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The map label for this gene is moaC

Identifier: 78189032

GI number: 78189032

Start: 1447930

End: 1448874

Strand: Reverse

Name: moaC

Synonym: Cag_1065

Alternate gene names: 78189032

Gene position: 1448874-1447930 (Counterclockwise)

Preceding gene: 78189033

Following gene: 78189031

Centisome position: 56.33

GC content: 50.79

Gene sequence:

>945_bases
ATGACATTTACCCACCTTGATGCACAAGGCACCGTTGCTATGGTTGATGTTTCAAGCAAGCCCGGTACTTTTCGTATGGC
ACGTGCAAGCGGTTACATTGCTATGCAACCCTCTACCATTGCACTGCTTACCGCCGATGCGCTGCCAAAAGGCAACGTGC
TTACCACCGCTAAAGTTGCGGCTGTAATGGCAGCTAAGCAAACCGCGAACCTTATTCCCCTTTGCCATCCACTGCTGCTT
TCGTGGGTTGATGTGCAATTTACTGTTAAAAGCGATCGTATTCTGATTGAGTCCATCGTAAAAACCAAAGAGTCCACCGG
TGTGGAGATGGAGGCGTTGACGGCGGTTTCGGTTGCGGCGCTAACTATTTACGATATGTGCAAAGCCGTTGATAAGGAGA
TGGAAATTGGAGTCATTCGTTTACTTGATAAAGTTGGCGGCAAATCGAGCCATCAGGAGAGCTACCGTCCACAAACGGCT
ATTTTAGTGCTCTCCGACTCTGTTTCAGCCGGTAAAAGTGTGGATAGATCGGGCGCAACCTTGCAGCAAGGTTTTGAAGC
GGCAGGTTGCACCGTGTGCGACATGCAGGTTATTGCGGATAATCAGGAGGAGATTATTGCGATGGTTGAGCAATGGGTGG
CGGCAGGTATTGAGCTTATTGTTACCACCGGTGGCACTGGGCTTGGAGCACGCGATGTAACCATTGATGCTCTGCTGCCA
CGCTTTACACGCCGTTTAACGGGCGTTGAACAAGCGCTCTTGCAATGGGGACAAGGCAAAACTCGCCGAGCAATGCTTTC
GCGCTTAGCCGCCGGCACCATTGGCAATTCATTGGTGATTTGCTTACCCGGTAGCACGGGCGCTGTGCGCGATGCTCTTG
AAGTACTTATTCCAACAATTTTCCACGCTTTTCAAATGATGCACGGGGAGGGACATAGCGCATGA

Upstream 100 bases:

>100_bases
CGCTTGCATGGGAATGCGGATTTGATGTTGCTCCCGAATCGCTTTATGCAAGAGCCACAGGTAAGTTATTTCCTCTCCCA
CAACCCTCTAACTCTCCTCT

Downstream 100 bases:

>100_bases
TAACCGTTGAAGCTGCACGCACACTTGTTCAACAATCCATTCAACCGCTTGGCACCGAGCAGTTACCCATTGCCGAAGCG
TTCGGACGCATTACCGCTGA

Product: bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA

Products: NA

Alternate protein names: Molybdenum cofactor biosynthesis protein C; Molybdenum cofactor biosynthesis protein B [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTFTHLDAQGTVAMVDVSSKPGTFRMARASGYIAMQPSTIALLTADALPKGNVLTTAKVAAVMAAKQTANLIPLCHPLLL
SWVDVQFTVKSDRILIESIVKTKESTGVEMEALTAVSVAALTIYDMCKAVDKEMEIGVIRLLDKVGGKSSHQESYRPQTA
ILVLSDSVSAGKSVDRSGATLQQGFEAAGCTVCDMQVIADNQEEIIAMVEQWVAAGIELIVTTGGTGLGARDVTIDALLP
RFTRRLTGVEQALLQWGQGKTRRAMLSRLAAGTIGNSLVICLPGSTGAVRDALEVLIPTIFHAFQMMHGEGHSA

Sequences:

>Translated_314_residues
MTFTHLDAQGTVAMVDVSSKPGTFRMARASGYIAMQPSTIALLTADALPKGNVLTTAKVAAVMAAKQTANLIPLCHPLLL
SWVDVQFTVKSDRILIESIVKTKESTGVEMEALTAVSVAALTIYDMCKAVDKEMEIGVIRLLDKVGGKSSHQESYRPQTA
ILVLSDSVSAGKSVDRSGATLQQGFEAAGCTVCDMQVIADNQEEIIAMVEQWVAAGIELIVTTGGTGLGARDVTIDALLP
RFTRRLTGVEQALLQWGQGKTRRAMLSRLAAGTIGNSLVICLPGSTGAVRDALEVLIPTIFHAFQMMHGEGHSA
>Mature_313_residues
TFTHLDAQGTVAMVDVSSKPGTFRMARASGYIAMQPSTIALLTADALPKGNVLTTAKVAAVMAAKQTANLIPLCHPLLLS
WVDVQFTVKSDRILIESIVKTKESTGVEMEALTAVSVAALTIYDMCKAVDKEMEIGVIRLLDKVGGKSSHQESYRPQTAI
LVLSDSVSAGKSVDRSGATLQQGFEAAGCTVCDMQVIADNQEEIIAMVEQWVAAGIELIVTTGGTGLGARDVTIDALLPR
FTRRLTGVEQALLQWGQGKTRRAMLSRLAAGTIGNSLVICLPGSTGAVRDALEVLIPTIFHAFQMMHGEGHSA

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=163, Percent_Identity=31.9018404907975, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI66932975, Length=163, Percent_Identity=31.9018404907975, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787001, Length=149, Percent_Identity=53.6912751677852, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787000, Length=156, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32566331, Length=151, Percent_Identity=43.046357615894, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17564954, Length=156, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574490, Length=162, Percent_Identity=49.3827160493827, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28574492, Length=151, Percent_Identity=49.6688741721854, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR020817
- InterPro:   IPR012247
- InterPro:   IPR001453
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC; PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 33298; Mature: 33167

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFTHLDAQGTVAMVDVSSKPGTFRMARASGYIAMQPSTIALLTADALPKGNVLTTAKVA
CCEEEECCCCCEEEEEECCCCCCEEEEECCCEEEECCCEEEEEEECCCCCCCEEHHHHHH
AVMAAKQTANLIPLCHPLLLSWVDVQFTVKSDRILIESIVKTKESTGVEMEALTAVSVAA
HHHHHHHHCCCCHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LTIYDMCKAVDKEMEIGVIRLLDKVGGKSSHQESYRPQTAILVLSDSVSAGKSVDRSGAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCH
LQQGFEAAGCTVCDMQVIADNQEEIIAMVEQWVAAGIELIVTTGGTGLGARDVTIDALLP
HHHCCCCCCCEEEEHHEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHH
RFTRRLTGVEQALLQWGQGKTRRAMLSRLAAGTIGNSLVICLPGSTGAVRDALEVLIPTI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
FHAFQMMHGEGHSA
HHHHHHHCCCCCCC
>Mature Secondary Structure 
TFTHLDAQGTVAMVDVSSKPGTFRMARASGYIAMQPSTIALLTADALPKGNVLTTAKVA
CEEEECCCCCEEEEEECCCCCCEEEEECCCEEEECCCEEEEEEECCCCCCCEEHHHHHH
AVMAAKQTANLIPLCHPLLLSWVDVQFTVKSDRILIESIVKTKESTGVEMEALTAVSVAA
HHHHHHHHCCCCHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LTIYDMCKAVDKEMEIGVIRLLDKVGGKSSHQESYRPQTAILVLSDSVSAGKSVDRSGAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCH
LQQGFEAAGCTVCDMQVIADNQEEIIAMVEQWVAAGIELIVTTGGTGLGARDVTIDALLP
HHHCCCCCCCEEEEHHEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHH
RFTRRLTGVEQALLQWGQGKTRRAMLSRLAAGTIGNSLVICLPGSTGAVRDALEVLIPTI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
FHAFQMMHGEGHSA
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]