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The map label for this gene is hutH [H]

Identifier: 78066951

GI number: 78066951

Start: 2567610

End: 2569133

Strand: Reverse

Name: hutH [H]

Synonym: Bcep18194_A5482

Alternate gene names: 78066951

Gene position: 2569133-2567610 (Counterclockwise)

Preceding gene: 78066953

Following gene: 78066950

Centisome position: 69.55

GC content: 67.91

Gene sequence:

>1524_bases
ATGATTACGTTGACCCCCGGCCACCTGACCCTCCCGCAACTGCGCCAGATCGCACGCGAATCCGTGCAACTGACGCTCGA
TCCGGCCAGCTTCGCGAAGATCGACGCCGGCGCGAAGGCCGTCGCCGACATCGCCGCGAAGGGCGAGCCGGCCTACGGCA
TCAACACCGGTTTCGGCCGCCTGGCCAGCACGCACATCCCGCACGACCAGCTCGAACTGCTGCAGAAGAACCTCGTGCTG
TCGCACGCGGTCGGCGTGGGCGAGCCGATGGCACGCTCGTCGGTGCGCCTGCTGATGGCACTGAAGCTGTCGAGCCTCGG
CCGCGGCCACTCGGGCATCCGTCGCGAAGTGATGGACGCGCTGATCAAGCTGTTCAACGCGGACGTGCTGCCGCTGATCC
CGGTGAAGGGCTCGGTCGGCGCATCGGGCGACCTGGCACCGCTCGCGCACATGTCGGCCGTGCTGCTGGGCGTCGGCGAA
GTGTTCATCCGCGGCGAGCGTGCAAGCGCACTCGACGGTCTGCGCGTTGCCGGCCTCGCGCCGCTGACGCTGCAGGCGAA
GGAAGGCCTCGCGCTGCTGAACGGCACGCAGGCATCGACCGCGCTGGCGCTCGACAACATGTTCTCGATCGAAGACCTGT
ACCGCACCGCGCTCGTCGCGGGCGCGCTGTCGGTCGACGCGGCTGCCGGTTCGGTGAAGCCGTTCGACGCACGCATTCAT
GAACTGCGCGGCCACCAGGGCCAGATCGACGCAGCTGCGTCGTATCGCGACCTGCTCGCAGGCTCGCCGATCAACCAGTC
GCACCTCGACTGCGACAAGGTGCAGGACCCGTACAGCCTGCGCTGCCAGCCGCAGGTGATGGGCGCGTGTCTGGACCAGA
TGCGCCATGCAGCCGACGTGCTGCTGGTCGAAGCGAACGCCGTGTCGGACAACCCGCTGATCTTCCCGGATACCGGCGAA
GTGCTGTCGGGCGGCAACTTCCACGCCGAACCCGTCGCGTTCGCGGCCGACAACCTCGCGCTCGCCGCATCGGAAATCGG
CGCACTGGCCGAACGCCGCATCGCGCTGCTGATCGACGCGACGCTGTCGGGCCTGCCCCCGTTCCTCGTGCGGGACGGCG
GCGTGAACTCGGGCTTCATGATCGCCCACGTGACGGCGGCTGCACTCGCATCGGAAAACAAGACGCTCGCGCACCCGGCG
TCGGTCGACTCGCTGCCGACTTCCGCGAACCAGGAAGACCACGTGTCGATGGCGACGTTCGCCGCGCGCAAGCTCGCCGA
CATCGCGGACAACACGAAGCACATCCTCGCGATCGAACTGCTGGCAGCCGCGCAAGGCGTCGACCTGCGCGCGCCGTACC
ACACGAGCCCGAAGCTGGCGCCCGTGATGGAAACGATCCGCGGCAAGGTCGCGCACTACGAACTCGACCACTACTTCGCA
CCGGATATCGCGGTGATCGCGAAGCTGGTCGGCGAGCGTGCGTTCGCGAAGGTCGCGCCGTTCTCGTTCGCGTCGGAACA
GTAA

Upstream 100 bases:

>100_bases
GAAACTCCTGAGTCGAAATCGGTGAAATACGGGTTGTCTAGACAAGTTGGCGTGGCTACACTTCAATCCATTCCGAACTT
GTCTAGACAGGATTGCTCAC

Downstream 100 bases:

>100_bases
GCCCATGAGCGCGCCGGTCTACCAGGAGATCAAGGATTTCATCCTGGGCCGCATCCACGCAGGCGAGTGGGAGGAGGGCG
ATCAGGTGCCGTCCGAGAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MITLTPGHLTLPQLRQIARESVQLTLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLMALKLSSLGRGHSGIRREVMDALIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASALDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNMFSIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHQGQIDAAASYRDLLAGSPINQSHLDCDKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAASEIGALAERRIALLIDATLSGLPPFLVRDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
PDIAVIAKLVGERAFAKVAPFSFASEQ

Sequences:

>Translated_507_residues
MITLTPGHLTLPQLRQIARESVQLTLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLMALKLSSLGRGHSGIRREVMDALIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASALDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNMFSIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHQGQIDAAASYRDLLAGSPINQSHLDCDKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAASEIGALAERRIALLIDATLSGLPPFLVRDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
PDIAVIAKLVGERAFAKVAPFSFASEQ
>Mature_507_residues
MITLTPGHLTLPQLRQIARESVQLTLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVL
SHAVGVGEPMARSSVRLLMALKLSSLGRGHSGIRREVMDALIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGE
VFIRGERASALDGLRVAGLAPLTLQAKEGLALLNGTQASTALALDNMFSIEDLYRTALVAGALSVDAAAGSVKPFDARIH
ELRGHQGQIDAAASYRDLLAGSPINQSHLDCDKVQDPYSLRCQPQVMGACLDQMRHAADVLLVEANAVSDNPLIFPDTGE
VLSGGNFHAEPVAFAADNLALAASEIGALAERRIALLIDATLSGLPPFLVRDGGVNSGFMIAHVTAAALASENKTLAHPA
SVDSLPTSANQEDHVSMATFAARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
PDIAVIAKLVGERAFAKVAPFSFASEQ

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=503, Percent_Identity=43.7375745526839, Blast_Score=413, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567831, Length=486, Percent_Identity=42.3868312757202, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53203; Mature: 53203

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLTPGHLTLPQLRQIARESVQLTLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGR
CEEECCCCCCHHHHHHHHHHCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
LASTHIPHDQLELLQKNLVLSHAVGVGEPMARSSVRLLMALKLSSLGRGHSGIRREVMDA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGEVFIRGERASALDGLRVAGLA
HHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCHHHHCCCCCCCCC
PLTLQAKEGLALLNGTQASTALALDNMFSIEDLYRTALVAGALSVDAAAGSVKPFDARIH
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ELRGHQGQIDAAASYRDLLAGSPINQSHLDCDKVQDPYSLRCQPQVMGACLDQMRHAADV
HHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCE
LLVEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAASEIGALAERRIALLIDA
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEEC
TLSGLPPFLVRDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATF
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
AARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHEEEECCCCCC
PDIAVIAKLVGERAFAKVAPFSFASEQ
CHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MITLTPGHLTLPQLRQIARESVQLTLDPASFAKIDAGAKAVADIAAKGEPAYGINTGFGR
CEEECCCCCCHHHHHHHHHHCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHH
LASTHIPHDQLELLQKNLVLSHAVGVGEPMARSSVRLLMALKLSSLGRGHSGIRREVMDA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LIKLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGVGEVFIRGERASALDGLRVAGLA
HHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCHHHHCCCCCCCCC
PLTLQAKEGLALLNGTQASTALALDNMFSIEDLYRTALVAGALSVDAAAGSVKPFDARIH
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ELRGHQGQIDAAASYRDLLAGSPINQSHLDCDKVQDPYSLRCQPQVMGACLDQMRHAADV
HHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCE
LLVEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLALAASEIGALAERRIALLIDA
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEEC
TLSGLPPFLVRDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATF
HHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
AARKLADIADNTKHILAIELLAAAQGVDLRAPYHTSPKLAPVMETIRGKVAHYELDHYFA
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHEEEECCCCCC
PDIAVIAKLVGERAFAKVAPFSFASEQ
CHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA