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The map label for this gene is moeA [H]

Identifier: 78189031

GI number: 78189031

Start: 1446707

End: 1447933

Strand: Reverse

Name: moeA [H]

Synonym: Cag_1064

Alternate gene names: 78189031

Gene position: 1447933-1446707 (Counterclockwise)

Preceding gene: 78189032

Following gene: 78189029

Centisome position: 56.29

GC content: 50.61

Gene sequence:

>1227_bases
ATGATAACCGTTGAAGCTGCACGCACACTTGTTCAACAATCCATTCAACCGCTTGGCACCGAGCAGTTACCCATTGCCGA
AGCGTTCGGACGCATTACCGCTGAAGCAATTCATGCGCCTTTTGCATTGCCACGTTTTACCAATGCCGCTATGGATGGCT
TTGCTGTGCGTTGGGACGATATTGCACAAGCATCCGACGCCACGCCAATAACGCTTACCGTGCAGGAGATGATTGCTGCT
GGCAGTGAGCCCACTGTGGCAATTTCGCAAGGTTGCTGCTCAGCAATTATGACGGGTGCTCCAATGCCGCAAGGGGCTGA
TACAGTAGTTCCCTTTGAGCAAACAAGCGGATTTGGCAGCAACAGCGTTACCATTTTTAAAGCCCCAAAGCGTCAAGCCA
ATGTGCGCTATGCAGGCGAAGAGGTGGCGGCGAATGAATTGCTGGTGGAGAATGGAGTAGCACTAAATCCTGCTGCACTA
TCGGTGCTTGCAAGCTTTGGGGTTGCTCAATTGAAGGTTCGTCGTCAACCACGAATTGCCATTATTACCGTAGGAGACGA
AGTGCAACTACCGGGGAAACCCTTAATAGGCGCTCAAATTTACAACTGCAACCGCTTTATGCTTGATGCCGCCTGCCGTT
CACTTGGCATAATTCCAACCTTTATTCACCACGCCCCCGACAACCGCGAAGTATTACGCCATTCGCTTGGCATGGCGCTC
ACCATGTGCGATATGCTCCTTACGGCTGGAGGCATTTCAACAGGAGAATTTGATTTTGTACAGAGCGAATTAACAGCGCT
TGGAATCAACAAACATTTTTGGAGCATTGCCCAAAAGCCGGGTAAACCGCTCTACTTTGGCACCTCACACGAAGGCAAAG
CCGTATTTGCGTTGCCGGGCAATCCCATTTCAGCCATTGTTTGCTTTGCCGCTTACGTGGTTGACGCACTTGCCCTGATG
CAAGGCAAAACCCTCAGCACATCACGCTTTACCGCAACCCTTGCCGAACCATTCCCCACCGATAAAAAACGCTACCGCTT
TTTACCCGGTATGGTGTGGGTGGATCGTGGGCAACTCTTTTGCAAAGCCGCAAGTAAGATAGAATCGCACATGATTACTT
CACTTTCGGGAGCAAACTGTTTACTTGAAGCCGAAGCCGCTCAATATGACCGTCCTGCTGGCGAGCTTATTACTTGCACC
ATGTTGCCGTGGGGGAAGGTTTGTTAA

Upstream 100 bases:

>100_bases
GCTTACCCGGTAGCACGGGCGCTGTGCGCGATGCTCTTGAAGTACTTATTCCAACAATTTTCCACGCTTTTCAAATGATG
CACGGGGAGGGACATAGCGC

Downstream 100 bases:

>100_bases
TTTTGGATTTATGATGACATTTATATACAATAAAAAAAGAGTGGCTCCTCGCTATTTTGAGTGGGTAAGGGCAGGTAAAG
TGAACTCGAATTTACTACCA

Product: molybdopterin binding domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MITVEAARTLVQQSIQPLGTEQLPIAEAFGRITAEAIHAPFALPRFTNAAMDGFAVRWDDIAQASDATPITLTVQEMIAA
GSEPTVAISQGCCSAIMTGAPMPQGADTVVPFEQTSGFGSNSVTIFKAPKRQANVRYAGEEVAANELLVENGVALNPAAL
SVLASFGVAQLKVRRQPRIAIITVGDEVQLPGKPLIGAQIYNCNRFMLDAACRSLGIIPTFIHHAPDNREVLRHSLGMAL
TMCDMLLTAGGISTGEFDFVQSELTALGINKHFWSIAQKPGKPLYFGTSHEGKAVFALPGNPISAIVCFAAYVVDALALM
QGKTLSTSRFTATLAEPFPTDKKRYRFLPGMVWVDRGQLFCKAASKIESHMITSLSGANCLLEAEAAQYDRPAGELITCT
MLPWGKVC

Sequences:

>Translated_408_residues
MITVEAARTLVQQSIQPLGTEQLPIAEAFGRITAEAIHAPFALPRFTNAAMDGFAVRWDDIAQASDATPITLTVQEMIAA
GSEPTVAISQGCCSAIMTGAPMPQGADTVVPFEQTSGFGSNSVTIFKAPKRQANVRYAGEEVAANELLVENGVALNPAAL
SVLASFGVAQLKVRRQPRIAIITVGDEVQLPGKPLIGAQIYNCNRFMLDAACRSLGIIPTFIHHAPDNREVLRHSLGMAL
TMCDMLLTAGGISTGEFDFVQSELTALGINKHFWSIAQKPGKPLYFGTSHEGKAVFALPGNPISAIVCFAAYVVDALALM
QGKTLSTSRFTATLAEPFPTDKKRYRFLPGMVWVDRGQLFCKAASKIESHMITSLSGANCLLEAEAAQYDRPAGELITCT
MLPWGKVC
>Mature_408_residues
MITVEAARTLVQQSIQPLGTEQLPIAEAFGRITAEAIHAPFALPRFTNAAMDGFAVRWDDIAQASDATPITLTVQEMIAA
GSEPTVAISQGCCSAIMTGAPMPQGADTVVPFEQTSGFGSNSVTIFKAPKRQANVRYAGEEVAANELLVENGVALNPAAL
SVLASFGVAQLKVRRQPRIAIITVGDEVQLPGKPLIGAQIYNCNRFMLDAACRSLGIIPTFIHHAPDNREVLRHSLGMAL
TMCDMLLTAGGISTGEFDFVQSELTALGINKHFWSIAQKPGKPLYFGTSHEGKAVFALPGNPISAIVCFAAYVVDALALM
QGKTLSTSRFTATLAEPFPTDKKRYRFLPGMVWVDRGQLFCKAASKIESHMITSLSGANCLLEAEAAQYDRPAGELITCT
MLPWGKVC

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=316, Percent_Identity=32.2784810126582, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI10880983, Length=316, Percent_Identity=32.2784810126582, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1787049, Length=394, Percent_Identity=34.010152284264, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=396, Percent_Identity=26.7676767676768, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17562606, Length=365, Percent_Identity=23.2876712328767, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=382, Percent_Identity=30.1047120418848, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24638841, Length=382, Percent_Identity=30.1047120418848, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43648; Mature: 43648

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVEAARTLVQQSIQPLGTEQLPIAEAFGRITAEAIHAPFALPRFTNAAMDGFAVRWDD
CEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEHHH
IAQASDATPITLTVQEMIAAGSEPTVAISQGCCSAIMTGAPMPQGADTVVPFEQTSGFGS
HHCCCCCCCEEEEHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCCCCEEECHHCCCCCC
NSVTIFKAPKRQANVRYAGEEVAANELLVENGVALNPAALSVLASFGVAQLKVRRQPRIA
CCEEEEECCCCCCCCEECCHHHHHHHHHHCCCCEECHHHHHHHHHCCHHEEEECCCCCEE
IITVGDEVQLPGKPLIGAQIYNCNRFMLDAACRSLGIIPTFIHHAPDNREVLRHSLGMAL
EEEECCCEECCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHH
TMCDMLLTAGGISTGEFDFVQSELTALGINKHFWSIAQKPGKPLYFGTSHEGKAVFALPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCCCCCCEEEEECC
NPISAIVCFAAYVVDALALMQGKTLSTSRFTATLAEPFPTDKKRYRFLPGMVWVDRGQLF
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHEECCCEEEEECCHHH
CKAASKIESHMITSLSGANCLLEAEAAQYDRPAGELITCTMLPWGKVC
HHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MITVEAARTLVQQSIQPLGTEQLPIAEAFGRITAEAIHAPFALPRFTNAAMDGFAVRWDD
CEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEHHH
IAQASDATPITLTVQEMIAAGSEPTVAISQGCCSAIMTGAPMPQGADTVVPFEQTSGFGS
HHCCCCCCCEEEEHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCCCCEEECHHCCCCCC
NSVTIFKAPKRQANVRYAGEEVAANELLVENGVALNPAALSVLASFGVAQLKVRRQPRIA
CCEEEEECCCCCCCCEECCHHHHHHHHHHCCCCEECHHHHHHHHHCCHHEEEECCCCCEE
IITVGDEVQLPGKPLIGAQIYNCNRFMLDAACRSLGIIPTFIHHAPDNREVLRHSLGMAL
EEEECCCEECCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHH
TMCDMLLTAGGISTGEFDFVQSELTALGINKHFWSIAQKPGKPLYFGTSHEGKAVFALPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCCCCCCEEEEECC
NPISAIVCFAAYVVDALALMQGKTLSTSRFTATLAEPFPTDKKRYRFLPGMVWVDRGQLF
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHEECCCEEEEECCHHH
CKAASKIESHMITSLSGANCLLEAEAAQYDRPAGELITCTMLPWGKVC
HHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]