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The map label for this gene is guaB [H]

Identifier: 78066770

GI number: 78066770

Start: 2353034

End: 2354494

Strand: Reverse

Name: guaB [H]

Synonym: Bcep18194_A5301

Alternate gene names: 78066770

Gene position: 2354494-2353034 (Counterclockwise)

Preceding gene: 78066771

Following gene: 78066769

Centisome position: 63.74

GC content: 65.78

Gene sequence:

>1461_bases
ATGCGTCTGATCCAAAAAGCACTCACTTTCGATGACGTGCTCCTCGTTCCCGCCTTTTCCGACGTTCTCCCGCGCGACAC
CAGCCTCAAGACCAAGCTGACCCGCAACATCTCCCTGAACATGCCGCTCGTGTCCGCCGCGATGGACACGGTCACCGAAG
GTCGCCTTGCGATCGCGATGGCACAGCAGGGTGGCGTCGGTATCGTCCACAAGAACCTGACGCCGGCCGAACAGGCCCGC
GAGGTCGCGAAGGTCAAGCGTTTCGAATCGGGCGTCGTCCGCGATCCGATCACGGTGCCGCCGCAAATGAAGGTGCGCGA
CGTGATCGCGCTGTCGCGCCAGCATGGCATCTCGGGCTTCCCGGTCGTCGAAGGCCCGCAACTCGTCGGCATCGTCACGA
ACCGCGACCTGCGTTTCGAAACCCGCCTCGATGAGCCGGTCAAGTCGATCATGACGCCGCGCGAGCGCCTCGTCACGGTC
AAGGAAGGCACGCCGCTCGCCGAAGCGAAGGCGCTGATGCACAGCCACCGTCTCGAGCGCGTGCTGGTCGTCAACGACGC
GTTCGAACTGCGCGGCCTGATGACCGTCAAGGACATCACGAAGCAAACCGAGCACCCGGACGCGTGCAAGGACGAACACG
GCAAGCTGCGCGCAGGCGCGGCGGTCGGCGTCGGTCCCGACAACGAAGAGCGCGTCGAGCTGCTGGTGCAGGCCGGCGTC
GACGTGATCGTCGTCGATACCGCGCACGGCCACAGCAAGGGCGTGCTCGAGCGCGTTCGCTGGGTCAAGCAGAACTTCCC
GCACGTCGAAGTGATCGGCGGCAACATCGCGACGGCCGCCGCCGCGAAGGCGCTCGTCGAATACGGCGCGGATGCAGTCA
AGGTCGGTATCGGCCCGGGCTCGATCTGCACGACGCGGATCGTCGCCGGTGTCGGCGTGCCGCAGATCAGCGCGATCGCG
AACGTCGCGGAAGCATTGAAGGGCACGGGCGTGCCGTGCATCGCCGACGGCGGCGTGCGCTTCTCGGGCGACGTGTCGAA
GGCCCTCGCGGCCGGCGCGAACGCGGTGATGATGGGCAGCATGTTCGCGGGCACCGAAGAGGCGCCGGGCGACGTGTTCC
TGTACCAGGGCCGTCAGTACAAGTCGTATCGCGGCATGGGTTCCGTCGGTGCGATGAAGGACGGCGCGGCAGACCGCTAC
TTCCAGGACAACTCGGCGAACATCGACAAGCTCGTGCCGGAAGGCATCGAAGGCCGTGTCGCGTACAAGGGTTCGGTCAA
CGCGATCCTGTTCCAGCTGGTCGGCGGTGTGCGCGCGAGCATGGGCTACTGCGGCTGCAAGACGATCGACGAGCTGCACG
ACAAGGCTGAATTCGTCCAGATCACCGCGGCGGGCATGCGCGAGTCGCACGTGCACGACGTGCAGATCACGAAGGAAGCG
CCGAACTACCACGTGGACTAA

Upstream 100 bases:

>100_bases
TTCGGCCCCCGAACGGCTGAAACCGGCTAAGCCGTTGTTCGTGTTGTGAAAATTCGCGGCGCTTCGCGTATAATTCGCTT
TTGCGCCCATAGGATTTGCC

Downstream 100 bases:

>100_bases
TTGCCGATGAAACCGCTGCTGCGAGCCGTGCTGATTGTCGATGCCGTACTGCTGCTGGCGTTCGGCGTGTTGTTCGTGCT
GACGCCCTGGCAGTCGCTCT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVAEALKGTGVPCIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCKTIDELHDKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD

Sequences:

>Translated_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVAEALKGTGVPCIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCKTIDELHDKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD
>Mature_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVAEALKGTGVPCIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCKTIDELHDKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=451, Percent_Identity=43.4589800443459, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=41.7536534446764, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=41.7536534446764, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=41.7536534446764, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI217035152, Length=475, Percent_Identity=41.6842105263158, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.0414937759336, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI217035148, Length=451, Percent_Identity=42.5720620842572, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI217035150, Length=451, Percent_Identity=40.3547671840355, Blast_Score=325, Evalue=9e-89,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=35.4961832061069, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=37.1428571428571, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=37.1428571428571, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=37.1428571428571, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=37.1428571428571, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=62.4229979466119, Blast_Score=579, Evalue=1e-166,
Organism=Escherichia coli, GI1786293, Length=238, Percent_Identity=33.6134453781513, Blast_Score=138, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=37.2384937238494, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71994389, Length=425, Percent_Identity=39.0588235294118, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=36.4016736401674, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=38.7295081967213, Blast_Score=352, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.2561983471074, Blast_Score=348, Evalue=9e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.0495867768595, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.8888888888889, Blast_Score=262, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=34.5070422535211, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=40.2061855670103, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=40.2061855670103, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=40.8577878103837, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51948; Mature: 51948

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCCHHEEECCEEECCCHHHHHHHHHCCCCEEEEE
AQQGGVGIVHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTVKEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECEEECCCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQNFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVAEALKGTGVPCIADGGVRFSGDVSKALAAGANAVMMGS
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHCCCCEEEECH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAILFQLVGGVRASMGYCGCKTIDELHDKAEFVQITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHEEEEEECCCCCCCCCEEEEEECC
PNYHVD
CCCCCC
>Mature Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCCHHEEECCEEECCCHHHHHHHHHCCCCEEEEE
AQQGGVGIVHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTVKEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECEEECCCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQNFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVAEALKGTGVPCIADGGVRFSGDVSKALAAGANAVMMGS
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHCCCCEEEECH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAILFQLVGGVRASMGYCGCKTIDELHDKAEFVQITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHEEEEEECCCCCCCCCEEEEEECC
PNYHVD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA