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The map label for this gene is ilvD2

Identifier: 78067262

GI number: 78067262

Start: 2906964

End: 2908637

Strand: Direct

Name: ilvD2

Synonym: Bcep18194_A5793

Alternate gene names: 78067262

Gene position: 2906964-2908637 (Clockwise)

Preceding gene: 78067259

Following gene: 78067263

Centisome position: 78.69

GC content: 67.26

Gene sequence:

>1674_bases
ATGGCTTACAACCGTCGCTCGAAGCACATCACGCAAGGTGTGGCCCGCTCGCCGAACCGCTCGATGTATTACGCACTCGG
CTACCAGAAGGACGATTTCGACAAGCCGATGGTCGGCATCGCGAACGGCCATTCGACGATCACGCCGTGCAATTCCGGCC
TGCAGCGCCTGTCGGACGCGGCCGTCGCGGCCGTGAAGGCGGCCGATGCGAACCCGCAGATCTTCGGCACGCCGACGATT
TCGGACGGCATGTCGATGGGCACCGAAGGCATGAAGTACTCGCTCGTGTCGCGCGAGGTGATCGCCGACTGCATCGAAAC
CTGCGTGCAGGGGCAATGGATGGACGGCGTGGTCGTCGTTGGCGGCTGCGACAAGAACATGCCGGGCGGGATGATCGCGC
TCGCACGCCTGAACGTGCCGGGCATCTACGTGTACGGCGGCACGATCCGCCCCGGCAACTGGAAAGGCCGGGACCTGACG
ATCGTGTCGTCGTTCGAGGCCGTCGGCGAATTCACGGCGGGCCGGATGTCGCAGGAGGATTTCGAAGGCGTCGAGCGGAA
CGCATGCCCGACGTCGGGCTCCTGCGGCGGGATGTACACCGCGAACACGATGAGCTCGTCGTTCGAGGCGCTCGGGATGT
CGCTGCTGTACTCGTCGACGATGGCGAACCCCGACCAGGAGAAGGTCGATTCGGCCGCCGAATCGGCACGCGTGCTCGTC
GAGGCCGTGAAGCGCGACCTGAAGCCGCGCGACATCATCACGAAGGAGTCGATCGAGAACGCGGTGTCGGTGATCATGGC
GACGGGCGGCTCGACCAATGCGGTGCTGCACTACCTCGCGATCGCGCACGCGGCCGAGGTCGACTGGACGATCGAGGACT
TCGAGCGCATCCGCAAGCGCGTGCCCGTGATCTGCGACCTGAAGCCGTCGGGGAAGTACGTCGCCACCGACCTGCACCGG
GCCGGCGGGATCCCGCAGGTGTTGAAGATCCTGCTCGACGCGGGGCTGCTGCACGGCGACTGCATGACGATCACCGGCCG
CACGATTGCCGACGAACTGAAGGACGTGCCGAGCGTGCCGCGCGCCGACCAGGACGTGATCTTCCCGATCGACCGCGCGC
TGTACAAGGAAGGCCACCTTGCCATCCTGAAAGGCAATCTCGCGGAAGACGGCGCGGTCGCGAAGATCACCGGCCTGAAG
AACCCGGTGATCACGGGCCCGGCACGCGTGTTCGACGACGAGCAGAGTGCGATGGATGCGATTCTCGGCGACCGGATCCG
CGCAGGCGACATCCTCGTGCTGCGCTACCTCGGCCCGAAGGGCGGCCCCGGCATGCCGGAAATGCTCGCGCCGACGTCCG
CGATCATCGGCAAGGGGCTCGGCGAATCGGTCGGCTTCATCACCGACGGCCGCTTCTCGGGCGGGACCTGGGGGATGGTG
GTCGGCCACGTCGCGCCCGAGGCGTTCGTCGGCGGCACGATCGCGCTCGTGCAGGAAGGCGACTCGATCACGATCGACGC
GCACCGGCTGCTGCTGCAGCTGAACGTCGACGATGCGGAACTCGCGCGCCGCCGCGCCGCATGGCAACAGCCGGCGCCAC
GCTACACCCGCGGCGTGCTCGCGAAATTCGCCGCGCTCGCCCGCCCGGCGAACCAGGGCGCCGTCACGGGTTGA

Upstream 100 bases:

>100_bases
AAATAATATATTGGACATCCCAATCCGGAAACTCCATTCTTGATTGATCCGAACCTGCACGCCGTTCACCGGCGTTGCCC
AGACAACGATGGAGTCCCCC

Downstream 100 bases:

>100_bases
TACGCGCCCGTCAAAAAATGCGACCCCAATAAACATGGCCGCCGGGGGAACGCGCAAAACGCGCTTTCCCTTTGCTTTTA
TAATGCGCGGACCATGTAGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 2

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MAYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMVGIANGHSTITPCNSGLQRLSDAAVAAVKAADANPQIFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARLNVPGIYVYGGTIRPGNWKGRDLT
IVSSFEAVGEFTAGRMSQEDFEGVERNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
EAVKRDLKPRDIITKESIENAVSVIMATGGSTNAVLHYLAIAHAAEVDWTIEDFERIRKRVPVICDLKPSGKYVATDLHR
AGGIPQVLKILLDAGLLHGDCMTITGRTIADELKDVPSVPRADQDVIFPIDRALYKEGHLAILKGNLAEDGAVAKITGLK
NPVITGPARVFDDEQSAMDAILGDRIRAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHRLLLQLNVDDAELARRRAAWQQPAPRYTRGVLAKFAALARPANQGAVTG

Sequences:

>Translated_557_residues
MAYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMVGIANGHSTITPCNSGLQRLSDAAVAAVKAADANPQIFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARLNVPGIYVYGGTIRPGNWKGRDLT
IVSSFEAVGEFTAGRMSQEDFEGVERNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
EAVKRDLKPRDIITKESIENAVSVIMATGGSTNAVLHYLAIAHAAEVDWTIEDFERIRKRVPVICDLKPSGKYVATDLHR
AGGIPQVLKILLDAGLLHGDCMTITGRTIADELKDVPSVPRADQDVIFPIDRALYKEGHLAILKGNLAEDGAVAKITGLK
NPVITGPARVFDDEQSAMDAILGDRIRAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHRLLLQLNVDDAELARRRAAWQQPAPRYTRGVLAKFAALARPANQGAVTG
>Mature_556_residues
AYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMVGIANGHSTITPCNSGLQRLSDAAVAAVKAADANPQIFGTPTIS
DGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARLNVPGIYVYGGTIRPGNWKGRDLTI
VSSFEAVGEFTAGRMSQEDFEGVERNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLVE
AVKRDLKPRDIITKESIENAVSVIMATGGSTNAVLHYLAIAHAAEVDWTIEDFERIRKRVPVICDLKPSGKYVATDLHRA
GGIPQVLKILLDAGLLHGDCMTITGRTIADELKDVPSVPRADQDVIFPIDRALYKEGHLAILKGNLAEDGAVAKITGLKN
PVITGPARVFDDEQSAMDAILGDRIRAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMVV
GHVAPEAFVGGTIALVQEGDSITIDAHRLLLQLNVDDAELARRRAAWQQPAPRYTRGVLAKFAALARPANQGAVTG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=604, Percent_Identity=37.9139072847682, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI2367371, Length=579, Percent_Identity=31.6062176165803, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786464, Length=468, Percent_Identity=35.4700854700855, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788157, Length=483, Percent_Identity=30.4347826086957, Blast_Score=185, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=560, Percent_Identity=45, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD2_BURS3 (Q39DS9)

Other databases:

- EMBL:   CP000151
- RefSeq:   YP_370031.1
- ProteinModelPortal:   Q39DS9
- SMR:   Q39DS9
- STRING:   Q39DS9
- GeneID:   3751023
- GenomeReviews:   CP000151_GR
- KEGG:   bur:Bcep18194_A5793
- NMPDR:   fig|269483.3.peg.6977
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- ProtClustDB:   PRK00911
- BioCyc:   BSP36773:BCEP18194_A5793-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59243; Mature: 59112

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMVGIANGHSTITPCNSGLQRLSDA
CCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCEECCHHHHHHHHHHH
AVAAVKAADANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHEECCCCCEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARLNVPGIYVYGGTIRPGNWKGRDLTIVSSFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCEEEEEECHHHHHHHHHCCCCHHH
FEGVERNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
HHCHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKRDLKPRDIITKESIENAVSVIMATGGSTNAVLHYLAIAHAAEVDWTIEDFERIRKR
HHHHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VPVICDLKPSGKYVATDLHRAGGIPQVLKILLDAGLLHGDCMTITGRTIADELKDVPSVP
CCEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCC
RADQDVIFPIDRALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSAMDA
CCCCCEEEEHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILGDRIRAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
HHCCCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHEE
VGHVAPEAFVGGTIALVQEGDSITIDAHRLLLQLNVDDAELARRRAAWQQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKFAALARPANQGAVTG
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMVGIANGHSTITPCNSGLQRLSDA
CCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCEECCHHHHHHHHHHH
AVAAVKAADANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHEECCCCCEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARLNVPGIYVYGGTIRPGNWKGRDLTIVSSFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCEEEEEECHHHHHHHHHCCCCHHH
FEGVERNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
HHCHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKRDLKPRDIITKESIENAVSVIMATGGSTNAVLHYLAIAHAAEVDWTIEDFERIRKR
HHHHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VPVICDLKPSGKYVATDLHRAGGIPQVLKILLDAGLLHGDCMTITGRTIADELKDVPSVP
CCEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCC
RADQDVIFPIDRALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSAMDA
CCCCCEEEEHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILGDRIRAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
HHCCCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHEE
VGHVAPEAFVGGTIALVQEGDSITIDAHRLLLQLNVDDAELARRRAAWQQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKFAALARPANQGAVTG
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA