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The map label for this gene is pyrG

Identifier: 78066884

GI number: 78066884

Start: 2481427

End: 2483079

Strand: Reverse

Name: pyrG

Synonym: Bcep18194_A5415

Alternate gene names: 78066884

Gene position: 2483079-2481427 (Counterclockwise)

Preceding gene: 78066885

Following gene: 78066883

Centisome position: 67.22

GC content: 62.61

Gene sequence:

>1653_bases
ATGACCAAATATGTTTTCGTCACCGGCGGCGTAGTTTCTTCCCTTGGCAAGGGTATTGCCGCCGCTTCCCTCGCCGCGAT
CCTCGAATCGCGCGGTCTGAAAGTCACCCTCCTCAAACTCGATCCCTACATCAACGTCGACCCCGGCACGATGAGCCCGT
TCCAGCACGGCGAAGTGTTCGTGACGGAAGATGGAGCGGAGACGGACCTCGACCTCGGCCACTATGAGCGCTTCATCAGC
ACGAAGATGCGCAAGGCCAACAACTTCACGACCGGCCAGATCTACGAATCGGTGATCCGCAAGGAACGCCGCGGCGATTA
TCTGGGCAAGACCGTGCAGGTCATTCCGCACATCACGAACGAAATCCAGGCGTTCATCGAGCGCGGGGCCGCGTCGGCCA
CCTGCGGTGAGCCGGATGTCGCGATCGTCGAGATCGGCGGCACGGTCGGCGACATCGAGTCGCTGCCGTTCCTGGAAGCC
GCGCGCCAGATGAGCCTGCGCCTCGGCCGCAACAGCGCGTGCTTCGTGCACCTGACGCTGGTGCCGTACGTCGCGACGGC
CGGCGAACTGAAGACGAAGCCGACCCAGCACAGCGTGCAGAAGCTGCGCGAGATCGGCATCCTGCCGCACGTGCTGCTGT
GCCGTGCGGACCGCCGCATTCCGGACGACGAATCGAAGAAGATCTCGATGTTCTCGAACGTGCCGGAAGACGCCGTGATC
TCGGTGTGGGACGCCGACAGCATCTACAAGATTCCGCAGATGCTGCACGACCAGGGCCTCGACCGCATCATCTGCGAAGA
GCTGAAGCTGTCGCCGAAGGATGCCGATCTGACCATGTGGTCGGAGCTCGTCGAGAAGCTCGAGAACCCGAAGCACGAAG
TGACGATCGGCATGGTCGGCAAGTATGTCGACCTGACCGAGTCGTACAAGTCGCTGATCGAGGCGCTGCGCCACGCATCG
CTGCACACGTCGACCAAGGTCAACATCGAATACATCGACTCGGAAGAGATCGAGACGAACGGCGTCGACAGCCTGAAGCA
CCTCGACGCCGTGCTGGTGCCGGGCGGTTTCGGCCGTCGCGGCACGGAAGGCAAGATCGCGGCGATCCGCTATGCGCGTG
AAGCCAAGGTGCCGTATCTCGGCATCTGCCTCGGCATGCAGCTCGCAGTGATCGAGTTCGCGCGCAACGTCGTCGGCCTG
AAGCAGGCGAACAGCACGGAATTCGAGCCGGACACGCCGGAACGCGTGGTCGCGCTGATCACCGAATGGTACGACCGCGA
CGGCAAGGTCGAGACGCGCACCGAGGAATCCGATCTCGGCGGTACGATGCGCCTGGGGTCGCAGCGCTGCCCGATCAAGC
CGGGCACGATGGCGGAAGAGATCTATGGCAAGGACGTGAACGAACGCCATCGCCACCGTTATGAAGTCAATAACCGCTTC
GTGCCCCAGCTCGAAGCCGGCGGCCTTATCATCAGCGCCCGTACCCCGAGCGAGGATCTGCCGGAAATGATGGAGCTGCC
GCGTTCGATGCACCCGTGGTTCGTCGGCGTCCAGTTCCACCCGGAATTCACGTCCACGCCGCGTGACGGTCATCCCCTCT
TCAAGTCATTCGTCGAAGCTGCGCTTGCCAACAAGCAAGCGCGCGGAGTGTAA

Upstream 100 bases:

>100_bases
GCTGGTGCGGGTCGGCACGAAAGGGCGCGATCATCGAGTCAATTGCTGAGAGAAAGGTGGGCTTTACGGTATAATCCGTT
TTTCCCGCGAGCATCCAGCG

Downstream 100 bases:

>100_bases
GCATGAAGCTGTGCGATTTCGAGGTCGGTCTCGACAAGCCTTTCTTCCTGATCGCGGGTACCTGCGTCGTCGAATCGGAG
CAAATGACGATCGACACGGC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVI
SVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLTMWSELVEKLENPKHEVTIGMVGKYVDLTESYKSLIEALRHAS
LHTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARNVVGL
KQANSTEFEPDTPERVVALITEWYDRDGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
VPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEAALANKQARGV

Sequences:

>Translated_550_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVI
SVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLTMWSELVEKLENPKHEVTIGMVGKYVDLTESYKSLIEALRHAS
LHTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARNVVGL
KQANSTEFEPDTPERVVALITEWYDRDGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
VPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEAALANKQARGV
>Mature_549_residues
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIST
KMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAA
RQMSLRLGRNSACFVHLTLVPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVIS
VWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLTMWSELVEKLENPKHEVTIGMVGKYVDLTESYKSLIEALRHASL
HTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARNVVGLK
QANSTEFEPDTPERVVALITEWYDRDGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRFV
PQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEAALANKQARGV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI28559085, Length=565, Percent_Identity=45.3097345132743, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI28559083, Length=565, Percent_Identity=45.3097345132743, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI221316689, Length=565, Percent_Identity=45.3097345132743, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI148491070, Length=562, Percent_Identity=45.5516014234875, Blast_Score=479, Evalue=1e-135,
Organism=Escherichia coli, GI1789142, Length=550, Percent_Identity=62.3636363636364, Blast_Score=689, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=40.5582922824302, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=41.7543859649123, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322563, Length=574, Percent_Identity=42.5087108013937, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=45.1785714285714, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI21357815, Length=505, Percent_Identity=43.7623762376238, Blast_Score=403, Evalue=1e-112,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61087; Mature: 60955

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
VPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCEE
SVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLTMWSELVEKLENPKHEVTIGMVG
EEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECC
KYVDLTESYKSLIEALRHASLHTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRR
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCC
GTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARNVVGLKQANSTEFEPDTPERVVALI
CCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
TEWYDRDGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
HHHHCCCCCEEECCCHHHCCCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
VPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEA
CCEECCCCEEEECCCCCCCHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ALANKQARGV
HHHCHHCCCC
>Mature Secondary Structure 
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
VPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCEE
SVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLTMWSELVEKLENPKHEVTIGMVG
EEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECC
KYVDLTESYKSLIEALRHASLHTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRR
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCC
GTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARNVVGLKQANSTEFEPDTPERVVALI
CCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
TEWYDRDGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
HHHHCCCCCEEECCCHHHCCCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
VPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEA
CCEECCCCEEEECCCCCCCHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ALANKQARGV
HHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA