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The map label for this gene is metG

Identifier: 78189366

GI number: 78189366

Start: 1867431

End: 1869548

Strand: Reverse

Name: metG

Synonym: Cag_1403

Alternate gene names: 78189366

Gene position: 1869548-1867431 (Counterclockwise)

Preceding gene: 78189367

Following gene: 78189365

Centisome position: 72.69

GC content: 48.21

Gene sequence:

>2118_bases
ATGTCCACTATGCCTCATTTTTCGCGCACGCTTGTTACTACAGCTCTCCCTTACGCCAACGGTCCAGTGCATCTCGGTCA
TTTAGCGGGAGTTTATCTTCCAGCCGATTTGTATGTCCGTTATAAACGGCTCAAGGGCGAGGATATTATTCATATTGGAG
GTTCTGACGAGCATGGTGTGCCGATTACGATTTCGGCTGAAAAAGAGGGCATTTCGCCACGCGATGTGGTGGATCGCTAT
CATGCCATGAATCTTGATGCCTTTACGCGCTGCGGCATCTCTTTCGATTATTATGGACGTACTTCGTCAGCCGTGCATCA
TGCAACAGCGCAAGAGTTTTTCTCCGATATAGAGCAAAAGGGCATTTTTCAGCAAAAAACTGAGAAGCTCTTTTTTGATC
TGCAAGCGGGACGATTTCTTTCTGACCGATATGTTACGGGTACCTGCCCTGTGTGCAACAACCCCGAAGCTAACGGCGAC
CAATGCGAGCAATGTGGCACACATCTTAGCCCGTTGGAGTTGCTTAATCCCAAAAGCAAGCTTTCCGATGCTACGCCCGA
ATTGCGCGAAACCTTGCACTGGTATTTTCCTCTTGGGCGCTTTCAAGCAGCGCTTGAGGAGTACGTTAATAGCCACGAAG
GGGAGTGGCGCCCAAATGTGGTGAATTACACGCGCACATGGTTCAAGCAAGGTTTAAACGACCGTGCCATTACGCGCGAT
CTTGATTGGGGCGTTGCCGTACCATTGCAAAGTGCGGAAGCGGTTGGTAAGGTGCTGTATGTGTGGTTTGATGCCGTGCT
TGGCTACATTTCATTTACTAAAGAGTGGGCAGCATTACAAGGCAATGCAGAGCTATGGAAAACCTATTGGCAAGATCCTG
AAACACGTCTTATCCATTTTATAGGAAAAGATAATGTGGTGTTCCATACGCTTATGTTTCCATCAATTCTTATGGCATGG
AATGAAGGGAAAACAACGGATTGCTATAATTTAGCCGATAATGTTCCTGCATCTGAATTTATGAATTTTGAGGGGAGAAA
ATTCTCTAAATCGCGCAACTATGCCGTTTATCTTGGAGAGTTTCTCGATAAATTCCCTGCCGATACCTTGCGTTATAGCA
TTGCTATGAATTATCCCGAAAGCAAGGATACCGACTTTAGTTGGCAGGATTTTCAAAATCGCACCAATGGCGAGCTTGCT
GATACGCTTGGCAACTTCATCAAGCGATCCATTGATTTTACCAACACCCGCTTTGAAGGCGTTGTGCCTGCTTCAGTAAC
TAAAGAAGAGTGGGACAATCTCGGTATTGATTGGCAAGCCACGTTAGAGCAGCTTGATAGCGCTTATGAAGGCTTCCACT
TTCGTGATGCAGCCACGCTTGGCATGGAGATTGCTCGTGCAGCCAATCGTTACCTCACGTCGTCCGAGCCTTGGAAAGTA
ATTAAGGTTGACCGTGAAGCTGCCGCTACAACAATGGCGCTGTCGCTTAACCTCTGCCATGCGCTCTCCATTGCGCTCTA
CCCCGTTATTCCCGAAACCTGCAACCGCATTCGCGCCATGCTGGGCTTTAGCGAACCGCTTGAAGCAACCATTCAGCGTG
GTACATCGCTCTTGAGCAGCTTGCTAACGCCAACGCTTCAGCAAGGGCACAAACTGAGGGAGCATTCGGAAATTCTCTTT
ACCAAAATTGAGGATAGCGCTATTGCCCCTGAGCTTGAAAAAATTGCAAAACTTATTGCCGAAGCCGAAAAGCGTGAAGC
GGCTTTAGCCGAAAGCCGCATTGAGTTTAAGCCAGCCATTAGCTTTGATGAGTTCCAAAAAGTTGACCTTCGCGTAGCAA
CCGTTGTGGCGGCTGAGCCTGTAGCAAAAGCCAACAAGTTGCTAAAATTGCGCGTGCAAGTAGGGAGCCTAACGCGCCAA
GTGCTTGCAGGCATTGCAAAGCATTACACGCCTGAGGAGATGGTGGGCAAGCAGGTGCTGCTTGTTGCTAACCTTGAAGA
GCGCACCATTCGTGGTGAACTGTCGCAAGGGATGATTCTTGCGGTTGAAAATAGTGATGGCAAACTCTTTATTGTGCAGC
CATCAGGTGAGGGAATTAACGGTCAGTCGGTGCAGTAA

Upstream 100 bases:

>100_bases
TGTGGTTATTCGTTACCAGCATAACAACCAAACGCGCCGCTTTCCTCTCGATAAGTTTAACGCTCTTTTTACCCGTCAAT
AATTTTTGGATTTTTTGGAT

Downstream 100 bases:

>100_bases
GGATGCTGGAAGGGGGCTTTTTAGAAAAAGAGCAATAAAGTATTTGGAAATAAGAAATTATTCCTTACCTTTAGGTCATT
ACATCGTGGGGTGGAGCAAT

Product: methionyl-tRNA synthetase

Products: NA

Alternate protein names: Methionine--tRNA ligase; MetRS

Number of amino acids: Translated: 705; Mature: 704

Protein sequence:

>705_residues
MSTMPHFSRTLVTTALPYANGPVHLGHLAGVYLPADLYVRYKRLKGEDIIHIGGSDEHGVPITISAEKEGISPRDVVDRY
HAMNLDAFTRCGISFDYYGRTSSAVHHATAQEFFSDIEQKGIFQQKTEKLFFDLQAGRFLSDRYVTGTCPVCNNPEANGD
QCEQCGTHLSPLELLNPKSKLSDATPELRETLHWYFPLGRFQAALEEYVNSHEGEWRPNVVNYTRTWFKQGLNDRAITRD
LDWGVAVPLQSAEAVGKVLYVWFDAVLGYISFTKEWAALQGNAELWKTYWQDPETRLIHFIGKDNVVFHTLMFPSILMAW
NEGKTTDCYNLADNVPASEFMNFEGRKFSKSRNYAVYLGEFLDKFPADTLRYSIAMNYPESKDTDFSWQDFQNRTNGELA
DTLGNFIKRSIDFTNTRFEGVVPASVTKEEWDNLGIDWQATLEQLDSAYEGFHFRDAATLGMEIARAANRYLTSSEPWKV
IKVDREAAATTMALSLNLCHALSIALYPVIPETCNRIRAMLGFSEPLEATIQRGTSLLSSLLTPTLQQGHKLREHSEILF
TKIEDSAIAPELEKIAKLIAEAEKREAALAESRIEFKPAISFDEFQKVDLRVATVVAAEPVAKANKLLKLRVQVGSLTRQ
VLAGIAKHYTPEEMVGKQVLLVANLEERTIRGELSQGMILAVENSDGKLFIVQPSGEGINGQSVQ

Sequences:

>Translated_705_residues
MSTMPHFSRTLVTTALPYANGPVHLGHLAGVYLPADLYVRYKRLKGEDIIHIGGSDEHGVPITISAEKEGISPRDVVDRY
HAMNLDAFTRCGISFDYYGRTSSAVHHATAQEFFSDIEQKGIFQQKTEKLFFDLQAGRFLSDRYVTGTCPVCNNPEANGD
QCEQCGTHLSPLELLNPKSKLSDATPELRETLHWYFPLGRFQAALEEYVNSHEGEWRPNVVNYTRTWFKQGLNDRAITRD
LDWGVAVPLQSAEAVGKVLYVWFDAVLGYISFTKEWAALQGNAELWKTYWQDPETRLIHFIGKDNVVFHTLMFPSILMAW
NEGKTTDCYNLADNVPASEFMNFEGRKFSKSRNYAVYLGEFLDKFPADTLRYSIAMNYPESKDTDFSWQDFQNRTNGELA
DTLGNFIKRSIDFTNTRFEGVVPASVTKEEWDNLGIDWQATLEQLDSAYEGFHFRDAATLGMEIARAANRYLTSSEPWKV
IKVDREAAATTMALSLNLCHALSIALYPVIPETCNRIRAMLGFSEPLEATIQRGTSLLSSLLTPTLQQGHKLREHSEILF
TKIEDSAIAPELEKIAKLIAEAEKREAALAESRIEFKPAISFDEFQKVDLRVATVVAAEPVAKANKLLKLRVQVGSLTRQ
VLAGIAKHYTPEEMVGKQVLLVANLEERTIRGELSQGMILAVENSDGKLFIVQPSGEGINGQSVQ
>Mature_704_residues
STMPHFSRTLVTTALPYANGPVHLGHLAGVYLPADLYVRYKRLKGEDIIHIGGSDEHGVPITISAEKEGISPRDVVDRYH
AMNLDAFTRCGISFDYYGRTSSAVHHATAQEFFSDIEQKGIFQQKTEKLFFDLQAGRFLSDRYVTGTCPVCNNPEANGDQ
CEQCGTHLSPLELLNPKSKLSDATPELRETLHWYFPLGRFQAALEEYVNSHEGEWRPNVVNYTRTWFKQGLNDRAITRDL
DWGVAVPLQSAEAVGKVLYVWFDAVLGYISFTKEWAALQGNAELWKTYWQDPETRLIHFIGKDNVVFHTLMFPSILMAWN
EGKTTDCYNLADNVPASEFMNFEGRKFSKSRNYAVYLGEFLDKFPADTLRYSIAMNYPESKDTDFSWQDFQNRTNGELAD
TLGNFIKRSIDFTNTRFEGVVPASVTKEEWDNLGIDWQATLEQLDSAYEGFHFRDAATLGMEIARAANRYLTSSEPWKVI
KVDREAAATTMALSLNLCHALSIALYPVIPETCNRIRAMLGFSEPLEATIQRGTSLLSSLLTPTLQQGHKLREHSEILFT
KIEDSAIAPELEKIAKLIAEAEKREAALAESRIEFKPAISFDEFQKVDLRVATVVAAEPVAKANKLLKLRVQVGSLTRQV
LAGIAKHYTPEEMVGKQVLLVANLEERTIRGELSQGMILAVENSDGKLFIVQPSGEGINGQSVQ

Specific function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation

COG id: COG0143

COG function: function code J; Methionyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 tRNA-binding domain

Homologues:

Organism=Homo sapiens, GI14043022, Length=664, Percent_Identity=33.433734939759, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI24308436, Length=583, Percent_Identity=24.8713550600343, Blast_Score=143, Evalue=4e-34,
Organism=Escherichia coli, GI1788432, Length=704, Percent_Identity=32.8125, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1789455, Length=88, Percent_Identity=32.9545454545455, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17540794, Length=576, Percent_Identity=35.5902777777778, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645096, Length=540, Percent_Identity=24.2592592592593, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71992781, Length=363, Percent_Identity=23.9669421487603, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321704, Length=571, Percent_Identity=34.5008756567426, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6321610, Length=540, Percent_Identity=23.1481481481481, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24655311, Length=575, Percent_Identity=35.1304347826087, Blast_Score=354, Evalue=1e-97,
Organism=Drosophila melanogaster, GI21358483, Length=552, Percent_Identity=25.5434782608696, Blast_Score=121, Evalue=2e-27,

Paralogues:

None

Copy number: 871 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): SYM_CHLCH (Q3AQR4)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379704.1
- ProteinModelPortal:   Q3AQR4
- SMR:   Q3AQR4
- STRING:   Q3AQR4
- GeneID:   3747162
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1403
- eggNOG:   COG0143
- HOGENOM:   HBG721667
- OMA:   SAYQPEQ
- ProtClustDB:   PRK00133
- BioCyc:   CCHL340177:CAG_1403-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00098
- InterPro:   IPR001412
- InterPro:   IPR015413
- InterPro:   IPR004495
- InterPro:   IPR014758
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR014729
- InterPro:   IPR002547
- InterPro:   IPR009080
- InterPro:   IPR013155
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01041
- TIGRFAMs:   TIGR00398
- TIGRFAMs:   TIGR00399

Pfam domain/function: PF08264 Anticodon_1; PF09334 tRNA-synt_1g; PF01588 tRNA_bind; SSF50249 Nucleic_acid_OB; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.10

Molecular weight: Translated: 79258; Mature: 79126

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50886 TRBD

Important sites: BINDING 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMPHFSRTLVTTALPYANGPVHLGHLAGVYLPADLYVRYKRLKGEDIIHIGGSDEHGV
CCCCCCHHHHHHHHHCCCCCCCEEEHHHCCEEECHHHHHHHHHCCCCCEEEECCCCCCCE
PITISAEKEGISPRDVVDRYHAMNLDAFTRCGISFDYYGRTSSAVHHATAQEFFSDIEQK
EEEEECCCCCCCHHHHHHHHHHCCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHC
GIFQQKTEKLFFDLQAGRFLSDRYVTGTCPVCNNPEANGDQCEQCGTHLSPLELLNPKSK
CHHHHHHHHHHEECCCCCEECCCEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHCCCHHH
LSDATPELRETLHWYFPLGRFQAALEEYVNSHEGEWRPNVVNYTRTWFKQGLNDRAITRD
HCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEC
LDWGVAVPLQSAEAVGKVLYVWFDAVLGYISFTKEWAALQGNAELWKTYWQDPETRLIHF
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEE
IGKDNVVFHTLMFPSILMAWNEGKTTDCYNLADNVPASEFMNFEGRKFSKSRNYAVYLGE
ECCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHCCCCCCCCCCCCCEEEEHHH
FLDKFPADTLRYSIAMNYPESKDTDFSWQDFQNRTNGELADTLGNFIKRSIDFTNTRFEG
HHHHCCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
VVPASVTKEEWDNLGIDWQATLEQLDSAYEGFHFRDAATLGMEIARAANRYLTSSEPWKV
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEE
IKVDREAAATTMALSLNLCHALSIALYPVIPETCNRIRAMLGFSEPLEATIQRGTSLLSS
EEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLTPTLQQGHKLREHSEILFTKIEDSAIAPELEKIAKLIAEAEKREAALAESRIEFKPAI
HHHHHHHHCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SFDEFQKVDLRVATVVAAEPVAKANKLLKLRVQVGSLTRQVLAGIAKHYTPEEMVGKQVL
CHHHHHHHCEEEEEHHHHCHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCHHHHCCEEE
LVANLEERTIRGELSQGMILAVENSDGKLFIVQPSGEGINGQSVQ
EEECCHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
STMPHFSRTLVTTALPYANGPVHLGHLAGVYLPADLYVRYKRLKGEDIIHIGGSDEHGV
CCCCCHHHHHHHHHCCCCCCCEEEHHHCCEEECHHHHHHHHHCCCCCEEEECCCCCCCE
PITISAEKEGISPRDVVDRYHAMNLDAFTRCGISFDYYGRTSSAVHHATAQEFFSDIEQK
EEEEECCCCCCCHHHHHHHHHHCCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHC
GIFQQKTEKLFFDLQAGRFLSDRYVTGTCPVCNNPEANGDQCEQCGTHLSPLELLNPKSK
CHHHHHHHHHHEECCCCCEECCCEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHCCCHHH
LSDATPELRETLHWYFPLGRFQAALEEYVNSHEGEWRPNVVNYTRTWFKQGLNDRAITRD
HCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEC
LDWGVAVPLQSAEAVGKVLYVWFDAVLGYISFTKEWAALQGNAELWKTYWQDPETRLIHF
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEE
IGKDNVVFHTLMFPSILMAWNEGKTTDCYNLADNVPASEFMNFEGRKFSKSRNYAVYLGE
ECCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHCCCCCCCCCCCCCEEEEHHH
FLDKFPADTLRYSIAMNYPESKDTDFSWQDFQNRTNGELADTLGNFIKRSIDFTNTRFEG
HHHHCCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
VVPASVTKEEWDNLGIDWQATLEQLDSAYEGFHFRDAATLGMEIARAANRYLTSSEPWKV
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEE
IKVDREAAATTMALSLNLCHALSIALYPVIPETCNRIRAMLGFSEPLEATIQRGTSLLSS
EEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLTPTLQQGHKLREHSEILFTKIEDSAIAPELEKIAKLIAEAEKREAALAESRIEFKPAI
HHHHHHHHCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SFDEFQKVDLRVATVVAAEPVAKANKLLKLRVQVGSLTRQVLAGIAKHYTPEEMVGKQVL
CHHHHHHHCEEEEEHHHHCHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCHHHHCCEEE
LVANLEERTIRGELSQGMILAVENSDGKLFIVQPSGEGINGQSVQ
EEECCHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA