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The map label for this gene is emrA [H]

Identifier: 78066115

GI number: 78066115

Start: 1629703

End: 1630917

Strand: Reverse

Name: emrA [H]

Synonym: Bcep18194_A4645

Alternate gene names: 78066115

Gene position: 1630917-1629703 (Counterclockwise)

Preceding gene: 78066116

Following gene: 78066114

Centisome position: 44.15

GC content: 65.6

Gene sequence:

>1215_bases
ATGAGCGACCAACAAAACGCCGCCGGCGCGCAGCCGCAGAACAACGGCAAGCGCAAACGGATGATGACGCTGCTCATCGC
GGTCATCGTGATCGCGGCCATCGCGTATGGCCTGTACTACTTCCTCGTCGCCCGCTTCCATGAAGGGACCGACGACGCGT
ACGTGAACGGCAACGTCGTGCAGATCACGCCGCAAGTCACCGGCACCGTGATCGCGGTGAAGGCCGACGATACGCAAACG
GTCAAGGCCGGCGATCCGCTCGTCGTGCTCGACCCGGCCGACTCGCAGGTCGCGCTGCAGCAGGCCGAAGCCAATCTCGC
ACAAACGGTGCGCCAGGTGCGCGGCCTGTTCGTCAACGATGATCAGTACCGCGCTCAGGTCGCGCTGCGCCAGTCCGACC
TGTCGAAGGCCGAGGACGACCTCCGCCGCCGCGTGGCCGTCGCACAGACGGGCGCCGTGTCGCAGGAAGAAATCTCGCAC
GCTCGCGACGCCGTTCGCGCCGCCCAGGCATCGCTTGACGCCTCACAGCAGCAACTCGCATCGAACCGCGCGCTGACCGC
CAACACGACGATCGCCTCGCATCCGAACGTGATGGCTGCGGCCGCGAAGGTTCGCGACGCGTACCTGGCAAACGCGCGTA
ACGTGCTGCCCGCGCCGGTCACCGGCTATGTCGCGAAGCGCTCGGTGCAGGTCGGCCAGCGCGTGTCGCCAGGCACGCCG
CTGATGTCGGTGGTGCCGCTGAACGCAGTGTGGGTCGATGCGAACTTCAAGGAAGTGCAGCTCAAGCACATGCGCATCGG
CCAGCCGGTCGAACTGACGGCCGACATCTATGGCTCGTCGGCGGTCTACCACGGCAAGGTGGTCGGCTTCTCGGCCGGTA
CGGGCTCGGCATTCTCGCTGCTGCCCGCGCAGAACGCGACGGGTAACTGGATCAAGGTCGTGCAGCGCCTGCCGGTGCGG
ATCGAACTCGATCCGAAGGATCTCGACAAGCACCCGTTGCGCATTGGCCTGTCGATGCAGGTCGACGTGGACATCAAGGA
CGAACGCGGCGACCAGCTCGTGAACGCGCCGAACACCGTCTACGAGACCAACGTGTTCGCGAAGTACGGCGACGAAGCCG
ATGCCGAAATCGCCCGCGTCATTGCCGAGAACGCAGGCAGCAACGCATCGGCGCCGGCCGCGTCGAAGTCGAATGCCGTC
GCGAAGATGATGTAA

Upstream 100 bases:

>100_bases
CTCGCCGCACCCGATGCCGACAAGCCGACAAAACAGGCCGCCAACTGATCCGGCGCCACCACTACGCAGACACTCGAAAT
AACGGACGGAGAAAATCGCC

Downstream 100 bases:

>100_bases
CCGTTCCGACTCCGGAAAAACAACCGACATGGCACAGGCTCCTGTCTCTCACCCGCCCTTGCAGGGCGGGCAACTCGTGA
TCGGGACGATCGCGGTATCG

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSDQQNAAGAQPQNNGKRKRMMTLLIAVIVIAAIAYGLYYFLVARFHEGTDDAYVNGNVVQITPQVTGTVIAVKADDTQT
VKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRQSDLSKAEDDLRRRVAVAQTGAVSQEEISH
ARDAVRAAQASLDASQQQLASNRALTANTTIASHPNVMAAAAKVRDAYLANARNVLPAPVTGYVAKRSVQVGQRVSPGTP
LMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSAVYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPVR
IELDPKDLDKHPLRIGLSMQVDVDIKDERGDQLVNAPNTVYETNVFAKYGDEADAEIARVIAENAGSNASAPAASKSNAV
AKMM

Sequences:

>Translated_404_residues
MSDQQNAAGAQPQNNGKRKRMMTLLIAVIVIAAIAYGLYYFLVARFHEGTDDAYVNGNVVQITPQVTGTVIAVKADDTQT
VKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRQSDLSKAEDDLRRRVAVAQTGAVSQEEISH
ARDAVRAAQASLDASQQQLASNRALTANTTIASHPNVMAAAAKVRDAYLANARNVLPAPVTGYVAKRSVQVGQRVSPGTP
LMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSAVYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPVR
IELDPKDLDKHPLRIGLSMQVDVDIKDERGDQLVNAPNTVYETNVFAKYGDEADAEIARVIAENAGSNASAPAASKSNAV
AKMM
>Mature_403_residues
SDQQNAAGAQPQNNGKRKRMMTLLIAVIVIAAIAYGLYYFLVARFHEGTDDAYVNGNVVQITPQVTGTVIAVKADDTQTV
KAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRQSDLSKAEDDLRRRVAVAQTGAVSQEEISHA
RDAVRAAQASLDASQQQLASNRALTANTTIASHPNVMAAAAKVRDAYLANARNVLPAPVTGYVAKRSVQVGQRVSPGTPL
MSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSAVYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPVRI
ELDPKDLDKHPLRIGLSMQVDVDIKDERGDQLVNAPNTVYETNVFAKYGDEADAEIARVIAENAGSNASAPAASKSNAVA
KMM

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=354, Percent_Identity=52.5423728813559, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1788711, Length=377, Percent_Identity=43.7665782493369, Blast_Score=323, Evalue=8e-90,
Organism=Escherichia coli, GI1790519, Length=317, Percent_Identity=31.5457413249211, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081951, Length=317, Percent_Identity=28.391167192429, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789637, Length=317, Percent_Identity=26.4984227129338, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43218; Mature: 43087

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQQNAAGAQPQNNGKRKRMMTLLIAVIVIAAIAYGLYYFLVARFHEGTDDAYVNGNVV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEE
QITPQVTGTVIAVKADDTQTVKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVND
EEECCCCEEEEEEECCCCCEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEECC
DQYRAQVALRQSDLSKAEDDLRRRVAVAQTGAVSQEEISHARDAVRAAQASLDASQQQLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
SNRALTANTTIASHPNVMAAAAKVRDAYLANARNVLPAPVTGYVAKRSVQVGQRVSPGTP
CCCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
LMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSAVYHGKVVGFSAGTGSAFSL
CEEEEECEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCEEEECEEEEEECCCCCEEEE
LPAQNATGNWIKVVQRLPVRIELDPKDLDKHPLRIGLSMQVDVDIKDERGDQLVNAPNTV
ECCCCCCCHHHHHHHHCCCEEEECHHCCCCCCEEEEEEEEEEEEECCCCCCEEECCCCCE
YETNVFAKYGDEADAEIARVIAENAGSNASAPAASKSNAVAKMM
EECCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure 
SDQQNAAGAQPQNNGKRKRMMTLLIAVIVIAAIAYGLYYFLVARFHEGTDDAYVNGNVV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEE
QITPQVTGTVIAVKADDTQTVKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVND
EEECCCCEEEEEEECCCCCEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEECC
DQYRAQVALRQSDLSKAEDDLRRRVAVAQTGAVSQEEISHARDAVRAAQASLDASQQQLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
SNRALTANTTIASHPNVMAAAAKVRDAYLANARNVLPAPVTGYVAKRSVQVGQRVSPGTP
CCCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
LMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSAVYHGKVVGFSAGTGSAFSL
CEEEEECEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCEEEECEEEEEECCCCCEEEE
LPAQNATGNWIKVVQRLPVRIELDPKDLDKHPLRIGLSMQVDVDIKDERGDQLVNAPNTV
ECCCCCCCHHHHHHHHCCCEEEECHHCCCCCCEEEEEEEEEEEEECCCCCCEEECCCCCE
YETNVFAKYGDEADAEIARVIAENAGSNASAPAASKSNAVAKMM
EECCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]