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The map label for this gene is hemA

Identifier: 78189476

GI number: 78189476

Start: 1989559

End: 1990839

Strand: Reverse

Name: hemA

Synonym: Cag_1516

Alternate gene names: 78189476

Gene position: 1990839-1989559 (Counterclockwise)

Preceding gene: 78189477

Following gene: 78189475

Centisome position: 77.4

GC content: 43.87

Gene sequence:

>1281_bases
ATGAACATCATTTCAGTTGGTGTCAACCACAAGACAGCACCTATTGAAATCCGTGAAAGAATCTCCCTTTCAGAAGTTCA
GAACAAGGAATTCATTACCGGACTTGTTTCCAGTGGACTTGCTCACGAGGCAATGGTACTTTCAACCTGCAACCGCACTG
AGTTGTATGTAGTACCAGCCATGCACGAAGTAACCGGCGAGTTTCTCAAAGAATATCTCATCTCTTACCGAGATGCCCGC
AAAGAGGTTCGTCCCGAACATTTTTTTAGCCGTTTTTATTGTAGTACTGCTCGCCACTTGTTTGAAGTTGCAAGCGCGAT
TGATTCGCTTGTGCTTGGTGAAGGGCAGATTCTTGGGCAGGTAAAAAATGCTTATCGCATTGCTGCTGAGGCTCAATGCG
CGGGCATTATGATTACCCGCCTTTGCCACACCGCTTTTAGTGTGGCTAAAAAGGTGAAAACCAAAACACGCATTATGGAA
GGTGCGGTTTCGGTGAGTTATGCAGCAGTGGAGTTGGCACAAAAAATTTTCTCCAACCTATCACTAAAAAAAGTGCTGTT
AGTTGGAGCGGGTGAAACAGGTGAGTTAGCGGCAAAACATATGTTTGCCAAAAATGCTCGCAATATTGTTATCACCAACC
GCACCATCTCCAAAGCCGAAGCTCTTGCCGAAGAGCTTGGCACCAATCAAGTCCTCCCTTACGAAAGCTACAAAGAGCAT
CTCCACGAGTTTGATATTATCATTACGGCAGTAAGCACCAAAGATTATGCCCTTACTGAAGCTGATATGCAGCCCGCAAT
GGCTCGCCGCAAACTGAAACCTGTTATTATTCTTGATCTTGGTTTGCCACGAAATGTTGATCCAAACATTTCAAAGCTCC
AAAATATGTTCTTGAAGGATATTGATGACCTCAAGCATATTATTGATAAGAACCTCGAAAAGAGACGCCGTGAGTTGCCA
AAGGTTCATGCGATTATTGAGGAAGAGCTTATTGCTTTTGGGCAGTGGATTAACACCCTAAAGGTGCGTCCAACTATTGT
GGATTTGCAGTCGAAGTTTATTGAAATTAAGGAGAAGGAGCTGGAGCGTTACCGTTATAAGGTGAGCGAAGAAGAGCTTC
AGCGCATGGAACATCTTACCGACCGCATTCTGAAAAAGATTCTGCACCATCCTATTAAAATGCTCAAGGCACCAATTGAT
ACCACTGATTCGATTCCAAGCCGTGTGAATTTGGTGCGTAACGTTTTTGACCTTGAAGAACCAAATCAGTCACATTTTTA
A

Upstream 100 bases:

>100_bases
TTTTAGTATTACTTCGCAATCACAGCGGCAGGCAGAACGGCAAAAGGCTCGTAACCGTATTCCGTTACGTTATTATCTTT
ATCACCTAAATACTCCTCTT

Downstream 100 bases:

>100_bases
ATCACCCAATAAACTCTGTAACAGCCTTGAAAAAACAGCTTATTATCGGCACCCGCTCCAGCCCCCTTGCATTGTGGCAG
GCAGAATTTACGAAAGCAGA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITGLVSSGLAHEAMVLSTCNRTELYVVPAMHEVTGEFLKEYLISYRDAR
KEVRPEHFFSRFYCSTARHLFEVASAIDSLVLGEGQILGQVKNAYRIAAEAQCAGIMITRLCHTAFSVAKKVKTKTRIME
GAVSVSYAAVELAQKIFSNLSLKKVLLVGAGETGELAAKHMFAKNARNIVITNRTISKAEALAEELGTNQVLPYESYKEH
LHEFDIIITAVSTKDYALTEADMQPAMARRKLKPVIILDLGLPRNVDPNISKLQNMFLKDIDDLKHIIDKNLEKRRRELP
KVHAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKELERYRYKVSEEELQRMEHLTDRILKKILHHPIKMLKAPID
TTDSIPSRVNLVRNVFDLEEPNQSHF

Sequences:

>Translated_426_residues
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITGLVSSGLAHEAMVLSTCNRTELYVVPAMHEVTGEFLKEYLISYRDAR
KEVRPEHFFSRFYCSTARHLFEVASAIDSLVLGEGQILGQVKNAYRIAAEAQCAGIMITRLCHTAFSVAKKVKTKTRIME
GAVSVSYAAVELAQKIFSNLSLKKVLLVGAGETGELAAKHMFAKNARNIVITNRTISKAEALAEELGTNQVLPYESYKEH
LHEFDIIITAVSTKDYALTEADMQPAMARRKLKPVIILDLGLPRNVDPNISKLQNMFLKDIDDLKHIIDKNLEKRRRELP
KVHAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKELERYRYKVSEEELQRMEHLTDRILKKILHHPIKMLKAPID
TTDSIPSRVNLVRNVFDLEEPNQSHF
>Mature_426_residues
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITGLVSSGLAHEAMVLSTCNRTELYVVPAMHEVTGEFLKEYLISYRDAR
KEVRPEHFFSRFYCSTARHLFEVASAIDSLVLGEGQILGQVKNAYRIAAEAQCAGIMITRLCHTAFSVAKKVKTKTRIME
GAVSVSYAAVELAQKIFSNLSLKKVLLVGAGETGELAAKHMFAKNARNIVITNRTISKAEALAEELGTNQVLPYESYKEH
LHEFDIIITAVSTKDYALTEADMQPAMARRKLKPVIILDLGLPRNVDPNISKLQNMFLKDIDDLKHIIDKNLEKRRRELP
KVHAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKELERYRYKVSEEELQRMEHLTDRILKKILHHPIKMLKAPID
TTDSIPSRVNLVRNVFDLEEPNQSHF

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=423, Percent_Identity=33.806146572104, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_CHLCH (Q3AQF4)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379814.1
- ProteinModelPortal:   Q3AQF4
- SMR:   Q3AQF4
- STRING:   Q3AQF4
- GeneID:   3747149
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1516
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   EVRPEHF
- ProtClustDB:   PRK00045
- BioCyc:   CCHL340177:CAG_1516-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48480; Mature: 48480

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITGLVSSGLAHEAMVLSTCNRTELYVVPA
CCEEEECCCCCCCCHHHHHHCCHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECC
MHEVTGEFLKEYLISYRDARKEVRPEHFFSRFYCSTARHLFEVASAIDSLVLGEGQILGQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VKNAYRIAAEAQCAGIMITRLCHTAFSVAKKVKTKTRIMEGAVSVSYAAVELAQKIFSNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SLKKVLLVGAGETGELAAKHMFAKNARNIVITNRTISKAEALAEELGTNQVLPYESYKEH
CEEHEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHH
LHEFDIIITAVSTKDYALTEADMQPAMARRKLKPVIILDLGLPRNVDPNISKLQNMFLKD
HHHHHEEEEEECCCCCEECHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
IDDLKHIIDKNLEKRRRELPKVHAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKE
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LERYRYKVSEEELQRMEHLTDRILKKILHHPIKMLKAPIDTTDSIPSRVNLVRNVFDLEE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
PNQSHF
CCCCCC
>Mature Secondary Structure
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITGLVSSGLAHEAMVLSTCNRTELYVVPA
CCEEEECCCCCCCCHHHHHHCCHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECC
MHEVTGEFLKEYLISYRDARKEVRPEHFFSRFYCSTARHLFEVASAIDSLVLGEGQILGQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VKNAYRIAAEAQCAGIMITRLCHTAFSVAKKVKTKTRIMEGAVSVSYAAVELAQKIFSNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SLKKVLLVGAGETGELAAKHMFAKNARNIVITNRTISKAEALAEELGTNQVLPYESYKEH
CEEHEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHH
LHEFDIIITAVSTKDYALTEADMQPAMARRKLKPVIILDLGLPRNVDPNISKLQNMFLKD
HHHHHEEEEEECCCCCEECHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
IDDLKHIIDKNLEKRRRELPKVHAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKE
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LERYRYKVSEEELQRMEHLTDRILKKILHHPIKMLKAPIDTTDSIPSRVNLVRNVFDLEE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
PNQSHF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA