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The map label for this gene is kdsA1 [H]

Identifier: 78066883

GI number: 78066883

Start: 2480570

End: 2481424

Strand: Reverse

Name: kdsA1 [H]

Synonym: Bcep18194_A5414

Alternate gene names: 78066883

Gene position: 2481424-2480570 (Counterclockwise)

Preceding gene: 78066884

Following gene: 78066882

Centisome position: 67.17

GC content: 63.74

Gene sequence:

>855_bases
ATGAAGCTGTGCGATTTCGAGGTCGGTCTCGACAAGCCTTTCTTCCTGATCGCGGGTACCTGCGTCGTCGAATCGGAGCA
AATGACGATCGACACGGCGGGCCGCCTGAAGGAGATCTGCGCGAAGCTGAACATTCCGTTCATCTACAAGTCGTCCTACG
ACAAGGCGAACCGCAGCTCGGGCAAGTCGTTTCGTGGCCTTGGAATGGACGAGGGCTTGCGGATCCTGTCCGAGGTGAAG
CGCCAGCTCGGCCTGCCGGTGCTGACCGACGTGCATTCGATCGACGAGATCGAGCAGGTCGCATCGGTCGTCGACGTGCT
GCAGACGCCGGCGTTCCTGTGCCGCCAGACCGATTTCATCCATGCGTGCGCGCGCTCGGGCAAGCCCGTCAACATCAAGA
AGGGCCAGTTCCTCGCGCCGCACGACATGAAGAACGTGATCGACAAGGCGCGCGAAGCGGCCCGTGAAGCGGGGCTGTCG
GAAGACCGCTTCATGGCGTGCGAGCGCGGTGTCTCGTTCGGCTACAACAATCTCGTGTCGGACATGCGTTCGCTCGCGAT
CATGCGCGAGACGAGCGCGCCGGTCGTGTTCGACGCGACCCACTCGGTGCAGCTGCCGGGCGGGCAGGGTACGAGCTCGG
GCGGCCAGCGCGAATTCGTGCCGGTGCTCGCACGTGCGGCGGTCGCGACGGGCGTCGCGGGCCTCTTCATGGAAACGCAC
CCGAATCCGGCCGAAGCAAAGTCGGATGGCCCGAACGCGGTGCCGCTGAACCGGATGGGTGCGCTGCTGGAGACCCTCGT
CACGCTCGACCAGGCGGTGAAGCGCAATCCGTTCCTGGAAAACGATTTCAATTAA

Upstream 100 bases:

>100_bases
TCCACCCGGAATTCACGTCCACGCCGCGTGACGGTCATCCCCTCTTCAAGTCATTCGTCGAAGCTGCGCTTGCCAACAAG
CAAGCGCGCGGAGTGTAAGC

Downstream 100 bases:

>100_bases
AGATCGAATGAACCTTGCGACGGCTTCGCGCGTCTGTAGCGAAAGCGGTTCAGGCGCGTGCGCCGTCGCAGTTTGAAGAA
TCCATCGTCATTCTCAGAGG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase 1; KDO-8-phosphate synthase 1; KDO 8-P synthase 1; KDOPS 1; Phospho-2-dehydro-3-deoxyoctonate aldolase 1 [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKLCDFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICAKLNIPFIYKSSYDKANRSSGKSFRGLGMDEGLRILSEVK
RQLGLPVLTDVHSIDEIEQVASVVDVLQTPAFLCRQTDFIHACARSGKPVNIKKGQFLAPHDMKNVIDKAREAAREAGLS
EDRFMACERGVSFGYNNLVSDMRSLAIMRETSAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAVATGVAGLFMETH
PNPAEAKSDGPNAVPLNRMGALLETLVTLDQAVKRNPFLENDFN

Sequences:

>Translated_284_residues
MKLCDFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICAKLNIPFIYKSSYDKANRSSGKSFRGLGMDEGLRILSEVK
RQLGLPVLTDVHSIDEIEQVASVVDVLQTPAFLCRQTDFIHACARSGKPVNIKKGQFLAPHDMKNVIDKAREAAREAGLS
EDRFMACERGVSFGYNNLVSDMRSLAIMRETSAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAVATGVAGLFMETH
PNPAEAKSDGPNAVPLNRMGALLETLVTLDQAVKRNPFLENDFN
>Mature_284_residues
MKLCDFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICAKLNIPFIYKSSYDKANRSSGKSFRGLGMDEGLRILSEVK
RQLGLPVLTDVHSIDEIEQVASVVDVLQTPAFLCRQTDFIHACARSGKPVNIKKGQFLAPHDMKNVIDKAREAAREAGLS
EDRFMACERGVSFGYNNLVSDMRSLAIMRETSAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAVATGVAGLFMETH
PNPAEAKSDGPNAVPLNRMGALLETLVTLDQAVKRNPFLENDFN

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=276, Percent_Identity=43.4782608695652, Blast_Score=247, Evalue=6e-67,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30892; Mature: 30892

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLCDFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICAKLNIPFIYKSSYDKANRSS
CCCCCCCCCCCCCEEEEECCCEEECCCEEECHHHHHHHHHHHCCCCEEECCCCCCCCCCC
GKSFRGLGMDEGLRILSEVKRQLGLPVLTDVHSIDEIEQVASVVDVLQTPAFLCRQTDFI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
HACARSGKPVNIKKGQFLAPHDMKNVIDKAREAAREAGLSEDRFMACERGVSFGYNNLVS
HHHHCCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
DMRSLAIMRETSAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAVATGVAGLFMETH
HHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PNPAEAKSDGPNAVPLNRMGALLETLVTLDQAVKRNPFLENDFN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLCDFEVGLDKPFFLIAGTCVVESEQMTIDTAGRLKEICAKLNIPFIYKSSYDKANRSS
CCCCCCCCCCCCCEEEEECCCEEECCCEEECHHHHHHHHHHHCCCCEEECCCCCCCCCCC
GKSFRGLGMDEGLRILSEVKRQLGLPVLTDVHSIDEIEQVASVVDVLQTPAFLCRQTDFI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
HACARSGKPVNIKKGQFLAPHDMKNVIDKAREAAREAGLSEDRFMACERGVSFGYNNLVS
HHHHCCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
DMRSLAIMRETSAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAVATGVAGLFMETH
HHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PNPAEAKSDGPNAVPLNRMGALLETLVTLDQAVKRNPFLENDFN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA