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The map label for this gene is atoC [H]

Identifier: 78189296

GI number: 78189296

Start: 1798169

End: 1799416

Strand: Reverse

Name: atoC [H]

Synonym: Cag_1331

Alternate gene names: 78189296

Gene position: 1799416-1798169 (Counterclockwise)

Preceding gene: 78189297

Following gene: 78189294

Centisome position: 69.96

GC content: 47.6

Gene sequence:

>1248_bases
ATGAAAGCCGAACCAGCACTTCTTGGGCATTCGCCCCTTATGCAGCAATTGCGCCAGCTTGCCATGCAAGTTGCTGAAAC
CGATATCACCGTTCTCATTATTGGCGAAACTGGCTCAGGCAAAGAGGTGTTGGCTCACTTTATCCATCACCATAGCCAGC
GTGCAAAAGGCAATTTTATTGCAGTGAATTGTGGAGCTATACCAGCGGGCATTTTGGAGTCGGAGCTTTTTGGGCATGAA
AAAGGGGCGTTTACGGGAGCGCAGCAAAGCCGTAAAGGGTATTTTGAGAGCGCTGACCGCGGTACTATTTTTTTAGATGA
AATAGGGGAAATGCCGCTTGAAACGCAGGTGAAGTTTCTTCGAGTTATTGAAAGTGGAGAATTTCAGCGGGTTGGTGCTT
CCGAAACCATTTACTCCGATGCTCGCATTATTGCAGCCACAAACCGCAACATGTATCAAGCGGTGGCTGAAAAAAATTTT
CGTGAAGATCTTTTTTATCGGCTTCGGAGCGTAGAGTTACAAATTCCCCCATTGCGCGAGCGTGGGAACGATGTGTTGCT
ACTTGCCGACCACTTTATGCGAAGTTACGAACGTAAGCATGGTATTCCTTTTGCGGGCTTTAGCCCCGATGCTGCTGAAA
TGATGCTACGCTATCCATGGCCTGGCAATGTGCGTGAGTTGCGTAATTTAATGGAGTCGCTGTTGGTGCTTGAAAAGGGG
AGGGAAATTGGCTCCGATACGCTTGAAAAGCATCTTGTGCAACGCAATCGCCACAAAAGCTTGGTGCACGATCCCTCAAA
ATCGGAGAAAAATGAGCTGCAAGTGATTTTTAGCAACATTTTGCAGTTGCGCCAAGAGGTGAGCGAACTTCGCATGATGG
TGCAACATTTGTTGCAAAACAGCCAACATGTGTCGGTGCCCATGCCCTTCACCATGCCGTTGTTACTACCCGATGCCTAT
ACCGAACCATCTCACACAAATCCGCCGAAAGCGCTTCATGCGTCCCCCATATCTCCAATATCCTCCATTTCTAATTCCTC
AAATACGCCAAATGAATCGGAGGCGGTTAAGGCTAAAGAACCAATTGCATTGCCCGAAAATAAGCCGCTTCGCTCATTAG
ATGAGGTTGAAAAAGAGTCCATTCGTGAAGCCTTAGAGCACCATAATGGCAACAAGCGCCAAATCGCACGTGCGCTTGGC
ATTACGGAACGAACCTTGTATCGTAAAATTAAGCAATACGGCTTGTGA

Upstream 100 bases:

>100_bases
TTATGCTACGGCTGAGGAGGCTCGCAAGGTTTCACGCGCTATTCCAATGCAATCGCTTACCGTTTCTGCTCAATAAGTTT
CTCATTGATTTTTTTCTCTT

Downstream 100 bases:

>100_bases
TGTTACACCTCATCAAAACGTTTGCGCCGCACTAACGCCATTGCAATAAACAAGCATGATGCGGCAAGCGCACCTTGCGG
CAACAGATCGGGATATTGGG

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKAEPALLGHSPLMQQLRQLAMQVAETDITVLIIGETGSGKEVLAHFIHHHSQRAKGNFIAVNCGAIPAGILESELFGHE
KGAFTGAQQSRKGYFESADRGTIFLDEIGEMPLETQVKFLRVIESGEFQRVGASETIYSDARIIAATNRNMYQAVAEKNF
REDLFYRLRSVELQIPPLRERGNDVLLLADHFMRSYERKHGIPFAGFSPDAAEMMLRYPWPGNVRELRNLMESLLVLEKG
REIGSDTLEKHLVQRNRHKSLVHDPSKSEKNELQVIFSNILQLRQEVSELRMMVQHLLQNSQHVSVPMPFTMPLLLPDAY
TEPSHTNPPKALHASPISPISSISNSSNTPNESEAVKAKEPIALPENKPLRSLDEVEKESIREALEHHNGNKRQIARALG
ITERTLYRKIKQYGL

Sequences:

>Translated_415_residues
MKAEPALLGHSPLMQQLRQLAMQVAETDITVLIIGETGSGKEVLAHFIHHHSQRAKGNFIAVNCGAIPAGILESELFGHE
KGAFTGAQQSRKGYFESADRGTIFLDEIGEMPLETQVKFLRVIESGEFQRVGASETIYSDARIIAATNRNMYQAVAEKNF
REDLFYRLRSVELQIPPLRERGNDVLLLADHFMRSYERKHGIPFAGFSPDAAEMMLRYPWPGNVRELRNLMESLLVLEKG
REIGSDTLEKHLVQRNRHKSLVHDPSKSEKNELQVIFSNILQLRQEVSELRMMVQHLLQNSQHVSVPMPFTMPLLLPDAY
TEPSHTNPPKALHASPISPISSISNSSNTPNESEAVKAKEPIALPENKPLRSLDEVEKESIREALEHHNGNKRQIARALG
ITERTLYRKIKQYGL
>Mature_415_residues
MKAEPALLGHSPLMQQLRQLAMQVAETDITVLIIGETGSGKEVLAHFIHHHSQRAKGNFIAVNCGAIPAGILESELFGHE
KGAFTGAQQSRKGYFESADRGTIFLDEIGEMPLETQVKFLRVIESGEFQRVGASETIYSDARIIAATNRNMYQAVAEKNF
REDLFYRLRSVELQIPPLRERGNDVLLLADHFMRSYERKHGIPFAGFSPDAAEMMLRYPWPGNVRELRNLMESLLVLEKG
REIGSDTLEKHLVQRNRHKSLVHDPSKSEKNELQVIFSNILQLRQEVSELRMMVQHLLQNSQHVSVPMPFTMPLLLPDAY
TEPSHTNPPKALHASPISPISSISNSSNTPNESEAVKAKEPIALPENKPLRSLDEVEKESIREALEHHNGNKRQIARALG
ITERTLYRKIKQYGL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=242, Percent_Identity=49.5867768595041, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1790299, Length=237, Percent_Identity=48.9451476793249, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789233, Length=249, Percent_Identity=48.5943775100402, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI87082117, Length=237, Percent_Identity=48.5232067510549, Blast_Score=237, Evalue=8e-64,
Organism=Escherichia coli, GI1788905, Length=252, Percent_Identity=46.4285714285714, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1789087, Length=234, Percent_Identity=46.5811965811966, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1790437, Length=237, Percent_Identity=45.9915611814346, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87082152, Length=242, Percent_Identity=46.2809917355372, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1786524, Length=241, Percent_Identity=47.7178423236515, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87081872, Length=227, Percent_Identity=46.6960352422907, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1787583, Length=237, Percent_Identity=38.3966244725738, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1789828, Length=267, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87081858, Length=241, Percent_Identity=32.3651452282158, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 46841; Mature: 46841

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAEPALLGHSPLMQQLRQLAMQVAETDITVLIIGETGSGKEVLAHFIHHHSQRAKGNFI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
AVNCGAIPAGILESELFGHEKGAFTGAQQSRKGYFESADRGTIFLDEIGEMPLETQVKFL
EEECCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCEEEHHHHCCCCHHHHHHHH
RVIESGEFQRVGASETIYSDARIIAATNRNMYQAVAEKNFREDLFYRLRSVELQIPPLRE
HHHHCCCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHCCEECCCHHH
RGNDVLLLADHFMRSYERKHGIPFAGFSPDAAEMMLRYPWPGNVRELRNLMESLLVLEKG
CCCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHC
REIGSDTLEKHLVQRNRHKSLVHDPSKSEKNELQVIFSNILQLRQEVSELRMMVQHLLQN
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SQHVSVPMPFTMPLLLPDAYTEPSHTNPPKALHASPISPISSISNSSNTPNESEAVKAKE
CCEEECCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHCCC
PIALPENKPLRSLDEVEKESIREALEHHNGNKRQIARALGITERTLYRKIKQYGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAEPALLGHSPLMQQLRQLAMQVAETDITVLIIGETGSGKEVLAHFIHHHSQRAKGNFI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
AVNCGAIPAGILESELFGHEKGAFTGAQQSRKGYFESADRGTIFLDEIGEMPLETQVKFL
EEECCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCEEEHHHHCCCCHHHHHHHH
RVIESGEFQRVGASETIYSDARIIAATNRNMYQAVAEKNFREDLFYRLRSVELQIPPLRE
HHHHCCCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHCCEECCCHHH
RGNDVLLLADHFMRSYERKHGIPFAGFSPDAAEMMLRYPWPGNVRELRNLMESLLVLEKG
CCCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHC
REIGSDTLEKHLVQRNRHKSLVHDPSKSEKNELQVIFSNILQLRQEVSELRMMVQHLLQN
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SQHVSVPMPFTMPLLLPDAYTEPSHTNPPKALHASPISPISSISNSSNTPNESEAVKAKE
CCEEECCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHCCC
PIALPENKPLRSLDEVEKESIREALEHHNGNKRQIARALGITERTLYRKIKQYGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]