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The map label for this gene is hutU [H]

Identifier: 78066949

GI number: 78066949

Start: 2565182

End: 2566870

Strand: Reverse

Name: hutU [H]

Synonym: Bcep18194_A5480

Alternate gene names: 78066949

Gene position: 2566870-2565182 (Counterclockwise)

Preceding gene: 78066950

Following gene: 78066948

Centisome position: 69.49

GC content: 66.02

Gene sequence:

>1689_bases
ATGAACCATCCGAAACACATCGATCCCCGTCTCGATCCGACCCGCACGATCCGTGCGCCGCGCGGCAGCGAGAAAGTCTG
CAAGACCTGGCTGGCCGAAGCGGCCTACCGGATGATCCAGAACAACCTCGACCCGGAAGTCGCCGAGCATCCGCATGCGC
TCGTCGTGTACGGCGGCATCGGCCGCGCGGCACGCAACTGGGAATGCTACGACCAGATCCTCGCGTCGCTGAAGGATCTC
GAAGAGAACGAGACGCTGCTGATCCAGTCGGGCAAGCCGGTCGGTGTGTTCCGCACGCACAAGGATGCGCCGCGCGTGCT
GCTCGCGAACTCGAACCTGGTGCCGCACTGGGCGAACTGGGATCACTTCCACGAGCTCGACCGCAAGGGCCTGATGATGT
ACGGCCAGATGACGGCCGGCAGCTGGATCTACATCGGCAGCCAGGGCATCGTTCAGGGCACCTATGAAACGTTCTTCTCG
GTCGCGAACCAGCACTTCAACGGCGATCCGTCGGGCCGCTGGATCCTGACGGGCGGCCTCGGCGGCATGGGCGGCGCGCA
GCCGCTGGCCGCGACGATGGCCGGTTTCTCGATGATCGCGGTCGAATGCGACGAGACCCGCATCGACTTCCGCCTGAAGA
CGCGCTACGTCGACAAGAAGGCAACGACGCTCGACGAAGCGCTCGGCATGATCGAGGAAGCGAAGCGCGACGGCAAGCCG
GTGTCGATCGGCCTGCTCGGCAACGCGGCCGACGTGTTCGCGGAACTCGTCACGCGCGGCATCACGCCGGATTGCGTGAC
CGACCAGACGAGCGCGCACGACCCGATCAACGGCTACCTGCCGCAAGGCTGGACCGTCGCGCAATGGCGCGAAGCGCAGA
AGGTCGATCCGCAGAGCATCGTGAAGGTCGCGAAGCAGTCGATGGCCGTCCAGGTGCGCGCAATGCTGGCGCTGCAGGAA
CGCGGTGCGGCGACGCTCGACTACGGCAACAACATCCGCCAGATGGCGCTGGAAATGGGTGTCGAGAACGCATTCGACTT
CCCGGGCTTCGTGCCGGCGTACATCCGCCCGCTGTTCTGCGAAGGCAAGGGCCCGTTCCGCTGGGTCGCGCTGTCGGGCG
ATCCGGAAGACATCTACAAGACCGACCAGAAGGTGAAGGAGCTGATCCCCGACGATCCGCACCTGCACAACTGGCTCGAC
ATGGCACGTGAGCGCATTGCGTTCCAGGGCCTGCCGGCACGGATCTGCTGGGTCGGCGTGAAGGATCGCTATCGCCTCGG
CCAGGCGTTCAACGAGATGGTCAAGAACGGCGAACTGAAGGCCCCGATCGTGATCGGCCGCGACCACCTGGACACCGGCT
CGGTTGCCAGCCCGAACCGCGAGACGGAATCGATGAAGGACGGTTCGGACGCCGTGAGCGACTGGCCGCTGCTGAACGCA
CTGCTGAACACCGCAGGCGGCGCTTCGTGGGTGTCGCTGCACCATGGCGGTGGTGTCGGCATGGGCTTCTCGCAGCACTC
GGGCGTCGTGATCGTCGCCGACGGTACCGCCGAAGCGCACGAGCGTCTCGGCCGCGTGCTGCTGAACGACCCGGCGACGG
GCGTGATGCGCCATGCGGATGCCGGCTACGAACTCGCGCAGCAGACGGCCCGCGAAGCCGGCCTGAAGCTGCCGATGCTC
GGCCGCTGA

Upstream 100 bases:

>100_bases
CGCCTCGGTGGCGAATCTGTGGCATCCCGGCAGCCGATACCGCTTCACCGGGCATTTCTGATTCCTATTTGATATTCATT
TTCCTTCGGGAGCAGTCGTC

Downstream 100 bases:

>100_bases
GCATGACGGCGCTCCACCAGGCGCCGGTGAACGCGACGATGATCCGCGCAGCGGATCTCGTCGCGTCGCCATGGAAGAAC
GGCGGCGGCGTGACGCGCGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKVCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRDGKP
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTAEAHERLGRVLLNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR

Sequences:

>Translated_562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKVCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRDGKP
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTAEAHERLGRVLLNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR
>Mature_562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKVCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRDGKP
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTAEAHERLGRVLLNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=576, Percent_Identity=34.0277777777778, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI260306182, Length=636, Percent_Identity=31.1320754716981, Blast_Score=279, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI71997891, Length=571, Percent_Identity=34.6760070052539, Blast_Score=314, Evalue=6e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61763; Mature: 61763

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPKHIDPRLDPTRTIRAPRGSEKVCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWECYDQILASLKDLEENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCC
DHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPSGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRDGKP
CCCCCCHHHHHHHCCCEEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSI
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
VKVAKQSMAVQVRAMLALQERGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFC
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTAEAHERLGRVLLNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCCEEECCCCHHHHHHCC
AGYELAQQTAREAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNHPKHIDPRLDPTRTIRAPRGSEKVCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWECYDQILASLKDLEENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCC
DHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPSGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRDGKP
CCCCCCHHHHHHHCCCEEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
VSIGLLGNAADVFAELVTRGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSI
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
VKVAKQSMAVQVRAMLALQERGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFC
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTAEAHERLGRVLLNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCCEEECCCCHHHHHHCC
AGYELAQQTAREAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]