BacMap

Definition	Chlorobium chlorochromatii CaD3 chromosome, complete genome.
Accession	NC_007514
Length	2,572,079

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The map label for this gene is fabG2 [H]

Identifier: 78189596

GI number: 78189596

Start: 2137154

End: 2137978

Strand: Reverse

Name: fabG2 [H]

Synonym: Cag_1639

Alternate gene names: 78189596

Gene position: 2137978-2137154 (Counterclockwise)

Preceding gene: 78189597

Following gene: 78189595

Centisome position: 83.12

GC content: 47.39

Gene sequence:

>825_bases
ATGCTCACGCTGCATCAAAAAGTTGCAATTATTACTGGTTCTACTCGAGGCATTGGCAAAGCTATAGCACAAGAATTTGT
GCGGCAGGGTGCCCGTGTGGTTATTACCTCATCCTCTCCTCAAAATGTTGAAGCTGCGTGTAAGGAATTTCCTGCTGGCA
GCGTTCATGGCATTGCGTGCAATGTAACGTCGCCTGCTGATATGGAACGGCTTGTACGCGAAAGTGTAGCTCATTTTGGA
CAGCTTGATTGCTTTATTAACAATGCCGGCATTTCCGATCCCTTCACCAACATTACCGAAAGCGATCCCGAAGCGTGGGG
TCGCGTGATTGATACCAATCTCAAAGGCACCTATAACGGCTGCCGTGCGGCTCTTATCTATTTTCTTACCAACAACAAGC
AAGGCAAAATTATTAACATGGCTGGCTCTGGCACCGATAAGGGGTCAAATACGCCATGGATTAGCGCTTACGGTTCCACG
AAAGCGGCTATTGCTCGCTTTACCTACGCTATTGCGGCAGAATATCGCCACACCAACATCTCCATTATGCTGCTGCATCC
AGGTTTAGTGCGCACCGGCATGGTAAGCACCGAGCATCCAACGCCTGAGTTGGAACGGCAGTTACGCACCTTTAACACCA
TTCTTGATATTTTTGCCCAACCACCAACGGTTGCCGCTTCATTAGCGGTAAAAATGGCATCGCCATGGAGCGATGGCAAA
AATGGCATCTATCTTTCGGCATTAAGCTCCCTCCGCAAAAAAAAATTGCTCATAAGCTATCCCTTCCGTAAACTCTTTAA
GAAGATAGATCGCCAAACTTATTAA

Upstream 100 bases:

>100_bases
GCTATTGAGCAAGGTGTGCCGTTAGAAACCTATGCCCAAGGACGCCCTGAACTGCAAGCAATGGTTGATGGCGCTCACGG
CAAATAAACTATTGAGTTGA

Downstream 100 bases:

>100_bases
GGGAAAGTGCTTATGCGGATCTTTGCTTGGTTATTGGTGATTGTTGCAGTTGTGCTGCAAGGGTGCTATAGTTTTTCTAC
CGAAAACCGTTTAACCCATC

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MLTLHQKVAIITGSTRGIGKAIAQEFVRQGARVVITSSSPQNVEAACKEFPAGSVHGIACNVTSPADMERLVRESVAHFG
QLDCFINNAGISDPFTNITESDPEAWGRVIDTNLKGTYNGCRAALIYFLTNNKQGKIINMAGSGTDKGSNTPWISAYGST
KAAIARFTYAIAAEYRHTNISIMLLHPGLVRTGMVSTEHPTPELERQLRTFNTILDIFAQPPTVAASLAVKMASPWSDGK
NGIYLSALSSLRKKKLLISYPFRKLFKKIDRQTY

Sequences:

>Translated_274_residues
MLTLHQKVAIITGSTRGIGKAIAQEFVRQGARVVITSSSPQNVEAACKEFPAGSVHGIACNVTSPADMERLVRESVAHFG
QLDCFINNAGISDPFTNITESDPEAWGRVIDTNLKGTYNGCRAALIYFLTNNKQGKIINMAGSGTDKGSNTPWISAYGST
KAAIARFTYAIAAEYRHTNISIMLLHPGLVRTGMVSTEHPTPELERQLRTFNTILDIFAQPPTVAASLAVKMASPWSDGK
NGIYLSALSSLRKKKLLISYPFRKLFKKIDRQTY
>Mature_274_residues
MLTLHQKVAIITGSTRGIGKAIAQEFVRQGARVVITSSSPQNVEAACKEFPAGSVHGIACNVTSPADMERLVRESVAHFG
QLDCFINNAGISDPFTNITESDPEAWGRVIDTNLKGTYNGCRAALIYFLTNNKQGKIINMAGSGTDKGSNTPWISAYGST
KAAIARFTYAIAAEYRHTNISIMLLHPGLVRTGMVSTEHPTPELERQLRTFNTILDIFAQPPTVAASLAVKMASPWSDGK
NGIYLSALSSLRKKKLLISYPFRKLFKKIDRQTY

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=191, Percent_Identity=32.9842931937173, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI5031737, Length=219, Percent_Identity=27.8538812785388, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=29.8969072164948, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI40254992, Length=233, Percent_Identity=26.6094420600858, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI19923817, Length=196, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI59889578, Length=214, Percent_Identity=30.3738317757009, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=31.0526315789474, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI31542939, Length=239, Percent_Identity=27.1966527196653, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI126723750, Length=194, Percent_Identity=29.3814432989691, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4758504, Length=200, Percent_Identity=30.5, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=27.1356783919598, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI224922801, Length=176, Percent_Identity=30.1136363636364, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI40254986, Length=237, Percent_Identity=25.7383966244726, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI10190704, Length=188, Percent_Identity=29.2553191489362, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=29.5336787564767, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI87082100, Length=202, Percent_Identity=32.1782178217822, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790717, Length=198, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787820, Length=186, Percent_Identity=28.494623655914, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082160, Length=210, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=25.4032258064516, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787526, Length=223, Percent_Identity=21.52466367713, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786701, Length=190, Percent_Identity=27.8947368421053, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=228, Percent_Identity=30.2631578947368, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17559104, Length=245, Percent_Identity=28.1632653061224, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17555612, Length=250, Percent_Identity=28.4, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=237, Percent_Identity=27.8481012658228, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=195, Percent_Identity=28.7179487179487, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=200, Percent_Identity=33.5, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=201, Percent_Identity=26.3681592039801, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=191, Percent_Identity=25.130890052356, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=196, Percent_Identity=26.530612244898, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=201, Percent_Identity=26.865671641791, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=204, Percent_Identity=25.4901960784314, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=27.5510204081633, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=199, Percent_Identity=27.1356783919598, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=202, Percent_Identity=27.7227722772277, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=204, Percent_Identity=25.4901960784314, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=205, Percent_Identity=26.8292682926829, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=205, Percent_Identity=26.3414634146341, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71997099, Length=214, Percent_Identity=27.1028037383178, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=213, Percent_Identity=24.4131455399061, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=195, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=204, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=202, Percent_Identity=26.2376237623762, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86565303, Length=220, Percent_Identity=25, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=202, Percent_Identity=29.2079207920792, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=203, Percent_Identity=25.1231527093596, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=195, Percent_Identity=27.6923076923077, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=255, Percent_Identity=28.2352941176471, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322226, Length=251, Percent_Identity=29.8804780876494, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=197, Percent_Identity=28.9340101522843, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322861, Length=218, Percent_Identity=28.4403669724771, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355319, Length=195, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI23397609, Length=206, Percent_Identity=31.0679611650485, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644339, Length=191, Percent_Identity=28.2722513089005, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640442, Length=209, Percent_Identity=29.6650717703349, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=26.7676767676768, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737361, Length=218, Percent_Identity=28.4403669724771, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639444, Length=256, Percent_Identity=26.953125, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571526, Length=195, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=194, Percent_Identity=27.319587628866, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24643142, Length=200, Percent_Identity=28.5, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665247, Length=203, Percent_Identity=29.5566502463054, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665243, Length=203, Percent_Identity=30.0492610837438, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221331216, Length=203, Percent_Identity=29.5566502463054, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221331218, Length=203, Percent_Identity=30.0492610837438, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357673, Length=197, Percent_Identity=27.9187817258883, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641232, Length=237, Percent_Identity=25.3164556962025, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 29912; Mature: 29912

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLHQKVAIITGSTRGIGKAIAQEFVRQGARVVITSSSPQNVEAACKEFPAGSVHGIAC
CCEECCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCCCCEEEE
NVTSPADMERLVRESVAHFGQLDCFINNAGISDPFTNITESDPEAWGRVIDTNLKGTYNG
ECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHEEECCCCCCCCC
CRAALIYFLTNNKQGKIINMAGSGTDKGSNTPWISAYGSTKAAIARFTYAIAAEYRHTNI
CEEEEEEEEECCCCCCEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHEEECCE
SIMLLHPGLVRTGMVSTEHPTPELERQLRTFNTILDIFAQPPTVAASLAVKMASPWSDGK
EEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
NGIYLSALSSLRKKKLLISYPFRKLFKKIDRQTY
CCEEHHHHHHHHHHHHEEECCHHHHHHHHHCCCC
>Mature Secondary Structure
MLTLHQKVAIITGSTRGIGKAIAQEFVRQGARVVITSSSPQNVEAACKEFPAGSVHGIAC
CCEECCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCCCCEEEE
NVTSPADMERLVRESVAHFGQLDCFINNAGISDPFTNITESDPEAWGRVIDTNLKGTYNG
ECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHEEECCCCCCCCC
CRAALIYFLTNNKQGKIINMAGSGTDKGSNTPWISAYGSTKAAIARFTYAIAAEYRHTNI
CEEEEEEEEECCCCCCEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHEEECCE
SIMLLHPGLVRTGMVSTEHPTPELERQLRTFNTILDIFAQPPTVAASLAVKMASPWSDGK
EEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
NGIYLSALSSLRKKKLLISYPFRKLFKKIDRQTY
CCEEHHHHHHHHHHHHEEECCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]