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The map label for this gene is dut

Identifier: 78189555

GI number: 78189555

Start: 2082155

End: 2082604

Strand: Reverse

Name: dut

Synonym: Cag_1595

Alternate gene names: 78189555

Gene position: 2082604-2082155 (Counterclockwise)

Preceding gene: 78189558

Following gene: 78189549

Centisome position: 80.97

GC content: 49.78

Gene sequence:

>450_bases
ATGCTCAATATAAAAATAGTTCGACTTCACCCATTAGCCACCCTGCCTGCTTATGCTACAGCACATGCGGCTGGCATGGA
TGTTGCCGCCTGCCTTGAGGCTCCCGTAAGCGTTGCCCCCTTTTCTACTGCACTTATTCCCACAGGTTTTGCTCTTGAGT
TGCCCATTGGTTACGAAGCACAATTGCGTCCTCGTAGCGGCTTAGCCTTGCGCTCTATGATTTCGCTGCCTAATACTCCA
GCAACCATTGATGCTGATTATCGTGGAGAGGTTAAGGTCATTCTTATTAATTATGGCAAAGAGCCATTTATGGTGCAACA
CGGCGATCGTATTGCTCAAATGGTGATTGCGCGTGTGGAGCAGGTGCAGTTTGAAGAGGTAGCCGAGTTGTCAGCAACGG
TACGGGGAGAAGGTGGCTTTGGGCATACGGGCATTGCAAGCGTGCAATAA

Upstream 100 bases:

>100_bases
AATAGATTCCATAAAGAAGACTTACTATTTTAATCATCTGACTCCCTACTGTCCACTCTCTACGTTCTAACCACCCAAAC
TTCTAACTCATCCTAACATT

Downstream 100 bases:

>100_bases
TACCGTTACAGCCATTATGTTTTGAGGGGTGTTGAAACAATCGAAACAAGCAAAAAAAATACGGATAAAGCTAAATGCCT
TATCCGTATTTAAATAATGG

Product: dUTP pyrophosphatase subfamily protein

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MLNIKIVRLHPLATLPAYATAHAAGMDVAACLEAPVSVAPFSTALIPTGFALELPIGYEAQLRPRSGLALRSMISLPNTP
ATIDADYRGEVKVILINYGKEPFMVQHGDRIAQMVIARVEQVQFEEVAELSATVRGEGGFGHTGIASVQ

Sequences:

>Translated_149_residues
MLNIKIVRLHPLATLPAYATAHAAGMDVAACLEAPVSVAPFSTALIPTGFALELPIGYEAQLRPRSGLALRSMISLPNTP
ATIDADYRGEVKVILINYGKEPFMVQHGDRIAQMVIARVEQVQFEEVAELSATVRGEGGFGHTGIASVQ
>Mature_149_residues
MLNIKIVRLHPLATLPAYATAHAAGMDVAACLEAPVSVAPFSTALIPTGFALELPIGYEAQLRPRSGLALRSMISLPNTP
ATIDADYRGEVKVILINYGKEPFMVQHGDRIAQMVIARVEQVQFEEVAELSATVRGEGGFGHTGIASVQ

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=143, Percent_Identity=40.5594405594406, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI4503423, Length=143, Percent_Identity=40.5594405594406, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI70906441, Length=143, Percent_Identity=40.5594405594406, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1790071, Length=146, Percent_Identity=42.4657534246575, Blast_Score=118, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71988561, Length=143, Percent_Identity=41.2587412587413, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319729, Length=142, Percent_Identity=34.5070422535211, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921126, Length=145, Percent_Identity=35.1724137931034, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24583610, Length=145, Percent_Identity=35.1724137931034, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_CHLCH (Q3AQ75)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379893.1
- ProteinModelPortal:   Q3AQ75
- SMR:   Q3AQ75
- STRING:   Q3AQ75
- GeneID:   3746670
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1595
- eggNOG:   COG0756
- HOGENOM:   HBG436079
- OMA:   LDLRACI
- ProtClustDB:   CLSK637750
- BioCyc:   CCHL340177:CAG_1595-MONOMER
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 15896; Mature: 15896

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 92-92

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIKIVRLHPLATLPAYATAHAAGMDVAACLEAPVSVAPFSTALIPTGFALELPIGYEA
CCEEEEEEEECCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCE
QLRPRSGLALRSMISLPNTPATIDADYRGEVKVILINYGKEPFMVQHGDRIAQMVIARVE
EECCCCCHHHHHHHCCCCCCCEEECCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHH
QVQFEEVAELSATVRGEGGFGHTGIASVQ
HHHHHHHHHHHHEEECCCCCCCCCCEECC
>Mature Secondary Structure
MLNIKIVRLHPLATLPAYATAHAAGMDVAACLEAPVSVAPFSTALIPTGFALELPIGYEA
CCEEEEEEEECCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCE
QLRPRSGLALRSMISLPNTPATIDADYRGEVKVILINYGKEPFMVQHGDRIAQMVIARVE
EECCCCCHHHHHHHCCCCCCCEEECCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHH
QVQFEEVAELSATVRGEGGFGHTGIASVQ
HHHHHHHHHHHHEEECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA