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The map label for this gene is msrA [H]

Identifier: 78067372

GI number: 78067372

Start: 3023768

End: 3024367

Strand: Reverse

Name: msrA [H]

Synonym: Bcep18194_A5903

Alternate gene names: 78067372

Gene position: 3024367-3023768 (Counterclockwise)

Preceding gene: 78067376

Following gene: 78067368

Centisome position: 81.87

GC content: 63.83

Gene sequence:

>600_bases
ATGCGTGCCGGTTGCCGACATCAACGAGGGACTGATTTCATGGTGAACGAGATGCTTGAAACCGCGACATTGGGAGGCGG
GTGTTTCTGGTGCACGGAGGCGGTGTTTCTCGATGTCGACGGCGTGACGGCCGTCCAGTCGGGCTACGCGGGCGGCCATA
CGCGCAACCCCGGCTATCGCGACATTTGCGAAGGCGATACGGGCCACGCGGAAGTCGTCAACGTGACGTTCGATCCGGCG
CGCATCGGCTATCGCGAGATCCTCGAGATCTTCTTCGCGACGCACGATCCGACCCAGTTGAACCGGCAGGGCAACGACGT
CGGCACGCAGTACCGGTCGGTCGTGTTCACCCATTCGGACGCGCAGCGCGACACGGCGCTCGACGTGATCCGCGAACTGG
AGCGCGAGCAGGTGTTCGGGCAGCCGATCGTCACGCAGGTGGTGCCGCTCGACGGCAACTACTGGCCGGCCGAGGATTAT
CACCAGAACTATTACGCGCGGAATCCGGGGCAGGGCTACTGCTCGGTCGTGATCGGGCCGAAGCTCGCGAAATTCCGGCA
GAAGTTCTCGCACCGGCTGAAGTCGCTGCGCGGCGCGTAA

Upstream 100 bases:

>100_bases
GCACTCTGTCAGGTTCGCGCGCGAGTGAGATACTTGCCGAAGTGCCGTTGCGACCCGCACGCGGGTGGGCAGCGGCGAGA
CGGAACGGTGGCGCCGGCGC

Downstream 100 bases:

>100_bases
ATGTGACCGCGACCGGCGCAAGCCGGTATCCAGTCGGGATCAAGCCGCCTCGTTGCGCCACTGCGCGCACGCGGCGGCGA
TCTCGCGCGCAAGCGCGATG

Product: protein-methionine-S-oxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MRAGCRHQRGTDFMVNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDICEGDTGHAEVVNVTFDPA
RIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVVFTHSDAQRDTALDVIRELEREQVFGQPIVTQVVPLDGNYWPAEDY
HQNYYARNPGQGYCSVVIGPKLAKFRQKFSHRLKSLRGA

Sequences:

>Translated_199_residues
MRAGCRHQRGTDFMVNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDICEGDTGHAEVVNVTFDPA
RIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVVFTHSDAQRDTALDVIRELEREQVFGQPIVTQVVPLDGNYWPAEDY
HQNYYARNPGQGYCSVVIGPKLAKFRQKFSHRLKSLRGA
>Mature_199_residues
MRAGCRHQRGTDFMVNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDICEGDTGHAEVVNVTFDPA
RIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVVFTHSDAQRDTALDVIRELEREQVFGQPIVTQVVPLDGNYWPAEDY
HQNYYARNPGQGYCSVVIGPKLAKFRQKFSHRLKSLRGA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=44.1717791411043, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=44.1717791411043, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI208609993, Length=114, Percent_Identity=44.7368421052632, Blast_Score=94, Evalue=8e-20,
Organism=Escherichia coli, GI1790665, Length=158, Percent_Identity=39.873417721519, Blast_Score=127, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=32.8859060402685, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=42.1383647798742, Blast_Score=112, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24664627, Length=171, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24664631, Length=171, Percent_Identity=32.1637426900585, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45553131, Length=161, Percent_Identity=31.6770186335404, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 22308; Mature: 22308

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAGCRHQRGTDFMVNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYR
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHECCEEEEECCCHHHHHCCCCCCCCCCCCCC
DICEGDTGHAEVVNVTFDPARIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVVFTHSD
HHCCCCCCCEEEEEEEECHHHCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHEEEEECCC
AQRDTALDVIRELEREQVFGQPIVTQVVPLDGNYWPAEDYHQNYYARNPGQGYCSVVIGP
CCHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCCCCHHHHCCCCCCCCCCCEEEEEECH
KLAKFRQKFSHRLKSLRGA
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRAGCRHQRGTDFMVNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYR
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHECCEEEEECCCHHHHHCCCCCCCCCCCCCC
DICEGDTGHAEVVNVTFDPARIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVVFTHSD
HHCCCCCCCEEEEEEEECHHHCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHEEEEECCC
AQRDTALDVIRELEREQVFGQPIVTQVVPLDGNYWPAEDYHQNYYARNPGQGYCSVVIGP
CCHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCCCCHHHHCCCCCCCCCCCEEEEEECH
KLAKFRQKFSHRLKSLRGA
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]