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The map label for this gene is neuA [H]

Identifier: 78189099

GI number: 78189099

Start: 1525876

End: 1526565

Strand: Reverse

Name: neuA [H]

Synonym: Cag_1132

Alternate gene names: 78189099

Gene position: 1526565-1525876 (Counterclockwise)

Preceding gene: 78189100

Following gene: 78189098

Centisome position: 59.35

GC content: 41.01

Gene sequence:

>690_bases
ATGCAAACAGTAGCTATAATTCCCGCACGAGGCGGCTCGAAAGGATTAAAATATAAAAACATCTATCCCGTTGCAGGTAA
ACCTTTACTTGCGTGGACAATTGAGCAAGCTCGTGCATCTCAATTCGTTGACAAAGTGTTTGTTTCAACTGATAGTGAAG
ATATTGCCGATATTGCCAAAGAGTATGGCGCTGAAGTTATTGAACGTCCAGCCGACATTGCAGGCGATAAAGCAACCTCT
GAATCAGCTATATTGCACGCACTCAATGTTATTCAAGCAGAACATCACATAACGGTAAGTGCTGTGGTATTTTTACAAGC
AACCTCACCATTGCGCAAACAAGGAGACATTGACGGTGCAATTGAGCTATTTCGCCGTGAGAATGCAGACTCGCTTATTT
CGGTTACAAAAGCTGATGATTTAACTATTTGGGAACAGCGTAAAAGTGGGGAGTGGGCAAGTGTGAATTTTGATTACCGT
AATCGTGGAATGCGCCAAGATCGCCCAGCACAGTTTATTGAGAATGGTTCAATTTATATGTTTACTCCCGAAACATTGCA
TCGCTTTAATAACCGTATTGGCGAAAAGCTTGTTGCTTATGAAATGGAGTTTTGGCAAACATGGGAAATTGATACTCTCA
ATGAGATTGAGTTAGTAGAATTTTATATGAAACGCAAAGGGTTGATGTGA

Upstream 100 bases:

>100_bases
GTATAGAATTGACTATGATTTTTACAACTACTAATCATAGTTAATCCATTAATCAGAAGAATCACAGTTCAAGACAAGAT
TTTAAAACAACCAAATAACT

Downstream 100 bases:

>100_bases
AAGAGTAGATACAGATAAGTTGTTATCAATTAACCATTTTTAAAAAAGCATCTTATGAACACGATTGGCACTTTTCCATT
TGGGCAACCAATTAAAAAGG

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MQTVAIIPARGGSKGLKYKNIYPVAGKPLLAWTIEQARASQFVDKVFVSTDSEDIADIAKEYGAEVIERPADIAGDKATS
ESAILHALNVIQAEHHITVSAVVFLQATSPLRKQGDIDGAIELFRRENADSLISVTKADDLTIWEQRKSGEWASVNFDYR
NRGMRQDRPAQFIENGSIYMFTPETLHRFNNRIGEKLVAYEMEFWQTWEIDTLNEIELVEFYMKRKGLM

Sequences:

>Translated_229_residues
MQTVAIIPARGGSKGLKYKNIYPVAGKPLLAWTIEQARASQFVDKVFVSTDSEDIADIAKEYGAEVIERPADIAGDKATS
ESAILHALNVIQAEHHITVSAVVFLQATSPLRKQGDIDGAIELFRRENADSLISVTKADDLTIWEQRKSGEWASVNFDYR
NRGMRQDRPAQFIENGSIYMFTPETLHRFNNRIGEKLVAYEMEFWQTWEIDTLNEIELVEFYMKRKGLM
>Mature_229_residues
MQTVAIIPARGGSKGLKYKNIYPVAGKPLLAWTIEQARASQFVDKVFVSTDSEDIADIAKEYGAEVIERPADIAGDKATS
ESAILHALNVIQAEHHITVSAVVFLQATSPLRKQGDIDGAIELFRRENADSLISVTKADDLTIWEQRKSGEWASVNFDYR
NRGMRQDRPAQFIENGSIYMFTPETLHRFNNRIGEKLVAYEMEFWQTWEIDTLNEIELVEFYMKRKGLM

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=211, Percent_Identity=35.5450236966825, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26004; Mature: 26004

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVAIIPARGGSKGLKYKNIYPVAGKPLLAWTIEQARASQFVDKVFVSTDSEDIADIAK
CCEEEEEECCCCCCCCEECEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHH
EYGAEVIERPADIAGDKATSESAILHALNVIQAEHHITVSAVVFLQATSPLRKQGDIDGA
HHCHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHCCCCHHH
IELFRRENADSLISVTKADDLTIWEQRKSGEWASVNFDYRNRGMRQDRPAQFIENGSIYM
HHHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEEEEHHHHCCCCCCCCHHHHCCCCEEE
FTPETLHRFNNRIGEKLVAYEMEFWQTWEIDTLNEIELVEFYMKRKGLM
ECHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQTVAIIPARGGSKGLKYKNIYPVAGKPLLAWTIEQARASQFVDKVFVSTDSEDIADIAK
CCEEEEEECCCCCCCCEECEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHH
EYGAEVIERPADIAGDKATSESAILHALNVIQAEHHITVSAVVFLQATSPLRKQGDIDGA
HHCHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHCCCCHHH
IELFRRENADSLISVTKADDLTIWEQRKSGEWASVNFDYRNRGMRQDRPAQFIENGSIYM
HHHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEEEEHHHHCCCCCCCCHHHHCCCCEEE
FTPETLHRFNNRIGEKLVAYEMEFWQTWEIDTLNEIELVEFYMKRKGLM
ECHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1398032; 7830552; 8113198; 8045888; 10710307 [H]