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The map label for this gene is iscS [H]

Identifier: 78066901

GI number: 78066901

Start: 2500807

End: 2502030

Strand: Reverse

Name: iscS [H]

Synonym: Bcep18194_A5432

Alternate gene names: 78066901

Gene position: 2502030-2500807 (Counterclockwise)

Preceding gene: 78066902

Following gene: 78066900

Centisome position: 67.73

GC content: 63.56

Gene sequence:

>1224_bases
ATGACCCAAGACACTCTCCACCTGCCCATCTATATGGATTACAGCGCGACGACGCCGGTCGACCCGCGCGTGGTCGACAA
GATGGTGCCGTACCTGCGCGAGCAGTTCGGCAACCCGGCGTCGCGCAGCCACGCGTATGGCTGGGACGCGGAGCGTGCGG
TCGAGGAAGCGCGCGAGAACGTGGCCGCGCTCGTGAACGCGGATCCGCGCGAGATCATCTGGACGTCCGGCGCCACGGAA
TCGGACAACCTCGCGATCAAGGGTGCCGCGAACTTCTACAAGGGCAAGGGCAAGCACATCATCACGGTGAAGACCGAGCA
CAAGGCCGTGCTCGATACGTGCCGCGAGCTCGAGCGTGACGGTTTCGAAGTCACCTACCTCGACGTGAAGGATGACGGCC
TGATCGACCTCGACGTGTTCAAGGCCGCGCTGCGCCCGGACACGATCCTCGTGTCGGTGATGCACGTGAACAACGAGATC
GGCGTGATCCAGGACATCGAGACGATCGGTGAAATCTGCCGCGAGAAGGGCATCGTGTTCCACGTCGACGCCGCCCAGTC
GACCGGCAAGGTCGAGATCGACCTCGCGAAGCTGAAGGTCGACCTGATGTCGTTCTCGGCGCACAAGACCTACGGCCCGA
AGGGTATCGGCGCGCTGTACGTGCGTCGCAAGCCGCGCGTGCGCATCGAAGCGCAGATGCACGGCGGCGGCCACGAGCGC
GGCATGCGTTCGGGCACGCTGGCGACGCACCAGATCGTCGGCATGGGCGAAGCGTTCCGTATCGCACGTGAAGAAATGGC
GACGGAAAACGAGCGCGTCCGCATGCTGCGCGACAAGCTGCTGCGCGGCCTGTCGCAAATCGAGGAAACGTACGTGAACG
GCGACATGGAACGCCGTGTCCCGCACAACCTCAACATCAGTTTCAACTTCGTCGAAGGCGAGTCGCTGATCATGGCGATC
AAGGACGTCGCGGTGTCGTCGGGCTCCGCATGCACGTCGGCGTCGCTGGAGCCGTCGTACGTGCTGCGTGCGCTCGGCCG
CAACGACGAGCTGGCACACAGCTCGATCCGCTTCACGGTCGGCCGCTTCACGACGGAGCAGGAAGTCGACTTCGTGATCA
ACCTGCTGAACAGCAAGATCGCGAAGCTGCGCGAACTCTCGCCGCTCTGGGAAATGCACCAGGAAGGCATCGATCTGTCG
ACGATCGAATGGGCCGCACACTGA

Upstream 100 bases:

>100_bases
GGCCCCAATTCGGTGTTCAACATCGCGAGTTCGTGAGCGCGAAAGCGCCGCCATACCCCACAACGTACATAGTCCCTGCA
CAGAATTCCCGGAGCGACAG

Downstream 100 bases:

>100_bases
GCGCCGGATTGAAGAACATACCCGCGGGCGGATTCGCGCACGCAGACGTTACGAGTCAAGGAGTCTGAGTCATGTCTTAC
AGCAACAAGGTTCTGGATCA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTQDTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEARENVAALVNADPREIIWTSGATE
SDNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERDGFEVTYLDVKDDGLIDLDVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIVFHVDAAQSTGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMATENERVRMLRDKLLRGLSQIEETYVNGDMERRVPHNLNISFNFVEGESLIMAI
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQEVDFVINLLNSKIAKLRELSPLWEMHQEGIDLS
TIEWAAH

Sequences:

>Translated_407_residues
MTQDTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEARENVAALVNADPREIIWTSGATE
SDNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERDGFEVTYLDVKDDGLIDLDVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIVFHVDAAQSTGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLATHQIVGMGEAFRIAREEMATENERVRMLRDKLLRGLSQIEETYVNGDMERRVPHNLNISFNFVEGESLIMAI
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQEVDFVINLLNSKIAKLRELSPLWEMHQEGIDLS
TIEWAAH
>Mature_406_residues
TQDTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEARENVAALVNADPREIIWTSGATES
DNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERDGFEVTYLDVKDDGLIDLDVFKAALRPDTILVSVMHVNNEIG
VIQDIETIGEICREKGIVFHVDAAQSTGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHERG
MRSGTLATHQIVGMGEAFRIAREEMATENERVRMLRDKLLRGLSQIEETYVNGDMERRVPHNLNISFNFVEGESLIMAIK
DVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQEVDFVINLLNSKIAKLRELSPLWEMHQEGIDLST
IEWAAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=58.5, Blast_Score=517, Evalue=1e-147,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=32.1256038647343, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI48994898, Length=404, Percent_Identity=73.019801980198, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1789175, Length=229, Percent_Identity=29.2576419213974, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787970, Length=218, Percent_Identity=27.9816513761468, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=401, Percent_Identity=60.8478802992519, Blast_Score=513, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17533177, Length=327, Percent_Identity=32.7217125382263, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=58.3959899749373, Blast_Score=509, Evalue=1e-145,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=57.5, Blast_Score=486, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45476; Mature: 45345

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREN
CCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERD
HHEEECCCCHHEEEECCCCCCCCEEEEECCHHHCCCCCEEEEEECCHHHHHHHHHHHHHC
GFEVTYLDVKDDGLIDLDVFKAALRPDTILVSVMHVNNEIGVIQDIETIGEICREKGIVF
CCEEEEEEECCCCEEEHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEE
HVDAAQSTGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
EEECCCCCCEEEEEHHHEEEEHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLATHQIVGMGEAFRIAREEMATENERVRMLRDKLLRGLSQIEETYVNGDMERRV
CCCCCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PHNLNISFNFVEGESLIMAIKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEE
GRFTTEQEVDFVINLLNSKIAKLRELSPLWEMHQEGIDLSTIEWAAH
ECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
TQDTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREN
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERD
HHEEECCCCHHEEEECCCCCCCCEEEEECCHHHCCCCCEEEEEECCHHHHHHHHHHHHHC
GFEVTYLDVKDDGLIDLDVFKAALRPDTILVSVMHVNNEIGVIQDIETIGEICREKGIVF
CCEEEEEEECCCCEEEHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEE
HVDAAQSTGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
EEECCCCCCEEEEEHHHEEEEHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLATHQIVGMGEAFRIAREEMATENERVRMLRDKLLRGLSQIEETYVNGDMERRV
CCCCCCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PHNLNISFNFVEGESLIMAIKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEE
GRFTTEQEVDFVINLLNSKIAKLRELSPLWEMHQEGIDLSTIEWAAH
ECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA