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The map label for this gene is uvrA [H]

Identifier: 78221355

GI number: 78221355

Start: 153799

End: 156612

Strand: Reverse

Name: uvrA [H]

Synonym: Gmet_0128

Alternate gene names: 78221355

Gene position: 156612-153799 (Counterclockwise)

Preceding gene: 78221356

Following gene: 78221347

Centisome position: 3.92

GC content: 64.0

Gene sequence:

>2814_bases
ATGGCACACGACACCATCATCGTCAAAGGCGCCTGCGAGCACAACCTCAAGTGCATCGACGTGGAGATCCCCCGGGACAA
GCTCGTGGTCATCACCGGCATCTCCGGCTCGGGGAAGTCGACCCTGGCCTTCGACACCATCTATGCCGAGGGGCAGCGCC
GCTACGTGGAGTCACTCTCCGCCTATGCCCGCCAGTTTCTGGAGCAGATGGAAAAGCCCGATGTGGAATCCATTGAGGGG
CTCTCTCCCGCCATCTCCATCGAGCAGAAGACCACGAGCAGAAACCCCCGCTCCACCGTGGGCACCGTTACCGAGATTTA
CGACTACCTCCGGCTTCTCTTCGCCCGGGTCGGCCATCCCCACTGCTACCAGTGCGGCAAAGAAATAACCTCCCAGACCG
TCTCCCAGATGGTTGACCAGATCATGGCCATGGCAACGGGGACCAAGCTCCAGCTCCTCTCCCCCATGGTCAGGGGGCGC
AAGGGGGAGTACCGAAAGGAGCTGGCCCAGCTCCGCAAGGACGGCTTCGCCCGGGTCATCGTGGATGGGGTACAGTACGA
GCTTGCCGAGGAGATTCCCCTCGACAAGAACAAGAAACACGATATCGATATCGTGGTGGACCGGCTCATCGTTAAGGCGG
GGATCGAGCGGCGCCTGGCCGATTCCCTGGAGACGGCCCTGAACCATGCCGAAGGGGTGGTGAAGGTGCAGGTCATCGAC
GGCGACACCATCCTCTTCTCAGAGGCCCTGGCCTGCATTGACTGCGGCATCTCCTACCCGGAGATGACCCCCCGGATGTT
CTCCTTCAACAATCCCTACGGCGCCTGCCCCGACTGCACCGGCCTCGGCACGCGGATGTATTTCGACCAGGAGCTGGTGG
TGCCGAACCCCGACCTCTCCATCCGCGACGGGGCCATCGTCCCGTGGGAGAAGCGGCTCTCCGGCTGGTACCACATGACC
CTCGACGCCCTGGCCAAGGCCTATGACTTCGACATCCAGACCCCGTTCAGGGAACTGCCGCAGAAGGTTCAGGAGGTGAT
CCTCCGGGGCTCCGGCGGCCGGAAAATCGAATTCTGGTGGGAGGAGGACGGTGGCCGCCGCCACACCTACACCAAGGAGT
TCGAAGGGGTGATCCCGAACCTGGAGCGGCGCTATCGGGAAAGCGACTCGGAGCAGGTCCACGAGGAGCTGGAGCGGTAC
ATGAACGTGATGCCGTGCCCCACCTGCGAAGGGGCGCGGCTAAAGAAGGAGGCGCTCCACGTGAAGGTGGCGGGGCGCGA
CATCCGACAGGTGACGGCCCTCTCCATCAAGGATGCCCTGGAGTACTTTGCCTCCCTGGCCCTGACCCCCAAGGAGGAGG
AGATCGCCCGCCGGATATTGAAGGAGATCCGGGAGCGGCTCAACTTCCTCGTGAACGTGGGGCTCGACTACCTCTCCCTG
GACCGGGCCTCCGGCACCCTCTCCGGCGGCGAGGGGCAGCGGATCAGGCTCGCCACCCAGATCGGCTCCAGCCTCGTGGG
GGTCCTCTACATCCTGGACGAGCCCTCCATCGGCCTCCACCAGCGGGACAACGGCCGGCTCCTCCAGACCTTGAAACACA
TGCGGGACATCGGCAACACGGTGCTCGTGGTGGAGCACGACGAGGAGACGATCCTGGAGGCGGACCACGTCCTCGACATG
GGGCCCGGCGCCGGGGAGCACGGGGGCCGCGTGGTGGCCCAGGGGACCCCGGCGGAGATCATGGCGAACCCCGCATCCCT
CACGGGGCGTTACCTCTCGGGGGAGCTCGCCATCGCGGTGCCGAAGAAGCGGAGAAAACCGAAACGCGTCATCACCGTGG
CAGGGGCCACGGAGAATAACTTGAAGGATGTCTCCGTGGACATCCCCCTTGGGGTCATGACCTGCGTCACCGGGGTATCC
GGATCGGGAAAATCGACCCTGGTCATCGACACCCTCTACAAGGTTCTGGGGCAGCGCCTCTACAAGAGCCGGGAGAAGGC
CGGGGCGGTGCGTGAAATTCGGGGGCTGGAGCAGCTGGACAAGGTCATCAACATCGACCAGTCCCCCATCGGCCGCACGC
CGCGCTCCAATCCCGCCACCTACACCGGCGTCTTCGCCGACATCCGTGACCTTTTCGCCCAGCTCCCCGAATCCAAGGTG
CGGGGCTACAAGCCGGGGCGCTACTCCTTCAACGTGAAGGGGGGGCGGTGCGAGGCGTGCTCCGGGGACGGGATCATCAA
GATCGAGATGCACTTTCTTCCCGATGTCTACGTCCAGTGCGAGGTCTGCAAGGGGGCCCGCTACAACCGGGAGACCCTGG
AGGTGACCTATAAGGGGAAATCCATAGCCCAGGTCCTGGACATGACCGTCTCCGAGGCACTGCGGTTTCTGGAGAACATC
CCGAAGATCAAAACGAAGCTCCAGACCCTGGAGGAAGTGGGGCTCGGCTACATCCGTCTCGGCCAGGCGGCCACGACGCT
GTCCGGCGGCGAGGCCCAGCGGGTAAAGCTCGCCAAGGAGCTGGCCCGCCGCGCCACCGGCCGCACCATCTACATCCTCG
ACGAGCCCACCACCGGCCTCCACTTCCACGACATCGCCAAACTCCTGGAGGTGCTGCGAAAGCTCGTGGAGGGGGGAAAC
ACCATCGTCATCATCGAGCACAATCTCGACGTCATCAAGACCGCCGATTACCTCATCGATCTCGGCCCCGAAGGGGGCGA
CCGGGGAGGTGAGGTGATCGCCACCGGCACTCCCGAGGAGGTGGCCAAGGTGACGCGATCATATACTGGGCAGTATTTGC
GGAAGTTGCTCTGA

Upstream 100 bases:

>100_bases
CGAAGGGTCGGCCCTTTTTTTATTCTGTTCCGTGCTATAGTATCTTTTTTGCCGGATGACTCCGGACCTAATCACCGCAT
ACCGAAGGAACCGAACCCCC

Downstream 100 bases:

>100_bases
GTCACCTTGAAAATCCTCCGTGATGCGGAGGATTTTCAAGGTGACTGACCGTGCGTGGATGTCAAAAAGGGGGGAGAACT
ACTTTTCTTCGGTAGGAACC

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 937; Mature: 936

Protein sequence:

>937_residues
MAHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLEQMEKPDVESIEG
LSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHPHCYQCGKEITSQTVSQMVDQIMAMATGTKLQLLSPMVRGR
KGEYRKELAQLRKDGFARVIVDGVQYELAEEIPLDKNKKHDIDIVVDRLIVKAGIERRLADSLETALNHAEGVVKVQVID
GDTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDQELVVPNPDLSIRDGAIVPWEKRLSGWYHMT
LDALAKAYDFDIQTPFRELPQKVQEVILRGSGGRKIEFWWEEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVHEELERY
MNVMPCPTCEGARLKKEALHVKVAGRDIRQVTALSIKDALEYFASLALTPKEEEIARRILKEIRERLNFLVNVGLDYLSL
DRASGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHMRDIGNTVLVVEHDEETILEADHVLDM
GPGAGEHGGRVVAQGTPAEIMANPASLTGRYLSGELAIAVPKKRRKPKRVITVAGATENNLKDVSVDIPLGVMTCVTGVS
GSGKSTLVIDTLYKVLGQRLYKSREKAGAVREIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKV
RGYKPGRYSFNVKGGRCEACSGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGKSIAQVLDMTVSEALRFLENI
PKIKTKLQTLEEVGLGYIRLGQAATTLSGGEAQRVKLAKELARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGN
TIVIIEHNLDVIKTADYLIDLGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKLL

Sequences:

>Translated_937_residues
MAHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLEQMEKPDVESIEG
LSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHPHCYQCGKEITSQTVSQMVDQIMAMATGTKLQLLSPMVRGR
KGEYRKELAQLRKDGFARVIVDGVQYELAEEIPLDKNKKHDIDIVVDRLIVKAGIERRLADSLETALNHAEGVVKVQVID
GDTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDQELVVPNPDLSIRDGAIVPWEKRLSGWYHMT
LDALAKAYDFDIQTPFRELPQKVQEVILRGSGGRKIEFWWEEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVHEELERY
MNVMPCPTCEGARLKKEALHVKVAGRDIRQVTALSIKDALEYFASLALTPKEEEIARRILKEIRERLNFLVNVGLDYLSL
DRASGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHMRDIGNTVLVVEHDEETILEADHVLDM
GPGAGEHGGRVVAQGTPAEIMANPASLTGRYLSGELAIAVPKKRRKPKRVITVAGATENNLKDVSVDIPLGVMTCVTGVS
GSGKSTLVIDTLYKVLGQRLYKSREKAGAVREIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKV
RGYKPGRYSFNVKGGRCEACSGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGKSIAQVLDMTVSEALRFLENI
PKIKTKLQTLEEVGLGYIRLGQAATTLSGGEAQRVKLAKELARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGN
TIVIIEHNLDVIKTADYLIDLGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKLL
>Mature_936_residues
AHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLEQMEKPDVESIEGL
SPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHPHCYQCGKEITSQTVSQMVDQIMAMATGTKLQLLSPMVRGRK
GEYRKELAQLRKDGFARVIVDGVQYELAEEIPLDKNKKHDIDIVVDRLIVKAGIERRLADSLETALNHAEGVVKVQVIDG
DTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDQELVVPNPDLSIRDGAIVPWEKRLSGWYHMTL
DALAKAYDFDIQTPFRELPQKVQEVILRGSGGRKIEFWWEEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVHEELERYM
NVMPCPTCEGARLKKEALHVKVAGRDIRQVTALSIKDALEYFASLALTPKEEEIARRILKEIRERLNFLVNVGLDYLSLD
RASGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHMRDIGNTVLVVEHDEETILEADHVLDMG
PGAGEHGGRVVAQGTPAEIMANPASLTGRYLSGELAIAVPKKRRKPKRVITVAGATENNLKDVSVDIPLGVMTCVTGVSG
SGKSTLVIDTLYKVLGQRLYKSREKAGAVREIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKVR
GYKPGRYSFNVKGGRCEACSGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGKSIAQVLDMTVSEALRFLENIP
KIKTKLQTLEEVGLGYIRLGQAATTLSGGEAQRVKLAKELARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGNT
IVIIEHNLDVIKTADYLIDLGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKLL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=940, Percent_Identity=58.936170212766, Blast_Score=1112, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 104118; Mature: 103987

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLS
CCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHH
AYARQFLEQMEKPDVESIEGLSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHP
HHHHHHHHHHCCCCHHHHCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
HCYQCGKEITSQTVSQMVDQIMAMATGTKLQLLSPMVRGRKGEYRKELAQLRKDGFARVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEE
VDGVQYELAEEIPLDKNKKHDIDIVVDRLIVKAGIERRLADSLETALNHAEGVVKVQVID
EHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
GDTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDQELVVPNPDLS
CCCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEECCEEECCCCCCC
IRDGAIVPWEKRLSGWYHMTLDALAKAYDFDIQTPFRELPQKVQEVILRGSGGRKIEFWW
CCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
EEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVHEELERYMNVMPCPTCEGARLKKEALH
CCCCCCCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHEE
VKVAGRDIRQVTALSIKDALEYFASLALTPKEEEIARRILKEIRERLNFLVNVGLDYLSL
EEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
DRASGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHMRDIGNT
CCCCCCCCCCCCCEEEEHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCE
VLVVEHDEETILEADHVLDMGPGAGEHGGRVVAQGTPAEIMANPASLTGRYLSGELAIAV
EEEEECCCHHHHHHHHHEECCCCCCCCCCEEEECCCCHHHHCCCHHHCCCEECCCEEEEC
PKKRRKPKRVITVAGATENNLKDVSVDIPLGVMTCVTGVSGSGKSTLVIDTLYKVLGQRL
CHHCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHH
YKSREKAGAVREIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCHHHH
RGYKPGRYSFNVKGGRCEACSGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGK
CCCCCCCEEEEECCCEECCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCEEEEEECCH
SIAQVLDMTVSEALRFLENIPKIKTKLQTLEEVGLGYIRLGQAATTLSGGEAQRVKLAKE
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEECCHHHCCCCCCHHHHHHHHH
LARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGNTIVIIEHNLDVIKTADYLID
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCEEEE
LGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKLL
ECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
AHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLS
CCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHH
AYARQFLEQMEKPDVESIEGLSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHP
HHHHHHHHHHCCCCHHHHCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
HCYQCGKEITSQTVSQMVDQIMAMATGTKLQLLSPMVRGRKGEYRKELAQLRKDGFARVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEE
VDGVQYELAEEIPLDKNKKHDIDIVVDRLIVKAGIERRLADSLETALNHAEGVVKVQVID
EHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
GDTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDQELVVPNPDLS
CCCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEECCEEECCCCCCC
IRDGAIVPWEKRLSGWYHMTLDALAKAYDFDIQTPFRELPQKVQEVILRGSGGRKIEFWW
CCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
EEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVHEELERYMNVMPCPTCEGARLKKEALH
CCCCCCCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHEE
VKVAGRDIRQVTALSIKDALEYFASLALTPKEEEIARRILKEIRERLNFLVNVGLDYLSL
EEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
DRASGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHMRDIGNT
CCCCCCCCCCCCCEEEEHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCE
VLVVEHDEETILEADHVLDMGPGAGEHGGRVVAQGTPAEIMANPASLTGRYLSGELAIAV
EEEEECCCHHHHHHHHHEECCCCCCCCCCEEEECCCCHHHHCCCHHHCCCEECCCEEEEC
PKKRRKPKRVITVAGATENNLKDVSVDIPLGVMTCVTGVSGSGKSTLVIDTLYKVLGQRL
CHHCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHH
YKSREKAGAVREIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCHHHH
RGYKPGRYSFNVKGGRCEACSGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGK
CCCCCCCEEEEECCCEECCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCEEEEEECCH
SIAQVLDMTVSEALRFLENIPKIKTKLQTLEEVGLGYIRLGQAATTLSGGEAQRVKLAKE
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEECCHHHCCCCCCHHHHHHHHH
LARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGNTIVIIEHNLDVIKTADYLID
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCEEEE
LGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKLL
ECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]