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The map label for this gene is map [H]

Identifier: 78066799

GI number: 78066799

Start: 2382501

End: 2383316

Strand: Direct

Name: map [H]

Synonym: Bcep18194_A5330

Alternate gene names: 78066799

Gene position: 2382501-2383316 (Clockwise)

Preceding gene: 78066782

Following gene: 78066800

Centisome position: 64.49

GC content: 65.07

Gene sequence:

>816_bases
ATGGCTATTACGCTCAAAAACGAACACGATATCGCCGAGATGCGCGTCGCCTGCCGTCTCGCGAGCGAAGTGCTCGACTT
CATCACGCCGCACGTCGTCGCGGGCGTCACGACCGCCGAACTCGACCGCCTCTGCCACGAGTTCATGCTCAACGAGCAGG
GCACGATCCCCGCGCCGCTGAACTACCAGCCGCCCGGCTACCCGCCGTACCCGAAGGCCACCTGCATTTCGGTCAACGAC
GTGATCTGCCACGGCATTCCCGGCGAGAAGGTGATCAAGAACGGCGATGCGCTGAACATCGACGTCACCGTGATCAAGAA
CGGTTACTTCGGCGACACGAGCCGCATGTTCATCGTCGGCGAAGGTTCGATCCTCGCGAAGCGCCTCGTGCAGACCACCT
ACGAATGCATGTGGCTCGGCATCGACCAGGTCAAGCCCGGCGCGCACCTCGGCGACATCGGCTACGCGATCCAGAAGCAC
GCGGAAGCGCAGGGCTACAGCGTCGTGCGCGAATACTGCGGCCACGGTATCGGCACGGTGTTCCACGAAGATCCGCAGGT
CGTCCACTACGGCCGCCCGGGCACCGGCATCGAACTGAAGGCCGGGATGATCTTCACGATCGAGCCGATGATCAACGCCG
GCAAGCGCGACATCCGCACGATGCCCGACCAGTGGACGGTCAAGACGCGCGACCGCAGCCTGTCGGCGCAGTGGGAGCAC
ACGGTGCTCGTCACCGAAACCGGCTACGACGTGCTGACCGTGTCCGCCGGCACGCCGGCGCGCCCCGTGTTCGCGCAACC
GGCAGCCGCCGTCTGA

Upstream 100 bases:

>100_bases
ACAATCCGCGAAAACCCGCATTCGCGCCGCCGGCAGGGGCTGCGACGCCTGCCAGAAGGTGCGATAATCCATCAATTCAC
CGCATTCCAGGCATACCTCG

Downstream 100 bases:

>100_bases
GCGCCGTCGCGCCAGCCCGCCCCACCCGCACCTGAACGGCCGCCCATGAGCGCTCACGCTGCCCCCTCGCCCGAAGCGCT
GTCGCGGCGCGCCGAATTCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MAITLKNEHDIAEMRVACRLASEVLDFITPHVVAGVTTAELDRLCHEFMLNEQGTIPAPLNYQPPGYPPYPKATCISVND
VICHGIPGEKVIKNGDALNIDVTVIKNGYFGDTSRMFIVGEGSILAKRLVQTTYECMWLGIDQVKPGAHLGDIGYAIQKH
AEAQGYSVVREYCGHGIGTVFHEDPQVVHYGRPGTGIELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEH
TVLVTETGYDVLTVSAGTPARPVFAQPAAAV

Sequences:

>Translated_271_residues
MAITLKNEHDIAEMRVACRLASEVLDFITPHVVAGVTTAELDRLCHEFMLNEQGTIPAPLNYQPPGYPPYPKATCISVND
VICHGIPGEKVIKNGDALNIDVTVIKNGYFGDTSRMFIVGEGSILAKRLVQTTYECMWLGIDQVKPGAHLGDIGYAIQKH
AEAQGYSVVREYCGHGIGTVFHEDPQVVHYGRPGTGIELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEH
TVLVTETGYDVLTVSAGTPARPVFAQPAAAV
>Mature_270_residues
AITLKNEHDIAEMRVACRLASEVLDFITPHVVAGVTTAELDRLCHEFMLNEQGTIPAPLNYQPPGYPPYPKATCISVNDV
ICHGIPGEKVIKNGDALNIDVTVIKNGYFGDTSRMFIVGEGSILAKRLVQTTYECMWLGIDQVKPGAHLGDIGYAIQKHA
EAQGYSVVREYCGHGIGTVFHEDPQVVHYGRPGTGIELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEHT
VLVTETGYDVLTVSAGTPARPVFAQPAAAV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=262, Percent_Identity=48.4732824427481, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI40385867, Length=252, Percent_Identity=39.2857142857143, Blast_Score=185, Evalue=3e-47,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=58.4313725490196, Blast_Score=312, Evalue=1e-86,
Organism=Escherichia coli, GI1788728, Length=254, Percent_Identity=24.8031496062992, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=252, Percent_Identity=46.8253968253968, Blast_Score=220, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6323273, Length=262, Percent_Identity=44.2748091603053, Blast_Score=219, Evalue=3e-58,
Organism=Drosophila melanogaster, GI21355531, Length=262, Percent_Identity=45.8015267175573, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=37.7510040160643, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29631; Mature: 29500

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITLKNEHDIAEMRVACRLASEVLDFITPHVVAGVTTAELDRLCHEFMLNEQGTIPAPL
CEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCC
NYQPPGYPPYPKATCISVNDVICHGIPGEKVIKNGDALNIDVTVIKNGYFGDTSRMFIVG
CCCCCCCCCCCCEEEEEECCEEEECCCCHHHHCCCCEEEEEEEEEECCCCCCCCEEEEEE
EGSILAKRLVQTTYECMWLGIDQVKPGAHLGDIGYAIQKHAEAQGYSVVREYCGHGIGTV
CCHHHHHHHHHHHHHHEEEEHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEE
FHEDPQVVHYGRPGTGIELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEH
EECCCCEEEECCCCCCEEEECCEEEEEECCCCCCCHHHHCCCCCEEEEECCCCCCCCCCE
TVLVTETGYDVLTVSAGTPARPVFAQPAAAV
EEEEEECCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AITLKNEHDIAEMRVACRLASEVLDFITPHVVAGVTTAELDRLCHEFMLNEQGTIPAPL
EEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCC
NYQPPGYPPYPKATCISVNDVICHGIPGEKVIKNGDALNIDVTVIKNGYFGDTSRMFIVG
CCCCCCCCCCCCEEEEEECCEEEECCCCHHHHCCCCEEEEEEEEEECCCCCCCCEEEEEE
EGSILAKRLVQTTYECMWLGIDQVKPGAHLGDIGYAIQKHAEAQGYSVVREYCGHGIGTV
CCHHHHHHHHHHHHHHEEEEHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEE
FHEDPQVVHYGRPGTGIELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEH
EECCCCEEEECCCCCCEEEECCEEEEEECCCCCCCHHHHCCCCCEEEEECCCCCCCCCCE
TVLVTETGYDVLTVSAGTPARPVFAQPAAAV
EEEEEECCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]