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The map label for this gene is macA [H]

Identifier: 78066504

GI number: 78066504

Start: 2069913

End: 2071103

Strand: Direct

Name: macA [H]

Synonym: Bcep18194_A5035

Alternate gene names: 78066504

Gene position: 2069913-2071103 (Clockwise)

Preceding gene: 78066502

Following gene: 78066505

Centisome position: 56.03

GC content: 71.54

Gene sequence:

>1191_bases
TTGCCGGCGCCGCTCGGGGCAAGCGCCGGCCGCGCTTGCCGGCTTCGTTCCGCTCTCGCTCTCACTTCATCTGGGGGTTT
CGTGAATCGCTCCGGTTCCCGCGCCGCGCTGCTGATCGGCGCCGCGTTTGTCCTCACCGCCTGTCATCCGAAAGAATCCG
CGCCGCCCGCCCCGCGCCCCGTCGTCGCGCTGCCCGCCCATGCCGACGACGCTGCCGTCGCCCGCACGCTCCCCGGCGAG
ATCCAGCCGCGCTACGCCACCCCGCTGTCGTTCCGCATCGCCGGCAAGATCATCGAGCGCAAGGTGCGCCTCGGCGATAC
GGTCAAGGTCGGCCAGGTCGTCGCGCTGCTCGACCCGTCCGACGTCGAGAAGAACGCCGCGAGCGCGCAGGCGCAACTCG
ATGCCGCGACGCACAGCCTCGCGTTTGCGAAGCAGCAGCTCGACCGCGATCGCGCACAGGCACGCGAAAACCTGATCGCG
ACCGCGCAGCTCGAGCAAACCGAGAACAGCTACACGTCGGCGCTCGCGCAGCGCGACCAGGCGCAGCAGCAGCTCGCGCT
CGCCAAGAACCAGCTCCGCTACGCGACGCTCGTCGCCGATCACGCGGGCTACATCACCGCCGAACAGGCCGACACCGGCC
AGAACGTGTCGGCCGGCCAGGCCGTCTACCAGCTCGCGTGGTCGGGCGACGTCGACGTCGTCAGCGACGCGCCTGAAGCC
GCGCTTGCGTCGCTCACGCCGGGCCACGCGGCCACCGTCACGCTGCCGTCGCTGCCGGGCCGCCAGTTCGCCGCGAAAGT
GCGCGAAATCGCGCCGGCCGCCGATCCGCAAAGCCGCACGTATCGCGTGAAGCTCACACTCGCCGCGCCCGATCCGGCGA
TCCGGCTCGGGATGACCGCCAGCGTCGCGTTCGACGGCGCACCGGTCACCGGCGACGCGCAGTCGATCACGCTGCCCGCA
ACCGCGCTGTTCCACGACGGCCAGCAACCGGCCGTGTGGGTCGTGCGCACGAAGGACGACACGCTCGAGCTGCGCCGCGT
CGACGTCGCGCGCTTCAACGAGCGCACGGTGACGGTGTCGCACGGGCTGCAGCCCGGCGAACGCGTGGTGCTGCAGGGCG
TGCACACGGTCAGCGCGGGCGAGAAGGTGCGCGCGATCGCGCCGCTGCATCCGGAGGACTTCGCATCGTGA

Upstream 100 bases:

>100_bases
GCAGTCTAGCACTATTTACCTTTCGGATTCATCTTTGCATTCAGATACAGGTGTGTATTAGAATTCGCCACAGTTTCTGA
AAGATGGTGTCCGCGCGCCG

Downstream 100 bases:

>100_bases
GCGTTTCCTACGAAGAAGGCCGCTTCAACCTGTCGGCGTGGGCGTTGCGCCACCAGGCGCTGGTCGTCTACCTGATCGCG
CTCGCGACGCTCGCGGGCAT

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MPAPLGASAGRACRLRSALALTSSGGFVNRSGSRAALLIGAAFVLTACHPKESAPPAPRPVVALPAHADDAAVARTLPGE
IQPRYATPLSFRIAGKIIERKVRLGDTVKVGQVVALLDPSDVEKNAASAQAQLDAATHSLAFAKQQLDRDRAQARENLIA
TAQLEQTENSYTSALAQRDQAQQQLALAKNQLRYATLVADHAGYITAEQADTGQNVSAGQAVYQLAWSGDVDVVSDAPEA
ALASLTPGHAATVTLPSLPGRQFAAKVREIAPAADPQSRTYRVKLTLAAPDPAIRLGMTASVAFDGAPVTGDAQSITLPA
TALFHDGQQPAVWVVRTKDDTLELRRVDVARFNERTVTVSHGLQPGERVVLQGVHTVSAGEKVRAIAPLHPEDFAS

Sequences:

>Translated_396_residues
MPAPLGASAGRACRLRSALALTSSGGFVNRSGSRAALLIGAAFVLTACHPKESAPPAPRPVVALPAHADDAAVARTLPGE
IQPRYATPLSFRIAGKIIERKVRLGDTVKVGQVVALLDPSDVEKNAASAQAQLDAATHSLAFAKQQLDRDRAQARENLIA
TAQLEQTENSYTSALAQRDQAQQQLALAKNQLRYATLVADHAGYITAEQADTGQNVSAGQAVYQLAWSGDVDVVSDAPEA
ALASLTPGHAATVTLPSLPGRQFAAKVREIAPAADPQSRTYRVKLTLAAPDPAIRLGMTASVAFDGAPVTGDAQSITLPA
TALFHDGQQPAVWVVRTKDDTLELRRVDVARFNERTVTVSHGLQPGERVVLQGVHTVSAGEKVRAIAPLHPEDFAS
>Mature_395_residues
PAPLGASAGRACRLRSALALTSSGGFVNRSGSRAALLIGAAFVLTACHPKESAPPAPRPVVALPAHADDAAVARTLPGEI
QPRYATPLSFRIAGKIIERKVRLGDTVKVGQVVALLDPSDVEKNAASAQAQLDAATHSLAFAKQQLDRDRAQARENLIAT
AQLEQTENSYTSALAQRDQAQQQLALAKNQLRYATLVADHAGYITAEQADTGQNVSAGQAVYQLAWSGDVDVVSDAPEAA
LASLTPGHAATVTLPSLPGRQFAAKVREIAPAADPQSRTYRVKLTLAAPDPAIRLGMTASVAFDGAPVTGDAQSITLPAT
ALFHDGQQPAVWVVRTKDDTLELRRVDVARFNERTVTVSHGLQPGERVVLQGVHTVSAGEKVRAIAPLHPEDFAS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=381, Percent_Identity=23.3595800524934, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082036, Length=325, Percent_Identity=24.6153846153846, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081796, Length=357, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41611; Mature: 41480

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPLGASAGRACRLRSALALTSSGGFVNRSGSRAALLIGAAFVLTACHPKESAPPAPRP
CCCCCCCCCCCHHHHHHHEEEECCCCEEECCCCCEEEEEEHHHHHEECCCCCCCCCCCCC
VVALPAHADDAAVARTLPGEIQPRYATPLSFRIAGKIIERKVRLGDTVKVGQVVALLDPS
EEEECCCCCCHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEECEEEEEECCC
DVEKNAASAQAQLDAATHSLAFAKQQLDRDRAQARENLIATAQLEQTENSYTSALAQRDQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHH
AQQQLALAKNQLRYATLVADHAGYITAEQADTGQNVSAGQAVYQLAWSGDVDVVSDAPEA
HHHHHHHHHHHHEEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCEECCCCHH
ALASLTPGHAATVTLPSLPGRQFAAKVREIAPAADPQSRTYRVKLTLAAPDPAIRLGMTA
HHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEECEEE
SVAFDGAPVTGDAQSITLPATALFHDGQQPAVWVVRTKDDTLELRRVDVARFNERTVTVS
EEEECCCCCCCCCCEEEECCCEEECCCCCCEEEEEEECCCCEEEEEEHHHHCCCEEEEEE
HGLQPGERVVLQGVHTVSAGEKVRAIAPLHPEDFAS
CCCCCCHHHHEEECEEECCCCCEEEECCCCCHHCCC
>Mature Secondary Structure 
PAPLGASAGRACRLRSALALTSSGGFVNRSGSRAALLIGAAFVLTACHPKESAPPAPRP
CCCCCCCCCCHHHHHHHEEEECCCCEEECCCCCEEEEEEHHHHHEECCCCCCCCCCCCC
VVALPAHADDAAVARTLPGEIQPRYATPLSFRIAGKIIERKVRLGDTVKVGQVVALLDPS
EEEECCCCCCHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEECEEEEEECCC
DVEKNAASAQAQLDAATHSLAFAKQQLDRDRAQARENLIATAQLEQTENSYTSALAQRDQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHH
AQQQLALAKNQLRYATLVADHAGYITAEQADTGQNVSAGQAVYQLAWSGDVDVVSDAPEA
HHHHHHHHHHHHEEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCEECCCCHH
ALASLTPGHAATVTLPSLPGRQFAAKVREIAPAADPQSRTYRVKLTLAAPDPAIRLGMTA
HHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEECEEE
SVAFDGAPVTGDAQSITLPATALFHDGQQPAVWVVRTKDDTLELRRVDVARFNERTVTVS
EEEECCCCCCCCCCEEEECCCEEECCCCCCEEEEEEECCCCEEEEEEHHHHCCCEEEEEE
HGLQPGERVVLQGVHTVSAGEKVRAIAPLHPEDFAS
CCCCCCHHHHEEECEEECCCCCEEEECCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]