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The map label for this gene is mutY [H]

Identifier: 78189104

GI number: 78189104

Start: 1531982

End: 1532827

Strand: Reverse

Name: mutY [H]

Synonym: Cag_1137

Alternate gene names: 78189104

Gene position: 1532827-1531982 (Counterclockwise)

Preceding gene: 78189105

Following gene: 78189103

Centisome position: 59.59

GC content: 51.89

Gene sequence:

>846_bases
ATGGAAGATTGGTTACCAAGTAAGCGGCAGATTGAGCAGCTTCAAGCAAAGGTTTTTGCTTTTTATGGGGAGCATGGGCG
AAGCTTTCCGTGGCGCAACACTACTGATCGTTATGCGGTTATGGTGAGCGAAGTGATGTTGCAGCAAACGCAAGCTGAGC
GGGTTGTTGAGCGTTTTGAGGCGTGGCTTGTGGCATTTCCAACGGTGCAAGCCTTAGCGGATGCGCCGCTGCGTGAGGTG
TTGGCGCTGTGGAGTGGGTTGGGGTACAATTCGCGTGCTGAGCGGTTACAGCGGTGTGCTCAAACCATTGTTGCTGATTT
TGGTGGTGTTGTGCCAGCTCTGCCGGAAGTTCTCTTGCAGTTGCCGGGGATTGGGGCTTATACCAGTCGCTCCATCCCAA
TTTTTGCCGATAATTTTGATGTTGCTACGGTGGATACCAATATTCGCCGTATTGTGTTGCATGAATTTGGTTTGCCTGAA
ACGCTCAAGCCGCGCGAGTTGCAAATGGTGGCAGATAGGTTGCTGCCGCATGGGCAAAGCCGTAAGTGGCACAATGCTTT
AATGGATTACGGAGCACTGCATCTTACAAGTCAGAAAAGTGGTATTCGTCCGTTAACGAGGCAATCAAAGTTTCAGGGTT
CACGGCGTTGGTATCGTGGGCAGATGTTAAAAGCGCTCTTGAAAACTGAAGCGCTACCGCTTGAGGCGCTGGAGGCAACA
TGGGCGGATTCCCCCTATTGCCTCCGTGATATTGCAAGCGATTTAGTGCGTGAAGGGTTGGTTGAGTACCATCCCAGCGC
ATCGGCTGACGATTCGCCGCTGTTGCGAATTCGTGGGAGTGGGTAA

Upstream 100 bases:

>100_bases
CTATGCAGCCGCACGTATTCGGCGTGGTGAAAAGGGGGCTGAAGTGGCTGAATATTTTGAGGAGCTGTAGAAAGGTTATC
ACGACACGACAAGAACACAG

Downstream 100 bases:

>100_bases
GGTTGTTGATTGCACAAAAACGGTTTCAAATGTAATACTAACAATTATAGCATTACAGTATGAATAACATGCAATATAAT
CGCCGATCCATCAGATTACA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MEDWLPSKRQIEQLQAKVFAFYGEHGRSFPWRNTTDRYAVMVSEVMLQQTQAERVVERFEAWLVAFPTVQALADAPLREV
LALWSGLGYNSRAERLQRCAQTIVADFGGVVPALPEVLLQLPGIGAYTSRSIPIFADNFDVATVDTNIRRIVLHEFGLPE
TLKPRELQMVADRLLPHGQSRKWHNALMDYGALHLTSQKSGIRPLTRQSKFQGSRRWYRGQMLKALLKTEALPLEALEAT
WADSPYCLRDIASDLVREGLVEYHPSASADDSPLLRIRGSG

Sequences:

>Translated_281_residues
MEDWLPSKRQIEQLQAKVFAFYGEHGRSFPWRNTTDRYAVMVSEVMLQQTQAERVVERFEAWLVAFPTVQALADAPLREV
LALWSGLGYNSRAERLQRCAQTIVADFGGVVPALPEVLLQLPGIGAYTSRSIPIFADNFDVATVDTNIRRIVLHEFGLPE
TLKPRELQMVADRLLPHGQSRKWHNALMDYGALHLTSQKSGIRPLTRQSKFQGSRRWYRGQMLKALLKTEALPLEALEAT
WADSPYCLRDIASDLVREGLVEYHPSASADDSPLLRIRGSG
>Mature_281_residues
MEDWLPSKRQIEQLQAKVFAFYGEHGRSFPWRNTTDRYAVMVSEVMLQQTQAERVVERFEAWLVAFPTVQALADAPLREV
LALWSGLGYNSRAERLQRCAQTIVADFGGVVPALPEVLLQLPGIGAYTSRSIPIFADNFDVATVDTNIRRIVLHEFGLPE
TLKPRELQMVADRLLPHGQSRKWHNALMDYGALHLTSQKSGIRPLTRQSKFQGSRRWYRGQMLKALLKTEALPLEALEAT
WADSPYCLRDIASDLVREGLVEYHPSASADDSPLLRIRGSG

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=216, Percent_Identity=35.6481481481481, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI6912520, Length=216, Percent_Identity=35.6481481481481, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI115298654, Length=216, Percent_Identity=35.6481481481481, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI115298652, Length=216, Percent_Identity=35.6481481481481, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI115298650, Length=216, Percent_Identity=35.6481481481481, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI115298648, Length=216, Percent_Identity=35.6481481481481, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI1789331, Length=227, Percent_Identity=33.0396475770925, Blast_Score=118, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 31773; Mature: 31773

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDWLPSKRQIEQLQAKVFAFYGEHGRSFPWRNTTDRYAVMVSEVMLQQTQAERVVERFE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AWLVAFPTVQALADAPLREVLALWSGLGYNSRAERLQRCAQTIVADFGGVVPALPEVLLQ
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LPGIGAYTSRSIPIFADNFDVATVDTNIRRIVLHEFGLPETLKPRELQMVADRLLPHGQS
CCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
RKWHNALMDYGALHLTSQKSGIRPLTRQSKFQGSRRWYRGQMLKALLKTEALPLEALEAT
CHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
WADSPYCLRDIASDLVREGLVEYHPSASADDSPLLRIRGSG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MEDWLPSKRQIEQLQAKVFAFYGEHGRSFPWRNTTDRYAVMVSEVMLQQTQAERVVERFE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AWLVAFPTVQALADAPLREVLALWSGLGYNSRAERLQRCAQTIVADFGGVVPALPEVLLQ
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LPGIGAYTSRSIPIFADNFDVATVDTNIRRIVLHEFGLPETLKPRELQMVADRLLPHGQS
CCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
RKWHNALMDYGALHLTSQKSGIRPLTRQSKFQGSRRWYRGQMLKALLKTEALPLEALEAT
CHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
WADSPYCLRDIASDLVREGLVEYHPSASADDSPLLRIRGSG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]