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The map label for this gene is mtnA

Identifier: 78221299

GI number: 78221299

Start: 88502

End: 89542

Strand: Reverse

Name: mtnA

Synonym: Gmet_0072

Alternate gene names: 78221299

Gene position: 89542-88502 (Counterclockwise)

Preceding gene: 78221300

Following gene: 78221298

Centisome position: 2.24

GC content: 66.95

Gene sequence:

>1041_bases
ATGTCCTTTAGAACTATCGAATGGCGCGACGACAAGGTAATAATGATCGACCAGACCCGGCTTCCGGGCGAAGAGGTCTA
CTGCGAGTACGGCGACTACAAGAGTGTGGCCGAGGCGATCCGGGGGATGATCATCCGGGGGGCGCCGGCCATCGGGGTGG
CGGCGGCCATGGGTGTGGCCCTGGGGGCCAGGGAGATCATCGCGGATACCCACGAGTCGTTCCTGCGGCAGCTGGATAAC
GTCTGCGACGTCCTGGCCCGCACCCGCCCCACGGCCGTGAACCTCTTCTGGGCCATCGAGCGTATGAAACGGGTGGCCGC
CGATAACTGCGGCGGTTCCCTGGACGAGGTGCGCGAAGTCCTCAAGGCCGAGGCGATCCGCATCGAGGAGGAGGATCTGG
CGCTCTGCAAGGCCATCGGCCGCCACGGCGCCGGCCTGATCCCCGAGGGGGCCACGGTACTCACCCACTGCAACGCCGGC
GGCCTTGCCACGGCCGGCTACGGTACGGCCCTGGGGGTCATCCGGGCGGCCCACGAGGCGGGGAAGAACATCCAGGTCTT
CGCCGACGAGACCCGCCCCTGGCTCCAGGGGGCGCGGCTCACGGCGTGGGAGCTCATGAAGGACGGCATCCCCGTGACCC
TCATTTCCGACAACATGGCCGGCTTCTTCATGAAGCGGGGCGAGATCACCTGCTGCGTGGTGGGAGCCGACCGGATCGCG
GCCAACGGCGACACGGCCAACAAGATCGGCACCTACAGCGTGGCGGTTCTGGCCAAGGAAAACAACATCCCCTTCTACGT
GGCGGCCCCCACCTCCACCCTCGACCTGTCGCTCGAAAACGGCGACCAGATCCCCATCGAGGAGCGCCACGCCCGGGAGG
TGACCCACCTCCAGGGGCTTCCCGTGGCGCCGGAGGGGATCGCGGTCCGCAATCCCGCCTTCGACGTGACGCCGGCCCGC
TACATCGCCGGCATCATCACCGAGAAGGGGGTGATTACCGGCGATTACACGGCGAAGCTCAAGGCCCTCGTGAAACCATG
A

Upstream 100 bases:

>100_bases
CGGTGGTGAACGAGCTGTTACTGAAGAAGCTCAAGGGGTGAGATTCAACTTGCTGTTCTCTGTGTCTCCGTGTCTCTGTG
GCAGATTGTGAGGGTTATTT

Downstream 100 bases:

>100_bases
CCCCTACCGATTCCCTGGCCCGCCGCCTGGAGGAGGCCATCGGCACCTCCCCCGACATCGACAACGACCAGCTCCTCATG
GCGCTCCTGGAGGAGCTGGG

Product: translation initiation factor 2B subunit I

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSFRTIEWRDDKVIMIDQTRLPGEEVYCEYGDYKSVAEAIRGMIIRGAPAIGVAAAMGVALGAREIIADTHESFLRQLDN
VCDVLARTRPTAVNLFWAIERMKRVAADNCGGSLDEVREVLKAEAIRIEEEDLALCKAIGRHGAGLIPEGATVLTHCNAG
GLATAGYGTALGVIRAAHEAGKNIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEITCCVVGADRIA
ANGDTANKIGTYSVAVLAKENNIPFYVAAPTSTLDLSLENGDQIPIEERHAREVTHLQGLPVAPEGIAVRNPAFDVTPAR
YIAGIITEKGVITGDYTAKLKALVKP

Sequences:

>Translated_346_residues
MSFRTIEWRDDKVIMIDQTRLPGEEVYCEYGDYKSVAEAIRGMIIRGAPAIGVAAAMGVALGAREIIADTHESFLRQLDN
VCDVLARTRPTAVNLFWAIERMKRVAADNCGGSLDEVREVLKAEAIRIEEEDLALCKAIGRHGAGLIPEGATVLTHCNAG
GLATAGYGTALGVIRAAHEAGKNIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEITCCVVGADRIA
ANGDTANKIGTYSVAVLAKENNIPFYVAAPTSTLDLSLENGDQIPIEERHAREVTHLQGLPVAPEGIAVRNPAFDVTPAR
YIAGIITEKGVITGDYTAKLKALVKP
>Mature_345_residues
SFRTIEWRDDKVIMIDQTRLPGEEVYCEYGDYKSVAEAIRGMIIRGAPAIGVAAAMGVALGAREIIADTHESFLRQLDNV
CDVLARTRPTAVNLFWAIERMKRVAADNCGGSLDEVREVLKAEAIRIEEEDLALCKAIGRHGAGLIPEGATVLTHCNAGG
LATAGYGTALGVIRAAHEAGKNIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEITCCVVGADRIAA
NGDTANKIGTYSVAVLAKENNIPFYVAAPTSTLDLSLENGDQIPIEERHAREVTHLQGLPVAPEGIAVRNPAFDVTPARY
IAGIITEKGVITGDYTAKLKALVKP

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=347, Percent_Identity=44.3804034582133, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI23943880, Length=337, Percent_Identity=38.5756676557863, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4503503, Length=227, Percent_Identity=30.8370044052863, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI78000156, Length=284, Percent_Identity=23.5915492957746, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI78000158, Length=284, Percent_Identity=23.5915492957746, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI187607323, Length=284, Percent_Identity=23.5915492957746, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=321, Percent_Identity=37.0716510903427, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17557123, Length=175, Percent_Identity=30.8571428571429, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325375, Length=402, Percent_Identity=35.0746268656716, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322878, Length=265, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357667, Length=360, Percent_Identity=41.3888888888889, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24651647, Length=360, Percent_Identity=41.3888888888889, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_GEOMG (Q39ZK3)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383046.1
- ProteinModelPortal:   Q39ZK3
- SMR:   Q39ZK3
- STRING:   Q39ZK3
- GeneID:   3739688
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0072
- NMPDR:   fig|269799.3.peg.135
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- PhylomeDB:   Q39ZK3
- ProtClustDB:   CLSK829258
- BioCyc:   GMET269799:GMET_0072-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37228; Mature: 37097

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: ACT_SITE 237-237 BINDING 89-89 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRTIEWRDDKVIMIDQTRLPGEEVYCEYGDYKSVAEAIRGMIIRGAPAIGVAAAMGVA
CCCEEEEECCCEEEEEECCCCCCHHEEEECCCHHHHHHHHHCEEEECCCHHHHHHHHHHH
LGAREIIADTHESFLRQLDNVCDVLARTRPTAVNLFWAIERMKRVAADNCGGSLDEVREV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LKAEAIRIEEEDLALCKAIGRHGAGLIPEGATVLTHCNAGGLATAGYGTALGVIRAAHEA
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHC
GKNIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEITCCVVGADRIA
CCCEEEEECCCCHHHCCCCCHHHHHHHCCCCEEEECCCCCEEEEECCCEEEEEEECCCEE
ANGDTANKIGTYSVAVLAKENNIPFYVAAPTSTLDLSLENGDQIPIEERHAREVTHLQGL
CCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCC
PVAPEGIAVRNPAFDVTPARYIAGIITEKGVITGDYTAKLKALVKP
CCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEECCHHHHHHEECCC
>Mature Secondary Structure 
SFRTIEWRDDKVIMIDQTRLPGEEVYCEYGDYKSVAEAIRGMIIRGAPAIGVAAAMGVA
CCEEEEECCCEEEEEECCCCCCHHEEEECCCHHHHHHHHHCEEEECCCHHHHHHHHHHH
LGAREIIADTHESFLRQLDNVCDVLARTRPTAVNLFWAIERMKRVAADNCGGSLDEVREV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LKAEAIRIEEEDLALCKAIGRHGAGLIPEGATVLTHCNAGGLATAGYGTALGVIRAAHEA
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHC
GKNIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEITCCVVGADRIA
CCCEEEEECCCCHHHCCCCCHHHHHHHCCCCEEEECCCCCEEEEECCCEEEEEEECCCEE
ANGDTANKIGTYSVAVLAKENNIPFYVAAPTSTLDLSLENGDQIPIEERHAREVTHLQGL
CCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCC
PVAPEGIAVRNPAFDVTPARYIAGIITEKGVITGDYTAKLKALVKP
CCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEECCHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA