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The map label for this gene is glmS [H]

Identifier: 78065934

GI number: 78065934

Start: 1423363

End: 1425180

Strand: Reverse

Name: glmS [H]

Synonym: Bcep18194_A4463

Alternate gene names: 78065934

Gene position: 1425180-1423363 (Counterclockwise)

Preceding gene: 78065935

Following gene: 78065932

Centisome position: 38.58

GC content: 65.51

Gene sequence:

>1818_bases
ATGTGTGGCATCGTCGGCGCGGTCGCGCAACGGGACATCGTCCCGATTCTGATTGAAGGTTTGCGTCGCCTCGAGTATCG
CGGCTACGATTCATGCGGCGTGGCGACGGTCGTCGACGGCCAGGCGCGTCGCGAACGCAGCGTGTCGCGCGTCGCCGATC
TCGACGCGCACGTGCGCACCGCCGGCCTGACCGGCAGCACCGGCATCGCGCACACGCGCTGGGCGACACACGGCGCGCCG
GCAACCTGCAACGCGCATCCGATCTTCTCGCGCGATGAAATCGCGCTCGTGCACAACGGCATCATCGAAAACCACGAAAC
GTTGCGCAAGCAACTTTCCGACGAGCACTACGAATTCGATGGCCAGACCGACACCGAGGTCGTCGCGCACCTGATCCACA
GCAAGTACCGCGGCGACCTGCTCGCCGCCGTGCGCGCGGCAACTTCACAGCTTCACGGCGCGTACGCGATCGCCGTGTTC
AGCAAGCACGAGCCGCAACGGCTGATCGGCGCGAAGGTCGGCTCACCGCTCGTCGTCGGCGTGAAGGACGGCGAATGCTT
TCTCGCCTCCGACGCGCTCGCGCTCGCCGGCATCACCGACCGCTTCATCTTTCTCGAGGAAGGCGACATCGTCGAGTTGA
CGCCTGGCGGCGTGCGCGTACTCGATCGCGGCGGCGCACCCGTCGAGCGCGCGGTGCAAACCATTTCCTCCGCGCAGGCC
GCGGTCGAACTCGGGCCGTACCGGCATTTCATGCAGAAGGAGATTTTCGAGCAACCGGAGGCCGTGGCCGCGACCATCCC
CGATGCGGGGCTGTTCGATCCGGCCGTATTCGGCCCGGACGCGGCACGGGCGTTCGAGCAGATCGACAACGTGCTGATTC
TTGCGTGCGGCACGAGTCACTATTCCGGCCTGACCGCGCGCCGCTGGCTTGAAACTATTGCGCGCGTGCCCGCGCAGGTC
GAGATTGCGAGCGAATACCGTTACAGTGACGCGCTCGCGACGCCGAATACGCTGGTGGTGAGCGTGTCGCAATCCGGCGA
GACCGCCGACACGCTCGCCGCGCTCAAGTACGCGCAGGCGCTCGGCCATATCGACACCTTGGCGATCTGCAACGTGCCGA
CCAGCGCGATGATGCGGCAGACCGGCCTGCGCTTCCTGACCCGGGCCGGCCCGGAAATCGGTGTCGCGTCCACCAAGGCG
TTCACGACGCAGCTCGTCGCGCTGTTCATTCTCGCCGTCACGCTCGGGAGGCTGCGCGGCTATGTCGACGATGCGCAGCT
TGCGCGCTATACGATGCAACTGCGGCGGCTGCCTGGCGCGCTCGAGGATGTGCTCGGGCTCGAACCGCAGATCGAGCGCT
GGGCGGCGGAATTCTCGCAACACGAGAATGCGCTGTTTCTCGGGCGCGGGCTGCACTACCCGATCGCGCTGGAAGGTGCG
CTGAAGCTGAAGGAGATTTCGTATATCCACGCGGAGGCGTATCCCGCGGGTGAGTTGAAGCATGGGCCGCTCGCGCTCGT
GACGCACACGATGCCTGTGGCGACGATTGCGCCGAACGACGCGCTGCTCGAAAAGCTGAAGTCGAACATGCAGGAAGTGC
GGGCGCGCGGCGGGCAGCTTTATGTGTTCGCCGATGCCGATACGCGGATCGACAACAGTGAAGGCGTGTCGGTGCTGCGG
ATGCCGGATTACTACGGGTTGTTGTCGCCGATCCTGCACGTGGTGCCGTTGCAGTTGCTCGCGTATCACGCGGCGTGTCT
GCGTGGCGCGGATATCGACAAGCCGAGGAATCTGGCGAAATCGGTGACGGTCGAGTGA

Upstream 100 bases:

>100_bases
CGCTCGATGCGGATTCACGACGGCGGCGGCAACGGCGACCGCATCGCGCTGATGCAACGGTGCGCGCGGTCCATGATGAC
TAACAGGGAGGTGACGTGTC

Downstream 100 bases:

>100_bases
CGGGGTTGGGTAACCCGGGGCGGACTGGGGAAGGTCTTCGAGGGATCTAACTGGCCCGCCCTACACGATTCGAACGTGTG
ACCTACGGCTTAGAAGGCCG

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSVSRVADLDAHVRTAGLTGSTGIAHTRWATHGAP
ATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFDGQTDTEVVAHLIHSKYRGDLLAAVRAATSQLHGAYAIAVF
SKHEPQRLIGAKVGSPLVVGVKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRGGAPVERAVQTISSAQA
AVELGPYRHFMQKEIFEQPEAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSHYSGLTARRWLETIARVPAQV
EIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQALGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKA
FTTQLVALFILAVTLGRLRGYVDDAQLARYTMQLRRLPGALEDVLGLEPQIERWAAEFSQHENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQLYVFADADTRIDNSEGVSVLR
MPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAKSVTVE

Sequences:

>Translated_605_residues
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSVSRVADLDAHVRTAGLTGSTGIAHTRWATHGAP
ATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFDGQTDTEVVAHLIHSKYRGDLLAAVRAATSQLHGAYAIAVF
SKHEPQRLIGAKVGSPLVVGVKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRGGAPVERAVQTISSAQA
AVELGPYRHFMQKEIFEQPEAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSHYSGLTARRWLETIARVPAQV
EIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQALGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKA
FTTQLVALFILAVTLGRLRGYVDDAQLARYTMQLRRLPGALEDVLGLEPQIERWAAEFSQHENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQLYVFADADTRIDNSEGVSVLR
MPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAKSVTVE
>Mature_605_residues
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSVSRVADLDAHVRTAGLTGSTGIAHTRWATHGAP
ATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFDGQTDTEVVAHLIHSKYRGDLLAAVRAATSQLHGAYAIAVF
SKHEPQRLIGAKVGSPLVVGVKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRGGAPVERAVQTISSAQA
AVELGPYRHFMQKEIFEQPEAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSHYSGLTARRWLETIARVPAQV
EIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQALGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKA
FTTQLVALFILAVTLGRLRGYVDDAQLARYTMQLRRLPGALEDVLGLEPQIERWAAEFSQHENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQLYVFADADTRIDNSEGVSVLR
MPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=36.4963503649635, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=35.7142857142857, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=53.2679738562092, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=239, Percent_Identity=27.6150627615063, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=718, Percent_Identity=33.2869080779944, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17532899, Length=444, Percent_Identity=36.9369369369369, Blast_Score=265, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17532897, Length=444, Percent_Identity=36.9369369369369, Blast_Score=265, Evalue=7e-71,
Organism=Saccharomyces cerevisiae, GI6322745, Length=462, Percent_Identity=37.6623376623377, Blast_Score=276, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=32.0185614849188, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=34.4660194174757, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323958, Length=373, Percent_Identity=24.9329758713137, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=35.0290697674419, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI28573187, Length=257, Percent_Identity=25.6809338521401, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24659598, Length=256, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65419; Mature: 65419

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSVSRVADLDAHVRT
CCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHEE
AGLTGSTGIAHTRWATHGAPATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHCCHHHHHHHHCCCCEECC
GQTDTEVVAHLIHSKYRGDLLAAVRAATSQLHGAYAIAVFSKHEPQRLIGAKVGSPLVVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCCCCEEEE
VKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRGGAPVERAVQTISSAQA
ECCCCEEEECCCHHHHCCCEEEEEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHH
AVELGPYRHFMQKEIFEQPEAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSH
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCC
YSGLTARRWLETIARVPAQVEIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQA
CCCHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
LGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKAFTTQLVALFILAVTLGRLRG
HCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
YVDDAQLARYTMQLRRLPGALEDVLGLEPQIERWAAEFSQHENALFLGRGLHYPIALEGA
CCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEECCC
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQL
EEHHHHHEEEECCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCEE
YVFADADTRIDNSEGVSVLRMPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAK
EEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
SVTVE
HCCCC
>Mature Secondary Structure
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSVSRVADLDAHVRT
CCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHEE
AGLTGSTGIAHTRWATHGAPATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHCCHHHHHHHHCCCCEECC
GQTDTEVVAHLIHSKYRGDLLAAVRAATSQLHGAYAIAVFSKHEPQRLIGAKVGSPLVVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCCCCEEEE
VKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRGGAPVERAVQTISSAQA
ECCCCEEEECCCHHHHCCCEEEEEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHH
AVELGPYRHFMQKEIFEQPEAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSH
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCC
YSGLTARRWLETIARVPAQVEIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQA
CCCHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
LGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKAFTTQLVALFILAVTLGRLRG
HCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
YVDDAQLARYTMQLRRLPGALEDVLGLEPQIERWAAEFSQHENALFLGRGLHYPIALEGA
CCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEECCC
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQL
EEHHHHHEEEECCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCEE
YVFADADTRIDNSEGVSVLRMPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAK
EEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
SVTVE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]