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The map label for this gene is hisD

Identifier: 78065000

GI number: 78065000

Start: 389555

End: 390871

Strand: Direct

Name: hisD

Synonym: Bcep18194_A3523

Alternate gene names: 78065000

Gene position: 389555-390871 (Clockwise)

Preceding gene: 78064999

Following gene: 78065001

Centisome position: 10.55

GC content: 69.25

Gene sequence:

>1317_bases
ATGTCCATCACCATCCGCAAGCTCGATTCGACGAGCGCAGGCTTCGGCGCCGAGCTGCGCGCGCTGCTCGCATTCGAGGC
GAGCGAAGACGCGGCGATCGAGCAATCGGTCGCGCAGATCCTCGCCGACGTGAAGTCGCGCGGCGACGCCGCGGTGCTCG
AATACACGAACCGCTTCGACCGGCTGAGCGCGAGCAGCATTGCCGCGCTGGAGCTGCCGCAGGACGCGCTGCAGACGGCG
CTCGACAGCCTCGCGCCGAAGGCGCGCGCGGCGCTGGAGGCGGCGGCCGCGCGCGTGCGCGCGTACCACGAGAAGCAGAA
GATCGAGTGCGGCACGCATAGCTGGCAGTACACGGAAAGCGACGGCACGGTGCTCGGCCAGAAGGTCACGCCGCTCGACC
GCGTCGGCCTGTACGTGCCGGGCGGCAAGGCCGCGTATCCGTCGTCGGTGCTGATGAACGCGATTCCCGCGCGTGTCGCG
GGCGTCGGCGAGATCGTGATGGTCGTGCCGACGCCGGACGGCGTGAAGAACGATCTCGTGCTCGCCGCAGCGCTGCTCGG
CGGCGTCGATCGCGTGTTCACGATCGGCGGCGCGCAGGCGGTCGGTGCGCTCGCCTACGGCACGGCGACGGTGCCGGCCG
TCGACAAGATCTGCGGCCCCGGCAACGCGTACGTCGCGTCGGCGAAGCGCCGTGTGTTCGGCACGGTCGGCATCGACATG
ATCGCCGGCCCGTCGGAAATTCTCGTGCTGTGCGACGGCACGACCGATCCGAACTGGGTCGCGATGGACCTGTTCTCGCA
GGCCGAGCACGACGAACTCGCGCAATCGATCCTGCTGTGCCCGGACGGTGCGTTCCTCGAGCGCGTCGAAAAGGCGATCG
ACGAGCTGCTGCCGTCGATGCCGCGCCAGGACGTGATCCGCGCGTCGCTCGAAGGCCGCGGCGCGCTGATCAAGGTGCGC
GACATGGCCGAAGCCTGCCGGATCGCGAACGACATCGCGCCCGAGCACCTGGAAATTTCCGCGCTGGAGCCGCAGCAATG
GGGCCAGCAGATCCGCCATGCGGGCGCGATCTTCCTCGGCCGCTACACGAGCGAGAGCCTCGGCGACTACTGCGCGGGCC
CGAACCACGTGCTGCCGACGTCGCGCACCGCGCGTTTCTCGTCGCCGCTCGGCGTGTACGACTTCATCAAGCGCTCGAGC
CTGATCGAGGTCAGTGCGGAAGGTGCACAGACGCTCGGCGAGATCGCATCCGAGCTCGCGTACGGCGAGGGGCTGCAGGC
GCACGCGAAGAGCGCCGAGTTCCGGATGAAGCACTGA

Upstream 100 bases:

>100_bases
TGCGCTGAAGTTGAAGCGCACGGCACTCAAGCCGATCCTCGACGCGTTCGAACGCGCGTCGCAGAATGGCGGTTGAGCGC
ATCACCGTAACGGAACTCCC

Downstream 100 bases:

>100_bases
CCACCCGCTGCGCGGGGCCGCGGCCGGCGCTGACGTGCCGCCCGGCCCGCTCCCGAAGGCCGGGGCTGGAGACACCTGAG
CAGGGCGGCAGCCGCCGCCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSITIRKLDSTSAGFGAELRALLAFEASEDAAIEQSVAQILADVKSRGDAAVLEYTNRFDRLSASSIAALELPQDALQTA
LDSLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTESDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDGAFLERVEKAIDELLPSMPRQDVIRASLEGRGALIKVR
DMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSAEGAQTLGEIASELAYGEGLQAHAKSAEFRMKH

Sequences:

>Translated_438_residues
MSITIRKLDSTSAGFGAELRALLAFEASEDAAIEQSVAQILADVKSRGDAAVLEYTNRFDRLSASSIAALELPQDALQTA
LDSLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTESDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDGAFLERVEKAIDELLPSMPRQDVIRASLEGRGALIKVR
DMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSAEGAQTLGEIASELAYGEGLQAHAKSAEFRMKH
>Mature_437_residues
SITIRKLDSTSAGFGAELRALLAFEASEDAAIEQSVAQILADVKSRGDAAVLEYTNRFDRLSASSIAALELPQDALQTAL
DSLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTESDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAG
VGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDMI
AGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDGAFLERVEKAIDELLPSMPRQDVIRASLEGRGALIKVRD
MAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSL
IEVSAEGAQTLGEIASELAYGEGLQAHAKSAEFRMKH

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=438, Percent_Identity=39.9543378995434, Blast_Score=281, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6319819, Length=409, Percent_Identity=34.718826405868, Blast_Score=230, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46414; Mature: 46283

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIRKLDSTSAGFGAELRALLAFEASEDAAIEQSVAQILADVKSRGDAAVLEYTNRFD
CCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RLSASSIAALELPQDALQTALDSLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTES
HCCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDGAFLERVEKAIDELLPSM
ECCCCEEEEEECCCCCCCEEEHHHHHCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHCC
PRQDVIRASLEGRGALIKVRDMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSAEGAQTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHH
YGEGLQAHAKSAEFRMKH
HCCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SITIRKLDSTSAGFGAELRALLAFEASEDAAIEQSVAQILADVKSRGDAAVLEYTNRFD
CEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RLSASSIAALELPQDALQTALDSLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTES
HCCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDGAFLERVEKAIDELLPSM
ECCCCEEEEEECCCCCCCEEEHHHHHCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHCC
PRQDVIRASLEGRGALIKVRDMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSAEGAQTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHH
YGEGLQAHAKSAEFRMKH
HCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA