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The map label for this gene is glyQS [H]

Identifier: 78188020

GI number: 78188020

Start: 38299

End: 39768

Strand: Reverse

Name: glyQS [H]

Synonym: Cag_0036

Alternate gene names: 78188020

Gene position: 39768-38299 (Counterclockwise)

Preceding gene: 78188023

Following gene: 78188019

Centisome position: 1.55

GC content: 49.32

Gene sequence:

>1470_bases
ATGAGCAATTCTGAGCAACAACGGGTACAGCGTGCGGCGCTTTCGCCCGATAAAGTTATGAGCAAGTTAGTATCGCTTGC
AAAACGGCGGGGCTTTGTTTTTCCCTCCTCTGAAATTTATGAAGGGCTTTCTGCCTGCTTTGATTACGGTCCGCTTGGCA
GTGAAATGAAGCGCACCATTAAAGAGCTGTGGTGGAACGCCATGACGCGCCGTCATCAAAATATTGTGGGCATTGATGCC
TCAATTATGATGAACCCTCGCGTGTGGGAGGCATCGGGGCATGTGGCAAGTTTTAACGATCCTATGATTGACGATAAAAC
CACGAAACGCCGCTACCGTGCCGACCATTTAATTGAAAATCATATTGAAAAGCTGCGTCGTGATGGCAAAGAGGAGGCAC
TTCAGCGCGTGCAAGCGACTTACGAAGCCGTAGGAAGTACTGAGGATTCCAATCGTGCGCTCTACGAGCTGATTCTTGCT
GAGGGCATTAAAGCGCCCGATACAGGTTCGGCTGATTGGACGGAGGTTCGTCAATTTAACCTGATGTTCCAGTGCAACAT
GGGCGCACTAAGCGACCGTTCGGGCATTGTTTATTTACGCCCCGAAACAGCACAAGGTATTTTTGTGAACTTCCACAATG
TGCGCGAAGCCTCTCGCATGAAGGTGCCATTTGGTATTGCTCAAATTGGTAAAGCTTTCCGTAACGAAATTGTGAAGGGG
AACTTCACCTTCCGCATGGTTGAGTTTGAGCAGATGGAGATGCAATATTTTGTAAAGCCCGGCACTCAGTTGGAGGCGTT
TGAAGCGTGGCGCGAAGAGCGCTTTGCATGGTACGTCAATTCGCTGGGAATTACGCCAAGCAAACTCCATTGGTACAAGC
ACGACAAACTTGCCCATTACGCCGACCTTGCTTACGACATTAAATTCGAGTTCCCCTTTGGCATTGAGGAAATTGAAGGT
ATTCACTCCCGTACCGATTTTGACCTCAAGCAGCATCAAGAGTATTCGGGTAAAAACATGGAGTACATTGATCAAACCAC
TAACGAGCGTTACATCCCTTACGTGGTTGAAACCTCCGCTGGTTGCGATCGTCTTTTCCTTGCCTTGCTTGCCGATGCCT
ACACCGAAGATGTGGTGGATGGCGAAGAGCGCGTGGTGCTGCGCCTTGCACCTCGTGTTGCTCCTGTAAAAGCAGCAATT
CTCCCCTTAATGAAAAAAGGTGGATTAGGCGAAAAAGCTATGGCGCTCTGCAACGAACTTTCAAGCTCCTACCTTGTGCA
GTACGATGATGCAGGCTCTATTGGTAAGCGCTATCGCCGTCAAGATGAAATTGGCACGCCATTCTGCATAACGGTTGACC
ATCAATCGCTTGAGGATGAGAGTGTAACGGTGCGCTATCGCGACAGCGCCGCGCAAGAGCGCATTGCACTATCGCGCGTT
CAGGAATTTCTTGCCACCAACCTTATTTAA

Upstream 100 bases:

>100_bases
TAAAAGGTAGTAGAATAGGTGGCTTTCTTATATTCCCACTTTTTGCACCCGACCGGGAGAGCACAATAACCGATTTTCCA
TTCTTTTACTTTTTTAAACC

Downstream 100 bases:

>100_bases
AGCCCTATGCAATACGATGTTGCGGTTATTGGAGGCGGTCCCTCAGGCGCTGTTGCAGCAGCAATGCTTGCTCGTGCAGG
ATTTTCGGTGGTGTTGCTTG

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSNSEQQRVQRAALSPDKVMSKLVSLAKRRGFVFPSSEIYEGLSACFDYGPLGSEMKRTIKELWWNAMTRRHQNIVGIDA
SIMMNPRVWEASGHVASFNDPMIDDKTTKRRYRADHLIENHIEKLRRDGKEEALQRVQATYEAVGSTEDSNRALYELILA
EGIKAPDTGSADWTEVRQFNLMFQCNMGALSDRSGIVYLRPETAQGIFVNFHNVREASRMKVPFGIAQIGKAFRNEIVKG
NFTFRMVEFEQMEMQYFVKPGTQLEAFEAWREERFAWYVNSLGITPSKLHWYKHDKLAHYADLAYDIKFEFPFGIEEIEG
IHSRTDFDLKQHQEYSGKNMEYIDQTTNERYIPYVVETSAGCDRLFLALLADAYTEDVVDGEERVVLRLAPRVAPVKAAI
LPLMKKGGLGEKAMALCNELSSSYLVQYDDAGSIGKRYRRQDEIGTPFCITVDHQSLEDESVTVRYRDSAAQERIALSRV
QEFLATNLI

Sequences:

>Translated_489_residues
MSNSEQQRVQRAALSPDKVMSKLVSLAKRRGFVFPSSEIYEGLSACFDYGPLGSEMKRTIKELWWNAMTRRHQNIVGIDA
SIMMNPRVWEASGHVASFNDPMIDDKTTKRRYRADHLIENHIEKLRRDGKEEALQRVQATYEAVGSTEDSNRALYELILA
EGIKAPDTGSADWTEVRQFNLMFQCNMGALSDRSGIVYLRPETAQGIFVNFHNVREASRMKVPFGIAQIGKAFRNEIVKG
NFTFRMVEFEQMEMQYFVKPGTQLEAFEAWREERFAWYVNSLGITPSKLHWYKHDKLAHYADLAYDIKFEFPFGIEEIEG
IHSRTDFDLKQHQEYSGKNMEYIDQTTNERYIPYVVETSAGCDRLFLALLADAYTEDVVDGEERVVLRLAPRVAPVKAAI
LPLMKKGGLGEKAMALCNELSSSYLVQYDDAGSIGKRYRRQDEIGTPFCITVDHQSLEDESVTVRYRDSAAQERIALSRV
QEFLATNLI
>Mature_488_residues
SNSEQQRVQRAALSPDKVMSKLVSLAKRRGFVFPSSEIYEGLSACFDYGPLGSEMKRTIKELWWNAMTRRHQNIVGIDAS
IMMNPRVWEASGHVASFNDPMIDDKTTKRRYRADHLIENHIEKLRRDGKEEALQRVQATYEAVGSTEDSNRALYELILAE
GIKAPDTGSADWTEVRQFNLMFQCNMGALSDRSGIVYLRPETAQGIFVNFHNVREASRMKVPFGIAQIGKAFRNEIVKGN
FTFRMVEFEQMEMQYFVKPGTQLEAFEAWREERFAWYVNSLGITPSKLHWYKHDKLAHYADLAYDIKFEFPFGIEEIEGI
HSRTDFDLKQHQEYSGKNMEYIDQTTNERYIPYVVETSAGCDRLFLALLADAYTEDVVDGEERVVLRLAPRVAPVKAAIL
PLMKKGGLGEKAMALCNELSSSYLVQYDDAGSIGKRYRRQDEIGTPFCITVDHQSLEDESVTVRYRDSAAQERIALSRVQ
EFLATNLI

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=360, Percent_Identity=31.3888888888889, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI70887790, Length=305, Percent_Identity=23.9344262295082, Blast_Score=80, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI32564541, Length=404, Percent_Identity=31.4356435643564, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17554996, Length=404, Percent_Identity=31.4356435643564, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6325338, Length=369, Percent_Identity=30.0813008130081, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319597, Length=401, Percent_Identity=27.930174563591, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357965, Length=375, Percent_Identity=33.0666666666667, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24664462, Length=375, Percent_Identity=33.0666666666667, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 56041; Mature: 55910

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSEQQRVQRAALSPDKVMSKLVSLAKRRGFVFPSSEIYEGLSACFDYGPLGSEMKRTI
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
KELWWNAMTRRHQNIVGIDASIMMNPRVWEASGHVASFNDPMIDDKTTKRRYRADHLIEN
HHHHHHHHHHHCCCEEECCCEEEECCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHH
HIEKLRRDGKEEALQRVQATYEAVGSTEDSNRALYELILAEGIKAPDTGSADWTEVRQFN
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHEE
LMFQCNMGALSDRSGIVYLRPETAQGIFVNFHNVREASRMKVPFGIAQIGKAFRNEIVKG
EEEEECCCCCCCCCCEEEECCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
NFTFRMVEFEQMEMQYFVKPGTQLEAFEAWREERFAWYVNSLGITPSKLHWYKHDKLAHY
CEEEEEEEHHHHHHHHEECCCCCHHHHHHHHHHHHEEEEHHCCCCHHHHEEECCCHHHHH
ADLAYDIKFEFPFGIEEIEGIHSRTDFDLKQHQEYSGKNMEYIDQTTNERYIPYVVETSA
HCEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCCCCCCCEEEECCC
GCDRLFLALLADAYTEDVVDGEERVVLRLAPRVAPVKAAILPLMKKGGLGEKAMALCNEL
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
SSSYLVQYDDAGSIGKRYRRQDEIGTPFCITVDHQSLEDESVTVRYRDSAAQERIALSRV
CCCEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHH
QEFLATNLI
HHHHHHCCC
>Mature Secondary Structure 
SNSEQQRVQRAALSPDKVMSKLVSLAKRRGFVFPSSEIYEGLSACFDYGPLGSEMKRTI
CCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
KELWWNAMTRRHQNIVGIDASIMMNPRVWEASGHVASFNDPMIDDKTTKRRYRADHLIEN
HHHHHHHHHHHCCCEEECCCEEEECCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHH
HIEKLRRDGKEEALQRVQATYEAVGSTEDSNRALYELILAEGIKAPDTGSADWTEVRQFN
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHEE
LMFQCNMGALSDRSGIVYLRPETAQGIFVNFHNVREASRMKVPFGIAQIGKAFRNEIVKG
EEEEECCCCCCCCCCEEEECCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
NFTFRMVEFEQMEMQYFVKPGTQLEAFEAWREERFAWYVNSLGITPSKLHWYKHDKLAHY
CEEEEEEEHHHHHHHHEECCCCCHHHHHHHHHHHHEEEEHHCCCCHHHHEEECCCHHHHH
ADLAYDIKFEFPFGIEEIEGIHSRTDFDLKQHQEYSGKNMEYIDQTTNERYIPYVVETSA
HCEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCCCCCCCEEEECCC
GCDRLFLALLADAYTEDVVDGEERVVLRLAPRVAPVKAAILPLMKKGGLGEKAMALCNEL
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
SSSYLVQYDDAGSIGKRYRRQDEIGTPFCITVDHQSLEDESVTVRYRDSAAQERIALSRV
CCCEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHH
QEFLATNLI
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]