Click here to switch to the map view.

The map label for this gene is fsr [H]

Identifier: 78066059

GI number: 78066059

Start: 1567625

End: 1568863

Strand: Reverse

Name: fsr [H]

Synonym: Bcep18194_A4588

Alternate gene names: 78066059

Gene position: 1568863-1567625 (Counterclockwise)

Preceding gene: 78066062

Following gene: 78066056

Centisome position: 42.47

GC content: 66.34

Gene sequence:

>1239_bases
ATGGAAACCAGCCTCGACACCGGCTCCGCCGGCGCAGCCGCCACCCAGCCGTCCGCGCCCCCCGTCGCCCGCACCGTGTA
CCCGGTGCTCGGCGCGATCAGCTTCTCGCACATGCTCAACGACATGATCCAGTCGTTGATCCTCGCGATCTATCCGATGC
TCAAGAGCCAGTTCGCGCTGTCGTTCGCGCAGATCGGCCTGATCACGCTCACCTACCAGATCACCGCATCGCTGCTGCAG
CCGCTCATCGGCCTCTATACCGACAAGCGTCCGAAACCGTATTCGCTGCCGGTCGGCATGGGCTTCACGCTCGCGGGGCT
GCTGCTGATGTCGGTCGCGACGAGTTTCCCGATGCTGCTGGTGGCCGCCGCGCTCGTCGGCTGCGGCTCGTCGGTGTTCC
ATCCCGAATCGTCGCGCGTCGCGCGGATGGCGTCGGGCGGCCAGCACGGGCTCGCGCAGTCGGTGTTCCAGGTTGGCGGC
AATGCGGGTTCAGCACTCGGGCCGCTGCTTGCCGCACTCGTGATCATTCCGCACGGCCAGCACAGCATCGCGTGGTTCTC
GGCGGCCGCGCTCGTCGCGATGATCGTGCTCACGCAGATCGGCCACTGGTACAAGAAGCATCCGTCGATGAAGAAGAAGG
CCGCGGCGGCCGGCCACCCGACGCTGTCGCGCGGCCGCGTGATGGGCGCGATCGGCGTGCTGGTGCTGCTCGTGTTCTCG
AAGTACTTCTACCTCGCGAGCATCAACAGCTATTTCACGTTCTACCTGATCGACAAGTTCCACCTGTCGGTGCAGGCCGC
GCAGATCCACCTGTTCGTGTTCCTCGCGGCCGTGGCGGCCGGCACGCTGATCGGCGGCCCGGTGGGCGACCGGATCGGCC
GCAAGTACGTGATCTGGGTATCGATCCTCGGCGTCGCACCGTTCACGCTGCTGCTGCCGTACGCTAACCTGTTCTGGACC
AGCGTGCTGACGGTGATCATCGGCATCGTGCTCGCGTCGGCATTCGCCGCGATCCTGGTCTACGCGACGGAACTGATGCC
CGGCAAGGTCGGGATGGTCGCGGGCCTGTTCTTCGGCTTCGCGTTCGGCCTCGGCGGAGTCGGCGCGGCCGTGCTCGGCC
AGCTCGCCGACGCGACGAGCATCACGTTCGTCTACAAGGTGTGCTCGTTCCTGCCGCTGATCGGCGTGCTGACGGTGTTC
CTGCCGAACCTCGAAAGCAGCCGGCGCAAGAAGGCGTGA

Upstream 100 bases:

>100_bases
TCTCGATACGCCACATTACACTTCTTTGACGCAGCAACGATTCAAGACGCGCCACTCCCCAGCAGCGCGCGCCCGCCACC
TCAACTCGTTCAGCTCTCAC

Downstream 100 bases:

>100_bases
CGAGCCGGCCGCGGCGTGCGCGCCGCGGCCGGTCGAATGGCTTGAATGAAGGAATGAAGAAAACGGCGGCGGCTTCAGGC
CGCCGTCGTTGCATGCAGCG

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
METSLDTGSAGAAATQPSAPPVARTVYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLLQ
PLIGLYTDKRPKPYSLPVGMGFTLAGLLLMSVATSFPMLLVAAALVGCGSSVFHPESSRVARMASGGQHGLAQSVFQVGG
NAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMIVLTQIGHWYKKHPSMKKKAAAAGHPTLSRGRVMGAIGVLVLLVFS
KYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTLLLPYANLFWT
SVLTVIIGIVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSITFVYKVCSFLPLIGVLTVF
LPNLESSRRKKA

Sequences:

>Translated_412_residues
METSLDTGSAGAAATQPSAPPVARTVYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLLQ
PLIGLYTDKRPKPYSLPVGMGFTLAGLLLMSVATSFPMLLVAAALVGCGSSVFHPESSRVARMASGGQHGLAQSVFQVGG
NAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMIVLTQIGHWYKKHPSMKKKAAAAGHPTLSRGRVMGAIGVLVLLVFS
KYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTLLLPYANLFWT
SVLTVIIGIVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSITFVYKVCSFLPLIGVLTVF
LPNLESSRRKKA
>Mature_412_residues
METSLDTGSAGAAATQPSAPPVARTVYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLLQ
PLIGLYTDKRPKPYSLPVGMGFTLAGLLLMSVATSFPMLLVAAALVGCGSSVFHPESSRVARMASGGQHGLAQSVFQVGG
NAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMIVLTQIGHWYKKHPSMKKKAAAAGHPTLSRGRVMGAIGVLVLLVFS
KYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTLLLPYANLFWT
SVLTVIIGIVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSITFVYKVCSFLPLIGVLTVF
LPNLESSRRKKA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=403, Percent_Identity=66.5012406947891, Blast_Score=498, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43370; Mature: 43370

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]