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The map label for this gene is argH [H]

Identifier: 78067229

GI number: 78067229

Start: 2870514

End: 2871923

Strand: Direct

Name: argH [H]

Synonym: Bcep18194_A5760

Alternate gene names: 78067229

Gene position: 2870514-2871923 (Clockwise)

Preceding gene: 78067228

Following gene: 78067230

Centisome position: 77.7

GC content: 68.16

Gene sequence:

>1410_bases
ATGACGTCCCAACTGCACAAAAAGGGCGAGGCCTGGTCGGCCCGCTTCTCGGAACCGATGTCCGAGCTGGTCAAGCGCTA
CACGTCGTCGGTATTTTTCGACAAGCGCCTCGCGCTCGTCGACATCGCCGGCTCGCTCGCGCACGCGAACATGCTCGCCG
CGCAGAAGATCATCAGCGCCGACGACCTGGCCGCGATCGAACGCGGGATGGCGCAAATCAAGGGCGAGATCGAGCGCGGC
GAATTCGAATGGCAGCTCGACCTGGAAGACGTCCACCTGAACATCGAGGCGCGCCTGACCGCGCTGATCGGCGACGCCGG
CAAGCGCCTGCATACGGGCCGCTCGCGTAACGACCAGGTCGCGACCGACATCCGCCTGTGGCTGCGCGGCGAGATCGACC
GCATCGGCGGCCTGCTGAACGACCTGCGCGGCGCGCTGCTCGACCTCGCGGAACAGAACGCCGACACGATCATGCCGGGC
TTCACGCACCTGCAGGTCGCCCAGCCCGTCACGTTCGGCCATCACCTGCTCGCGTACGTCGAGATGTTCTCGCGCGACGC
GGAGCGCATGCGCGACTGCCGCACCCGCGTGAACCGCCTGCCGCTCGGCGCGGCCGCGCTCGCCGGCACGAGCTACCCGA
TCGACCGTCACGCCGTGGCGAAGACGCTCGGCTTCGACGGTATCTGCGCGAACTCGCTCGACGCGGTGTCGGATCGCGAC
TTTGCGATCGAATTCACGGCCGCCTCCGCGCTCGTGATGACGCACGTGTCGCGCTTCTCCGAAGAACTCGTGCTGTGGAT
GAGCCCGCGCGTCGGCTTCATCGACATCGCCGACCGCTTCTGCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACCCGG
ACGTGCCCGAGCTCGCGCGCGGCAAGACGGGCCGCGTGAACGGCCACCTGATGGCGCTGCTGACGCTGATGAAGGGCCAG
CCGCTCGCGTACAACAAGGACAACCAGGAAGACAAGGAACCGCTGTTCGACACGGTCGACACCGTCGCCGACACGCTGCG
GATCTTCGCCGAGATGGTTGCCGGCATCACCGTGAAGCCGGACGCGATGCGCGCGGCCGCGCTGCAGGGCTTCTCGACCG
CCACCGACCTCGCCGACTACCTCGTGAAGCGCGGCCTGCCGTTCCGCGATGCGCACGAAGCCGTCGCGCACGCCGTGAAG
GTCTGCGACGACCGCGGCATCGACCTGGCCGACCTGACGCTCGACGAGATGAAGCAGGAACTGCCGAACGTCGCGCACCT
GATCGGCGAAGACGTGTTCGGCTACCTGACGCTCGAGGGCTCGGTCGCCAGCCGCAACCACCCGGGCGGCACCGCGCCCG
ACCAGGTGCGTGCGGCGGTCAAGGCGGCGCGCGCCGCGCTCGGCCAGTAA

Upstream 100 bases:

>100_bases
CCGCCCCCGACGGGCTTGTGCCGGACACCCGGCCGCGAATGCTAAAATCACCGGATTCCTCGGCGGCGCACGCCGCTCAA
TCTCCCTTCGAAGAATCGCC

Downstream 100 bases:

>100_bases
GCCTGCTGTTCCGGACGGACGCCTTTGGCGTCCGTTTTTCATTCGGGCGGCCGTCGCGCCGCCCATCGCCTTCCCTGCTT
CCCGAATGCCGCCGATGACC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISADDLAAIERGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALLDLAEQNADTIMPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
VCDDRGIDLADLTLDEMKQELPNVAHLIGEDVFGYLTLEGSVASRNHPGGTAPDQVRAAVKAARAALGQ

Sequences:

>Translated_469_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISADDLAAIERGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALLDLAEQNADTIMPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
VCDDRGIDLADLTLDEMKQELPNVAHLIGEDVFGYLTLEGSVASRNHPGGTAPDQVRAAVKAARAALGQ
>Mature_468_residues
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISADDLAAIERGMAQIKGEIERGE
FEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALLDLAEQNADTIMPGF
THLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRDF
AIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKV
CDDRGIDLADLTLDEMKQELPNVAHLIGEDVFGYLTLEGSVASRNHPGGTAPDQVRAAVKAARAALGQ

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=39.4793926247288, Blast_Score=347, Evalue=9e-96,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=39.4793926247288, Blast_Score=347, Evalue=9e-96,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=37.3101952277657, Blast_Score=318, Evalue=9e-87,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=37.0932754880694, Blast_Score=308, Evalue=5e-84,
Organism=Escherichia coli, GI1790398, Length=458, Percent_Identity=44.9781659388646, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=40.3050108932462, Blast_Score=334, Evalue=2e-92,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.2932166301969, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.2932166301969, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51309; Mature: 51178

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGGLLNDLRGALLDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHH
EMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDDRGIDLADLTLDEMKQE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LPNVAHLIGEDVFGYLTLEGSVASRNHPGGTAPDQVRAAVKAARAALGQ
HHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISA
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGGLLNDLRGALLDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHH
EMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDDRGIDLADLTLDEMKQE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LPNVAHLIGEDVFGYLTLEGSVASRNHPGGTAPDQVRAAVKAARAALGQ
HHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA