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The map label for this gene is kduD [C]

Identifier: 78067285

GI number: 78067285

Start: 2932496

End: 2933269

Strand: Reverse

Name: kduD [C]

Synonym: Bcep18194_A5816

Alternate gene names: 78067285

Gene position: 2933269-2932496 (Counterclockwise)

Preceding gene: 78067286

Following gene: 78067284

Centisome position: 79.4

GC content: 65.12

Gene sequence:

>774_bases
GTGGCAACTCATACGCTCGCAGACAAGGTCGTCCTGATCGCAGGCGGCGCAAAGAATCTCGGCGGCCTGATCGCGCGGGA
TCTGGCGAGCCACGGCGCGAAGGCCGTGGCGATTCATTACAACAGTGCCGCATCGCAGGCGCAGGCCGAGGAAACGGCTG
CCGCGGTGCGTGCCGCCGGCGCGGAAGCGGCAACGTTCCAGGGCGACCTGACGACGGCCGCCGCGGTCGAGAAGCTGTTC
GACGACGCGAAGCAGCACTTCGGTAAGATCGATATCGCGATCAACACGGTCGGCAAGGTGCTGAAGAAGCCGTTCACCGA
GATCAGCGAGGCCGAGTACGACGAGATGTTCGCGGTGAACAGCAAGTCGGCGTTCTTCTTCATCAAGGAAGCGGGGCGGC
ACCTCGAGGATCACGGCAAGCTCGTCACGCTCGTGACGTCGCTGCTCGGCGCGTTCACGCCGTTCTATGCGGCGTACGAA
GGGTCGAAGGCGCCGGTCGAGCATTTCACGCGCGCGGCGTCGAAGGAATACGGCGCGCGCGGGATCTCGGTGACGGCCGT
CGGTCCGGGCCCGATGGACACGCCGTTCTTCTACCCGGCCGAAGGCGCCGATGCGGTCGCTTATCACAAGACGGCGGCCG
CGCTGTCGCCGTTCAGCAAGACGGGCCTGACCGACATCGAGGACGTCGTGCCGTTCATCCGCCATCTCGTCACCGACGGC
TGGTGGATCACGGGCCAGACGATCCTGATCAACGGCGGCTATACGACCAAGTAA

Upstream 100 bases:

>100_bases
GGATCGTTTTTCTGGATAATCCATCCAGCCGCGACTGGCTGACCGGTGCGTCGCGCGTGCCTACACTCCAAGCTTCGTTC
AACGAGAAAAGGAGTCAACC

Downstream 100 bases:

>100_bases
CCGACCCGGCAACGGGCCGCGCGGGCGCACCGCAATGGCGCGTTTGCGTGGACAATGGACGGGCGCGTGGCCTCGCGGCT
GCGTGCCCGTTTTCTCTGTG

Product: short chain dehydrogenase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAASQAQAEETAAAVRAAGAEAATFQGDLTTAAAVEKLF
DDAKQHFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYE
GSKAPVEHFTRAASKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDG
WWITGQTILINGGYTTK

Sequences:

>Translated_257_residues
MATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAASQAQAEETAAAVRAAGAEAATFQGDLTTAAAVEKLF
DDAKQHFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYE
GSKAPVEHFTRAASKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDG
WWITGQTILINGGYTTK
>Mature_256_residues
ATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAASQAQAEETAAAVRAAGAEAATFQGDLTTAAAVEKLFD
DAKQHFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYEG
SKAPVEHFTRAASKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDGW
WITGQTILINGGYTTK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=25.6603773584906, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=24.3243243243243, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789208, Length=266, Percent_Identity=27.4436090225564, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=24.8, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=26.7716535433071, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=28.0612244897959, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI2367365, Length=188, Percent_Identity=27.6595744680851, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1789378, Length=192, Percent_Identity=27.6041666666667, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=25.8426966292135, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=195, Percent_Identity=27.1794871794872, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=264, Percent_Identity=25.7575757575758, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=28.1368821292776, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=29.1187739463602, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=26.6917293233083, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=26.2357414448669, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=26.8939393939394, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=25.390625, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=25.3787878787879, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=24.1106719367589, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=28.2527881040892, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=25.187969924812, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=199, Percent_Identity=30.1507537688442, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=25.7575757575758, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=25.6809338521401, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=23.8805970149254, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=27.027027027027, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355319, Length=265, Percent_Identity=29.4339622641509, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=26.2745098039216, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24643142, Length=255, Percent_Identity=25.8823529411765, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI23397609, Length=188, Percent_Identity=28.1914893617021, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 27139; Mature: 27008

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAASQAQAEETAAAVRAAG
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCC
AEAATFQGDLTTAAAVEKLFDDAKQHFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVN
CCCEEECCCHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHCCHHHHEEEC
SKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYEGSKAPVEHFTRAASKEYGAR
CCCEEEEEHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
GISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDG
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCC
WWITGQTILINGGYTTK
EEEECCEEEEECCCCCC
>Mature Secondary Structure 
ATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAASQAQAEETAAAVRAAG
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCC
AEAATFQGDLTTAAAVEKLFDDAKQHFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVN
CCCEEECCCHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHCCHHHHEEEC
SKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYEGSKAPVEHFTRAASKEYGAR
CCCEEEEEHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
GISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDG
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCC
WWITGQTILINGGYTTK
EEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]