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The map label for this gene is ispD

Identifier: 78066723

GI number: 78066723

Start: 2306849

End: 2307559

Strand: Reverse

Name: ispD

Synonym: Bcep18194_A5254

Alternate gene names: 78066723

Gene position: 2307559-2306849 (Counterclockwise)

Preceding gene: 78066728

Following gene: 78066722

Centisome position: 62.47

GC content: 70.6

Gene sequence:

>711_bases
GTGACTCCCCGACTTTTCGCCCTGATTCCCTGTGCCGGTACCGGCAGCCGTTCCGGCTCGGCCGTGCCGAAACAATACCG
CACGCTGGCCGGCCGCGCGCTGCTGCACTACACGCTTGCCGCGTTCGACGCGTGCAGCGAATTCGCACAGACGCTCGTCG
TCCTCGCGCCCGACGATTCCCATTTCGACGCACGCCGCTTCGCGGGCCTGCGCTTCGCGGTGCGCCGCTGCGGCGGCGGC
TCGCGCCAGGCGTCGGTGCTGAACGGGCTGCTCGAACTGGCCGAATTCGGCGCGACCGACCACGACTGGGTGCTGGTGCA
CGACGCCGCGCGCCCGGGCATCACGCCGGAGCTGATCCGCACGCTGGTCGCGACGCTGAAGGACGATCCGGTCGGCGGCA
TCGTCGCGCTGCCGGTGGCCGATACGCTCAAGCGCGTGCCGGCCGGCGGCGACGCGATCGCGCGCACCGAGTCGCGCGAC
GCGCTGTGGCAGGCGCAGACGCCGCAGATGTTCCGCATCGGCATGCTGCGCGAGGCGATCCTGCGCGCGCAGCGCGAAGG
GCACGACCTGACCGACGAAGCGAGCGCGATCGAATGGGCCGGCCATACGCCGCGCGTCGTGCAGGGCAGCCTGCGCAATT
TCAAGGTCACGTACCCGGAAGATTTCGCGCTCGCGGAAGCGATCCTCGCGCGTTCCACGAACGCTTCCTGA

Upstream 100 bases:

>100_bases
ACAGGGGTGGCGTGCACGGGCGCATCGCGGTGCGCCGGTCGAGACGAAAGACCTATTATAAAATCCGCTTCTCGATTTCA
TCTTTCCGGCGTTTCCTTTC

Downstream 100 bases:

>100_bases
CTTTCACCCCCTCACAATCGGAATACGCATGGATTTCAGAATCGGACAAGGCTACGACGTGCACCAGCTCGTCGAGGGGC
GCCCCCTCATCATCGGCGGC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDSHFDARRFAGLRFAVRRCGGG
SRQASVLNGLLELAEFGATDHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRD
ALWQAQTPQMFRIGMLREAILRAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARSTNAS

Sequences:

>Translated_236_residues
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDSHFDARRFAGLRFAVRRCGGG
SRQASVLNGLLELAEFGATDHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRD
ALWQAQTPQMFRIGMLREAILRAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARSTNAS
>Mature_235_residues
TPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDSHFDARRFAGLRFAVRRCGGGS
RQASVLNGLLELAEFGATDHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRDA
LWQAQTPQMFRIGMLREAILRAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARSTNAS

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=233, Percent_Identity=24.8927038626609, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789104, Length=228, Percent_Identity=40.3508771929825, Blast_Score=157, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25445; Mature: 25314

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDS
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGGSRQASVLNGLLELAEFGATDHDWVLVHDAARPGITPELIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
TLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRDALWQAQTPQMFRIGMLREAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHH
LRAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARSTNAS
HHHHHCCCCCCCCHHHHHCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDS
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGGSRQASVLNGLLELAEFGATDHDWVLVHDAARPGITPELIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
TLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRDALWQAQTPQMFRIGMLREAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHH
LRAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARSTNAS
HHHHHCCCCCCCCHHHHHCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA