKAVK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=130, Percent_Identity=38.4615384615385, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI19557636, Length=140, Percent_Identity=34.2857142857143, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI24308049, Length=150, Percent_Identity=34.6666666666667, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI7706339, Length=148, Percent_Identity=34.4594594594595, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI310110104, Length=147, Percent_Identity=36.734693877551, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI10863927, Length=147, Percent_Identity=37.4149659863946, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310129267, Length=149, Percent_Identity=35.5704697986577, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI310120620, Length=149, Percent_Identity=35.5704697986577, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI5454154, Length=176, Percent_Identity=32.9545454545455, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI5031987, Length=150, Percent_Identity=38.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI169214050, Length=166, Percent_Identity=33.7349397590361, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI256017253, Length=147, Percent_Identity=36.734693877551, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI221139811, Length=147, Percent_Identity=36.734693877551, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI256017251, Length=147, Percent_Identity=36.734693877551, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI239751853, Length=150, Percent_Identity=34, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI113428306, Length=150, Percent_Identity=34, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI22547212, Length=137, Percent_Identity=33.5766423357664, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI7657473, Length=137, Percent_Identity=33.5766423357664, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI22547215, Length=137, Percent_Identity=33.5766423357664, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1789763, Length=198, Percent_Identity=56.5656565656566, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=59.6273291925466, Blast_Score=180, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71980594, Length=136, Percent_Identity=41.1764705882353, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71980590, Length=136, Percent_Identity=41.1764705882353, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17532641, Length=162, Percent_Identity=32.0987654320988, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=142, Percent_Identity=34.5070422535211, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=144, Percent_Identity=32.6388888888889, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=127, Percent_Identity=36.2204724409449, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=191, Percent_Identity=33.5078534031414, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=138, Percent_Identity=39.8550724637681, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17986117, Length=186, Percent_Identity=30.1075268817204, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922912, Length=136, Percent_Identity=37.5, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922376, Length=174, Percent_Identity=30.4597701149425, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24652460, Length=140, Percent_Identity=33.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549139, Length=194, Percent_Identity=33.5051546391753, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357249, Length=127, Percent_Identity=32.2834645669291, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664125, Length=161, Percent_Identity=36.0248447204969, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357783, Length=161, Percent_Identity=36.0248447204969, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21377; Mature: 21377

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRIILALTICGLFSVLLIAGNADAAAKAEKAKNPVVLMETTLGPVKIELYPDKAPVSV
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCH
KNFLDYVNSGFYNGTIFHRVIPGFMAQGGGFTADRKQKETKAPIKNEAANGLKNDRGTIA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHCCCCCCCCCEE
MARTANPDSATAQFFINVVNNDGLNRPNPDGFGYAVFGKVVEGMDVVDKIVATPTQRLNM
EEECCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHE
VFANLPVTPVVITSMKAVK
EEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MFKRIILALTICGLFSVLLIAGNADAAAKAEKAKNPVVLMETTLGPVKIELYPDKAPVSV
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCH
KNFLDYVNSGFYNGTIFHRVIPGFMAQGGGFTADRKQKETKAPIKNEAANGLKNDRGTIA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHCCCCCCCCCEE
MARTANPDSATAQFFINVVNNDGLNRPNPDGFGYAVFGKVVEGMDVVDKIVATPTQRLNM
EEECCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHE
VFANLPVTPVVITSMKAVK
EEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]