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The map label for this gene is hdrA [H]

Identifier: 78189543

GI number: 78189543

Start: 2065744

End: 2067996

Strand: Reverse

Name: hdrA [H]

Synonym: Cag_1583

Alternate gene names: 78189543

Gene position: 2067996-2065744 (Counterclockwise)

Preceding gene: 78189544

Following gene: 78189542

Centisome position: 80.4

GC content: 45.32

Gene sequence:

>2253_bases
ATGGCAGATGAAAAGAAAATTGGAGTGTATCTCTGTACCGGCTGCGGCATTGGTGAGGCGCTGAATATTGATGAGCTTGA
AGCTGTAGCTAAAAAAGAGTTTAAAGTTCCTATTTGTAAACGGCATGAATTTTTGTGCAGCCGTGATGGATTGCAGGTTA
TTAAAGATGATATGAATAATGAAGGGGTGAATAAAGTGGTGGTTGCTGCTTGTTCGCCTCGCGTTCATACCGATCTTTTT
GCCTTTGACCCCATGAAGTATGTGGTTGAGCGCGTTAATTTGCGTGAGCAAGTGGTGTGGACACAGCCAAAAACCGATGC
GGGTAAAGAGGGGAGCCAGTTAATGGCAGCCGATTATCTTCGTATGGGTATTACTCGTATTGGTAAATCCAATGCGCATG
AGCCAAAAATTATAGATGTTAATCGCACCTTATTGATTGTAGGTGGTGGTGTAACGGGTCTTACTGCGGCTCTTGAAGCT
TCGCAAGCAGGCTATAAATCGGTGATTGTTGAAAAAAGCGGTGAGCTTGGTGGTAACGCTAAAAAAATGTTCAAGGTGTT
CCCAACCGCTCCACCCTTTGCTGAGCTTGAAAAGCCAACCATTGATAACAAAATTCAAGCCGCTAAAAACGATAGCAATA
TTACGATTCACACGAATGCTACCGTTGCTTGTATTGAAGGTGGTCCGGGTATGTACAAGGTTACCATTGATAAAAATGGT
GCCTCCGATACCTTTGATGCTGGTGCTGTAGTGCTTGCTTCAGGATGGCGCCCTTACGATCCATCCAATCTTGGTGGGTT
AGGCTATGGCAAATTCCGTAATGTTATTACCAACCTCCAAATGGAGGAGATGGTTACGAAGAACAATGGGAAAGTTCTTC
GTCCATCCGATGGTAAAATTGCTAAAAGCGTTGTTTTTGTGCAGTGCGCTGGGCAGCGTGATGAAAAGCATGTGCCCTAC
TGTTCAACCGTTTGCTGTAACGTATCACTCAAGCAAGCAAAGTATGTGCGTGAATCAAATCCCGATGCTGGTGCTTTTGT
GATTTATAAAGATATGCGCACGCTTGGTTTGTATGAGAATTTCTACAAAACAGCGCAAGATGACGAGGGTATTTTTCTTG
CAAAAGGTGAAGTGCTTGGCATTCAAGAGGGACCTGAAGGCAACCTCTACGTTGAAATAAACAACCAGTTGCTTGGCATG
AAAATGCAAATCAATGCCGACTTAGTGGTGCTTGCAACGGGTATGGTTTCAGGCATGGTGCCGGAAGATCGTGGGGTGAA
TAACCTTACGCCAGAGTACATTGGCAATCTTGTGAAAAGAGAGACCTCTGATGGTGAAATTGTTGATCTTGAGCCATTAA
GCTTAGCGTTGAATTTGAAATATCGTCAGGGACCAGAAATGCCACATCTCAAGTGGGGCTTCCCTGATTCTCATTTTATT
TGCTTCCCTTACGAAACACGTCGTACCGGTATTTATTCAGCGGGTGCTGTTCGCCATCCTATGGATGCGGTTCAGTCGGT
TGCTGATGCTACGGGTGCCGCTTTAAAAGCTATTCAGTGCATTGAGCTAACTGCTCAGGGACGTGCTGTTCATCCAAGAA
CGTGGGATCGTACCTATCCTGAAATTCGTTTTGAAAGCTGCACGCAGTGCCGCCGCTGTACGGTAGAGTGCCCATTTGGT
GCGTATGATGAAGAGAGCAACGGTACACCGTTGCAATATCCATCGCGTTGCCGTCGTTGCGGTGTTTGCATGGGAGCTTG
CCCTCAGCGTGTTATCTCCTTTAAGGATTACAGTGTTGATATGATTTCATCCATGCTGAAAACCATTGAAGTGCCTGATT
CTGGTACCTTTGTTATTGGTTTTGTGTGTGAGAATGATGCGTATCCTGCCTTTGATATGGTAGGGCTGAATCGTATGGCG
CTCAATACCAACTTCCGCTTTATTTCATTGCGTTGCCTTGGTGGTTTAAACCTTGTGTGGATTGCCGATGCGCTTTCGCG
TGGTGTTGATGGCATTCTTTTACTTGGTTGCAAATATGGTGATGATTACCAGTGCCACTACGTTAAAGGTAGCCAAATGG
CAAATGAGCGACTTGGTAAAGTGCAGGAGACGCTTGATCGCTTAATGTTGGAATCGGAGCGTGTTGAGCAGGTGCAGCTT
GCCATTAACGATTGGCAGAAGCTCCCCTCAATTCTTGAGGAGTTTGCAAAGAAGATTGAAGATATTGGTGAGAACCCGTA
CAAGGGCTTTTAA

Upstream 100 bases:

>100_bases
TACCGGTGTAGCAAAACGTCCTTCTGATGTTACAACCTCTCTTCAGGACGCAACCGGCGTCGCATTGAAAAGCATTCAAA
GTTTGGTAAGGAGTTAAAAC

Downstream 100 bases:

>100_bases
ATGATAATAACCATGGTGAAGAGGGTAATAGGAGTTTGTTCCTATGCCCTCTTTGCATGATTTTACTGTTGATAATTTTG
GAGGTTTTTTATGGCTCAAA

Product: heterodisulfide reductase, subunit A/hydrogenase subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MADEKKIGVYLCTGCGIGEALNIDELEAVAKKEFKVPICKRHEFLCSRDGLQVIKDDMNNEGVNKVVVAACSPRVHTDLF
AFDPMKYVVERVNLREQVVWTQPKTDAGKEGSQLMAADYLRMGITRIGKSNAHEPKIIDVNRTLLIVGGGVTGLTAALEA
SQAGYKSVIVEKSGELGGNAKKMFKVFPTAPPFAELEKPTIDNKIQAAKNDSNITIHTNATVACIEGGPGMYKVTIDKNG
ASDTFDAGAVVLASGWRPYDPSNLGGLGYGKFRNVITNLQMEEMVTKNNGKVLRPSDGKIAKSVVFVQCAGQRDEKHVPY
CSTVCCNVSLKQAKYVRESNPDAGAFVIYKDMRTLGLYENFYKTAQDDEGIFLAKGEVLGIQEGPEGNLYVEINNQLLGM
KMQINADLVVLATGMVSGMVPEDRGVNNLTPEYIGNLVKRETSDGEIVDLEPLSLALNLKYRQGPEMPHLKWGFPDSHFI
CFPYETRRTGIYSAGAVRHPMDAVQSVADATGAALKAIQCIELTAQGRAVHPRTWDRTYPEIRFESCTQCRRCTVECPFG
AYDEESNGTPLQYPSRCRRCGVCMGACPQRVISFKDYSVDMISSMLKTIEVPDSGTFVIGFVCENDAYPAFDMVGLNRMA
LNTNFRFISLRCLGGLNLVWIADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLESERVEQVQL
AINDWQKLPSILEEFAKKIEDIGENPYKGF

Sequences:

>Translated_750_residues
MADEKKIGVYLCTGCGIGEALNIDELEAVAKKEFKVPICKRHEFLCSRDGLQVIKDDMNNEGVNKVVVAACSPRVHTDLF
AFDPMKYVVERVNLREQVVWTQPKTDAGKEGSQLMAADYLRMGITRIGKSNAHEPKIIDVNRTLLIVGGGVTGLTAALEA
SQAGYKSVIVEKSGELGGNAKKMFKVFPTAPPFAELEKPTIDNKIQAAKNDSNITIHTNATVACIEGGPGMYKVTIDKNG
ASDTFDAGAVVLASGWRPYDPSNLGGLGYGKFRNVITNLQMEEMVTKNNGKVLRPSDGKIAKSVVFVQCAGQRDEKHVPY
CSTVCCNVSLKQAKYVRESNPDAGAFVIYKDMRTLGLYENFYKTAQDDEGIFLAKGEVLGIQEGPEGNLYVEINNQLLGM
KMQINADLVVLATGMVSGMVPEDRGVNNLTPEYIGNLVKRETSDGEIVDLEPLSLALNLKYRQGPEMPHLKWGFPDSHFI
CFPYETRRTGIYSAGAVRHPMDAVQSVADATGAALKAIQCIELTAQGRAVHPRTWDRTYPEIRFESCTQCRRCTVECPFG
AYDEESNGTPLQYPSRCRRCGVCMGACPQRVISFKDYSVDMISSMLKTIEVPDSGTFVIGFVCENDAYPAFDMVGLNRMA
LNTNFRFISLRCLGGLNLVWIADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLESERVEQVQL
AINDWQKLPSILEEFAKKIEDIGENPYKGF
>Mature_749_residues
ADEKKIGVYLCTGCGIGEALNIDELEAVAKKEFKVPICKRHEFLCSRDGLQVIKDDMNNEGVNKVVVAACSPRVHTDLFA
FDPMKYVVERVNLREQVVWTQPKTDAGKEGSQLMAADYLRMGITRIGKSNAHEPKIIDVNRTLLIVGGGVTGLTAALEAS
QAGYKSVIVEKSGELGGNAKKMFKVFPTAPPFAELEKPTIDNKIQAAKNDSNITIHTNATVACIEGGPGMYKVTIDKNGA
SDTFDAGAVVLASGWRPYDPSNLGGLGYGKFRNVITNLQMEEMVTKNNGKVLRPSDGKIAKSVVFVQCAGQRDEKHVPYC
STVCCNVSLKQAKYVRESNPDAGAFVIYKDMRTLGLYENFYKTAQDDEGIFLAKGEVLGIQEGPEGNLYVEINNQLLGMK
MQINADLVVLATGMVSGMVPEDRGVNNLTPEYIGNLVKRETSDGEIVDLEPLSLALNLKYRQGPEMPHLKWGFPDSHFIC
FPYETRRTGIYSAGAVRHPMDAVQSVADATGAALKAIQCIELTAQGRAVHPRTWDRTYPEIRFESCTQCRRCTVECPFGA
YDEESNGTPLQYPSRCRRCGVCMGACPQRVISFKDYSVDMISSMLKTIEVPDSGTFVIGFVCENDAYPAFDMVGLNRMAL
NTNFRFISLRCLGGLNLVWIADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLESERVEQVQLA
INDWQKLPSILEEFAKKIEDIGENPYKGF

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR003813
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4; PF02662 FlpD [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 82698; Mature: 82567

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADEKKIGVYLCTGCGIGEALNIDELEAVAKKEFKVPICKRHEFLCSRDGLQVIKDDMNN
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCC
EGVNKVVVAACSPRVHTDLFAFDPMKYVVERVNLREQVVWTQPKTDAGKEGSQLMAADYL
CCCCEEEEEECCCCCCCCEEEECHHHHHHHHHCCHHEEEEECCCCCCCCCCCHHHHHHHH
RMGITRIGKSNAHEPKIIDVNRTLLIVGGGVTGLTAALEASQAGYKSVIVEKSGELGGNA
HHHHHHHCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCH
KKMFKVFPTAPPFAELEKPTIDNKIQAAKNDSNITIHTNATVACIEGGPGMYKVTIDKNG
HHHEEECCCCCCHHHCCCCCCCCHHECCCCCCCEEEEECCEEEEEECCCCEEEEEEECCC
ASDTFDAGAVVLASGWRPYDPSNLGGLGYGKFRNVITNLQMEEMVTKNNGKVLRPSDGKI
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCEEECCCCCCC
AKSVVFVQCAGQRDEKHVPYCSTVCCNVSLKQAKYVRESNPDAGAFVIYKDMRTLGLYEN
EEEEEEEEECCCCCCCCCCCHHHHEECCCHHHHHHHHCCCCCCCEEEEEECHHHHHHHHH
FYKTAQDDEGIFLAKGEVLGIQEGPEGNLYVEINNQLLGMKMQINADLVVLATGMVSGMV
HHHCCCCCCCEEEECCEEEEECCCCCCCEEEEECCCEEEEEEEECCCEEEEEEHHHHCCC
PEDRGVNNLTPEYIGNLVKRETSDGEIVDLEPLSLALNLKYRQGPEMPHLKWGFPDSHFI
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCEEEEEEEEECCCCCCCCEECCCCCCCEE
CFPYETRRTGIYSAGAVRHPMDAVQSVADATGAALKAIQCIELTAQGRAVHPRTWDRTYP
EEECHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCEECCCCCCCCCC
EIRFESCTQCRRCTVECPFGAYDEESNGTPLQYPSRCRRCGVCMGACPQRVISFKDYSVD
CCCHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHHCCHHCCCHHHHHCCCCCCHH
MISSMLKTIEVPDSGTFVIGFVCENDAYPAFDMVGLNRMALNTNFRFISLRCLGGLNLVW
HHHHHHHHEECCCCCCEEEEEEECCCCCCCCHHCCCCEEEEECCEEEEEEEECCCCCEEE
IADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLESERVEQVQL
EHHHHHCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AINDWQKLPSILEEFAKKIEDIGENPYKGF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ADEKKIGVYLCTGCGIGEALNIDELEAVAKKEFKVPICKRHEFLCSRDGLQVIKDDMNN
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCC
EGVNKVVVAACSPRVHTDLFAFDPMKYVVERVNLREQVVWTQPKTDAGKEGSQLMAADYL
CCCCEEEEEECCCCCCCCEEEECHHHHHHHHHCCHHEEEEECCCCCCCCCCCHHHHHHHH
RMGITRIGKSNAHEPKIIDVNRTLLIVGGGVTGLTAALEASQAGYKSVIVEKSGELGGNA
HHHHHHHCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCH
KKMFKVFPTAPPFAELEKPTIDNKIQAAKNDSNITIHTNATVACIEGGPGMYKVTIDKNG
HHHEEECCCCCCHHHCCCCCCCCHHECCCCCCCEEEEECCEEEEEECCCCEEEEEEECCC
ASDTFDAGAVVLASGWRPYDPSNLGGLGYGKFRNVITNLQMEEMVTKNNGKVLRPSDGKI
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCEEECCCCCCC
AKSVVFVQCAGQRDEKHVPYCSTVCCNVSLKQAKYVRESNPDAGAFVIYKDMRTLGLYEN
EEEEEEEEECCCCCCCCCCCHHHHEECCCHHHHHHHHCCCCCCCEEEEEECHHHHHHHHH
FYKTAQDDEGIFLAKGEVLGIQEGPEGNLYVEINNQLLGMKMQINADLVVLATGMVSGMV
HHHCCCCCCCEEEECCEEEEECCCCCCCEEEEECCCEEEEEEEECCCEEEEEEHHHHCCC
PEDRGVNNLTPEYIGNLVKRETSDGEIVDLEPLSLALNLKYRQGPEMPHLKWGFPDSHFI
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCEEEEEEEEECCCCCCCCEECCCCCCCEE
CFPYETRRTGIYSAGAVRHPMDAVQSVADATGAALKAIQCIELTAQGRAVHPRTWDRTYP
EEECHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCEECCCCCCCCCC
EIRFESCTQCRRCTVECPFGAYDEESNGTPLQYPSRCRRCGVCMGACPQRVISFKDYSVD
CCCHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHHCCHHCCCHHHHHCCCCCCHH
MISSMLKTIEVPDSGTFVIGFVCENDAYPAFDMVGLNRMALNTNFRFISLRCLGGLNLVW
HHHHHHHHEECCCCCCEEEEEEECCCCCCCCHHCCCCEEEEECCEEEEEEEECCCCCEEE
IADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLESERVEQVQL
EHHHHHCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AINDWQKLPSILEEFAKKIEDIGENPYKGF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]