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The map label for this gene is fghA [H]

Identifier: 78067403

GI number: 78067403

Start: 3057641

End: 3058489

Strand: Reverse

Name: fghA [H]

Synonym: Bcep18194_A5934

Alternate gene names: 78067403

Gene position: 3058489-3057641 (Counterclockwise)

Preceding gene: 78067404

Following gene: 78067398

Centisome position: 82.79

GC content: 69.73

Gene sequence:

>849_bases
ATGCTCGAACTCGTTTCCTCGCATGCGTGCCACGGCGGCGAGCAGCGTTTCTACCGTCACGATTCGGCGGCCATCGGCCT
GCCGATGAAGTTCTCGGTGTACCTGCCGCCGCAGGCCGCGCACGGCCGCGTGCCGGCGCTGTTCTATCTCGCGGGGCTCA
CGTGCACCGACGAGACGTTCGCGATCAAGGCCGGCGCGCAGCAATACGCGGCGCAGCACGGCATCGCGCTCGTGATGCCC
GACACGAGCCCGCGCGGCGCGGGCGTGCCGGGCGAGACCGACGCATGGGACTTCGGCGTTGGCGCGGGCTTCTACGTCGA
TGCGACCGAGGCGCCGTGGTCCGCGCATTACCGGATGGAGTCGTACGTGACGGGTGAGCTGCGCGAGCTGGTCGCGGCCG
AGCTGCCGATCGACGGCGCGCGGCTCGGGATCTTCGGCCATTCGATGGGCGGGCACGGCGCGCTGACGCTCGCGTTGCGC
CATCCGGGCCTGTACCGGTCGGTGTCGGCGTTCGCGCCGATCGCCGCGCCGACGCGCTGCCCGTGGGGCGAGAAGGCGTT
CTCGGGTTATCTGGGCGCCGATCGCGAAGCGTGGAAGGCACACGACGCGAGCGAACTCGTCGCGCGCGCCGATGCGCCGA
AGTTCGCGGACGGCATCCTGGTCGATCAGGGCCTCGCCGACCAGTTCCTCGCGAACCAGTTGAACCCCGACGTGTTCGAA
GCCGCGTGCGCGAAGGCCGGCCAGCCGCTGACGCTGCGTCGTCATGCAGGCTACGACCACGGCTACTACTTCATCTCGAC
GTTCATCGCCGATCACATCGCGCATCACGCGCGCGTGCTCGCACGGTGA

Upstream 100 bases:

>100_bases
CACACGCTGCCGCTCGAGCGGATCAACGAAGGCTTCGACCTGATGAAGGCCGGCGAGTCGATCCGTTCGGTCGTGCTGTA
CTGACCGGGAGCGTACCGCG

Downstream 100 bases:

>100_bases
GCGGGCAGGGAAGCAGGTAACGCACACGGCGCGCCGCACGATCGCGGGCGCATGCGAAAACGCCGGCGCTGCCCTCGGGC
ACGCCGGCGTTTTTCATTAC

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETFAIKAGAQQYAAQHGIALVMP
DTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSAHYRMESYVTGELRELVAAELPIDGARLGIFGHSMGGHGALTLALR
HPGLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADREAWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
AACAKAGQPLTLRRHAGYDHGYYFISTFIADHIAHHARVLAR

Sequences:

>Translated_282_residues
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETFAIKAGAQQYAAQHGIALVMP
DTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSAHYRMESYVTGELRELVAAELPIDGARLGIFGHSMGGHGALTLALR
HPGLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADREAWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
AACAKAGQPLTLRRHAGYDHGYYFISTFIADHIAHHARVLAR
>Mature_282_residues
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETFAIKAGAQQYAAQHGIALVMP
DTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSAHYRMESYVTGELRELVAAELPIDGARLGIFGHSMGGHGALTLALR
HPGLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADREAWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
AACAKAGQPLTLRRHAGYDHGYYFISTFIADHIAHHARVLAR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=56.4285714285714, Blast_Score=345, Evalue=4e-95,
Organism=Escherichia coli, GI1788477, Length=281, Percent_Identity=51.2455516014235, Blast_Score=281, Evalue=4e-77,
Organism=Escherichia coli, GI1786551, Length=279, Percent_Identity=47.6702508960573, Blast_Score=279, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=49.4661921708185, Blast_Score=284, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=38.3838383838384, Blast_Score=199, Evalue=3e-52,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=53.7102473498233, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=53.7102473498233, Blast_Score=303, Evalue=6e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30289; Mature: 30289

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETF
CCCCCCCCCCCCCHHHHEECCCCEECCCEEEEEEECCCCCCCCCCEEEHEECCEECCCEE
AIKAGAQQYAAQHGIALVMPDTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSAHYRME
EEECCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHEEHH
SYVTGELRELVAAELPIDGARLGIFGHSMGGHGALTLALRHPGLYRSVSAFAPIAAPTRC
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCC
PWGEKAFSGYLGADREAWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
CCCHHHHHCCCCCCCHHHHCCCHHHHHHHCCCCCHHCCEEECCCHHHHHHHHCCCHHHHH
AACAKAGQPLTLRRHAGYDHGYYFISTFIADHIAHHARVLAR
HHHHHCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETF
CCCCCCCCCCCCCHHHHEECCCCEECCCEEEEEEECCCCCCCCCCEEEHEECCEECCCEE
AIKAGAQQYAAQHGIALVMPDTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSAHYRME
EEECCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHEEHH
SYVTGELRELVAAELPIDGARLGIFGHSMGGHGALTLALRHPGLYRSVSAFAPIAAPTRC
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCC
PWGEKAFSGYLGADREAWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
CCCHHHHHCCCCCCCHHHHCCCHHHHHHHCCCCCHHCCEEECCCHHHHHHHHCCCHHHHH
AACAKAGQPLTLRRHAGYDHGYYFISTFIADHIAHHARVLAR
HHHHHCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]