BacMap

Definition	Burkholderia sp. 383 chromosome 1, complete genome.
Accession	NC_007510
Length	3,694,126

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The map label for this gene is hmuV [H]

Identifier: 78067254

GI number: 78067254

Start: 2900068

End: 2900883

Strand: Reverse

Name: hmuV [H]

Synonym: Bcep18194_A5785

Alternate gene names: 78067254

Gene position: 2900883-2900068 (Counterclockwise)

Preceding gene: 78067255

Following gene: 78067253

Centisome position: 78.53

GC content: 71.2

Gene sequence:

>816_bases
ATGACGGGGGCCGCACTGCACGCCACGGCCGGTGACATGAACTACGCGGCCGTCGGCCTGACGCTGAAGGCCGGCGCGCG
CACGCTGCTCGACGGCTTCACCCAGGTGTTTCGTCCCGGCGAAATCTGGTGCGTCGCCGGGCCGAACGGCGCGGGCAAGA
CGACGCTGCTCGCGACACTCGCGGGGCTGCAGCCGCCGGCCGGCGGACACGTCGAGATCGACGGCCGGCCGCTTGCCGCA
TGGCCGCCCGAGCAACTCGCGCAGCGCCGTGCGCTGATGCCGCAGCAACTGCACGACGCATTCAGCGCGACCGTATTCGA
CACGGTGTTGCTCAACCGCTTTCCGTATCTCGGGGGTTGGGGCTGGGAGCGTGACGGCGATCGCGCGGCCGCGCGCGACG
CGCTGGCGACGTTCGATCTCACGGCTCTGGCGTCGCGCGACGTGCTGTCGCTGTCGGGCGGCGAGCGCCAGCGCGTCGCG
CTGGCCGCGACGCTGTGTCAGGATGCGCCGCTGATGCTGCTCGACGAGCCGCTCGCGCATCTCGACCTGCATCACCAGAT
CGATTGCCTGACCGCGCTGGCCGCATGGCTCGACGCGGGCCCGCGCACGGTGCTGTTCTCGTGCCATGATCTGAATCTCG
CGCGGCGTTTCGCGACGCATGCGCTGTTGCTCGACGGCCGCGGCCACGCGTGGGCCGGCCCCGTGCACGACGTGCTGACG
CCCGAGCGCGCGAGCGATGCGTTCGGTTATCCGCTCGTGCTGATCCGCGAGAATGGCCGCGATGCGCTGCTGCCGGCGTG
GCCCGAGCGACAATGA

Upstream 100 bases:

>100_bases
CACGCACTGCGATCGCGCCCGCGCAACTGCCGGTCGGCGTGATGACCGCATTGATCGGCGTGCCGGTGTTCCTGTGGATG
TTGTTGAGGAGGCCGATGCG

Downstream 100 bases:

>100_bases
CCCTTTCTTTTCCGATGCGCGGCGCACACCGCGCCAACGACACGGCTTTTCGATGACGACCTCGACCCACTTCCCGCCCG
CGATCGCGCCGCTCGACGAT

Product: ABC cobalamin/Fe3+-siderophore transporter, ATPase subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTGAALHATAGDMNYAAVGLTLKAGARTLLDGFTQVFRPGEIWCVAGPNGAGKTTLLATLAGLQPPAGGHVEIDGRPLAA
WPPEQLAQRRALMPQQLHDAFSATVFDTVLLNRFPYLGGWGWERDGDRAAARDALATFDLTALASRDVLSLSGGERQRVA
LAATLCQDAPLMLLDEPLAHLDLHHQIDCLTALAAWLDAGPRTVLFSCHDLNLARRFATHALLLDGRGHAWAGPVHDVLT
PERASDAFGYPLVLIRENGRDALLPAWPERQ

Sequences:

>Translated_271_residues
MTGAALHATAGDMNYAAVGLTLKAGARTLLDGFTQVFRPGEIWCVAGPNGAGKTTLLATLAGLQPPAGGHVEIDGRPLAA
WPPEQLAQRRALMPQQLHDAFSATVFDTVLLNRFPYLGGWGWERDGDRAAARDALATFDLTALASRDVLSLSGGERQRVA
LAATLCQDAPLMLLDEPLAHLDLHHQIDCLTALAAWLDAGPRTVLFSCHDLNLARRFATHALLLDGRGHAWAGPVHDVLT
PERASDAFGYPLVLIRENGRDALLPAWPERQ
>Mature_270_residues
TGAALHATAGDMNYAAVGLTLKAGARTLLDGFTQVFRPGEIWCVAGPNGAGKTTLLATLAGLQPPAGGHVEIDGRPLAAW
PPEQLAQRRALMPQQLHDAFSATVFDTVLLNRFPYLGGWGWERDGDRAAARDALATFDLTALASRDVLSLSGGERQRVAL
AATLCQDAPLMLLDEPLAHLDLHHQIDCLTALAAWLDAGPRTVLFSCHDLNLARRFATHALLLDGRGHAWAGPVHDVLTP
ERASDAFGYPLVLIRENGRDALLPAWPERQ

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system [H]

COG id: COG1120

COG function: function code PH; ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI73747915, Length=209, Percent_Identity=29.6650717703349, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI108773784, Length=196, Percent_Identity=27.5510204081633, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI108773782, Length=196, Percent_Identity=27.5510204081633, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI46592956, Length=195, Percent_Identity=31.7948717948718, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI46592915, Length=196, Percent_Identity=31.6326530612245, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI46592898, Length=196, Percent_Identity=31.6326530612245, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI46592978, Length=196, Percent_Identity=31.6326530612245, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI46592971, Length=195, Percent_Identity=31.7948717948718, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI46592964, Length=194, Percent_Identity=31.4432989690722, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI31657092, Length=232, Percent_Identity=26.2931034482759, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI157502203, Length=163, Percent_Identity=33.1288343558282, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI157502201, Length=163, Percent_Identity=33.1288343558282, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI9955963, Length=211, Percent_Identity=29.8578199052133, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI156105685, Length=215, Percent_Identity=27.906976744186, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1786345, Length=246, Percent_Identity=33.739837398374, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1786803, Length=237, Percent_Identity=35.4430379746835, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790739, Length=230, Percent_Identity=36.0869565217391, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1788002, Length=221, Percent_Identity=36.1990950226244, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786253, Length=218, Percent_Identity=33.9449541284404, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081709, Length=224, Percent_Identity=30.3571428571429, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1789891, Length=264, Percent_Identity=29.9242424242424, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787712, Length=199, Percent_Identity=31.6582914572864, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788225, Length=215, Percent_Identity=30.2325581395349, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789873, Length=213, Percent_Identity=30.9859154929577, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082267, Length=227, Percent_Identity=28.1938325991189, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786872, Length=185, Percent_Identity=29.1891891891892, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786563, Length=205, Percent_Identity=31.7073170731707, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789032, Length=206, Percent_Identity=30.0970873786408, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786698, Length=191, Percent_Identity=29.3193717277487, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87081834, Length=192, Percent_Identity=31.7708333333333, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788165, Length=237, Percent_Identity=29.957805907173, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787112, Length=210, Percent_Identity=30.952380952381, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081791, Length=169, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790544, Length=235, Percent_Identity=28.0851063829787, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787029, Length=190, Percent_Identity=29.4736842105263, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787370, Length=221, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790467, Length=194, Percent_Identity=28.8659793814433, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787143, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788761, Length=220, Percent_Identity=28.6363636363636, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789593, Length=224, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1786703, Length=205, Percent_Identity=32.1951219512195, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789672, Length=207, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788450, Length=211, Percent_Identity=26.5402843601896, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789751, Length=202, Percent_Identity=30.6930693069307, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787972, Length=194, Percent_Identity=29.3814432989691, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789864, Length=208, Percent_Identity=25.9615384615385, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786319, Length=176, Percent_Identity=28.9772727272727, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081782, Length=247, Percent_Identity=27.9352226720648, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1787089, Length=223, Percent_Identity=27.3542600896861, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1786653, Length=217, Percent_Identity=27.6497695852535, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17539902, Length=255, Percent_Identity=30.9803921568627, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555800, Length=223, Percent_Identity=26.9058295964126, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115533592, Length=244, Percent_Identity=25.4098360655738, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320296, Length=196, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650855, Length=213, Percent_Identity=27.2300469483568, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650853, Length=213, Percent_Identity=27.2300469483568, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281362751, Length=205, Percent_Identity=27.3170731707317, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR015863
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 29094; Mature: 28963

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGAALHATAGDMNYAAVGLTLKAGARTLLDGFTQVFRPGEIWCVAGPNGAGKTTLLATL
CCCCEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
AGLQPPAGGHVEIDGRPLAAWPPEQLAQRRALMPQQLHDAFSATVFDTVLLNRFPYLGGW
HCCCCCCCCEEEECCEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
GWERDGDRAAARDALATFDLTALASRDVLSLSGGERQRVALAATLCQDAPLMLLDEPLAH
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCEEEECCCHHH
LDLHHQIDCLTALAAWLDAGPRTVLFSCHDLNLARRFATHALLLDGRGHAWAGPVHDVLT
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHEEEECCCCCCCCCCHHHHCC
PERASDAFGYPLVLIRENGRDALLPAWPERQ
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TGAALHATAGDMNYAAVGLTLKAGARTLLDGFTQVFRPGEIWCVAGPNGAGKTTLLATL
CCCEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
AGLQPPAGGHVEIDGRPLAAWPPEQLAQRRALMPQQLHDAFSATVFDTVLLNRFPYLGGW
HCCCCCCCCEEEECCEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
GWERDGDRAAARDALATFDLTALASRDVLSLSGGERQRVALAATLCQDAPLMLLDEPLAH
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCEEEECCCHHH
LDLHHQIDCLTALAAWLDAGPRTVLFSCHDLNLARRFATHALLLDGRGHAWAGPVHDVLT
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHEEEECCCCCCCCCCHHHHCC
PERASDAFGYPLVLIRENGRDALLPAWPERQ
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA