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The map label for this gene is mvaB [H]

Identifier: 78067778

GI number: 78067778

Start: 3475073

End: 3476005

Strand: Direct

Name: mvaB [H]

Synonym: Bcep18194_A6309

Alternate gene names: 78067778

Gene position: 3475073-3476005 (Clockwise)

Preceding gene: 78067777

Following gene: 78067779

Centisome position: 94.07

GC content: 68.92

Gene sequence:

>933_bases
ATGACGTTCCCCACCGCCGTCAAGATCGTCGAAGTCGGCCCGCGCGACGGGCTGCAGAACGAGAAGACCTTCGTGCCGAC
CGACGTGAAGATCGCACTCGTCGACCGGCTGTCGCACGCCGGCTTCCGCAACGTCGAGGCCGCGTCGTTCGTGTCGCCGA
AATGGGTGCCTCAGATGGCCGACGGCGCCGACGTGATGGCCGGCATCGAGCGCCGCGCGGGCACCGTATATTCGGTGCTC
ACGCCGAACCTGAAGGGCTTCGAGAATGCGGTCGCCGCGCGCGCCGACGAGGTCGTGATCTTCGGCGCGGCGAGCGAGGC
GTTCTCGCAGCGGAACATCAACTGCAGCATCGCCGAAAGCATCGCGCGCTTCGAGCCCGTCGCGAAGGCGGCGAAGGATG
CGGGTCTGCGGCTGCGCGGCAGCGTGTCGTGCACGCTCGGCTGCCCGTACCAGGGTGAAGTGCCGGTCGCATCGGTCGTC
GACGTCGTCGAGCGCTTCGCGGCACTCGGCTGCGACGAGATCGACATCGCCGACACGATCGGCGTCGGTACGCCGAAGCG
CACGCGCGAAGTGCTCGCGGCCGTCACGCGCGTGTTCCCGCGCGAACGCCTGTCGGGCCACTTCCACGACACCTACGGCC
AGGCGCTCGCGAACATCTACGCGGCGCTGTTCGAAGGGATCGAGATCTTCCACGCGTCGGTCGCCGGCCTCGGCGGCTGC
CCGTACGCGAAGGGTGCGACAGGCAACGTCGCGACCGAGGACGTGCTGTACCTGATGCAAGGCCTCGGCATCGACACCGG
CATCGATCTCGCGGAGGTCGTCGCCGCCGGCGACTTCATCTCGAACGCGATCGGCCGCGCGAACGTGTCGCGCGCCGGTC
GCGCACTGCTCGCCAAGGCGCAGAGCGCGGCCGACGCCGCGAATTGCGTATGA

Upstream 100 bases:

>100_bases
TCGCCGGCAAGATCCGCGCGCTCGAGCGCGGCGAGCGCGTCGGCGGCATCGTCGACTACGCACGCGGCTACTGAACCTAC
AAGCAAACCAGGAGACAACC

Downstream 100 bases:

>100_bases
CCCCGGTATTCGACGGATTCCTCAACATGACGACACCTGCTTCATTCGATTCCCTCCCCGATTCCGCGCGACGCGTCGCG
CTGCTGCTGCGCGAGCGCGG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTFPTAVKIVEVGPRDGLQNEKTFVPTDVKIALVDRLSHAGFRNVEAASFVSPKWVPQMADGADVMAGIERRAGTVYSVL
TPNLKGFENAVAARADEVVIFGAASEAFSQRNINCSIAESIARFEPVAKAAKDAGLRLRGSVSCTLGCPYQGEVPVASVV
DVVERFAALGCDEIDIADTIGVGTPKRTREVLAAVTRVFPRERLSGHFHDTYGQALANIYAALFEGIEIFHASVAGLGGC
PYAKGATGNVATEDVLYLMQGLGIDTGIDLAEVVAAGDFISNAIGRANVSRAGRALLAKAQSAADAANCV

Sequences:

>Translated_310_residues
MTFPTAVKIVEVGPRDGLQNEKTFVPTDVKIALVDRLSHAGFRNVEAASFVSPKWVPQMADGADVMAGIERRAGTVYSVL
TPNLKGFENAVAARADEVVIFGAASEAFSQRNINCSIAESIARFEPVAKAAKDAGLRLRGSVSCTLGCPYQGEVPVASVV
DVVERFAALGCDEIDIADTIGVGTPKRTREVLAAVTRVFPRERLSGHFHDTYGQALANIYAALFEGIEIFHASVAGLGGC
PYAKGATGNVATEDVLYLMQGLGIDTGIDLAEVVAAGDFISNAIGRANVSRAGRALLAKAQSAADAANCV
>Mature_309_residues
TFPTAVKIVEVGPRDGLQNEKTFVPTDVKIALVDRLSHAGFRNVEAASFVSPKWVPQMADGADVMAGIERRAGTVYSVLT
PNLKGFENAVAARADEVVIFGAASEAFSQRNINCSIAESIARFEPVAKAAKDAGLRLRGSVSCTLGCPYQGEVPVASVVD
VVERFAALGCDEIDIADTIGVGTPKRTREVLAAVTRVFPRERLSGHFHDTYGQALANIYAALFEGIEIFHASVAGLGGCP
YAKGATGNVATEDVLYLMQGLGIDTGIDLAEVVAAGDFISNAIGRANVSRAGRALLAKAQSAADAANCV

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=294, Percent_Identity=57.1428571428571, Blast_Score=356, Evalue=1e-98,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=54.9488054607508, Blast_Score=347, Evalue=7e-96,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=54.9488054607508, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI260654708, Length=134, Percent_Identity=50.7462686567164, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17510563, Length=305, Percent_Identity=48.1967213114754, Blast_Score=301, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24582381, Length=289, Percent_Identity=56.0553633217993, Blast_Score=345, Evalue=3e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32459; Mature: 32328

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFPTAVKIVEVGPRDGLQNEKTFVPTDVKIALVDRLSHAGFRNVEAASFVSPKWVPQMA
CCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
DGADVMAGIERRAGTVYSVLTPNLKGFENAVAARADEVVIFGAASEAFSQRNINCSIAES
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHCCCCHHHHHH
IARFEPVAKAAKDAGLRLRGSVSCTLGCPYQGEVPVASVVDVVERFAALGCDEIDIADTI
HHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTPKRTREVLAAVTRVFPRERLSGHFHDTYGQALANIYAALFEGIEIFHASVAGLGGC
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYLMQGLGIDTGIDLAEVVAAGDFISNAIGRANVSRAGRALLAKA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSAADAANCV
HHHHHHHCCC
>Mature Secondary Structure 
TFPTAVKIVEVGPRDGLQNEKTFVPTDVKIALVDRLSHAGFRNVEAASFVSPKWVPQMA
CCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
DGADVMAGIERRAGTVYSVLTPNLKGFENAVAARADEVVIFGAASEAFSQRNINCSIAES
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHCCCCHHHHHH
IARFEPVAKAAKDAGLRLRGSVSCTLGCPYQGEVPVASVVDVVERFAALGCDEIDIADTI
HHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTPKRTREVLAAVTRVFPRERLSGHFHDTYGQALANIYAALFEGIEIFHASVAGLGGC
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYLMQGLGIDTGIDLAEVVAAGDFISNAIGRANVSRAGRALLAKA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSAADAANCV
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]