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The map label for this gene is gyrA [H]

Identifier: 78221233

GI number: 78221233

Start: 6570

End: 9143

Strand: Direct

Name: gyrA [H]

Synonym: Gmet_0005

Alternate gene names: 78221233

Gene position: 6570-9143 (Clockwise)

Preceding gene: 78221232

Following gene: 78221234

Centisome position: 0.16

GC content: 63.25

Gene sequence:

>2574_bases
ATGCTTGAACAGACCCTGAACAAGACTGCCGTCAATATCGAAGACGAGATGAAACGCTCGTACATGGACTACGCCATGAG
CGTCATCATCGGCCGGGCCCTCCCCGACGTGCGGGACGGCCTGAAGCCGGTGCACCGGCGTTGCCTCTACGCCATGTACG
ACATGGGGAACGATTACAACAAGCCCTACAAGAAGTCGGCCCGGGTGGTCGGTGACGTGATCGGTAAGTACCACCCCCAC
GGCGACACGGCGGCCTACGACACCATCGTCCGGATGGCCCAGGACTTCTCCCTCCGCTACCCCTTGGTGGATGGCCAGGG
GAACTTCGGCTCCGTGGACGGCGACTCGCCTGCGGCCATGCGGTACACCGAAATCCGGATGGAGCAGCTGGCCCACGAGC
TCCTGAACGATCTGGAGAAGGAGACTGTTGACCTGGGGTTCAACTACGACGGCTCCCTCACGGAGCCGCTGGTGCTCCCC
TCCAAGTTCCCGAACCTCCTGGTGAACGGCTCTTCGGGGATCGCCGTCGGCATGGCCACCAACATCCCCCCCCATAACCT
CTCGGAGGTCATCGACGGGATCATTGCCACCATCGGGAACCCGCACATAAGCTTCGAGGAGCTCCTGGCCCTGGTCCCCG
GTCCCGATTTCCCCACCGGCGGGTTCATCTACGGCCGGGAGGGGATCCTCCAGGGGTACCGGACCGGCCGCGGCATCGTC
CAGATGCGAGCCCGGGCCAGCATCGAAACCCACAAGAAGACCGAGCGCCAGTCCATTGTCGTCACCGAGATTCCCTACCA
GGTGAACAAGGCGAACCTCATCACCAAGATCGCCGAGCTGGTGCGGGAGAAGAAGCTGGAGGGGATCAGCGACATCCGCG
ACGAGTCCGACCGGGACGGGATGCGGATCGTCATCGATCTCAAGAGGGACGAGAATCCCCAGGTGATCCTCAACCACCTC
TACAAGCAGACCCAGATGCAGACCTCCTTCGGCATCAACATGCTCGCCATCGTGGCGGGACGGCCGAAGGTCCTGACGCT
TCAGGACGCCATCGGCCACTTCATCGACCATCGCCGCGAGATCGTCACCCGGCGCACCATCTTCGATCTCAAGAAGGCCG
AGGCCCGGGCCCACATATTGGAAGGCTACAAGATTGCTCTCGACTGGCTCGACGCGGTCATCGAGCTGATCCGGGGGTCA
AAGACCCCGGCCGAGGCCCGGGAAGGGCTCATGTCAGGCCTCTTTTCCGACGAGGAGTGGCTCCAGAAGATGGGGCTCCC
CCTGCCGGCCATCCACAGCCAGTACCAGAAACCGGTGCGCCTCACCGAGGTCCAGGCCCAGGAGATCCTCAACCTGCGGC
TCCACCGCCTCACGGGTCTGGAGCGGGACAAGATCCTCCAGGAGTACGAGGACATCCTCAAGTACATCGCCCGTCTCAAG
GAGATCCTCGCCTCCGAGGCGGAGATCCTCAAGATCATCGTGGGAGAGCTGCGGGAACTGAAGGAAAAGTTCGGCGACGA
GCGCCGCACCGAGATCGTGGACCGGAGCGCCGAGATCTCCCTGGAGGACACCATCGTCGAGGAGGACGTGGTGGTCACCG
TCTCCCACACCGGCTACATCAAGCGGACCGCCGTCTCCCAGTACCGTTCCCAGCGCCGGGGGGGGAAGGGGAAGACCGGC
ATGAAGACCAAGGAGGAGGATTTCGTCGAGCACCTCTTCGTCGCCTCCAGCAAGGACTTCATGCTCTTCTTCACCGACGC
CGGCAAGGTCTACCAGATCAAGGTATACGAGATTCCCGAGGGGGGGCGCGCCACCCGTGGCAAGGCCATCGTCAACCTCC
TGAACCTCCAAGAGAACGAGCAGATCACCGCCATCCTCTCGGTGAAGGGGTTCGACGACGAGCGAAACATTCTCATGGCG
ACCCGCCTCGGGGTCGTGAAGAAAAGCCCCCTGCGGGAGTACGCCAACATCCGGAGCGGCGGGATCATCGCCGTGAACCT
GGACGAGGAGGACAAGCTCATTGCCGTGGCCCTCACCGACGGGCGGCAGGACGTACTCCTGGCATCCAGGAACGGCAAGT
CGATCCGCTTCCACGAGGAGGACGCCCGTCCCATGGGGCGCGTGTCGCGCGGGGTGCGGGGAATGACCCTGGAGGACGAC
GACGTGGTGATCGGCATGGAAGTCATCAACCCGAGCGCCACCGGTTCAACCATCTTCACTGTCACCGAGAACGGCTTCGG
CAAGCGGACCGAGCTGGACGAGTATCGGGTCCAGTCCCGGGGGGGCAAGGGGATCATCACCATCAAGACCACCGAGCGCA
ACGGCTGCGTCGTGGACATCATGCAGGTGACCGACGAGAACGACCTCATGCTCATCACCGACCAGGGGAAGATCCTCCGG
ATACCGGTGGCCCCCTTCTCGGTCATCGGCCGCAACACCCAGGGGGTCAGGCTCATGACCGCCGAACAGAACGAGCGGAT
CGTGGCCGTAGCCAAGCTGGCCGAAAAGGATGAGGGAGATGAGGGGCCCGACAGCGGCGATGACCTTCCCGAGGCGGAGG
TTGTCGAGGAGTAG

Upstream 100 bases:

>100_bases
CCAGGTGGAGCCCCGCCGGGACTTCATCGAGAAGAACGCCCTGAACGTGTCGAACCTCGACATCTGATGACCGATATTAG
TAATTATCCGAGGAAACAGA

Downstream 100 bases:

>100_bases
CCGCGACGGACAGCGGCCCGAGACCGGATGATGCGTATTTTCCGGCCGCGGGTCCCTGGTCCCCGGTTCCCGCCTATGAA
AAGTAATCGCAGCATCGACA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 857; Mature: 857

Protein sequence:

>857_residues
MLEQTLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYNKPYKKSARVVGDVIGKYHPH
GDTAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAMRYTEIRMEQLAHELLNDLEKETVDLGFNYDGSLTEPLVLP
SKFPNLLVNGSSGIAVGMATNIPPHNLSEVIDGIIATIGNPHISFEELLALVPGPDFPTGGFIYGREGILQGYRTGRGIV
QMRARASIETHKKTERQSIVVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDGMRIVIDLKRDENPQVILNHL
YKQTQMQTSFGINMLAIVAGRPKVLTLQDAIGHFIDHRREIVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGS
KTPAEAREGLMSGLFSDEEWLQKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYEDILKYIARLK
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYIKRTAVSQYRSQRRGGKGKTG
MKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPEGGRATRGKAIVNLLNLQENEQITAILSVKGFDDERNILMA
TRLGVVKKSPLREYANIRSGGIIAVNLDEEDKLIAVALTDGRQDVLLASRNGKSIRFHEEDARPMGRVSRGVRGMTLEDD
DVVIGMEVINPSATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDIMQVTDENDLMLITDQGKILR
IPVAPFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGDEGPDSGDDLPEAEVVEE

Sequences:

>Translated_857_residues
MLEQTLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYNKPYKKSARVVGDVIGKYHPH
GDTAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAMRYTEIRMEQLAHELLNDLEKETVDLGFNYDGSLTEPLVLP
SKFPNLLVNGSSGIAVGMATNIPPHNLSEVIDGIIATIGNPHISFEELLALVPGPDFPTGGFIYGREGILQGYRTGRGIV
QMRARASIETHKKTERQSIVVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDGMRIVIDLKRDENPQVILNHL
YKQTQMQTSFGINMLAIVAGRPKVLTLQDAIGHFIDHRREIVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGS
KTPAEAREGLMSGLFSDEEWLQKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYEDILKYIARLK
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYIKRTAVSQYRSQRRGGKGKTG
MKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPEGGRATRGKAIVNLLNLQENEQITAILSVKGFDDERNILMA
TRLGVVKKSPLREYANIRSGGIIAVNLDEEDKLIAVALTDGRQDVLLASRNGKSIRFHEEDARPMGRVSRGVRGMTLEDD
DVVIGMEVINPSATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDIMQVTDENDLMLITDQGKILR
IPVAPFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGDEGPDSGDDLPEAEVVEE
>Mature_857_residues
MLEQTLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYNKPYKKSARVVGDVIGKYHPH
GDTAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAMRYTEIRMEQLAHELLNDLEKETVDLGFNYDGSLTEPLVLP
SKFPNLLVNGSSGIAVGMATNIPPHNLSEVIDGIIATIGNPHISFEELLALVPGPDFPTGGFIYGREGILQGYRTGRGIV
QMRARASIETHKKTERQSIVVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDGMRIVIDLKRDENPQVILNHL
YKQTQMQTSFGINMLAIVAGRPKVLTLQDAIGHFIDHRREIVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGS
KTPAEAREGLMSGLFSDEEWLQKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYEDILKYIARLK
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYIKRTAVSQYRSQRRGGKGKTG
MKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPEGGRATRGKAIVNLLNLQENEQITAILSVKGFDDERNILMA
TRLGVVKKSPLREYANIRSGGIIAVNLDEEDKLIAVALTDGRQDVLLASRNGKSIRFHEEDARPMGRVSRGVRGMTLEDD
DVVIGMEVINPSATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDIMQVTDENDLMLITDQGKILR
IPVAPFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGDEGPDSGDDLPEAEVVEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=346, Percent_Identity=23.9884393063584, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI19913406, Length=315, Percent_Identity=25.7142857142857, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1788562, Length=868, Percent_Identity=55.9907834101382, Blast_Score=934, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=700, Percent_Identity=36, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=524, Percent_Identity=24.4274809160305, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=170, Percent_Identity=31.1764705882353, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17136538, Length=360, Percent_Identity=25.2777777777778, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 95950; Mature: 95950

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQTLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYN
CCCHHHCHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KPYKKSARVVGDVIGKYHPHGDTAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEECCCCCCCCCCCCCCCHH
RYTEIRMEQLAHELLNDLEKETVDLGFNYDGSLTEPLVLPSKFPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLSEVIDGIIATIGNPHISFEELLALVPGPDFPTGGFIYGREGILQGYRTGRGIV
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCCE
QMRARASIETHKKTERQSIVVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDG
EHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
MRIVIDLKRDENPQVILNHLYKQTQMQTSFGINMLAIVAGRPKVLTLQDAIGHFIDHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHHHHHHHH
IVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGSKTPAEAREGLMSGLFSDEEW
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHH
LQKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYEDILKYIARLK
HHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEHHHEECCCEEEEEECCCCH
KRTAVSQYRSQRRGGKGKTGMKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPE
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCC
GGRATRGKAIVNLLNLQENEQITAILSVKGFDDERNILMATRLGVVKKSPLREYANIRSG
CCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEHHCHHCCCHHHHHHCCCCC
GIIAVNLDEEDKLIAVALTDGRQDVLLASRNGKSIRFHEEDARPMGRVSRGVRGMTLEDD
CEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCHHHHHHCCCCCCEECCC
DVVIGMEVINPSATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDI
CEEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEE
MQVTDENDLMLITDQGKILRIPVAPFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGD
EEECCCCCEEEEECCCCEEEEECCCHHHHCCCCCCEEEEEECCCCCEEEEEHHHHCCCCC
EGPDSGDDLPEAEVVEE
CCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MLEQTLNKTAVNIEDEMKRSYMDYAMSVIIGRALPDVRDGLKPVHRRCLYAMYDMGNDYN
CCCHHHCHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KPYKKSARVVGDVIGKYHPHGDTAAYDTIVRMAQDFSLRYPLVDGQGNFGSVDGDSPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEECCCCCCCCCCCCCCCHH
RYTEIRMEQLAHELLNDLEKETVDLGFNYDGSLTEPLVLPSKFPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLSEVIDGIIATIGNPHISFEELLALVPGPDFPTGGFIYGREGILQGYRTGRGIV
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCCE
QMRARASIETHKKTERQSIVVTEIPYQVNKANLITKIAELVREKKLEGISDIRDESDRDG
EHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
MRIVIDLKRDENPQVILNHLYKQTQMQTSFGINMLAIVAGRPKVLTLQDAIGHFIDHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHHHHHHHH
IVTRRTIFDLKKAEARAHILEGYKIALDWLDAVIELIRGSKTPAEAREGLMSGLFSDEEW
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHH
LQKMGLPLPAIHSQYQKPVRLTEVQAQEILNLRLHRLTGLERDKILQEYEDILKYIARLK
HHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EILASEAEILKIIVGELRELKEKFGDERRTEIVDRSAEISLEDTIVEEDVVVTVSHTGYI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEHHHEECCCEEEEEECCCCH
KRTAVSQYRSQRRGGKGKTGMKTKEEDFVEHLFVASSKDFMLFFTDAGKVYQIKVYEIPE
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCC
GGRATRGKAIVNLLNLQENEQITAILSVKGFDDERNILMATRLGVVKKSPLREYANIRSG
CCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEHHCHHCCCHHHHHHCCCCC
GIIAVNLDEEDKLIAVALTDGRQDVLLASRNGKSIRFHEEDARPMGRVSRGVRGMTLEDD
CEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCHHHHHHCCCCCCEECCC
DVVIGMEVINPSATGSTIFTVTENGFGKRTELDEYRVQSRGGKGIITIKTTERNGCVVDI
CEEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEE
MQVTDENDLMLITDQGKILRIPVAPFSVIGRNTQGVRLMTAEQNERIVAVAKLAEKDEGD
EEECCCCCEEEEECCCCEEEEECCCHHHHCCCCCCEEEEEECCCCCEEEEEHHHHCCCCC
EGPDSGDDLPEAEVVEE
CCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]