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The map label for this gene is pepQ [H]

Identifier: 78065077

GI number: 78065077

Start: 473232

End: 475046

Strand: Direct

Name: pepQ [H]

Synonym: Bcep18194_A3601

Alternate gene names: 78065077

Gene position: 473232-475046 (Clockwise)

Preceding gene: 78065076

Following gene: 78065078

Centisome position: 12.81

GC content: 70.25

Gene sequence:

>1815_bases
ATGAATGCCCGTCTTCCCGAAGTCTCGCCGGTGCCGGCCCGCCTCGCGCTGCTGCGTGGCGCCATGGCCCGCGAGGACCT
GGCCGCCTATCTCGTGCCGTCCGCCGATCCCCATCTGTCCGAGTACCTGCCGGAGCGCTGGCAGGCCCGCCGCTGGCTGT
CCGGCTTCACGGGCTCGGTCGGCACGCTGGTCGTGACCGCGGATTTCGCGGGGTTGTGGGTCGACAGCCGCTACTGGGTG
CAGGCCGATGCCGAACTGGCCGGCACGGGCGTGCAACTGATGAAGATGACGGGCGGGCAGCAGAGCGCGCCGCACGTCGA
CTGGCTCGCGCAGAACGTGGTGGCCGGTGCGACGGTCGGCGTCGACGGCGCCGTGCTCGGCGTCGCGGCCGCACGCGGGC
TGACGAGCGCGCTGAACGCACGCGGCATCGCGCTGCGCACCGACCTCGACCTGCTCGACGCGATCTGGCCCGAGCGGCCG
GGTCTGCCCGGCGACGCGGTGTTCGAGCACACGGCGCCGCAGGCCGACACGACGCGCGCGAGCAAGCTGGCCGAAGTGCG
CCGCGCGATGCACGCGCAGGGTGCGCAATGGCATTTCGTGTCGACGCTCGACGACCTCGCATGGCTGTTCAACCTGCGCG
GCGCCGACGTCAACTTCAATCCCGTATTCGTTGCGCACGCAATGATCGGCGCCGATCGCGCGACGCTGTTCGTCGCCGAC
GGCAAGGTGTCGCCGGCGCTGGCCGCATCGCTCGCGAAGGATGGCGTCGACGTTCGCGCCTACGACGCCGCGCGCGCCGC
GCTTGCGGCGCTGCCTGACGGCGCGACGCTGCTGATCGACCCGCGCCGCGTGACGTTCGGCACGCTCGAGGCCGTGCCGG
CCGGCGTGAAGCTCGTCGAGGCCGTGAATCCGTCGACGTTCGCGAAGTCGCGCAAGACGTCCGCGGAGATCGAGCACGTG
CGCGTGACGATGGAACACGACGGCGCAGCACTCGCGGAATTCTTCACGTGGTTCGAGCAGGCCGTGAACCGCGAGACGAT
CACCGAGCTGACGATCGAGGAAAAACTCACGGCCGCACGTGCGCGGCGCCCCGGCTACGTGTCGGCGAGCTTCGCGACGA
TCGCCGGTTTCAACGCGAACGGTGCGATGCCGCACTACCACGCGACGCCGGAGTCGCACGCGACGATCGCCGGCGACGGC
CTGCTGCTGATCGATTCGGGCGGCCAGTACGTGACGGGTACGACCGACATCACGCGCGTCGTGCCGGTCGGCACCGTCAG
CGACCTGCAGCGGCGCGATTTCACGATCGTGCTGAAGTCGATGATGGCGCTGTCGCGCGCCCGCTTCCCGCGCGGCATCC
GCTCGCCGATGCTCGACGCGATCGCGCGCGCACCGATGTGGGCGGCTGGGCTCGACTACGGCCACGGCACGGGGCACGGC
GTCGGCTACTTCCTGAACGTGCACGAAGGCCCGCAGGTGATCTCGCACTACGCGCCGGCCGAGCCGCACACGGCGATGGA
AGAGGGCATGATCACGTCGATCGAGCCGGGCGTGTACCGTCCCGGCCAGTGGGGCATCCGGATCGAGAACCTGGTCGTGA
ACCGCGCGGCCGGGCAGACGGAATTCGGCGATTTCCTCGCGTTCGAGACCCTGACGCTGTGCCCGATCGACACGCGCTGC
GTGCTGATCGAGATGCTGCACGACGACGAGCGCGCGTGGCTGAACACGTATCACGCGACGGTGCGTGAGCGCGTCGGCCG
GCACCTGAGCGGCGATGCGAAGGCGTGGCTCGACGCACGCACGCAGCCGATCTGA

Upstream 100 bases:

>100_bases
CGAGACGCTCGAATGGCCGGTCTGCACCGGTGTCGCGTTCCTCGTCGTAGCCGTGACGGTTGCGCTGTCGGCCCGTCGCT
GAATGTTCTCAGGTGAAATC

Downstream 100 bases:

>100_bases
CACGACAAGCGATAACGGCCGGACCACGGCCGAGCGACACAACCGAGGGCAAGCAATGGCAGGCACCGCAGTGATCGTGG
TCGACATGCAGCGCGGGCTG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MNARLPEVSPVPARLALLRGAMAREDLAAYLVPSADPHLSEYLPERWQARRWLSGFTGSVGTLVVTADFAGLWVDSRYWV
QADAELAGTGVQLMKMTGGQQSAPHVDWLAQNVVAGATVGVDGAVLGVAAARGLTSALNARGIALRTDLDLLDAIWPERP
GLPGDAVFEHTAPQADTTRASKLAEVRRAMHAQGAQWHFVSTLDDLAWLFNLRGADVNFNPVFVAHAMIGADRATLFVAD
GKVSPALAASLAKDGVDVRAYDAARAALAALPDGATLLIDPRRVTFGTLEAVPAGVKLVEAVNPSTFAKSRKTSAEIEHV
RVTMEHDGAALAEFFTWFEQAVNRETITELTIEEKLTAARARRPGYVSASFATIAGFNANGAMPHYHATPESHATIAGDG
LLLIDSGGQYVTGTTDITRVVPVGTVSDLQRRDFTIVLKSMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPHTAMEEGMITSIEPGVYRPGQWGIRIENLVVNRAAGQTEFGDFLAFETLTLCPIDTRC
VLIEMLHDDERAWLNTYHATVRERVGRHLSGDAKAWLDARTQPI

Sequences:

>Translated_604_residues
MNARLPEVSPVPARLALLRGAMAREDLAAYLVPSADPHLSEYLPERWQARRWLSGFTGSVGTLVVTADFAGLWVDSRYWV
QADAELAGTGVQLMKMTGGQQSAPHVDWLAQNVVAGATVGVDGAVLGVAAARGLTSALNARGIALRTDLDLLDAIWPERP
GLPGDAVFEHTAPQADTTRASKLAEVRRAMHAQGAQWHFVSTLDDLAWLFNLRGADVNFNPVFVAHAMIGADRATLFVAD
GKVSPALAASLAKDGVDVRAYDAARAALAALPDGATLLIDPRRVTFGTLEAVPAGVKLVEAVNPSTFAKSRKTSAEIEHV
RVTMEHDGAALAEFFTWFEQAVNRETITELTIEEKLTAARARRPGYVSASFATIAGFNANGAMPHYHATPESHATIAGDG
LLLIDSGGQYVTGTTDITRVVPVGTVSDLQRRDFTIVLKSMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPHTAMEEGMITSIEPGVYRPGQWGIRIENLVVNRAAGQTEFGDFLAFETLTLCPIDTRC
VLIEMLHDDERAWLNTYHATVRERVGRHLSGDAKAWLDARTQPI
>Mature_604_residues
MNARLPEVSPVPARLALLRGAMAREDLAAYLVPSADPHLSEYLPERWQARRWLSGFTGSVGTLVVTADFAGLWVDSRYWV
QADAELAGTGVQLMKMTGGQQSAPHVDWLAQNVVAGATVGVDGAVLGVAAARGLTSALNARGIALRTDLDLLDAIWPERP
GLPGDAVFEHTAPQADTTRASKLAEVRRAMHAQGAQWHFVSTLDDLAWLFNLRGADVNFNPVFVAHAMIGADRATLFVAD
GKVSPALAASLAKDGVDVRAYDAARAALAALPDGATLLIDPRRVTFGTLEAVPAGVKLVEAVNPSTFAKSRKTSAEIEHV
RVTMEHDGAALAEFFTWFEQAVNRETITELTIEEKLTAARARRPGYVSASFATIAGFNANGAMPHYHATPESHATIAGDG
LLLIDSGGQYVTGTTDITRVVPVGTVSDLQRRDFTIVLKSMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPHTAMEEGMITSIEPGVYRPGQWGIRIENLVVNRAAGQTEFGDFLAFETLTLCPIDTRC
VLIEMLHDDERAWLNTYHATVRERVGRHLSGDAKAWLDARTQPI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=612, Percent_Identity=36.7647058823529, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI264681565, Length=612, Percent_Identity=34.9673202614379, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI93141226, Length=606, Percent_Identity=33.1683168316832, Blast_Score=335, Evalue=7e-92,
Organism=Escherichia coli, GI1788728, Length=179, Percent_Identity=35.7541899441341, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17509539, Length=594, Percent_Identity=33.3333333333333, Blast_Score=304, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI25149105, Length=615, Percent_Identity=27.3170731707317, Blast_Score=229, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6322999, Length=651, Percent_Identity=30.7219662058372, Blast_Score=288, Evalue=2e-78,
Organism=Drosophila melanogaster, GI17137632, Length=613, Percent_Identity=33.768352365416, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI161078230, Length=606, Percent_Identity=28.2178217821782, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI21357287, Length=606, Percent_Identity=28.2178217821782, Blast_Score=244, Evalue=9e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65112; Mature: 65112

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARLPEVSPVPARLALLRGAMAREDLAAYLVPSADPHLSEYLPERWQARRWLSGFTGSV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GTLVVTADFAGLWVDSRYWVQADAELAGTGVQLMKMTGGQQSAPHVDWLAQNVVAGATVG
EEEEEEECCCEEEECCEEEEEECCHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEC
VDGAVLGVAAARGLTSALNARGIALRTDLDLLDAIWPERPGLPGDAVFEHTAPQADTTRA
CCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHH
SKLAEVRRAMHAQGAQWHFVSTLDDLAWLFNLRGADVNFNPVFVAHAMIGADRATLFVAD
HHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCCCEEEEEEC
GKVSPALAASLAKDGVDVRAYDAARAALAALPDGATLLIDPRRVTFGTLEAVPAGVKLVE
CCCCHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCEEEECCCEEEECHHHHCCCCCEEEE
AVNPSTFAKSRKTSAEIEHVRVTMEHDGAALAEFFTWFEQAVNRETITELTIEEKLTAAR
CCCCHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
ARRPGYVSASFATIAGFNANGAMPHYHATPESHATIAGDGLLLIDSGGQYVTGTTDITRV
HCCCCCEEECCCEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCEEECCCCCEEE
VPVGTVSDLQRRDFTIVLKSMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCC
VGYFLNVHEGPQVISHYAPAEPHTAMEEGMITSIEPGVYRPGQWGIRIENLVVNRAAGQT
EEEEEEECCCHHHHHHCCCCCCCHHHHCCCEEECCCCCCCCCCCCEEEEEEEEECCCCCC
EFGDFLAFETLTLCPIDTRCVLIEMLHDDERAWLNTYHATVRERVGRHLSGDAKAWLDAR
CHHHHHHHHEEEECCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
TQPI
CCCC
>Mature Secondary Structure
MNARLPEVSPVPARLALLRGAMAREDLAAYLVPSADPHLSEYLPERWQARRWLSGFTGSV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GTLVVTADFAGLWVDSRYWVQADAELAGTGVQLMKMTGGQQSAPHVDWLAQNVVAGATVG
EEEEEEECCCEEEECCEEEEEECCHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEC
VDGAVLGVAAARGLTSALNARGIALRTDLDLLDAIWPERPGLPGDAVFEHTAPQADTTRA
CCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHH
SKLAEVRRAMHAQGAQWHFVSTLDDLAWLFNLRGADVNFNPVFVAHAMIGADRATLFVAD
HHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCCCEEEEEEC
GKVSPALAASLAKDGVDVRAYDAARAALAALPDGATLLIDPRRVTFGTLEAVPAGVKLVE
CCCCHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCEEEECCCEEEECHHHHCCCCCEEEE
AVNPSTFAKSRKTSAEIEHVRVTMEHDGAALAEFFTWFEQAVNRETITELTIEEKLTAAR
CCCCHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
ARRPGYVSASFATIAGFNANGAMPHYHATPESHATIAGDGLLLIDSGGQYVTGTTDITRV
HCCCCCEEECCCEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCEEECCCCCEEE
VPVGTVSDLQRRDFTIVLKSMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCC
VGYFLNVHEGPQVISHYAPAEPHTAMEEGMITSIEPGVYRPGQWGIRIENLVVNRAAGQT
EEEEEEECCCHHHHHHCCCCCCCHHHHCCCEEECCCCCCCCCCCCEEEEEEEEECCCCCC
EFGDFLAFETLTLCPIDTRCVLIEMLHDDERAWLNTYHATVRERVGRHLSGDAKAWLDAR
CHHHHHHHHEEEECCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
TQPI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]