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The map label for this gene is apbA [H]

Identifier: 78067381

GI number: 78067381

Start: 3033026

End: 3033970

Strand: Reverse

Name: apbA [H]

Synonym: Bcep18194_A5912

Alternate gene names: 78067381

Gene position: 3033970-3033026 (Counterclockwise)

Preceding gene: 78067382

Following gene: 78067380

Centisome position: 82.13

GC content: 69.42

Gene sequence:

>945_bases
ATGAGGATTGCCATTCTGGGCGCGGGCGCAATGGGCTCGCTGTTCGGCGGGCGGCTGGCCGAAAGCGGCGAGGCCGTCAC
GCTGATCGACGTGAACGATGCGCATCTCGATGCGATTCGCCGCGACGGCCTATGCATCGATGATGATCGGGGCGAACGAC
GCATCCGTACGCTGCAGGTCGTGCGGCCGGAAACCGCGCAAGCGGATGCGGCCGCAGCGTCCGATACACCGTTCGACCTG
CTGATCGTTTTCACGAAGTCGCTGCATACGCGTACCGCACTCGACGGCGTGCGTGCATTGCTCAAGCGAGACGCGCATGT
GCTGACGCTGCAGAACGGGCTCGGCAACGTCGAGACGCTGAATGCGTTCGTGCCGCTCGAACGCATCCTGGTCGGCGTGA
CGACGTGGCCGGCCGACGCGGCGGGGCCGGCACACGTGCGCTCGCACGGCGCGGGCACGATCCGCATGATGACGGCCGAC
GGCGCGGCGCGCCCGTTCGCGGCGACGGTGGCCGATACGCTGTCGCGCGCGGGGCTCGCTTGCACGCTCGACGCCGACGT
GTGGGCCGCGATCTGGGAGAAGGTCGCGTTCAACGCGGCGCTCAACACGCTGTGCGCGGCGACGGGCTGCACGGTCGACC
AGCTCGGCAATCATCACGACGGGCCGCGGCTCGCGCTCGCGATCGCGGCCGAGGTGGCCGCCGTCGCCCGCGCGAAGGGC
ATCGCGGTCGACGGCGAACGTATCGCGCGCAACGTCGAGCATGCGATCCACGAGCATCGCGGCCATCGTCCGTCGATGCT
GCAGGACGTACTTGCGGGCCGTCGCACGGAAATCGACGCGATCAGCGGCAAGGTCGTCGCGGCCGCGCGCGAAGCGGGCG
TGGCGGTGCCGCATGCGGAAACGCTGCTCGCGCTGGTCCGGCTGATCGACGCACGGATGAACTGA

Upstream 100 bases:

>100_bases
ACTTCGGCGGCAAGGCCGGCATCGCGGCGTTCACGGACCTGCGCTGGATCACGGTGCAGACGGCACCGCGCCACTATCCG
TTCTGACGAGGCCGCCGACG

Downstream 100 bases:

>100_bases
GCATCAGGCCGGCGGCGCGGCTTGCGCCGCACGACGAGACGAGCACGCCGCGCGCAGGCGACGACGCCGGATCGGGACGG
GTTGGACGAGACACCGGAGC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRIAILGAGAMGSLFGGRLAESGEAVTLIDVNDAHLDAIRRDGLCIDDDRGERRIRTLQVVRPETAQADAAAASDTPFDL
LIVFTKSLHTRTALDGVRALLKRDAHVLTLQNGLGNVETLNAFVPLERILVGVTTWPADAAGPAHVRSHGAGTIRMMTAD
GAARPFAATVADTLSRAGLACTLDADVWAAIWEKVAFNAALNTLCAATGCTVDQLGNHHDGPRLALAIAAEVAAVARAKG
IAVDGERIARNVEHAIHEHRGHRPSMLQDVLAGRRTEIDAISGKVVAAAREAGVAVPHAETLLALVRLIDARMN

Sequences:

>Translated_314_residues
MRIAILGAGAMGSLFGGRLAESGEAVTLIDVNDAHLDAIRRDGLCIDDDRGERRIRTLQVVRPETAQADAAAASDTPFDL
LIVFTKSLHTRTALDGVRALLKRDAHVLTLQNGLGNVETLNAFVPLERILVGVTTWPADAAGPAHVRSHGAGTIRMMTAD
GAARPFAATVADTLSRAGLACTLDADVWAAIWEKVAFNAALNTLCAATGCTVDQLGNHHDGPRLALAIAAEVAAVARAKG
IAVDGERIARNVEHAIHEHRGHRPSMLQDVLAGRRTEIDAISGKVVAAAREAGVAVPHAETLLALVRLIDARMN
>Mature_314_residues
MRIAILGAGAMGSLFGGRLAESGEAVTLIDVNDAHLDAIRRDGLCIDDDRGERRIRTLQVVRPETAQADAAAASDTPFDL
LIVFTKSLHTRTALDGVRALLKRDAHVLTLQNGLGNVETLNAFVPLERILVGVTTWPADAAGPAHVRSHGAGTIRMMTAD
GAARPFAATVADTLSRAGLACTLDADVWAAIWEKVAFNAALNTLCAATGCTVDQLGNHHDGPRLALAIAAEVAAVARAKG
IAVDGERIARNVEHAIHEHRGHRPSMLQDVLAGRRTEIDAISGKVVAAAREAGVAVPHAETLLALVRLIDARMN

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=318, Percent_Identity=29.2452830188679, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320057, Length=344, Percent_Identity=24.4186046511628, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33048; Mature: 33048

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAILGAGAMGSLFGGRLAESGEAVTLIDVNDAHLDAIRRDGLCIDDDRGERRIRTLQV
CEEEEEECCHHHHHHCCHHCCCCCEEEEEECCCHHHHHHHHCCCEEECCCCCHHHHEEEE
VRPETAQADAAAASDTPFDLLIVFTKSLHTRTALDGVRALLKRDAHVLTLQNGLGNVETL
ECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
NAFVPLERILVGVTTWPADAAGPAHVRSHGAGTIRMMTADGAARPFAATVADTLSRAGLA
HHHHHHHHHHEEEECCCCCCCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCEE
CTLDADVWAAIWEKVAFNAALNTLCAATGCTVDQLGNHHDGPRLALAIAAEVAAVARAKG
EEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
IAVDGERIARNVEHAIHEHRGHRPSMLQDVLAGRRTEIDAISGKVVAAAREAGVAVPHAE
CEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHCCCEEEEHHHCCCCCCCHH
TLLALVRLIDARMN
HHHHHHHHHHHCCC
>Mature Secondary Structure
MRIAILGAGAMGSLFGGRLAESGEAVTLIDVNDAHLDAIRRDGLCIDDDRGERRIRTLQV
CEEEEEECCHHHHHHCCHHCCCCCEEEEEECCCHHHHHHHHCCCEEECCCCCHHHHEEEE
VRPETAQADAAAASDTPFDLLIVFTKSLHTRTALDGVRALLKRDAHVLTLQNGLGNVETL
ECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
NAFVPLERILVGVTTWPADAAGPAHVRSHGAGTIRMMTADGAARPFAATVADTLSRAGLA
HHHHHHHHHHEEEECCCCCCCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCEE
CTLDADVWAAIWEKVAFNAALNTLCAATGCTVDQLGNHHDGPRLALAIAAEVAAVARAKG
EEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
IAVDGERIARNVEHAIHEHRGHRPSMLQDVLAGRRTEIDAISGKVVAAAREAGVAVPHAE
CEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHCCCEEEEHHHCCCCCCCHH
TLLALVRLIDARMN
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]