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The map label for this gene is clpA [H]

Identifier: 78067319

GI number: 78067319

Start: 2966055

End: 2968355

Strand: Reverse

Name: clpA [H]

Synonym: Bcep18194_A5850

Alternate gene names: 78067319

Gene position: 2968355-2966055 (Counterclockwise)

Preceding gene: 78067320

Following gene: 78067318

Centisome position: 80.35

GC content: 63.62

Gene sequence:

>2301_bases
ATGATTGCCCAGGAATTGGAAGTCAGCCTGCACATGGCGTTCATGGAAGCACGCCAGGCGCGCCATGAGTTCATTACGGT
CGAGCATTTGCTGCTGGCCCTGCTGGATAATCCGACGGCAGCCGAGGTGTTGCGCGCGTGCGCGGCAAACATCGAGGACT
TGCGTCAGAACCTGCGCAATTTCATCCACGACAACACACCTACCGTCCCGGGCACCGACGATGTCGATACCCAGCCGACG
CTGGGTTTCCAGCGCGTGATCCAGCGCGCGATCATGCACGTCCAGTCGACGTCGAACGGCAAGAAGGAAGTGACCGGCGC
GAATGTGCTGGTCGCGATCTTCGGCGAGAAGGATTCGCACGCCGTGTACTACCTGCAGCAGCAGGGCGTCACGCGCCTCG
ATGTCGTGAACTTCATTTCGCACGGCATCGCGAAGACGAACAACGGCGAAGCCGCGAAGTCGGCCGATGCGAATGCGGAA
AGCGAAGACGCGAATGCGCAGAAGGAAACGCCGCTCGCGCAATTCACGCAGAACCTGAACCAGATGGCGAAGGACGGCCG
CATCGATCCGCTGATCGGTCGCGAGCCCGAGGTCGAGCGCGTGGTCCAGGTGCTGTGCCGTCGCCGCAAGAACAATCCGC
TGCTCGTCGGCGAGGCCGGTGTCGGCAAGACCGCGATCGCGGAAGGGCTCGCCTATCGCATTACGCGCGGCGAAGTGCCG
GACATCCTCGCGAACGCGCAGGTCTACTCGCTCGACATGGGCGCGCTGCTCGCGGGCACCAAGTATCGCGGCGATTTCGA
GCAACGTCTGAAGACGGTGCTGAAGGAGCTGAAGGAGCGTCCGCACGCGATCCTGTTCATCGACGAAATCCATACGCTGA
TCGGCGCGGGCGCCGCGTCGGGCGGCACGCTCGATGCGTCGAACCTGCTGAAGCCGGCGCTGTCGTCGGGCGTGCTGAAG
TGCATCGGCGCGACCACGTTCACCGAATATCGCGGCATCTTCGAGAAGGATGCGGCGCTGTCGCGGCGCTTCCAGAAGGT
CGACGTGACGGAGCCGACCGTCGAGCAGACGGTCGCGATCCTGCGTGGGCTGAAGTCGCGCTTCGAGGAGCATCACGGCG
TCAAGTATTCGTCGGGTGCGCTGTCGGCCGCGGCCGAACTGTCGGCGCGCTTCATCACCGACCGCCACTTGCCCGACAAG
GCGATCGACGTGATCGACGAAGCGGGTGCCGCCCAGCGCATCCTGCCGAAGTCGAAGCAGAAGAAGACGATCGGCAAGAG
CGAGATCGAGGAAATCATCTCGAAGATCGCGCGTGTGCCGCCGCAGAGCGTGTCGCAGGACGACCGCAGCAAGCTGCAGA
CGCTCGATCGCGACTTGAAGAGCGTCGTGTTCGGCCAGGATCCGGCGATCGACGCACTGGCCGCCTCGATCAAGATGGCG
CGCGCGGGCCTCGGCAAGATGGACAAGCCGATCGGTGCGTTCCTGTTCTCCGGCCCGACGGGCGTCGGCAAGACCGAAGT
GGCGCGCCAGCTCGCGTTCACGCTCGGCATCGAGCTGATCCGCTTCGACATGTCGGAATACATGGAGCGTCACGCGGTGA
GCCGCCTGATCGGCGCGCCGCCGGGCTACGTCGGGTTCGACCAGGGTGGCCTGCTGACCGAAGCCGTCACGAAGAAGCCG
CACTGCGTGCTGCTGCTCGACGAAATCGAGAAGGCGCATCCGGACATCTTCAACGTGCTGCTGCAGGTGATGGACCACGG
CACGCTGACGGACAACAACGGCCGCAAGGCGGATTTCCGCAACGTCATCATCATCATGACGACGAACGCGGGCGCCGAGT
CGATGCAGAAGGCGACGATCGGCTTCACGACGCGCCGCGAGACGGGCGACGAGATGACCGACATCAAGCGTCTGTTCACG
CCGGAGTTCCGCAACCGCCTGGATTCGATCATCAGCTTCCGCTCGCTCGATGAGGAAATCATCATGCGCGTGGTCGACAA
GTTCCTGATCCAGCTCGAGGAACAGCTGCACGAGAAGAAGGTCGACGCGCTCTTCACCGACGCGTTGCGCAAGCATCTCG
CGAAGCACGGCTTCGACCCGCTGATGGGCGCGCGGCCGATGCAGCGACTGATCCAGGACACGATCCGGCGCGCGCTGGCC
GACGAGCTGCTGTTCGGCAAGCTCGTCAACGGCGGCCACGTGACGGTCGATGTCGACGAAAACGACAAGGTGCAGTTGTC
GTTCGACAAGCTGGCGAATCCGCCGCACAAGCCGAACGAAGAGGCGGTCGAAGTCGAATAA

Upstream 100 bases:

>100_bases
GTGGGGTCTATACGCGGGACATCGCGTCGACCAAGGTTGAGCAAGTCGTTACCCATGCGCGGCAGGCCGGGCATCCGCTG
CAGTGCGTGATGGAGGAAGC

Downstream 100 bases:

>100_bases
GCGATAATTCGTTGTTCATGCGAACGGCGCGGGAAGTTCTCCGCGCCGTTTCGTTTTATCTGGCGCCGGCGGCGCGATGG
TGGTGCAGGGGAGTGGCAAC

Product: AAA ATPase, Clp

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 766; Mature: 766

Protein sequence:

>766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTNNGEAAKSADANAE
SEDANAQKETPLAQFTQNLNQMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGVLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMTDIKRLFT
PEFRNRLDSIISFRSLDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVQLSFDKLANPPHKPNEEAVEVE

Sequences:

>Translated_766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTNNGEAAKSADANAE
SEDANAQKETPLAQFTQNLNQMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGVLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMTDIKRLFT
PEFRNRLDSIISFRSLDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVQLSFDKLANPPHKPNEEAVEVE
>Mature_766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTNNGEAAKSADANAE
SEDANAQKETPLAQFTQNLNQMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGVLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMTDIKRLFT
PEFRNRLDSIISFRSLDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVQLSFDKLANPPHKPNEEAVEVE

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=332, Percent_Identity=28.9156626506024, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1787109, Length=759, Percent_Identity=61.0013175230567, Blast_Score=961, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=401, Percent_Identity=45.6359102244389, Blast_Score=306, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=259, Percent_Identity=55.984555984556, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323002, Length=304, Percent_Identity=46.3815789473684, Blast_Score=262, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84452; Mature: 84452

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTNNGEAAKSADANAESEDANAQKETPLAQFTQNLN
EEEEEHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHH
QMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCCC
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGVLKCIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
HHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKATIGFTTRRETGDEMTDIKRLFTPEFRNRLDSIISFRSLDEEI
CEEEEEECCCCHHHHHHHHHCCEECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCHHH
IMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVNGGHVTVDVDENDKVQLSFDKLANPPHKPNEEAVEVE
HHHHHHHHCCCCEEEEEECCCCCEEEEHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTNNGEAAKSADANAESEDANAQKETPLAQFTQNLN
EEEEEHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHH
QMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCCC
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGVLKCIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
HHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKATIGFTTRRETGDEMTDIKRLFTPEFRNRLDSIISFRSLDEEI
CEEEEEECCCCHHHHHHHHHCCEECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCHHH
IMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVNGGHVTVDVDENDKVQLSFDKLANPPHKPNEEAVEVE
HHHHHHHHCCCCEEEEEECCCCCEEEEHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]