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The map label for this gene is pcaK [H]

Identifier: 78066374

GI number: 78066374

Start: 1922535

End: 1923875

Strand: Direct

Name: pcaK [H]

Synonym: Bcep18194_A4904

Alternate gene names: 78066374

Gene position: 1922535-1923875 (Clockwise)

Preceding gene: 78066373

Following gene: 78066378

Centisome position: 52.04

GC content: 67.11

Gene sequence:

>1341_bases
ATGGCTGCGTCGTCGGACGAGGCAGTACTTTCCGTATTCGATACACGCCCGATGGGGCGGCTGCAATGGCTTGCGTTGTC
GTTGTGTGGTCTCTGCATGGTCGTCGATGGATACGACGTGCAGGCGATGGCCTATGCTGCGCCGGCCTTGATGAAGACAT
GGGGGATCGAGCGGACGGTGCTGGGGCCCGTGTTCAGCGCGGGGTTGCTCGGGATGTTCGCCGGGTCGCTGCTGCTCGCC
GGGCTGGCGGACAGGATCGGGCGCCGGCCGCTGCTCGTCGCGGCGAGCATGTGGGTGGCCGGCTGTATGGCGGTGACGGC
GCATGCGGGCTCGCTCGACCAACTGATCGCGATCCGGTTCGCAGCCGGTGTCGGCATGGGCGCGATCGTGCCCAATGCGA
TGTCGCTGGCGGGCGAGTACAGCCCGAGCCGCCTTCGCATCACGCTGATGATGGCGGTCTCGTCCGGCTACATTGCGGGC
GGTGTGCTGGGCGGCGCCGTGGCCGCGTTCGTCATTGAAACCTTCGGATGGCGCGGGGTGTTCGACGTGGGAGCGTTGCT
GACGGCGATACTGTCCGTGGCGATGTGGATGGTCTTGCCCGAATCGATCCAGTTTGCGCTGGCACGACGCCCGGGACGAC
CGCAAACGCTGCGCCTTCTTCAGCGTGCGGTGCCCAACGCGACGTTGCCGCCCGGGTTCCGTACGGAACGGCCGGATCGA
CAACCTGCGGTGGCGACGCTGTTCGGAGAAGGGCGAGCCGTGGCGACGCCGCTGCTGTGGGGCGCGAACTTCGCCAACAT
GCTGTGCGCGTATTTCCTTGCCGCGTGGATTCCGTTGCTGATGGCCGGTAACGGCGCGTCGCCCGGTATGCCTGTGCTCG
CGGGTACGGCCTTGTGGCTGGGTGGCCTGCTCGGCAACTGGCTGCTCGGATTGCTGATCGATCGCAGGGGCTACGCCGTG
GTGCTGATCGCGAACTTCGTGGCCGGCGGCATGGCCATTGCCGGGATCAGCGTGTTCCACGCTTTTCCGGTTCCTGCACT
GGCTTGCATCGCATTCGCCGGCTTTTGCGTGCTCGGCGGACAATCCGGGCTCAATGCGCTGGCCGTCGTCCTTTATCCGA
GCGCGGCGCGTGCGACCGGCGCTGGATGGGCGCTTGGCGTCGGGCGCCTCGGTGCGGTGCTGGGGCCCGTTGCAGGTGGA
TACCTGATGGCAATGACTTGGACAGCGGAGCAGACCTTGATCGCGTCCGCGTTGCCTGCAGTGGCTGCGGCAGTAGCGGT
CGGCATGCTCGGTCGGCTCCGCCGGCAGGGTGCCGCATCGGTCGCTCAGACCGCAGCCTGA

Upstream 100 bases:

>100_bases
ACCGCGATCACGCGGCCGTCCAGATCGTCACGAGGCGACGGAGGTTTGCGACGAATCTGCCGCAATTGAAGAAGCCTGTC
AGGGTATGGAGGAGACAATC

Downstream 100 bases:

>100_bases
AGCCTGCCGCGCGCAGGATCCAGGCAGTACGTCATCAAACTGCCCGGCCGTCCGACGTTCGATTCGGCGCAACCGGGCAG
CGTCAGGTTTGCGGCGGCTC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAASSDEAVLSVFDTRPMGRLQWLALSLCGLCMVVDGYDVQAMAYAAPALMKTWGIERTVLGPVFSAGLLGMFAGSLLLA
GLADRIGRRPLLVAASMWVAGCMAVTAHAGSLDQLIAIRFAAGVGMGAIVPNAMSLAGEYSPSRLRITLMMAVSSGYIAG
GVLGGAVAAFVIETFGWRGVFDVGALLTAILSVAMWMVLPESIQFALARRPGRPQTLRLLQRAVPNATLPPGFRTERPDR
QPAVATLFGEGRAVATPLLWGANFANMLCAYFLAAWIPLLMAGNGASPGMPVLAGTALWLGGLLGNWLLGLLIDRRGYAV
VLIANFVAGGMAIAGISVFHAFPVPALACIAFAGFCVLGGQSGLNALAVVLYPSAARATGAGWALGVGRLGAVLGPVAGG
YLMAMTWTAEQTLIASALPAVAAAVAVGMLGRLRRQGAASVAQTAA

Sequences:

>Translated_446_residues
MAASSDEAVLSVFDTRPMGRLQWLALSLCGLCMVVDGYDVQAMAYAAPALMKTWGIERTVLGPVFSAGLLGMFAGSLLLA
GLADRIGRRPLLVAASMWVAGCMAVTAHAGSLDQLIAIRFAAGVGMGAIVPNAMSLAGEYSPSRLRITLMMAVSSGYIAG
GVLGGAVAAFVIETFGWRGVFDVGALLTAILSVAMWMVLPESIQFALARRPGRPQTLRLLQRAVPNATLPPGFRTERPDR
QPAVATLFGEGRAVATPLLWGANFANMLCAYFLAAWIPLLMAGNGASPGMPVLAGTALWLGGLLGNWLLGLLIDRRGYAV
VLIANFVAGGMAIAGISVFHAFPVPALACIAFAGFCVLGGQSGLNALAVVLYPSAARATGAGWALGVGRLGAVLGPVAGG
YLMAMTWTAEQTLIASALPAVAAAVAVGMLGRLRRQGAASVAQTAA
>Mature_445_residues
AASSDEAVLSVFDTRPMGRLQWLALSLCGLCMVVDGYDVQAMAYAAPALMKTWGIERTVLGPVFSAGLLGMFAGSLLLAG
LADRIGRRPLLVAASMWVAGCMAVTAHAGSLDQLIAIRFAAGVGMGAIVPNAMSLAGEYSPSRLRITLMMAVSSGYIAGG
VLGGAVAAFVIETFGWRGVFDVGALLTAILSVAMWMVLPESIQFALARRPGRPQTLRLLQRAVPNATLPPGFRTERPDRQ
PAVATLFGEGRAVATPLLWGANFANMLCAYFLAAWIPLLMAGNGASPGMPVLAGTALWLGGLLGNWLLGLLIDRRGYAVV
LIANFVAGGMAIAGISVFHAFPVPALACIAFAGFCVLGGQSGLNALAVVLYPSAARATGAGWALGVGRLGAVLGPVAGGY
LMAMTWTAEQTLIASALPAVAAAVAVGMLGRLRRQGAASVAQTAA

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=407, Percent_Identity=25.3071253071253, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI87081723, Length=419, Percent_Identity=32.2195704057279, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI87082231, Length=188, Percent_Identity=27.6595744680851, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788074, Length=359, Percent_Identity=24.5125348189415, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=416, Percent_Identity=26.6826923076923, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45772; Mature: 45641

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASSDEAVLSVFDTRPMGRLQWLALSLCGLCMVVDGYDVQAMAYAAPALMKTWGIERTV
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCHHH
LGPVFSAGLLGMFAGSLLLAGLADRIGRRPLLVAASMWVAGCMAVTAHAGSLDQLIAIRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AAGVGMGAIVPNAMSLAGEYSPSRLRITLMMAVSSGYIAGGVLGGAVAAFVIETFGWRGV
HHCCCCHHHCCHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCH
FDVGALLTAILSVAMWMVLPESIQFALARRPGRPQTLRLLQRAVPNATLPPGFRTERPDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
QPAVATLFGEGRAVATPLLWGANFANMLCAYFLAAWIPLLMAGNGASPGMPVLAGTALWL
CCCEEEEECCCCEEECHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
GGLLGNWLLGLLIDRRGYAVVLIANFVAGGMAIAGISVFHAFPVPALACIAFAGFCVLGG
HHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
QSGLNALAVVLYPSAARATGAGWALGVGRLGAVLGPVAGGYLMAMTWTAEQTLIASALPA
CCCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHH
VAAAVAVGMLGRLRRQGAASVAQTAA
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AASSDEAVLSVFDTRPMGRLQWLALSLCGLCMVVDGYDVQAMAYAAPALMKTWGIERTV
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCHHH
LGPVFSAGLLGMFAGSLLLAGLADRIGRRPLLVAASMWVAGCMAVTAHAGSLDQLIAIRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AAGVGMGAIVPNAMSLAGEYSPSRLRITLMMAVSSGYIAGGVLGGAVAAFVIETFGWRGV
HHCCCCHHHCCHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCH
FDVGALLTAILSVAMWMVLPESIQFALARRPGRPQTLRLLQRAVPNATLPPGFRTERPDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
QPAVATLFGEGRAVATPLLWGANFANMLCAYFLAAWIPLLMAGNGASPGMPVLAGTALWL
CCCEEEEECCCCEEECHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
GGLLGNWLLGLLIDRRGYAVVLIANFVAGGMAIAGISVFHAFPVPALACIAFAGFCVLGG
HHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
QSGLNALAVVLYPSAARATGAGWALGVGRLGAVLGPVAGGYLMAMTWTAEQTLIASALPA
CCCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHH
VAAAVAVGMLGRLRRQGAASVAQTAA
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]