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The map label for this gene is pyrH

Identifier: 78189603

GI number: 78189603

Start: 2144063

End: 2144782

Strand: Reverse

Name: pyrH

Synonym: Cag_1646

Alternate gene names: 78189603

Gene position: 2144782-2144063 (Counterclockwise)

Preceding gene: 78189604

Following gene: 78189601

Centisome position: 83.39

GC content: 46.39

Gene sequence:

>720_bases
ATGCTTCACTACAAGCGCATTTTGCTGAAATTAAGTGGCGAGTCGCTCGCGGGAGAGGATGGCTATGGCATTAATGCTGG
GGTGCTTGACCAGTATGCCGAAGAGATTAGCGAAGCTCGTGATATGGGGGCGCAAATTGCCCTCGTGATTGGTGGTGGCA
ACATTTTCCGTGGGGTGTCGCAAGCGGCGGCAAATATGGATAGGGTACAAGCCGATTATATGGGCATGTTAGCCACCGTT
ATTAATTCGTTAGCATTTCAAGATGCGTTGGAGCGTAAAGGTGTTTTTACTCGTTTGCTAACGGCTATTTCAATGGAGCA
AATTGCTGAGCCGTTTATTCGGCGCCGTGCCATTCGCCACCTTGAAAAAGGGCGTGTGGTTATTTTTGGTGCAGGCACCG
GTAACCCCTATTTTACAACCGATACGGCGGCATCGTTACGGGCAATTGAAATTGAAGCCGATATTATTGTAAAAGGCACC
CGTGTTGATGGCATTTATGATTCCGATCCCGAAAAAAATGCCAATGCCCAATTTTTCCCCGATATCTCCTACCTTGATGT
TTTCCATAAAAAATTAGGGGTTATGGATATGACGGCAATCACGCTGTGTAGTGAGAATTCGCTCCCTATTGTGGTGATGA
ATATGAATGAAAAAGGGAACCTTTCACGATTGTTGCGTGGCGAAAAAGTTGGCTCATTAGTGCATCACGAAGGAGTGTAA

Upstream 100 bases:

>100_bases
TTTTTTGCTCTTGAGATGGGTTGGCAAGAGAGCCGTTGTAAGCGGAAATATGTTACTAACGGAACCAATTTTTTGGAATT
TGTAAGGAGGGGAGAGAGAT

Downstream 100 bases:

>100_bases
CGGTTTGTTGATGTTTCAAGTTTGGGAATGTAAGTCGTTGTAAATCAACACATAGAGGTTACTCAATATCATCATCCATT
GTGGATGTTGTAGGAAAAAA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MLHYKRILLKLSGESLAGEDGYGINAGVLDQYAEEISEARDMGAQIALVIGGGNIFRGVSQAAANMDRVQADYMGMLATV
INSLAFQDALERKGVFTRLLTAISMEQIAEPFIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADIIVKGT
RVDGIYDSDPEKNANAQFFPDISYLDVFHKKLGVMDMTAITLCSENSLPIVVMNMNEKGNLSRLLRGEKVGSLVHHEGV

Sequences:

>Translated_239_residues
MLHYKRILLKLSGESLAGEDGYGINAGVLDQYAEEISEARDMGAQIALVIGGGNIFRGVSQAAANMDRVQADYMGMLATV
INSLAFQDALERKGVFTRLLTAISMEQIAEPFIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADIIVKGT
RVDGIYDSDPEKNANAQFFPDISYLDVFHKKLGVMDMTAITLCSENSLPIVVMNMNEKGNLSRLLRGEKVGSLVHHEGV
>Mature_239_residues
MLHYKRILLKLSGESLAGEDGYGINAGVLDQYAEEISEARDMGAQIALVIGGGNIFRGVSQAAANMDRVQADYMGMLATV
INSLAFQDALERKGVFTRLLTAISMEQIAEPFIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADIIVKGT
RVDGIYDSDPEKNANAQFFPDISYLDVFHKKLGVMDMTAITLCSENSLPIVVMNMNEKGNLSRLLRGEKVGSLVHHEGV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=51.9480519480519, Blast_Score=248, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CHLCH (Q3AQ27)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379941.1
- HSSP:   P65938
- ProteinModelPortal:   Q3AQ27
- SMR:   Q3AQ27
- STRING:   Q3AQ27
- GeneID:   3747664
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1646
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   CCHL340177:CAG_1646-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26124; Mature: 26124

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 72-72 BINDING 160-160 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHYKRILLKLSGESLAGEDGYGINAGVLDQYAEEISEARDMGAQIALVIGGGNIFRGVS
CCCHHEEHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
QAAANMDRVQADYMGMLATVINSLAFQDALERKGVFTRLLTAISMEQIAEPFIRRRAIRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADIIVKGTRVDGIYDSDPEKNANAQFFP
HHCCCEEEEECCCCCCEEECCCCCCEEEEEEEEEEEEECCEECCCCCCCCCCCCCCEECC
DISYLDVFHKKLGVMDMTAITLCSENSLPIVVMNMNEKGNLSRLLRGEKVGSLVHHEGV
CHHHHHHHHHHHCCHHHHHEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLHYKRILLKLSGESLAGEDGYGINAGVLDQYAEEISEARDMGAQIALVIGGGNIFRGVS
CCCHHEEHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
QAAANMDRVQADYMGMLATVINSLAFQDALERKGVFTRLLTAISMEQIAEPFIRRRAIRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEADIIVKGTRVDGIYDSDPEKNANAQFFP
HHCCCEEEEECCCCCCEEECCCCCCEEEEEEEEEEEEECCEECCCCCCCCCCCCCCEECC
DISYLDVFHKKLGVMDMTAITLCSENSLPIVVMNMNEKGNLSRLLRGEKVGSLVHHEGV
CHHHHHHHHHHHCCHHHHHEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA